maxxipaws maxxiSAMe SAM-e Supplement for Dogs, 5.3-oz

By maxxipaws
Rated 4.4286 out of 5 stars
$62.99Chewy Price
$59.84Autoship Price
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About This Item


  • Made in the USA with the highest quality, wholesome ingredients available and lab-tested for purity and potency.
  • Contains a proprietary and potent blend of essential vitamins, including B6 and B12, as well as thiamine and riboflavin.
  • Easy and all-natural way to give pets the S-adenosylmethionine that they need for optimal liver and brain functioning.
  • Easy-to-use powder allows for more accurate dosing, faster absorption, and increased results over traditional tablets.
  • Perfect for naturally promoting liver health in all pets and supporting cognitive function in aging companion animals.

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Nutritional Information

Feeding Instructions


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Top IngredientsActive Ingredients: S-Adenosylmethionine (SAM-E), Cynara Scolymus (Artichoke Leaf Extract: 4:1), Choline (Bitartrate)...Active Ingredients: S-Adenosyl-L-Methionine, N-Acetyl Cysteine, L-Taurine...Active Ingredients: Certified Organic Milk Thistle Seed (Silybum Marianum)., Inactive Ingredients: Deionized Water, Natural Bacon Flavor (Glycerin-Based)...Ingredients per capsule: Milk Thistle Extract 100 mg (EMed-MT premium providing 80% Silymarin and 30% silybinin) Inositol 20 mg Choline 20 mg DL-Methionine(pharmaceutical grade) 20 mg Pantothenic Acid (calcium pantothenate) 10 mg Vitamin B-1 (thiamine) 5 mg Vitamin B-2 (riboflavin) 5 mg Vitamin B-6 (pyridoxine) 5 mg Alpha Lipoic Acid 5 mg Vitamin B-12 (cyanocobalamin) 10 mcg Inactive ingredients: Gelatin‚ glycerin‚ silica and water....Active Ingredients: Certified Organic Dandelion Root (Taraxacum Officinale), Inactive Ingredients: Deionized Water, Natural Bacon Flavor...
Breed SizeExtra Small Breeds, Small Breeds, Medium Breeds...Extra Small Breeds, Small Breeds, Medium Breeds...Extra Small Breeds, Small Breeds, Medium Breeds...Extra Small Breeds, Small Breeds, Medium Breeds...Extra Small Breeds, Small Breeds, Medium Breeds...
Health FeatureBrain Health, Liver CareBrain Health, Liver CareLiver CareLiver CareDiabetic Support, Digestive Health, Liver Care
LifestagePuppy, Adult, SeniorPuppy, Adult, SeniorPuppy, Kitten, Adult, SeniorAdultAdult
Food FlavorUnflavoredUnflavoredMeat, Liver, BaconUnflavoredMeat, Liver, Bacon
Special DietNon-GMO
Food FormFood Topping, SupplementSupplementSupplementFood Topping, SupplementSupplement

Questions & Answers

17 Customer Questions

Does this have to be given on an empty stomach? I have been sprinkling over his meals. His liver recheck is in 10 days and I just read somewhere it needs to be given on an empty tummy..I hope I haven't been doing it wrong?
Answer by ChewyJun 13, 2019
This supplement is recommended to be administered with food.

Does the powder have a flavor that when put on their food is overwhelming and dog won't eat. Can I mix the 1/2 scoop with water put in a dog feeding syringe and feed it?
Answer by ChewyNov 10, 2017
This item does not contain any artificial flavors, so it has natural flavor. The taste is mild and most pets enjoy it. It is recommended this be administered and mixed with food.

is the scoop graduated by 1/4 scoop, 1/2 and 3/4 scoop for feeding.
Answer by ChewyMay 09, 2018
Use at the rate of 1 scoop per 30 lb of body weight daily, divided between 2 servings for maximum results. Scoop included. 1 scoop = 2.5 g. These are maintenance doses. It is recommended to double the daily dosage for the first few weeks while getting the condition under control. 90 day supply for 20 lb dog

Does this need to be given on an empty stomach 1 hour before a meal?
Answer by ChewyJun 16, 2019
This supplement can be feed with or without food.

ReviewsWrite a Review

Rated 4.4286 out of 5 stars
28 Ratings
Would recommend to a friend

28 Customer Reviews

Rated 4 out of 5 stars
By Hannah on Jun 16, 2023
Top 1000 Contibutor

Mixed feelings

I have faith that this is a very good product and definitely helps my dogs, but they hate the taste. I have to go to great lengths to hide this in their food and even then they’ll barely eat it. If I don’t add this to their food, they gobble everything down.

Rated 4 out of 5 stars
By MelC on Feb 26, 2023

Not overly palatable, but effective

It contains the liver supplement recommended for our dog by her oncologist, since the chemo that she's on can cause liver problems. Too bad they can't come up with something that does the job but also tastes good. We end up giving it to her with her dry dog food, with a little chicken broth poured over it and then the supplement sprinkled on top.

Rated 5 out of 5 stars
By Robin on Nov 11, 2022

Great product!

My vet recommended SAM-e for my older dog's liver function. I read the rave reviews where people said their dogs were completely different with this supplement. My 10 year-old dog is acting like a puppy and I think it's the powder. He has a lot more energy and a better attitude. Liver values are stable. He rejected it a little bit at first but now he wolfs it down along with his food.

Rated 5 out of 5 stars
By Jojo on Mar 27, 2023

Dog medicine

This is working great for my dog. The pills were too big so this works great.

Rated 5 out of 5 stars
By 123kjc on Mar 27, 2021

No more pill

My vet prescribed Denamarin for my dog when elevated liver enzymes showed up on his yearly blood work. However, he wouldn't take the pill in a treat or pill pocket and I hated having to pill him. MaxxiSame was the answer. It can be sprinkled on food and eaten with his meals; or do what I do and mix it with chicken baby food and it becomes a special treat. No problems now getting him to eat it. Please note; the directions and figuring out the product strength can be a little confusing so read the package info very carefully if you are using it in place of the denamarin pills (you will also need to purchase the milk thistle separately as that is in the pills but not in the maxxiSame ). Highly recommend this product if you don't like pilling your dog.

Rated 5 out of 5 stars
By Samantha on Mar 29, 2021

Brought liver levels down!

Tried this after our dog’s bloodwork came back with very high liver levels. MaxxiSAMe brought levels back to acceptable range in under two mo the. They’ve stayed in a good place for the past two years with continuous use, even while taking rimadyl. Our boy can’t take pills so this a good alternative. He doesn’t seem to notice the powder in his food.

Rated 5 out of 5 stars
By James on Jan 20, 2021

Worked perfect but

My 18 year old cat was having explosive diarrhea. He has elevated liver enzymes but not severely. This stuff worked 100% on the diarrhea. The SAMe makes him sleep all the time. I took him off this for two weeks and he was active and still no diarrhea. After that the diarrhea is back. I'll have to start this back up but I wish there was something similar to this that would work and not knock him out. Please reply if you have an idea. This is also made for cats. Thanks

Rated 5 out of 5 stars
By StuDowling on Feb 5, 2021

Pretty Good

This stuff smells bad but it's easier than getting my dog to swallow a Denamarin tablet. Plus it's got B vitamins you're supposed to give with SAM-e whereas Denamarin does not. Add some Milk Thistle extract and you've basically got Denamarin that you can put on their food instead of trying to force a giant horse pill on them.

Rated 2 out of 5 stars
By OwnerOfOneDoggie on May 4, 2021

Hard to get dog to eat it

Even though the ingredients look great, it’s hard to get my dog to eat this even if I put it on top of his food

Rated 5 out of 5 stars
By Lobo on Jan 14, 2021

So easy to use!

I will only purchase my pet medical and nutritional supplies from CHEWY! I'm confident in their products and their service is great. I previously purchased a sAME product in pill form that was not usable for a small dog. I now use the powdered sAME product and very satisfied that I am giving the right dose ( includes a small scooper). Order arrived timely and packaged well. Price is competitive.