Prana Pets Lignans & Melatonin with Biotin for Cushing's Disease Support for Dogs, 26+ lbs, 90 count

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At a Glance

  • Senior Care
  • Made in USA
  • All Lifestages

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About This Item

Details

  • This herbal remedy helps reduce the extreme thirst and excessive urination associated with Cushing’s disease.
  • Added biotin supports healthy skin, coat, and nails.
  • A combination of melatonin and flaxseed lignans helps your furry friend maintain a normal hormonal balance.
  • By reducing thirst, these tablets can also alleviate excessive urination.
  • Lignans and Melatonin Blend may help relieve your pal’s constant panting.

Ingredient Information

Feeding Instructions

Learn More About Prana Pets From Our Team of Experts

Natural Remedies from Prana Pets

Prana Pets helps pets—and their people—live their best lives with natural remedies that ease common issues and support whole-body wellness. With Prana Pets as your holistic health partner, you can feel confident you’re giving your pets the best.

Ingredients Backed By Science

These proprietary formulas are crafted just for cats and dogs using premium, human-grade ingredients. Backed by science and rooted in nature, each blend is designed to support your pet’s health with the safest, most effective natural remedies.

Only The Good Stuff

Prana Pets formulas are free from unnecessary fillers and made with only high-quality, purposeful ingredients. Every drop, chew or scoop is packed with the natural goodness your pet needs—nothing more, nothing less.

Safety You Can Trust

Prana Pets products are vet-recommended and made in the USA in FDA-inspected, cGMP-compliant facilities. They are third-party lab tested for safety, purity, and quality, so you can feel confident giving your pet natural support you can trust.

About Prana Pets

At Prana Pets, everything they do is fueled by unconditional love—the same kind our pets show us every day. From carefully crafted formulas to caring customer support, they’re there to help you return that love with the best care possible.

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Questions & Answers

9 Customer Questions

What type of vegetables are included in the ingredients?

My dogs on Vetsulin will this supplement interfere?

Are there side effects with this supplement?

Answer by Chewy • Sep 15, 2022
Prana Pets employs only natural substances, therefore there won't be any negative side effects or interactions with other treatments.

How big are the tablets?

Answer by Chewy • May 31, 2022
These tablets are close to the size of an Advil and they can be crushed up to mix in with food, if wanted.
Reviews
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4.4
Rated 4.4 out of 5 stars
194 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

80% Positive

Effectiveness

84% Positive

Ingredients

91% Positive

Long-Term Benefits

86% Positive

74 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Kara on Nov 29, 2025

This prolonged my dog’s life

My dog was diagnosed with Cushings Disease a couple years ago. We decided against the very expensive treatment. She is an older dog, so we were just going to make

My dog was diagnosed with Cushings Disease a couple years ago. We decided against the very expensive treatment. She is an older dog, so we were just going to make sure she didn’t have any pain and help her the best way we could naturally. We started this supplement and immediately saw a change in her. What we thought was gonna be the beginning of the end, added an additional two years to her life. It caused the patches in her hair to grow in and really helped stop her from gulping water every day.

Rated 5 out of 5 stars
By Shannon on Jan 16, 2026

Great Product

This product works great for my lab with severe Cushings disease. She loves the taste and takes it with no problem.

This product works great for my lab with severe Cushings disease. She loves the taste and takes it with no problem.

Rated 5 out of 5 stars
By Margaret on Sep 14, 2025

Ozzie has Atypical Cushing's

Ozzie has Atypical Cushing's and his vet wants to avoid the actual drugs for as long as possible because they can do some damage and are hard to dose without over

Ozzie has Atypical Cushing's and his vet wants to avoid the actual drugs for as long as possible because they can do some damage and are hard to dose without over doing it. He is doing fabulous on this. Not over drinking or peeing in the house. He has lost some muscle but seems very comfortable. I am way happier giving him this for as long as I can before we use the stronger stuff.

Rated 5 out of 5 stars
By Lissa on Aug 29, 2025

Improved health!

My vet recommended these when she suspected Cushings. While waiting for test results, I started this supplement and the improvement in skin and coat has been great

My vet recommended these when she suspected Cushings. While waiting for test results, I started this supplement and the improvement in skin and coat has been great. My dog’s overall anxiety level has also greatly decreased.

Rated 3 out of 5 stars
By Sally on Oct 26, 2025

Hollistic before Pharma

My pet might have Cushings so trying something Hollistic before drugs that affect other things

My pet might have Cushings so trying something Hollistic before drugs that affect other things

Rated 5 out of 5 stars
By Valerie on Jun 24, 2025

Satisfied

I purchased the above items because my dog was borderline Cushing’s disease. Rather than putting him on medication that could possibly have side effects. I decided

I purchased the above items because my dog was borderline Cushing’s disease. Rather than putting him on medication that could possibly have side effects. I decided go holistically. I have to say my dog was collapsing and finding it hard to walk he is now upright and moving around as if he was years younger

Rated 1 out of 5 stars
By Buddy on Aug 26, 2025

Don't waste your time

This didn't work for my dog who might have Cushing disease. I purchased Flax lignans and melatonin separate and saw immediate improvement.

This didn't work for my dog who might have Cushing disease. I purchased Flax lignans and melatonin separate and saw immediate improvement.

Rated 5 out of 5 stars
By Dawn on Mar 6, 2025

Decrease in water intake, calmness

Our dog was diagnosed with Cushing’s in January. I started her on Prana pets adrenal support drops plus a new food (Bil Jac), reduced her snacks to only liver bites

Our dog was diagnosed with Cushing’s in January. I started her on Prana pets adrenal support drops plus a new food (Bil Jac), reduced her snacks to only liver bites (she’s a Puggle), and saw a significant difference within approx 4 weeks. She was however anxious acting at night so I added these at night after dinner. She has been so much more calm, water I take reduced even more, and has lost some weight (she’s is overweight). I will continue this routine, and will be going up on her adrenal support drops even more over next couple weeks (I added these slowly). THANK YOU FOR HELPING OUR BABY!

Rated 5 out of 5 stars
By Johnny on Oct 4, 2025

Prompt delivery

Very fast service and great customer services

Very fast service and great customer services

Rated 2 out of 5 stars
By MelI on Feb 8, 2025

Was hopeful

Worked great first 4 months, now not as great. I wanted to avoid the stronger, more expenses be meds that had warnings for dog and humans. Going to my to try for

Worked great first 4 months, now not as great. I wanted to avoid the stronger, more expenses be meds that had warnings for dog and humans. Going to my to try for another month. Her excessive panting is coming back and it breaks my heart to see her panting and restless all night etc.