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Most prescriptions are delivered within 3-5 days.Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.
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Item Number | 146169 |
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Common Brand Name(s) | Trifexis, Comfortis |
For Use With | Dogs |
Generic Name | Spinosad, Milbemycin Oxime |
Administration Form | Oral |
Repels or Prevents | Fleas, Heartworms |
Kills or Treats | Fleas, Roundworms, Hookworms, Whipworms |
Breed Size | Small Breeds, Medium Breeds |
Product Form | Chewable Tablet |
Strength | 560 mg Spinosad and 9.3 mg Milbemycin Oxime |
Health Condition | Heartworms, Fleas, Hookworms, Roundworms, Whipworms |
Drug Type | Parasiticide |
Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.
When used as prescribed, side effects while using Trifexis are rare. Symptoms of GI distress and skin irritation can occur. Vomiting, diarrhea, lethargy, lack of appetite, and itching and reddening of the skin have been reported. Vomiting may be more likely in puppies under 14 weeks of age. If your dog is truly allergic to Trifexis or to the dying of parasites, she may exhibit symptoms such as facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If your dog experiences any of these symptoms, call your veterinarian or a local emergency veterinarian immediately.
Always communicate with your veterinarian about any medications, vitamins, or supplements your dog is already taking. Some serious adverse reactions have been documented when used with other spinosad and ivermectin medications simultaneously. No known food interactions have been reported.
The use of ivermectin at higher than FDA approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, re-dose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
560 mg Spinosad and 9.3 mg Milbemycin Oxime.
Trifexis is a beef-flavored chewable tablet and may be given from your hand, mixed in with food or placed in a treat. Give Trifexis with food for maximum effectiveness. To ensure heartworm prevention, observe your dog for one hour after dosing. If your dog vomits within an hour of administration, re-dose with another full dose.
Store at controlled room temperatures between 68° - 77°F.
Trifexis is a monthly, chewable tablet for dogs. Trifexis kills fleas and prevents flea infestations on dogs, treats and controls adult hookworm*, whipworm and roundworm infections, and prevents heartworm disease. Trifexis is for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. If you do not administer Trifexis monthly throughout the year, continue administering the medication for at least three months following the last exposure to mosquitoes.
Spinosad and milbemycin oxime are the two active ingredients in Trifexis.
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.1
Yes, Trifexis is a prescription medicine approved by the Food and Drug Administration and should be obtained only through a licensed veterinarian with whom you have a proper veterinarian-client-pet relationship.
Ask your veterinarian about the use of Trifexis prior to use in breeding females. The safe use of Trifexis in male dogs intended for breeding has not been evaluated.
As with all medicines, sometimes side effects may occur. In some cases, dogs vomited after receiving Trifexis. If vomiting occurs within an hour of administration, redose with another full dose. During field studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear. All reactions were regarded as mild.
The most common adverse reactions based on post-approval adverse drug event reporting are vomiting, depression/lethargy, pruritus, anorexia, trembling/shaking, atazia, seizures, hypersalivation and skin reddening.
In a laboratory study of spinosad alone, this active ingredient of Trifexis started to kill fleas within 30 minutes and killed 100% of the fleas on dogs within 4 hours. Trifexis kills fleas before they can lay eggs.
Trifexis prevents heartworm disease in dogs by killing certain stages that develop after an infected mosquito bites a dog. As with other heartworm preventives, Trifexis does not kill adult heartworms. Speak to your veterinarian about treatment options if your dog is diagnosed with an adult heartworm infection.
Trifexis acts in the same way as other monthly heartworm preventives, by killing L3 and L4 larval stages before they molt to the final adult stage.
No, Trifexis is not labeled to kill or repel ticks. Trifexis is labeled for the prevention of heartworm disease on dogs, to kill adult fleas on dogs and to treat and control adult hookworm, roundworm and whipworm infections in dogs. There are no known contraindications between Trifexis and medications commonly used against ticks.
No, Trifexis will not treat a tapeworm infection. Trifexis is indicated for the prevention of heartworm disease in dogs, for the prevention and treatment of flea infestations on dogs and the treatment and control of adult hookworm, adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
This product is amazing! I highly recommend it because it works very well, but since it is a pill (which sucks but there is a way around it!), it was hard to give to my little dude until I thought to myself, why not crumble the pill and mash it up and give it to him?. That is exactly what I did, before taking the actual pill out of the silver packaging, I literally ever so slightly try to smash the pill in the packaging, once I think it is powdery, I then open the packaging from the little corner and voila! You have a powdery pill. What do you do from there on you may think? Either put the powdery pill in a treat (pill pocket, or some cheese) or put it into the food, one way or another your pup will consume the pill in a non pill form, this has been working pretty decently for me for a while! Hope this helps some folks who have been having trouble with this stuff! It costs a pretty penny but works amazingly!
"Trifexis works great, but our dogs hate it!" Is pretty much the theme in Trifexis reviews. I am here to offer a solution I discovered: Wrap Trifexis in raw ground beef and dogs will love medicine time. This is based on experience, check my resume below. Every month for years, I hated when my calendar alerted me to give our dogs their Trifexis. I found myself staring in the fridge for a tasty left over, a fine aged cheese, crappy cheese, cheese-food-product, hot dogs, sausage, bacon, dog treats and fish sauce, ground it into dust using a mortar and pestle and mixed with peanut butter... literally nothing could mask their Trifexis. Ultimately, after the air would fill with words I can't have our son repeat and yelling about why such an expensive dog pill was clearly not made by dog people for dogs my wife would offer up her services. Her finger would take the now gooey pill stuck to her finger like a booger and cram it down their throats. Not cool and the dogs weren't having fun either. The vet had no suggestions beyond what had already been tried. One day the calendar notification dinged on my phone and the dreaded word "Trifexis" appeared. I grabbed the dogs boxes of Trifexis cut the pills in quarters as usual (knowing that they really detect the whole pill) and opened the fridge in search of a masking agent. Then, something unusual happened, as if the heavens opened up, a beam of fridge light shined down from above onto some ground beef waiting for me to transform it into chili and beans that night. I grabbed a chunk of it and made Trifexis stuffed meatballs out of each piece of pill! The dogs gobbled up their medicine and wanted more! I received my first Michelin Star and now, finally, I live a more stress-free life. My potty mouth has turned into laughter and praise. The dogs running and hiding behind the sofa has turned into salivating and tail wagging. And we all live happily ever after. We love Trifexis calendar notifications now!
I am very happy with the smooth transaction between Chewy and my vet. I prefer this product to the ones my vet Keeps in stock.
I think Trifexis works really well, and I was very happy to be giving my dog an organic product like spinosad. However.... my dog HATES the pills. They seem to be the only thing on the planet this dog will not happily wolf down. No tricks worked--he left it in his food bowl, ate the treat around it and spit out the pill, etc. I tried crushing but it's pretty hard to crush. Even shoving it all the way to the back of his throat didn't work. I ended up having to DISSOLVE it in some green bean juice and pour it on his food. I wouldn't mind that, but I can't find any info anywhere about whether dissolving it decreases its effectiveness. So... we used up his prescription and switched to another brand. I'd still prefer to use Trifexis if I could.
My dog would not eat this pill no matter if I used peanut butter, cheese whiz, wrapped inside meat, pill pockets and mixed with wet food. I would force the pill down his throat. He didn't like that and neither did I. So I was forced to change to Heartgard and NexGard. It might be a good item but if your dog won't take it, then its a waste of money.
Easy to give your dog and seems to work great. Easy to order also.
I am so happy this is working for our 6 month old beagle. This does it all! I really don’t like the oil based coverage and have heard some negative comments on the seresto for very young small dogs. Have used them for years on my big dogs, no problem.
My 40lb mutt has had great results, and I can't complain on its intent. I agree with some others on smell, as it is a chalky type aromatic when you crunch it up. Speaking of crunching, my dog will not eat this standalone. I use a small bit of wet food and no issue. Little pricey, but I'm content on execution, and delighted with results. Buying from Chewy will definitely save you money as well compared to vet costs.
Everything went great and right on time!! Everyone was cooperative and nice
I had the hardest time getting my dogs to swallow these pills. They hated them! The pills worked okay, but I would never buy again because they were not worth the headache.