Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box)

By Trifexis
Rated 4.6034 out of 5 stars
Prescription Item
Slide 1 of 10
Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box), 6 Chewable Tablets (6-mos. supply) slide 1 of 10
Slide 1 of 10
Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box), 6 Chewable Tablets (6-mos. supply) slide 1 of 10

$125.99Chewy Price
$119.69Autoship Price
Autoship (Save an extra 5%)
Choose Autoship at checkout for regular deliveries.

Why Autoship?

  • FREE access to chat with licensed vets 7 days a week.
  • Save 5% on all future Autoship orders.
  • No fees, no commitments - cancel Autoship anytime.
This item requires prescription approval.

Delivery TimeA badge for delivery times
Medications ship separately. Delivery times may vary.



In Stock
FREE 1-3 day shipping
We'll collect your pet's prescription information at Checkout.



Frequently Bought Together

This Item - Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box), 6 Chewable Tablets (6-mos. supply)
Rated 4.6034 out of 5 stars
295
$125.99Chewy Price
Trifexis Chewable Tablet for Dogs, 20.1-40 lbs, (Green Box), 6 Chewable Tablets (6-mos. supply)
Rated 4.567 out of 5 stars
194
$129.19Chewy Price
Revolution Topical Solution for Dogs, 5.1-10 lbs, (Purple Box), 6 Doses (6-mos. supply)
Rated 4.5269 out of 5 stars
93
$126.99Chewy Price
Total Price: $0.00

About This Item

Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

Play Video: Learn More About Trifexis From Our Team of Experts
Learn More About Trifexis From Our Team of Experts

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Magenta5-10 lbs140 mg Spinosad & 2.3 mg Milbemycin OximeAdminister orally once a month✓-Click Here
Orange10.1-20 lbs270 mg Spinosad & 4.5 mg Milbemycin OximeAdminister orally once a month✓-Click Here
Green20.1-40 lbs560 mg Spinosad & 9.3 mg Milbemycin OximeAdminister orally once a month✓-Click Here
Blue40.1-60 lbs810 mg Spinosad & 13.5 mg Milbemycin OximeAdminister orally once a month✓-Click Here
Brown60.1-120 lbs1620 mg Spinosad & 27 mg Milbemycin OximeAdminister orally once a month✓-Click Here


About Trifexis

Dosed By Weight

Trifexis comes in five different strengths to provide custom-tailored dosing for a wide range of dogs. Just one tablet provides the correct amount your pup needs to protect him for a whole month from 5 different types of parasites. Trifexis works for dogs 8 weeks and older, with dosing for dogs from 5 pounds to 120 pounds—and beyond!

5 - 10 LBS
Shop Now

10.1 - 20 LBS
Shop Now

20.1 - 40 LBS
Shop Now

40.1 - 60 LBS
Shop Now

60.1 - 120 LBS
Shop Now

Indication

Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Important Safety Information

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
Trifexis Product Label

About Trifexis

Trifexis is a once-a-month, beef-flavored tablet that provides broad protection against a range of parasites. It kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Protect your dog with convenient parasite protection that lasts all month long.
Shop Trifexis

ReviewsWrite a Review

4.6
Rated 4.6034 out of 5 stars
295 Reviews
95%
Would recommend to a friend
1
5.4237
5%
2
2.0339
2%
3
2.0339
2%
4
7.7966
8%
5
82.7119
83%

295 Customer Reviews



Rated 5 out of 5 stars
By Chelsea on Jun 25, 2022

Trifexis Medication

My grandma told me about ordering my dogs medication on this website. I didn't think the process would be so easy. They do all the work, and contact your Vet! Definitely will be doing this process again!


Rated 5 out of 5 stars
By Izzabud on May 16, 2022

Great News Chewy

IZZABUD has been on this since she was a puppy and old enough to be placed on this medication Dr Gradis recommended it 4 yrs ago wow how time Flies she is still using this product I've never had problems with flies or ticks or heart worm problems she's my baby girl and We Love the Product Thank you Chewy for helping us out


Rated 2 out of 5 stars
By MKL77 on Jun 23, 2022

It's a no from me.

I had the hardest time getting my dogs to swallow these pills. They hated them! The pills worked okay, but I would never buy again because they were not worth the headache.


Rated 5 out of 5 stars
By Peggy on Jul 7, 2022

Very pleased!

This is the first time we ordered from chewy.com and we were very pleased. It came quickly. Not hard to order and we got exactly what we wanted


Rated 5 out of 5 stars
By Patsy on Jun 19, 2022

Quick and Easy

This order was delayed by our vet for a few days but lo and behold 2 days after I cleared it up with them the pills arrived. Chewy does a great job with speed and accuracy.


Rated 3 out of 5 stars
By dani on Apr 26, 2022

not for picky eaters

The product works. My dog is just a spoiled baby. She's small and the very hard texture of the treat either upsets her or hurts her teeth. She seemed to have initially liked the smell/flavor but then had a lot of trouble chewing the super hard pill. Now she refuses to take it. I have to crush it and mix it with a high value treat like hot dog or real chicken. I'm stuck with this since the topical medicine gives her a rash. Dear Trifexis, please make a softer treat for tiny dogs.


Rated 5 out of 5 stars
By JES75 on Feb 27, 2022

Thank YOU Trifexis

I adopted a feral dog last year and I had a continual peeing in the home on my 'rug', he probably thought was 'grass'.... It happened usually once or twice a month... I finally figured out it was the other (sorry can't name the other as it may be against the law?) flea pills that I was using - so a vet tech suggested I try the Trifexis - lo and behold it works!!! Apparently he was allergic something in the other prescription that didn't 'agree' with him - he's doing WONDERFULLY now and is a GREAT dog! Yes it's expensive, but I was ssssooo stressed out and at my wits end - and now we're all calmer and doing great....


Rated 5 out of 5 stars
By Kitt on Mar 22, 2022

Has worked for my dogs for years!

Have never had an issue with Trifexis and I love ordering thru Chewy's pharmacy because it's fast and convenient. I don't give the dogs the entire pill at once because they're picky and won't eat it. I give half in the morning and half in the evening in a peanut butter pill pocket and they think they're getting a treat! Overall, my girls have done great on Trifexis!


Rated 5 out of 5 stars
By Liser on Feb 12, 2022

No more fleas

First time ordering from Chewy very easy from Vet sending in RX to getting whole process from order to door was less than a week. My dog is spoiled so have to smash it add a little water and use a syringe to administer to him. He hasn't been on a couple months and my neighbor has a lot of outside dogs that she use no flea meds on so my poor baby had multiple on him when I gave meds and within minutes you can see the black spots which are the dead fleas. 100% a great product.


Rated 5 out of 5 stars
By Pets on Mar 11, 2022

Appreciative

I have been very pleased with my experience dealing with Chewy for my pets. I also want to Thank Chewy for the beautiful white rose arrangement I received with sympathy of losing our baby Midnight in February. That was very considerate and shows they really care. Again, Thank You for remembering us during that time. Debra Windhausen