Trifexis Chewable Tablet for Dogs, 60.1-120 lbs, (Brown Box)

By Trifexis
Rated 4.339 out of 5 stars
Prescription Item

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$282.72Chewy Price
$268.58Autoship Price
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Usually arrives in 3-5 days
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Medications ship separately. Delivery times may vary.

Frequently Bought Together

Apoquel (oclacitinib) Tablets for Dogs, 16-mg, 1 tablet
Rated 4.622 out of 5 stars
$2.70Chewy Price
Total Price: $424.46

About This Item


Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Trifexis From Our Team of Experts
Learn More About Trifexis From Our Team of Experts

About Trifexis

Dosed By Weight

Trifexis comes in five different strengths to provide custom-tailored dosing for a wide range of dogs. Just one tablet provides the correct amount your pup needs to protect him for a whole month from 5 different types of parasites. Trifexis works for dogs 8 weeks and older, with dosing for dogs from 5 pounds to 120 pounds—and beyond!

5 - 10 LBS
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10.1 - 20 LBS
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20.1 - 40 LBS
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40.1 - 60 LBS
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60.1 - 120 LBS
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Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Important Safety Information

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
Trifexis Product Label

About Trifexis

Trifexis is a once-a-month, beef-flavored tablet that provides broad protection against a range of parasites. It kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Protect your dog with convenient parasite protection that lasts all month long.
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ReviewsWrite a Review

Rated 4.339 out of 5 stars
295 Ratings
Would recommend to a friend

295 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 2 out of 5 stars
By Sarah472 on Sep 8, 2023


The tablets are hard and are HUGE. I don't see any dog wanting to eat this. It would be so much better if they made it a chewable because this is NOT chewable. I have to dissolve it in hot water and mix it with something I cook for him or he won't eat it. At this point the 2 chews are easier than this 3 in 1. If you guys could make it in to an actual chewable I would give this product 5 stars. Being a 3 in 1 is supposed to make dosing easier not harder.

Rated 1 out of 5 stars
By Heather on Aug 13, 2023

Not appetizing

Usually my dogs will eat anything and everything. When I try to give them this tablet they run for their lives. I’ve tried to put it in cheese and soft dog food and they don’t want anything to do with it. My one dog I can pill easily because she is used to taking meds but my other dog clamps down. It has a strong smell and even I want to gag thinking about what it must taste like. I’m switching them to the topical revolution.

Rated 5 out of 5 stars
By Twins1 on Aug 13, 2023

Excellent medicine for dogs it work fast in less then an hours no more fleas.and I don't have to give one pill every months like Dr recommended it I give my dog only when I see fleas really recommended, good pills

Rated 5 out of 5 stars
By Trifexis on Jul 29, 2023

Love It!

So my dog, Macy, has been on Trifexis for years and she has allergies too. So whenever she was younger Trifexis was one of the only tabs to help her out. She has gotten older and it still works great on her

Rated 5 out of 5 stars
By JulesnGus on Jul 18, 2023

Tastes awful works grwat

Gus loathes these but I gring them up in some wet food and he forgets they're there! Haven't a flea (or + for heartworm) in 5 years with him or previous 7 years with my other dogs

Rated 3 out of 5 stars
By Derg on Aug 1, 2023

Don’t like taste

My only complaint it is a hard tablet my dog does not want therefore eliminating ease of dosing. Wish it was soft chewable with good taste.

Rated 2 out of 5 stars
By Sierra on Jun 23, 2023

Don;t like the tast. Didn't stop the fleas.

Sierra took it the first day then never again. Tried everything even spit out the pill pocket. Sierra was still scratching and biting at her back all the time.

Rated 5 out of 5 stars
By Alan on May 7, 2023

Easy ordering

We've used Trifexus pills for our basset hound, Annabelle, for years. But we lost our veterinarian last year, and our new one doesn't sell medicine. Ordering from Chewy is easy and fast. I'm very satisfied with the process.

Rated 5 out of 5 stars
By Barbara on May 12, 2023

Works great!

My dog Rebel has been on Trifexis for years. He hates taking the big tablet but it's kept him healthy so he'll continue to get it, like it or not. Thankfully it's only once a month.

Rated 5 out of 5 stars
By Misha on May 17, 2023

Easy and fast

So much nice to have this delivered to your door step! Just provide the veterinarian information and chewy does all the work! Thank you so much