Frontline Plus Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs, slide 1 of 1

Frontline Plus Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs

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Help protect your pup from pests with Frontline Plus Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs. This treatment kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks. It’s formulated with two active ingredients—fipronil and (S)-methoprene—to help disrupt the flea life cycle and inhibit future infestations. Plus, it’s designed to be waterproof after 24 hours, fast-acting, and long-lasting—one easy topical application works for 30 days. This treatment is paw-fect for medium dogs, weighing 23 to 44 pounds.

Key Benefits
  • Promotes a fast-acting and long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle.
  • Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
  • Simply apply once a month.
  • Designed for a waterproof protection after 24 hours.

Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing dogs. Consult with veterinarian before using on sick, medicated or aged animals. Keep cats away from treated dogs for 24 hours or until product has dried. If applied to a cat or ingested by a cat, contact your veterinarian immediately.

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

See all items by Frontline

  • Item Number
  • Usage
  • Lifestage
    Adult, Senior, Puppy
  • Breed Size
    Small Breeds, Medium Breeds
  • Product Form
  • Health Condition
    Fleas, Ticks

Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.

  • Snap open the tip of the Frontline applicator away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
  • Squeeze applicator to apply entire contents in a single spot on the skin monthly.
  • Allow 24 hours before bathing or swimming.

Additional Tips

  • Remove dog's collar
  • Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
  • Avoid touching the wet application spot.
  • Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
  • Give each of your dogs its own complete dose.

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
Dog Weight FRONTLINE Plus for Dogs
5-22 lbs Small (Orange Box)
23-44 lbs Medium (Blue Box)
45-88lbs Large (Purple Box)
89-132 lbs Extra Large (Red Box)

How does FRONTLINE® PLUS for Dogs work?

FRONTLINE® PLUS for Dogs contains the active ingredients fipronil and (S)-methoprene. The dual action protects your dog against fleas and ticks.

FRONTLINE® PLUS for Dogs spreads from the single point of applidogion, rapidly covering the entire dog and localizing in the hair, on the surface of the skin and in the sebaceous glands. These glands act as a reservoir, continuously replenishing FRONTLINE® PLUS for Dogs onto the skin and hair coat, so it keeps working even if the dog gets wet. Fleas and ticks are killed quickly after coming into contact with a treated dog. Fleas and ticks do not need to bite in order to die.

FRONTLINE® PLUS for Dogs also has the additional ingredient (S)-methoprene. This ingredient is an insect growth regulator (IGR) which prevents all flea stages (eggs, larvae, and pupae) from developing.

One dose (pipette) of FRONTLINE® Plus for Dogs should be applied once per month to protect against fleas and ticks. Year-round application is essential for pets in many parts of the country.

Do I need to use other flea & tick treatments while using FRONTLINE® Plus for Dogs?

No, FRONTLINE® Plus for Dogs is an effective treatment against fleas and ticks that works for a full month. If applied correctly and on a regular monthly basis, you do not need to use any other treatments while using FRONTLINE® Plus for Dogs.

Do I need to treat my dog for fleas and ticks even in colder months?

Yes, although the likelihood of your dog being affected by fleas decreases in the winter months, climates can vary and result in mild winters, favoring the survival of fleas outdoors for much longer. Fleas can also continue to develop indoors in homes thanks to warmer temperatures. Ticks can also be a problem year-round with some species of ticks attempting to acquire a host when temperatures are just above freezing. Therefore, it’s important to keep protecting your dog throughout the year.

My dog doesn’t go outside much, do I still need to treat them for fleas and ticks?

Yes, even ‘indoor-only’ dogs can become exposed to fleas. For instance, ‘indoor-only’ dogs still spend time outdoors whether it be to go on a walk or just going to the bathroom outside. Your dog can pick up fleas and ticks in your own backyard! Your dog could also be exposed if an untreated animal visits your home or if you or a friend brings in fleas on shoes or clothing.

Why might I see fleas on my dog after treatment?

You are likely seeing NEW fleas on your pet, which are jumping on your dog as it moves through infested areas in and around your home. These fleas will be killed by FRONTLINE® PLUS for Dogs before they can reproduce. Depending on the severity of the existing infestation, you may continue to see new fleas jumping on your pet for three months or more. To prevent new infestations, continue to apply FRONTLINE® PLUS for Dogs MONTHLY throughout the year.

FRONTLINE® PLUS for Dogs kills fleas by overstimulating the flea nervous system, and hyperexcited fleas may move to the top of the haircoat before they die. So, seeing fleas on top of the haircoat after applying FRONTLINE® PLUS for Dogs can be an indication that the product is working.

FRONTLINE® PLUS for Dogs kills ticks, but after treatment, ticks may still attach to your pet. If you see an attached tick on your dog, it is recommended for the tick to be removed and discarded (please see CDC recommendations on Tick Removal).

What is the best way to remove a flea infestation in my home?

Flea infestations are unpleasant for you and your dog, and can take three months or more to resolve, so be patient. Follow these steps to help resolve the problem:

  1. Ensure all pets in your home are treated with an appropriate product, such as FRONTLINE® PLUS for Dogs on dogs and FRONTLINE® PLUS for Cats on cats, at the recommended intervals for at least three consecutive months.
  2. Vacuum more often than usual – ideally daily – and focus on places your dog spends a lot of time, for example, carpets, the floor and furniture.
  3. Regularly wash your dog's bedding in hot water.
  4. Ensure your dog has access to all the same parts of the home that they usually do. Fleas present in those areas will be killed when they hop onto your treated dog.
  5. In some cases, it may be helpful to contact a pest control specialist.

What are the signs of fleas on my dog?

Apart from visually seeing fleas on your dog or in your home, other signs that your dog might have fleas include increased itching, scratching, licking, nibbling and over-grooming which can lead to damaged hairs or patches of hair loss. You may also see small dark red or black specks on your dog’s skin, bedding or on furniture.

How do dogs pick up fleas?

Dogs pick up fleas from anywhere untreated dogs have been – indoors or outdoors. Fleas on an untreated dog (or other animal host) can lay many eggs. Each female flea can lay up to 50 eggs per day. These eggs fall off into the environment, and over a period of weeks to months, these eggs develop into new adult fleas ready to jump onto your dog.

Why is it important to use the correct pack size for my dog’s weight?

Using the correct pack size ensures your dog receives the optimum dose for which the product has been shown to be effective.

Can my dog get wet right after applying FRONTLINE® Plus for Dogs?

Your dog needs to be dry at the time FRONTLINE® Plus for Dogs is applied and remain dry 24 hours after application.

Where can I find the expiration date for FRONTLINE® Plus for Dogs and how long will it last once I’ve bought it?

FRONTLINE® Plus for Dogs has no expiration date.

How long does it take FRONTLINE® Plus for Dogs to start working?

A study showed that within 12 hours, FRONTLINE® Plus for Dogs killed 100% of fleas.

What should I do before I treat my dog?

Read entire label and enclosed directions before each use.

Can my cat be around my dog after application?

Keep cats away from treated dogs for 24 hours or until product has dried. If applied to a cat or ingested by a cat, contact your veterinarian immediately.

Can FRONTLINE® PLUS for Dogs be used on any breed of dog?

Yes, FRONTLINE® PLUS for Dogs can be used on any breed of dog.

My dog is pregnant/lactating. Can I use FRONTLINE® PLUS for Dogs during this time?

FRONTLINE® PLUS for Dogs is approved for use in pregnant and lactating dogs.

I did not see the answer to my questions. Where can I find the additional information?

If you have any additional questions about our FRONTLINE® Plus for Dogs, feel free to reach out to the Veterinary Technical Solutions Team anytime at 1-888-637-4251.

About FRONTLINE Plus Dog Flea & Tick Treatment

Trusted for Over 20 Years

Made with two active ingredients, FRONTLINE Plus for Dogs kills adult fleas and ticks and prevents new infestations by killing flea eggs and larvae. This fast-acting, long-lasting topical formulation provides protection for a full 30 days.

Product Grouping

Breaks the Flea Life Cycle

FRONTLINE Plus contains fipronil and (S)-methoprene to kill existing adult fleas as well as flea eggs and larvae. After application, FRONTLINE Plus rapidly spreads to cover the entire surface of your dog’s body, localizing in the hair, on the skin and in the oil glands. This helps provide continuous protection for a full month, preventing future infestations if properly applied every month.

From Puppies to Adults

FRONTLINE Plus for Dogs comes in four sizes: Small, for dogs 5-22 lbs., Medium, for dogs 23-44 lbs., Large, for dogs 45-88 lbs., and Extra Large, for dogs 89-132 lbs. It is approved for use in canines 8 weeks of age or older who weigh over 5 lbs.


How to Apply

Part your dog’s hair between their shoulders, place the applicator tip just above their skin, and apply the entire contents of the applicator.* Avoid contact with the treated area until dry and repeat every 30 days for maximum efficacy.

*Read full instructions before each use.

Product Guide

FRONTLINE Plus offers protection for dogs in most sizes and weights. Choose the option best fitted for your pet.

5 - 22 lbs
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23 - 44 lbs
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45 - 88 lbs
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89 - 132 lbs
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FRONTLINE Plus has been trusted by pet parents for over 20 years. It combines two active ingredients to kill existing fleas and ticks and prevent new infestations from developing. The easy-to-apply, topical formula protects pets for up to 30 days and can be used on puppies as young as 8 weeks, weighing over 5 lbs. Help your best friend enjoy a pest-free lifestyle year-round with FRONTLINE!


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