Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box)

By Trifexis
Rated 4.5333 out of 5 stars
Prescription Item

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$129.14Chewy Price
$122.68Autoship Price
(Save an extra 5%)

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FREE delivery
Usually arrives in 3-5 days
We'll collect your pet's prescription information at Checkout.

This item requires prescription approval.

Medications ship separately. Delivery times may vary.

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About This Item


Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Trifexis From Our Team of Experts
Learn More About Trifexis From Our Team of Experts

About Trifexis

Dosed By Weight

Trifexis comes in five different strengths to provide custom-tailored dosing for a wide range of dogs. Just one tablet provides the correct amount your pup needs to protect him for a whole month from 5 different types of parasites. Trifexis works for dogs 8 weeks and older, with dosing for dogs from 5 pounds to 120 pounds—and beyond!

5 - 10 LBS
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10.1 - 20 LBS
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20.1 - 40 LBS
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40.1 - 60 LBS
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60.1 - 120 LBS
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Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Important Safety Information

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
Trifexis Product Label

About Trifexis

Trifexis is a once-a-month, beef-flavored tablet that provides broad protection against a range of parasites. It kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Protect your dog with convenient parasite protection that lasts all month long.
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ReviewsWrite a Review

Rated 4.5333 out of 5 stars
345 Ratings
Would recommend to a friend

340 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 3 out of 5 stars
By Lewbelle on Sep 4, 2023

No tick protection

My 2 Boston terriers were on Nexgard, but needed the heartworm prevention as well. I did some research and a lot of vets say that 1 pill a month vs 2 is easier for owners and their pets. So I switched them to Trifexis, being under the impression by the vet (I should have researched instead of listening to the vet) that it was for fleas/ticks/heart worms. They have been on it for less than a month, and I’m already finding checks on them. We live in Florida which has a significant amount of ticks. Lyme disease and ehrlichiosis being the top 2 tick related diseases in Florida. This product is quite expensive and I ordered a 6 month supply and used auto ship (cheaper that way) and I am very disappointed that I wasted so much money without getting the prevention they need to be flea and tick free.

Rated 5 out of 5 stars
By Marion on Sep 15, 2023


Mikey won't get his 1st does till tue 17th of Sept. He's been on this same flea med for awhile. This does will be the 1st through Chewy. It works awesome and through Chewy a more affordable. I got the 6 month filling, Six months I don't have to worry when to order again. Ty Chewy.

Rated 5 out of 5 stars
By LA on Aug 18, 2023


TRIFEXIS is very effective. I have a female pug and she’s very sensitive to medications. TRIFEXIS has worked great for the past seven years, with no side effects. I give half in the morning with dab of peanut butter and the other half in the evening.

Rated 5 out of 5 stars
By Kathy on Aug 25, 2023

Great protection

Trifexis is great for protecting my dogs against fleas, worms and heart worms. I never have to worry about those pests. The pill is easy to take. Chewy did a great job in contacting my Vet and sending the tablets to me very quickly.

Rated 5 out of 5 stars
By Beefume on Jul 31, 2023

Works like a charm!

We love Trifexis, our girls have been on it for a long time and have never had heartworms even though we live in muggy Florida!! The bonus of this med is that it kills fleas - they may pick them up outside but they do not live to be an infestation! This was our first time ordering from Chewy! Super fast turn around time!!

Rated 4 out of 5 stars
By Pugmama on Aug 2, 2023

I think it works??

Started this as more mosquitoes are in my area, and I wanted to protect my pug also from heartworms. I started this by itself, but I noticed fleas and ticks were still jumping on him, so I now use it in combination with Frontline

Rated 5 out of 5 stars
By Betty on Jul 21, 2023


Impressed that you contacted my current vet to get the flea treatment prescription transferred. Now no more trips to the vet for purchases. No more worries, Chewy will send a refill as needed. Love the convenience.

Rated 5 out of 5 stars
By Alma on May 31, 2023

Great Price

I purchased this because it is easier to keep up with and more affordable. I used to have the monthly pill sent to me with Allivet. But getting this 6 month one saved me over $50 dollars, plus I had a coupon which saved me more. Definitely, I will be reordering!

Rated 5 out of 5 stars
By lita on Aug 15, 2023


I had a small problem and the lady I spoke with resolved it very quickly! And couldn't have been nicer!!

Rated 1 out of 5 stars
By Patrish on Jun 24, 2023

I did try this on 3 dogs, awful tasting to them. A real struggle to get them to take it, I will switch to something else when the supply is gone,