Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs

By Frontline Plus
Rated 4.0974 out of 5 stars
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Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply) slide 1 of 14
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Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply) slide 1 of 14

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This Item - Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
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About This Item

  • Promotes a fast-acting and long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle.
  • Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
  • Simply apply once a month.
  • Designed for a waterproof protection after 24 hours.
Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

Shop Frontline

* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil , (S)-methoprene , Pyriproxyfen.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.
LifestageAdult, Puppy, SeniorAdult, Puppy, SeniorAdultAdult, Senior, PuppyPuppy, Adult, Senior
Breed SizeMedium Breeds, Large BreedsLarge BreedsLarge BreedsSmall Breeds, Medium BreedsExtra Small Breeds, Small Breeds

Questions & Answers

30 Customer Questions

What would happen if I give my dog who is slightly under the weight limit the same amount as my dog who is slightly over the weight limit? I don't want anything to happen to her but I'd much rather just split the 6 month pack between them as I've never used this brand before.
Answer by ChewyDec 05, 2017
You may be slightly under or over as long as your dog is within 5 pounds of the limit. If not, we recommend going with the next size.

How does it protect your dog when you only apply by the back of the neck
Answer by ChewyNov 21, 2017
Once FRONTLINE Plus is applied, it stores itself in the oil glands in your pet's skin. It then self-distributes continuously for one month to your pet's hair and skin through the hair follicles, killing fleas and ticks.

Can this be taken by a dog that also takes a heart worm pill with flea prevention in it?
Answer by ChewyJun 09, 2021
We encourage speaking with your Veterinarian before combining flea and tick preventatives, for the safest opinion.

What type of ticks is Frontline effective on? As there are 6 different types of ticks in my area and not all Tropicals cover all 6.
Answer by ChewyJun 11, 2019
Frontline Plus treats against Lone Star Ticks, American Dog Ticks, Deer Ticks, Brown Dog Ticks, and Western Blacklegged Ticks.

ReviewsWrite a Review

Rated 4.0974 out of 5 stars
1293 Reviews
Would recommend to a friend

1293 Customer Reviews

Rated 5 out of 5 stars
By katieB on Jul 28, 2022

yes it works

20+ year frontline user here, yes this works. I apply frontline once a month in different spots all over my dog, I have no idea what the actual instructions say but I really don’t care, I put it everywhere and it works. Put it on their head, tail, neck, hips, etc. you also need to understand your dog CAN NOT get wet for 3 days, that means no jumping in a pond, no bathes, no sprinkler time, no water on their body at all. Do this and a tick might crawl on them but it will immediately die. We live on a farm and this is all we have used for 20+ years of dogs, one of which lived to be 19. It’s one of the oldest and most studied tick treatments on the market and made in Germany, I only trust this brand.

Rated 1 out of 5 stars
By MelG on Jul 18, 2022

Waste of Money DOESN'T WORK!!!

If I could give this product 0 stars, I would. My dogs have fleas so I thought this would be a good solution to our problem. IT DIDN'T WORK AT ALL. I gave them 2 applications, 2 weeks apart because the first application did nothing. The 2nd application was just as useless. I went to my vet and he told me that Frontline hasn't worked on fleas in years!!!! It may be affective for ticks but NOT FLEAS!! I spent $175 on Frontline Flea Treatment for my dogs and cats (DIDN'T WORK ON THE CATS EITHER), and it was a COMPLETE WASTE OF MONEY. The fact that Chewy sells this product as a flea treatment makes me question their integrity as a business. DO NOT BUY THIS PRODUCT. IT'S A WASTE OF TIME AND MONEY!!

Rated 3 out of 5 stars
By Dogmom on Jul 21, 2022

$$$ overpriced

I don't know how I didn't realize I paid double the price for Frontline at Chewys until now. It's my fault I didn't pay more attention but I'm severely upset with myself that I got charged the same price for a topical solution when I could of got NexGard for the same price. Frontline is easily 40.00 everwhere-not 70 dollars!! I hate using topical solutions and even though it has worked I feel it's not worth paying the price Chewy is selling it for. I recommend the chewable kind over topical - if at this pricepoint for sure.

Rated 5 out of 5 stars
By AJ007 on Jul 6, 2022

Frontline Flea & Tick

I don't like to apply chemicals or have my dog ingest a pesticide and go into her bloodstream, so I opt for Frontline (absorbed by oil glands and effective prevention of fleas and ticks for large dogs for 1 month). No adverse effects/waterproof. I don't use this regularly, and my dogs have never had bugs, thankfully. I had to order in a rush when I was travelling, as my friend thought she saw a tick on my dog's paw. Chewy are so fab, they delivered the items in less than 24 hours! My friend lives in a wooded area so it's possible the risk of deer ticks is higher, but I was more impressed with Chewy delivering to my friend so quickly! I love this company and the staff - don't ever change as you have customers for life! Thank you so very much!

Rated 5 out of 5 stars
By alibi on Jul 10, 2022

Works for us

Living in North Carolina fleas and ticks are a year-round issue. I had used frontline successfully in the past and then switched to a Seresto collar. My dog did fine with his first Seresto but seemed irritated by the second one so I went back to frontline. I will continue to use it unless it lessens in effectiveness after time (which is why I switched to the collar in the first place.) But it took years before frontline seemed less effective. It's a good solution to fleas and ticks.

Rated 1 out of 5 stars
By Joey on Aug 8, 2022

Frontline Did Not Work!

We treated our dog the first of the month. By the third week he was scratching and I gave him a bath to find six fleas in the water. We treated him again and he never stopped scratching. A neighbor told me that her vet said fleas have become immune to Frontline. I believe it!

Rated 5 out of 5 stars
By suze on Aug 13, 2022

Takes care of fleas and ticks

I've used several types of flea and tick products. Some don't work, while others seem to irritate my boy's skin. With Frontline Plus, I don't worry about fleas and ticks, nor does it seem to bother my boy, as cheaper brands do

Rated 2 out of 5 stars
By Nicole on Jul 1, 2022

Doesn't work after several months

My dog hasn't ever had fleas before. We switched from K-9 Advantix to Frontline, and I understand it takes a few months to fully adjust but I have been applying Frontline as directed for months now and I don't see that it is working. For the first time, my dog got fleas and it doesn't seem like this topical medication helps at all. It may work for others, but it definitely didn't work for us which is a disappointment after spending a lot due to other's great reviews.

Rated 5 out of 5 stars
By Sven on Aug 4, 2022

Fast shipping

Been meaning to get my dog started on heartworm meds for a while now but haven’t gotten around to it. Noticed the mosquitos came out in droves this week so i quickly ordered this and it was delivered the next day along with frontline.

Rated 1 out of 5 stars
By GypsysMom on Aug 11, 2022

Waste of money

I bought this for my 2 dogs. Applied it as instructed, and waited. After 2weeks, both dogs had more fleas than before using the product. I would highly recommend you to seek out a product that actually works.