Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box), 6 Chewable Tablets (6-mos. supply)

Trifexis is a monthly, chewable tablet for dogs. Trifexis kills fleas and prevents flea infestations on dogs, treats and controls adult hookworm*, whipworm and roundworm infections, and prevents heartworm disease. Trifexis is for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. If you do not administer Trifexis monthly throughout the year, continue administering the medication for at least three months following the last exposure to mosquitoes.

• Trifexis is an oral monthly product that rapidly kills fleas on dogs and is effective in preventing heartworm disease and treatment and control of adult hookworm (A. caninum), adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight and greater.
• Trifexis is approved by the FDA as safe and effective when used according to the label.
• Spinosad, one of the active ingredients in Trifexis, began to kill fleas on dogs 30 minutes after administration with 100% effectiveness within 4 hours in a well-controlled laboratory study.
• Trifexis continues to kill fleas for a full month after treatment.
• Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus (itching) as a direct result of eliminating the fleas.
• Trifexis is available in five strengths. Each tablet is formulated to provide a minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime according to body weight.

• In a well-controlled laboratory study, Trifexis was 100% effective against induced heartworm infections in dogs when administered for three consecutive monthly doses.
• In well-controlled laboratory studies, a single dose of Trifexis at labeled dose was effective in removing roundworms, whipworms and hookworms (A. caninum).
• In a well-controlled laboratory study, spinosad alone began to kill fleas 30 minutes after administration and demonstrated 100% effectiveness within 4 hours.
• Spinosad kills fleas on dogs before they can lay eggs. If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment. In field studies conducted in households with existing flea infestations of varying severity, flea reductions of 98.0 to 99.8% were observed during the course of three monthly treatments with spinosad alone. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus (itching) as a direct result of eliminating the fleas.

Spinosad and milbemycin oxime are the two active ingredients in Trifexis.

The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.

The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.1

Yes, Trifexis is a prescription medicine approved by the Food and Drug Administration and should be obtained only through a licensed veterinarian with whom you have a proper veterinarian-client-pet relationship.

Ask your veterinarian about the use of Trifexis prior to use in breeding females. The safe use of Trifexis in male dogs intended for breeding has not been evaluated.

As with all medicines, sometimes side effects may occur. In some cases, dogs vomited after receiving Trifexis. If vomiting occurs within an hour of administration, redose with another full dose. During field studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear. All reactions were regarded as mild.

The most common adverse reactions based on post-approval adverse drug event reporting are vomiting, depression/lethargy, pruritus, anorexia, trembling/shaking, atazia, seizures, hypersalivation and skin reddening.

In a laboratory study of spinosad alone, this active ingredient of Trifexis started to kill fleas within 30 minutes and killed 100% of the fleas on dogs within 4 hours. Trifexis kills fleas before they can lay eggs.

Trifexis prevents heartworm disease in dogs by killing certain stages that develop after an infected mosquito bites a dog. As with other heartworm preventives, Trifexis does not kill adult heartworms. Speak to your veterinarian about treatment options if your dog is diagnosed with an adult heartworm infection.

Trifexis acts in the same way as other monthly heartworm preventives, by killing L3 and L4 larval stages before they molt to the final adult stage.

No, Trifexis is not labeled to kill or repel ticks. Trifexis is labeled for the prevention of heartworm disease on dogs, to kill adult fleas on dogs and to treat and control adult hookworm, roundworm and whipworm infections in dogs. There are no known contraindications between Trifexis and medications commonly used against ticks.

No, Trifexis will not treat a tapeworm infection. Trifexis is indicated for the prevention of heartworm disease in dogs, for the prevention and treatment of flea infestations on dogs and the treatment and control of adult hookworm, adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.