FRONTLINE PLUS Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs, 6 Doses (6-mos. supply) -

Frontline Plus Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs

By Frontline Plus
Rated 4.0508 out of 5 stars
Pet Weight

New Customers Only: Spend 49+ Get $20 eGift Card + Free Shipping with code: WELCOME

$75.99Chewy Price
$72.19Autoship Price
Autoship (Save an extra 5%)

Why Autoship?

  • Save 5% on all future Autoship orders
  • Set your schedule based on your pet's needs
  • No fees, no commitments - skip, change or cancel anytime.

In Stock
FREE 1-3 day shipping

About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

See More





Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

Questions & Answers

22 Customer Questions

What is the difference between Frontline Gold and Frontline Plus?
Answer by ChewyJun 03, 2020
Both products are effective against ticks, fleas, and lice in both immature and adult versions. The only difference is that Frontline Gold kills fleas faster than Frontline Plus does. Frontline Gold has added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop in to adult fleas. Both products require monthly applications and are safe to use in all dogs and puppies above 8 weeks of age.

Does the fle/tick have to bite the dog before the medication works i.e. the medication is systemically absorbed and flea/tick must ingest rather than just coming into skin contact before it is lethal?
Answer by ChewySep 25, 2017
This treatment kills fleas and ticks through contact with your pet's haircoat, no biting is necessary.

Does Frontline contain Isoxazoline?
Answer by ChewyMay 25, 2020
This flea and tick treatment does not contain Isoxazoline. For a complete ingredient list, click on the 'Ingredients' tab, just under the product photos.

How many months do you need to apply frontline plus.
Answer by ChewyAug 15, 2018
This treatment is available in 3 doses or 6 doses which provides 3 months of protection or 6 months of protection. The amount needed depends on the severity of the infestation. In a study, FRONTLINE Plus began killing fleas 4 hours after application. Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.

ReviewsWrite a Review

Rated 4.0508 out of 5 stars
649 Reviews
Would recommend to a friend

649 Customer Reviews

Filter by reviews that mention

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Marlie on Mar 15, 2023

Dog tested Lyme +

My poodle has been on Frontline Plus monthly since she was 2 months old. Today at 10 months she has tested positive for Lyme disease and will need to be treated with antibiotics for a month. This could have canceled her surgery today as Lyme can affect platelets, but thankfully did not in her case. Cannot recommend.

Rated 1 out of 5 stars
By Lynn on Jan 29, 2023

Very disappointed

This is the second time I received frontline from Chewy where the box holding the medicine was already open. Not ordering from them again. Who knows what someone might have switched the medicine for. I have had other companies tell me they no longer sell this because someone tampered with their medicine. I thought Chewy would be more careful with their products. Guess not

Rated 5 out of 5 stars
By Julieko48 on Mar 24, 2023

The right product

I tried a different flea treatment and it didn't work. Chewy had the one that we've used in the past. It came in time and I was able to ward off additional infestation.

Rated 1 out of 5 stars
By Gabby on Mar 7, 2023

Would not recommend

I have two dogs, thought I would try it out. I have used three months supply for both of them and yet I continue to find fleas crawling in their white fur. Would not recommend.

Rated 5 out of 5 stars
By FoxterrierOwner on Nov 17, 2022

Great product

We live in a tick infested area of the country. Product is easy to apply and repels ticks in my dog who spends a lot of time outdoors. While we find an occasional tick crawling on his fur after hikes in the woods, the ticks do not attach to our dog. Very happy with this product!

Rated 1 out of 5 stars
By Bobbi on Mar 17, 2023

Not very effective

Dog still has fleas. Waste of money. Hi fffffffffffffffffffffffff

Rated 5 out of 5 stars
By Proudparent on Jan 25, 2023

Good product

We have used this product for years. No adverse effects on our dog with no fleas or ticks. Works well.

Rated 5 out of 5 stars
By G444 on Mar 27, 2023

Terrific product

As always your delivery was prompt and correct. Thanks!

Rated 5 out of 5 stars
By Bbmmrrbb on Nov 4, 2022

Not a single tick!

Love everything about this- no ticks, easy to apply, dries quick, doesn't smell. pharmacy worked directly with my vet to get it approved, had it in days!

Rated 1 out of 5 stars
By Lorena01 on Feb 24, 2023

This does it work

I had to switch to prescription, this does not work.