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Our pharmacy prepares and ships prescription medications separately to ensure proper handling.
Most prescriptions are delivered within 3-5 days.Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.
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Item Number | 296788 |
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Common Brand Name(s) | Trifexis, Comfortis |
For Use With | Dogs |
Generic Name | Spinosad, Milbemycin Oxime |
Administration Form | Oral |
Repels or Prevents | Fleas, Heartworms |
Kills or Treats | Fleas, Roundworms, Hookworms, Whipworms |
Breed Size | Large Breeds |
Product Form | Chewable Tablet |
Strength | 1620 mg Spinosad and 27 mg Milbemycin Oxime |
Health Condition | Heartworms, Fleas, Hookworms, Roundworms, Whipworms |
Drug Type | Parasiticide |
Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.
When used as prescribed, side effects while using Trifexis are rare. Symptoms of GI distress and skin irritation can occur. Vomiting, diarrhea, lethargy, lack of appetite, and itching and reddening of the skin have been reported. Vomiting may be more likely in puppies under 14 weeks of age. If your dog is truly allergic to Trifexis or to the dying of parasites, she may exhibit symptoms such as facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If your dog experiences any of these symptoms, call your veterinarian or a local emergency veterinarian immediately.
Always communicate with your veterinarian about any medications, vitamins, or supplements your dog is already taking. Some serious adverse reactions have been documented when used with other spinosad and ivermectin medications simultaneously. No known food interactions have been reported.
The use of ivermectin at higher than FDA approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, re-dose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
1620 mg Spinosad and 27 mg Milbemycin Oxime.
Trifexis is a beef-flavored chewable tablet and may be given from your hand, mixed in with food or placed in a treat. Give Trifexis with food for maximum effectiveness. To ensure heartworm prevention, observe your dog for one hour after dosing. If your dog vomits within an hour of administration, re-dose with another full dose.
Store at controlled room temperatures between 68° - 77°F.
Trifexis is a monthly, chewable tablet for dogs. Trifexis kills fleas and prevents flea infestations on dogs, treats and controls adult hookworm*, whipworm and roundworm infections, and prevents heartworm disease. Trifexis is for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. If you do not administer Trifexis monthly throughout the year, continue administering the medication for at least three months following the last exposure to mosquitoes.
Spinosad and milbemycin oxime are the two active ingredients in Trifexis.
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.1
Yes, Trifexis is a prescription medicine approved by the Food and Drug Administration and should be obtained only through a licensed veterinarian with whom you have a proper veterinarian-client-pet relationship.
Ask your veterinarian about the use of Trifexis prior to use in breeding females. The safe use of Trifexis in male dogs intended for breeding has not been evaluated.
As with all medicines, sometimes side effects may occur. In some cases, dogs vomited after receiving Trifexis. If vomiting occurs within an hour of administration, redose with another full dose. During field studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear. All reactions were regarded as mild.
The most common adverse reactions based on post-approval adverse drug event reporting are vomiting, depression/lethargy, pruritus, anorexia, trembling/shaking, atazia, seizures, hypersalivation and skin reddening.
In a laboratory study of spinosad alone, this active ingredient of Trifexis started to kill fleas within 30 minutes and killed 100% of the fleas on dogs within 4 hours. Trifexis kills fleas before they can lay eggs.
Trifexis prevents heartworm disease in dogs by killing certain stages that develop after an infected mosquito bites a dog. As with other heartworm preventives, Trifexis does not kill adult heartworms. Speak to your veterinarian about treatment options if your dog is diagnosed with an adult heartworm infection.
Trifexis acts in the same way as other monthly heartworm preventives, by killing L3 and L4 larval stages before they molt to the final adult stage.
No, Trifexis is not labeled to kill or repel ticks. Trifexis is labeled for the prevention of heartworm disease on dogs, to kill adult fleas on dogs and to treat and control adult hookworm, roundworm and whipworm infections in dogs. There are no known contraindications between Trifexis and medications commonly used against ticks.
No, Trifexis will not treat a tapeworm infection. Trifexis is indicated for the prevention of heartworm disease in dogs, for the prevention and treatment of flea infestations on dogs and the treatment and control of adult hookworm, adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
The tablets are hard and are HUGE. I don't see any dog wanting to eat this. It would be so much better if they made it a chewable because this is NOT chewable. I have to dissolve it in hot water and mix it with something I cook for him or he won't eat it. At this point the 2 chews are easier than this 3 in 1. If you guys could make it in to an actual chewable I would give this product 5 stars. Being a 3 in 1 is supposed to make dosing easier not harder.
Usually my dogs will eat anything and everything. When I try to give them this tablet they run for their lives. I’ve tried to put it in cheese and soft dog food and they don’t want anything to do with it. My one dog I can pill easily because she is used to taking meds but my other dog clamps down. It has a strong smell and even I want to gag thinking about what it must taste like. I’m switching them to the topical revolution.
Excellent medicine for dogs it work fast in less then an hours no more fleas.and I don't have to give one pill every months like Dr recommended it I give my dog only when I see fleas really recommended, good pills
So my dog, Macy, has been on Trifexis for years and she has allergies too. So whenever she was younger Trifexis was one of the only tabs to help her out. She has gotten older and it still works great on her
Gus loathes these but I gring them up in some wet food and he forgets they're there! Haven't a flea (or + for heartworm) in 5 years with him or previous 7 years with my other dogs
My only complaint it is a hard tablet my dog does not want therefore eliminating ease of dosing. Wish it was soft chewable with good taste.
Sierra took it the first day then never again. Tried everything even spit out the pill pocket. Sierra was still scratching and biting at her back all the time.
We've used Trifexus pills for our basset hound, Annabelle, for years. But we lost our veterinarian last year, and our new one doesn't sell medicine. Ordering from Chewy is easy and fast. I'm very satisfied with the process.
My dog Rebel has been on Trifexis for years. He hates taking the big tablet but it's kept him healthy so he'll continue to get it, like it or not. Thankfully it's only once a month.
So much nice to have this delivered to your door step! Just provide the veterinarian information and chewy does all the work! Thank you so much