maxxipaws maxxiSAMe SAM-e Supplement for Dogs, 5.3-oz

Skip image gallery
Slide 1 of 12

At a Glance

  • Non-GMO
  • Brain Health
  • All Lifestages
  • All Breeds
$44.89 First Time Autoship Price
this order
Save 50% (up to $20) today when you set up Autoship. 
$61.65 Autoship Price
(-5%) future orders
  • Keep saving 5% on every order
  • Get deliveries on your schedule
  • Skip, change, or cancel anytime
$64.89 Chewy Price
($12.25 /oz)
Save $11.85 (-15%)
$76.74 List Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card + Free Shipping with code: WELCOME
Promo, Buy select food, Get 20% off select supplements
In Stock
FREE 1-3 day delivery
Free 365-day returns

No interest if paid in full in 6 months on PayPal purchases of $149+. .

About This Item

Details

  • Made in the USA with the highest quality, wholesome ingredients available and lab-tested for purity and potency.
  • Contains a proprietary and potent blend of essential vitamins, including B6 and B12, as well as thiamine and riboflavin.
  • Easy and all-natural way to give pets the S-adenosylmethionine that they need for optimal liver and brain functioning.
  • Easy-to-use powder allows for more accurate dosing, faster absorption, and increased results over traditional tablets.
  • Perfect for naturally promoting liver health in all pets and supporting cognitive function in aging companion animals.

Ingredient Information

Instructions

FAQ

Learn More About maxxipaws From Our Team of Experts

Frequently bought together

Questions & Answers

15 Customer Questions

Does this have to be given on an empty stomach? I have been sprinkling over his meals. His liver recheck is in 10 days and I just read somewhere it needs to be given on an empty tummy..I hope I haven't been doing it wrong?

Answer by Chewy • Jun 13, 2019
This supplement is recommended to be administered with food.

is the scoop graduated by 1/4 scoop, 1/2 and 3/4 scoop for feeding.

Answer by Chewy • May 09, 2018
Use at the rate of 1 scoop per 30 lb of body weight daily, divided between 2 servings for maximum results. Scoop included. 1 scoop = 2.5 g. These are maintenance doses. It is recommended to double the daily dosage for the first few weeks while getting the condition under control. 90 day supply for 20 lb dog

Does this have to be refrigerated after opening? If so, I have had it for 3 weeks and not refrigerated. Is it ok to still feed it?

Answer by Chewy • May 15, 2019
It's recommended to store this supplement in a cool dry place to ensure the freshness and effectiveness of the ingredients. It is not strictly necessary to keep it in the fridge after opening but we generally recommend doing so as this is the best way to ensure these conditions are met.

Is this human grade?

Answer by Chewy • May 04, 2023
This supplement is made with human grade ingredients.
Reviews
Write a Review
4.1
Rated 4.1 out of 5 stars
57 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Dosage and Administration

82% Positive

Effectiveness

78% Positive

Ingredients

92% Positive

Nutritional Value

87% Positive

43 Customer Reviews

Rated 4 out of 5 stars
By Danny on Oct 20, 2025

Smaller scoop and finer ground powder. Great quality and quantity

Although my 90lb Labrador Bleu eats almost anything, he really isn’t a fan of this SAMe! I’ve bought empty capsules to put it in, but that requires too many capsules

Although my 90lb Labrador Bleu eats almost anything, he really isn’t a fan of this SAMe! I’ve bought empty capsules to put it in, but that requires too many capsules and too many Pill Pockets to equal just a scoop. We’re figuring it out as we go! I do think I have noticed a positive difference in Bleu, but it’s always hard to tell seeing as he is changing frequently due to being 9+ and on actual rx meds that fluctuate. But definitely Zero bad response to this SAMe supplement! We’re still tail wagging happy! Lol!

Rated 5 out of 5 stars
By Karna on Sep 21, 2025

Very helpful

My elderly dog started symptoms of sundowners, panic at night, couldn’t settle down and my sister recommended this product. It has actually helped! And my vet

My elderly dog started symptoms of sundowners, panic at night, couldn’t settle down and my sister recommended this product. It has actually helped! And my vet highly approves of its benefits for brain health.

Rated 5 out of 5 stars
By Maria on Dec 27, 2025

Fast delivery good costumer service.

Very pleasant and professional attitude.

Very pleasant and professional attitude.

Rated 3 out of 5 stars
By Tony on May 4, 2025

Daisy isn't a fan

I bought the powder based on negative reviews for the horse pill. I put some on Daisy's dry food in her bowl. She sniffed it and stepped back. She literally switched

I bought the powder based on negative reviews for the horse pill. I put some on Daisy's dry food in her bowl. She sniffed it and stepped back. She literally switched her bowl with the cat bowl, and ate the cat food. When the cat came in to eat, he sniffed it and proceeded to cover it up..... He walked over to the litter box and ate that instead.

Rated 5 out of 5 stars
By misssmaggie on May 21, 2025

My baby loves it!!!

I do not have to try to cover over the smell...it is like she does not know it is in her food!!! This is much better than the previous brand we were purchasing

I do not have to try to cover over the smell...it is like she does not know it is in her food!!! This is much better than the previous brand we were purchasing. I should say thank you to them for discontinuing their product!!!

Rated 1 out of 5 stars
By Wendy on Dec 26, 2024

Just Cancelled My Autoship Due to Recent Quality

I had this as an autoship for quite awhile with no problems. But the last two shipments have been terrible. I hate leaving a bad review, because I've never had this

I had this as an autoship for quite awhile with no problems. But the last two shipments have been terrible. I hate leaving a bad review, because I've never had this problem before with this product ever. The first time I opened one and saw rock hard lumps, I thought it was maybe a "one off" and I just broke up the lumps. But each shipment seemed to be getting progressively worse. The one I had received before this one, I ran the hard lump through my coffee bean grinder, because I was having trouble breaking it up. The one in the photo above is one that I opened last night and you can see another rock hard lump. I just cancelled the auto-ship. For what I've been paying, I expect better quality than this.

Rated 1 out of 5 stars
By Pearl on Mar 7, 2025

Second jar with even larger clumps/rocks inside

I ordered my first jar and it had a huge clump inside and expires in less than a year. The second jar to replace this defective one 3 large clumps inside. Both jars

I ordered my first jar and it had a huge clump inside and expires in less than a year. The second jar to replace this defective one 3 large clumps inside. Both jars expire January 2026.

Rated 1 out of 5 stars
By Holly on Dec 7, 2024

Rotten

My dog loves this in the form of the chews shaped like hearts. I’ve been getting it on A mazon. I decided to try the powder. I’ve always trusted Chewy more than

My dog loves this in the form of the chews shaped like hearts. I’ve been getting it on A mazon. I decided to try the powder. I’ve always trusted Chewy more than random sellers on that other site, so I added it to my auto-ship. Not only is it rotten and smelly, I have to go through the hassle of returning it in order to get my refund. Despite me sending a photo via Chat Help. This is disappointing. I’m rethinking my entire reliance on Chewy now. For my Senior with CKD and liver cancer, one bad dose or food poisoning, could be toxic enough to kill him. Add to that the lack of a good faith refund with an image of a rotten product is enough to go back to easy breezy A mazon.

Rated 5 out of 5 stars
By Donna on Feb 27, 2025

More vitality

My Rottweiler has a liver condition. He’s on a special diet is doing well. But when I put him on Maxi paws, he seemed to have more vitality.

My Rottweiler has a liver condition. He’s on a special diet is doing well. But when I put him on Maxi paws, he seemed to have more vitality.

Rated 5 out of 5 stars
By Sue on Jul 12, 2025

Easy to use

It has improved Maggie’s liver numbers!

It has improved Maggie’s liver numbers!