Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs

By Frontline
Rated 4.1138 out of 5 stars
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Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply) slide 1 of 12
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Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply) slide 1 of 12

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About This Item

  • Promotes a fast-acting and long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle.
  • Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
  • Simply apply once a month.
  • Designed for a waterproof protection after 24 hours.
Play Video: Learn More About Frontline From Our Team of Experts
Learn More About Frontline From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients: Fipronil 9.80%, (S)-methoprene 8.80%.
Breed SizeMedium Breeds, Large BreedsLarge BreedsSmall Breeds, Medium BreedsExtra Small & Toy Breeds, Small BreedsMedium Breeds, Large Breeds

Questions & Answers

30 Customer Questions

What would happen if I give my dog who is slightly under the weight limit the same amount as my dog who is slightly over the weight limit? I don't want anything to happen to her but I'd much rather just split the 6 month pack between them as I've never used this brand before.
Answer by ChewyDec 05, 2017
You may be slightly under or over as long as your dog is within 5 pounds of the limit. If not, we recommend going with the next size.

How does it protect your dog when you only apply by the back of the neck
Answer by ChewyNov 21, 2017
Once FRONTLINE Plus is applied, it stores itself in the oil glands in your pet's skin. It then self-distributes continuously for one month to your pet's hair and skin through the hair follicles, killing fleas and ticks.

Can this be taken by a dog that also takes a heart worm pill with flea prevention in it?
Answer by ChewyJun 09, 2021
We encourage speaking with your Veterinarian before combining flea and tick preventatives, for the safest opinion.

What type of ticks is Frontline effective on? As there are 6 different types of ticks in my area and not all Tropicals cover all 6.
Answer by ChewyJun 11, 2019
Frontline Plus treats against Lone Star Ticks, American Dog Ticks, Deer Ticks, Brown Dog Ticks, and Western Blacklegged Ticks.

ReviewsWrite a Review

Rated 4.1138 out of 5 stars
1248 Reviews
Would recommend to a friend

1248 Customer Reviews

Rated 3 out of 5 stars
By Kathy on Apr 23, 2022

Seems to work, but dog hates it.

I've used Frontlline for many years on different dogs, and it works, as I've never noticed any fleas, ticks or other nasty critters on my dogs after using it regularly. That being said, all my dogs hated having it applied. And I mean HATE. They would hide when I brought it out of the closet, and attempt to rub it off afterwards by rubbing along the side of the couch, the carpet, or rolling in the grass outside in an effort to get it off. I don't know why. With my current dog, because of my experience with previous dogs disliking the product, I started using an oral product instead, but it was so expensive, and required a prescription, so I went back to Frontline again. It works, but like my other dogs, she hates it being applied to her skin. Maybe it's the smell, maybe the feeling of cold liquid on her back? I don't know what's the big deal, it's only a few drops. Anyway, this is the fourth dog I've had that has hated it.

Rated 5 out of 5 stars
By CollieMom on May 17, 2022

Use Frontline Plus - Why? - Because it works.

I have used Frontline Plus on all my dogs for as long as they have been making it. It works. That's just what I want. I have never had side effects from this product. It does the job.

Rated 5 out of 5 stars
By FurMama on Mar 5, 2022


I’ve never used Frontline before, I’ve always used a different similarly priced brand. 2021 in our area was the worst I’ve ever seen for fleas and we are still fighting the fight, currently. So, I gave in and ordered Frontline for all our fur babies (2 cats and 5 dogs). While applying it to one of the dogs, a flea walked by, I grabbed it with my Frontline covered fingers and when I went to kill it with my fingernails it was already dead. Maybe 20 seconds had lapsed. I’m sold, forever!

Rated 5 out of 5 stars
By FinleysFriend on Apr 7, 2022

Shipments to our house

We wish you would only send ONE bag of dog food in One carton !!!! Putting two in each carton makes it very difficult for us to bring them inside and , I'm sure not easy on the delivery people either. That's why we are now only ordering one bag at a time .

Rated 1 out of 5 stars
By Natalie on Apr 28, 2022

Does not work

We have 4 dogs we noticed no fleas within the first day but just 1 week later and it seems like it has gotten worse. We will be going back to the vet for our nexgard seeing as this did not work

Rated 5 out of 5 stars
By GoldenDoodles on Mar 20, 2022

Love this product

I’ve always used this in the past. We purchased a puppy and the vet said to use the chewable flea med. Well it didn’t set well with my puppy, so after two times I stopped and went back to Frontline. It’s a proven product that works and doesn’t cause my dogs or cats to get sick

Rated 5 out of 5 stars
By Rachel on Apr 9, 2022

Great for my dog!

Been using this for my 68 pound lab retriever for 4 years still works great! You put it right between the shoulder blades and she can’t get it off. Normally it’s fully dry by nighttime if we put it on in the morning.

Rated 4 out of 5 stars
By Cats on Apr 14, 2022

Jury’s Out

The first application certainly seems to have worked better than the Pet Armour. I am holding my breath and will have to order more rounds but so far, this product is an improvement.

Rated 4 out of 5 stars
By Cokjakester on Apr 11, 2022

Works great but

Works great but extremely expensive! Have been using since it first hit the market. Always had great success, never any flea or tic issues. Just so darn expensive. Especially for 2 dogs.

Rated 5 out of 5 stars
By FP22 on Mar 31, 2022

Works so well!

Frontline Plus worked so well!!! I would definitely recommend this product for anyone looking to keep fleas at bay! We’ve tried other brands in the past, but nothing worked as well as this one!!