Frontline Plus Flea & Tick Spot Treatment for Dogs, 23-44 lbs
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Help protect your pup from pests with FRONTLINE Plus For Dogs Flea & Tick Medium Breed Dog Spot Treatment. This treatment helps kill adult fleas, flea eggs, flea larvae, chewing lice, and ticks. It’s formulated with two active ingredients—fipronil and (S)-methoprene—to help disrupt the flea life cycle and inhibit future infestations. Plus, it’s designed to be waterproof, fast-acting, and long-lasting. This treatment is paw-fect for pooches who are eight weeks old and older.
Key Benefits- Promotes a fast-acting and long-lasting protection from fleas and ticks.
- Formulated with two active ingredients to help disrupt the flea life cycle.
- Helps kill adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
- Simply apply once a month.
- Designed for a waterproof protection.
Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately.
Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
Important Information
Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.
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Item Number49538
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UsageTreatment
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BrandMerial, Boehringer Ingelheim
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LifestageAdult, Senior, Puppy
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Breed SizeSmall Breeds, Medium Breeds
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Product FormSolution
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Health ConditionFleas, Ticks
Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.
- Snap open the tip of the Frontline applicator away from your body and face.
- Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
- Squeeze applicator to apply entire contents in a single spot on the skin monthly.
- Allow 24 hours before bathing or swimming.
Additional Tips
- Remove dog's collar
- Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
- Avoid touching the wet application spot.
- Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
- Give each of your dogs its own complete dose.
Frequency of Application
- When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
- FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
- FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
- FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
- FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
- FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
Where is this product sourced from?
We source all our products from manufacturer approved distributors or directly from the manufacturers. Chewy takes pride in ensuring that our furry friends’ wellbeing is always our top priority. We have worked hard to partner with all of the manufactures to deliver 100% authentic products
How does FRONTLINE Plus kill fleas and ticks?
FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.
How long does it take for FRONTLINE Plus to kill fleas?
In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2
Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?
No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.
Why am I seeing more fleas on my pet after applying FRONTLINE Plus?
Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.
After using FRONTLINE Plus, I still see fleas in my home. Why?
The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.
Does FRONTLINE Plus have an expiration date?
No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.
How long after application can my pet be bathed or go swimming?
FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.
Can I use it if my pet is on medication?
Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.
Can I use FRONTLINE Plus if I have already applied another flea and tick control product?
Before using, consult your veterinarian.
Does FRONTLINE Plus kill anything else besides fleas and ticks?
You bet. FRONTLINE Plus also kills chewing lice.
Can FRONTLINE Plus be used on pets other than dogs and cats?
No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.
Can I apply it more than once a month?
Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.
How old does my pet need to be in order to have FRONTLINE Plus applied?
At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.
What is the best number to call regarding any specific product questions?
For any specific product questions, please call Boehringer Ingelheim Animal Health’s customer service line number at 1-888-637-4251.

Keeping Your Pets Protected Against Ticks and Fleas
FRONTLINE Plus will help you protect your pet from irritating fleas and ticks. It is a simple-to-use topical treatment that is easy to apply and provides lasting protection for a full 30 days. This flea and tick protection contains two powerful ingredients to stop fleas and ticks in their tracks and help prevent future flea infestations.


The Flea and Tick Protection Vets Have Trusted for Nearly 20 Years
FRONTLINE Plus is a veterinarian-recommended flea and tick treatment that is both fast-acting and long-lasting. It works to break the flea life cycle and also kills adult ticks that may transmit diseases. It offers waterproof protection as well, so you can rest assured knowing that FRONTLINE Plus has your pets covered with FRONTLINE Plus for Dogs and FRONTLINE Plus for Cats.
Tough Ingredients To Arm Pets as Young as 8 Weeks
FRONTLINE Plus for Dogs is approved for puppies at least 8 weeks old and weighing as little as 5 lbs all the way to senior dogs. And with FRONTLINE Plus for Cats, kittens weighing at least 1.5 pounds can start protection as young as 8 weeks, too. To stop fleas and ticks in their tracks and prevent future flea infestations, FRONTLINE Plus uses two tough ingredients, fipronil and (S)-methoprene. Fipronil kills adult fleas and ticks that come into contact with your pet, while (S)-methoprene works to kill flea eggs and larvae before they can develop.


Tough on Fleas and Ticks, Easy to Apply
Applying FRONTLINE Plus for Dogs and FRONTLINE Plus for Cats is simple and quick.Simply part your pet's hair between the shoulders, place the applicator tip just above the skin, and squeeze directly onto the skin. Avoid contact with the treated area until dry. Read the entire product label before each use. Once applied, FRONTLINE Plus will protect your pet from fleas and ticks for a full 30 days. Monthly application is simple so peace of mind comes easy month after month. As long as FRONTLINE Plus is fighting, you can forget about fleas and ticks.
About FRONTLINE Plus
FRONTLINE Plus is a trusted flea and tick control product that has been recommended by veterinarians for nearly 20 years. This topical flea and tick treatment uses two tough ingredients, fipronil and (S)-methoprene, which have been tested and proven to protect your pet from fleas and ticks and prevent new flea infestations for a full 30 days.

Customer Reviews
84% Recommend
84% of reviewersrecommend this product
You've Already Reviewed This Item
537 Reviews
Showing 1-10 of 537 Reviews
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Don't buy this
By ChaCha on Feb 4, 2021
My dog is allergic to flea bites and I got this to try to see if it would work I treated both my car and dog with frontline and I feel like I see more fleas on them NOW then I did before!!!! Never buying this again it was an absolute waste of money and I think everyone should steer clear of this!
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Doesn’t appear to work
By Xxxxxx on Feb 14, 2021
My dogs are outdoor, country dogs. I was hoping to get them some flea and tick relief by using this product but it doesn’t appear to be working. I can still see fleas on them and they are still rolling in the grass trying to scratch and get relief.
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Great choices
By Dragonfire on Feb 22, 2021
I buy this item every couple months and chewy has great prices and you receive what you order quickly I definitely recommend to other pet parents
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Dog has fleas
By Samuel on Dec 15, 2020
My 6.5 month old puppy went in for her spay surgery today and the vet informed me that she has fleas. The vet told me that Frontline is not effective and that the only product they recommend now is Seresto collars. I will be returning this product and not recommending to anyone!
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Doesn't work!
By AnimalLover on Nov 11, 2020
I got this for my inside cat and dog. We've used it for 2 months in a row and the fleas are still not gone. We don't have carpet or rugs, they are just on the animals. I'm tired of me and my 3 year old getting eaten alive by fleas! It seems like it works for the first week or so then they are back long before the next dose is due. Horrible product and we used it for years several years ago. I'm very disappointed.
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Frontline, old product
By Kiki on Oct 22, 2020
Bought 2 different treatments for my puppy and neither worked so I got Frontline as it was supposed to be the best. Four days after treatment she was still covered in fleas. I took her to the vet and he stated that fleas are to "comfortable" with Frontline. He prescribed me NexGard and the fleas were dying instantly. My indoor puppy went crazy for a bit because the fleas went crazing dying. I literally saw them on dead my german shepherds hair. Thank God she will now have relieve, me also.
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Not worth it
By Seamus on Dec 9, 2020
Ten years and now had two boxes that didnt work. Used two vials a month apart for fleas. Box says should last 3 months. Drvided to buy another box. Same issue again. Bought another brand which seems to be working. Tg.
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Terrible Product
By Dontbuy on Dec 31, 2020
Chewy is a great site with great products but this one was a joke. Doesn't work one bit, I used one and the fleas seemed to like it so I threw the rest away.
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Worked great and swift
By RoxysView on Dec 15, 2020
I was dosed with my Frontline Plus the day I got it and I was so relieved to be rid of some pesky flees. I'm now comfortable and back on my game!! 3 paws up as that is all I have!!
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Any flea meds last a month?
By KayC on Jan 2, 2021
Got these drops first of dec. Its the second of jan and i have started seeing fleas again. Almost 30 day...any one find a longer lasting flea med?