FRONTLINE PLUS for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) Purple Box -

Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs

By Frontline Plus
Rated 4.0672 out of 5 stars
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$75.99Chewy Price
$81.99Chewy Price
$72.19Autoship Price
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About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil , (S)-methoprene , Pyriproxyfen.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients: Fipronil 9.8%, (S)-Methoprene 8.8%.
LifestageAdult, Puppy, SeniorAdult, Puppy, SeniorAdultAdult, Senior, PuppyAdult
Breed SizeMedium Breeds, Large BreedsLarge BreedsLarge BreedsSmall Breeds, Medium BreedsLarge Breeds, Giant Breeds

Questions & Answers

31 Customer Questions

What would happen if I give my dog who is slightly under the weight limit the same amount as my dog who is slightly over the weight limit? I don't want anything to happen to her but I'd much rather just split the 6 month pack between them as I've never used this brand before.
Answer by ChewyDec 05, 2017
You may be slightly under or over as long as your dog is within 5 pounds of the limit. If not, we recommend going with the next size.

How does it protect your dog when you only apply by the back of the neck
Answer by ChewyNov 21, 2017
Once FRONTLINE Plus is applied, it stores itself in the oil glands in your pet's skin. It then self-distributes continuously for one month to your pet's hair and skin through the hair follicles, killing fleas and ticks.

Can this be taken by a dog that also takes a heart worm pill with flea prevention in it?
Answer by ChewyJun 09, 2021
We encourage speaking with your Veterinarian before combining flea and tick preventatives, for the safest opinion.

What type of ticks is Frontline effective on? As there are 6 different types of ticks in my area and not all Tropicals cover all 6.
Answer by ChewyJun 11, 2019
Frontline Plus treats against Lone Star Ticks, American Dog Ticks, Deer Ticks, Brown Dog Ticks, and Western Blacklegged Ticks.

ReviewsWrite a Review

Rated 4.0672 out of 5 stars
1339 Reviews
Would recommend to a friend

1339 Customer Reviews

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Rated 1 out of 5 stars
By Didntwork on Jan 19, 2023

Did not work

We have 2 dogs both using Frontline. It discolored 1 dog’s fur in a few spots (per the vet) and the worst, they had live fleas on them after months of being shampooed regularly and Frontline applied as directed.

Rated 1 out of 5 stars
By roxy on Nov 22, 2022

Didn't work

My dog has been on Frontline monthly preventative for years. Recently I found live fleas on her just 4 days after her Frontline dose. Continued to find live fleas on her for 3-4 days until her vet prescribed Capstar to kill the adult fleas. That worked quickly. She was flea free for about 4 days and now finding fleas on her again so clearly the Frontline is not working. All carpet has been vacuumed daily and treated with flea spray, all bedding washed daily etc.

Rated 2 out of 5 stars
By Sherry on Nov 1, 2022

Not Working

I use to buy this product for my dogs all the time and we never had an issue with fleas. But a pet store told me to try the flea collar they had that they were great and would last for months. Well for the first time ever my dogs got infested with fleas, So I did everything I could to kill the existing fleas with flea shampoo and Dawn. Then i went back to Frontline. Don't know if they changed the ingredients or if we have super fleas but there are atill active fleas. I do the second dose in 2 weeks. Hopefully it will kick in and start working. I will try the second dose before I say buy it or not.

Rated 4 out of 5 stars
By Emjay on Nov 4, 2022

Good Product, But Price Increased $5 after 5 days

This is a good product that has been effective for us for many, many years. However, I am dropping one star because the fluctuation in prices is insane. About 5 days ago, I checked and wrote down the price of a 3-month dose supply on my notes. It was $33.23 with autoship. Now, 5 days later on November 4, 2022, it is $38.94! That is ridiculous. I have seen similar price changes in other products I use for my pets, and have seen $10-$20 (additional) change in prices in a span of a few days. Terrible.

Rated 1 out of 5 stars
By Leesa on Nov 24, 2022

Unfortunately it caused issues

I put it on my dog and it didn’t keep the ticks away. She can’t walk now and now has lymes. It is heartbreaking that it didn’t work and now she is suffering currently. I know she will get better but I never wanted her to have this.

Rated 1 out of 5 stars
By Caren on Dec 14, 2022

Does not work anymore

I have used this product for many years and it seems it has stopped working. Now in the middle of getting the fleas out of our home. Had to move to prescription flea control.

Rated 5 out of 5 stars
By Poncho on Dec 14, 2022

Keeps me flea and tick free

I'm not really happy about this stuff being put on me, but my human buddy tells me it's good for me. That's good enough for me. WOOOF WOOOF

Rated 5 out of 5 stars
By Krandy123 on Sep 4, 2022

I've been using Frontline on my dogs for 37 years

I've been using Frontline on my dogs for 37 years. Why? Because it works. In all that time we've never had a flea infestation or a tick problem with any of our Doberman Pinschers. That seems like a good track record to me. This year, however, for the first time, our new rescue Dobie has had a terrible time with fleas. It doesn't surprise us because the change in the climate has affected everything in our household, from the dogs to our rose garden toe our vegetable gardens. Things are simply burning up. Our roses crumble like potato chips and on 8 tomato plants we have harvested 6 tomatoes! Usually, we have so many tomatoes we have to give them away, and the same with the roses. But with the intense heat, and, I believe, the thinning of the ozone layer, the sun feels so much hotter and seems to be burning everything up--including us--like it has never done before. We thought perhaps our Dobie had developed a tolerance for the Frontline, so we tried another brand of flea treatment and it made no difference. Now we're back to Frontline and we'll stick with it. After 37 flealess years, I think we'd be foolish to start experimenting now. As the cliche goes, "If it ain't broke, don't try to fix it."

Rated 1 out of 5 stars
By Rick on Dec 9, 2022

What's wrong with this product

I've used Frontline for years without problems but the last 2 packages don't seem to work and my dogs are simply when I've used it.What changed?

Rated 1 out of 5 stars
By Mjenn on Oct 31, 2022

Fleas are resistant

We have been using frontline for years no problem. There has been a recent influx of stray cats around and we have a flea infestation. The vet said frontline no longer works. Not one flea has died on my dog after biting.