Zymox Otic Dog & Cat Ear Infection Treatment with Hydrocortisone

By Zymox
Rated 4.854 out of 5 stars
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$99.99Chewy Price
$129.99Chewy Price
$94.99Autoship Price
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Top IngredientsActive Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...Natural Enzymes, Lysozyme, Lactoferrin, Lactoperoxidase.Water, Propylene Glycol, Isopropanol...Active: Sd-Alcohol 40-2, 10%; Lactic Acid, 1.76%; Benzoic Acid...
Health FeatureEar CareEar CareEar CareEar CareEar Care
Breed SizeSmall Breeds, Medium Breeds, Large Breeds
Packaging TypeBulk

About This Item

  • Effectively treats acute and chronic otitis externa due to bacterial, fungal and yeast infections. This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Contains three active enzymes that have shown to be antibacterial, antifungal and antiviral.
  • Hydrocortisone helps to provide relief from itching and inflammation.
  • Three-point enzyme system destroys antibiotic resistant microorganisms, including Staphylococcus.
  • Made in the USA.
Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

Questions & Answers

56 Customer Questions

Is this safe for cats as well ?
Answer by SuzannaMay 14, 2021

Will the 1.25 ounce bottle be enough to treat 1 dog, both ears?
Answer by ChewyOct 08, 2017
The 1.25 ounce bottle will provide more than 2 weeks worth of daily maintenance to both ears.

how long do you massage the base of your pet's ear and keep the liquid in the ear canal?
Answer by ChewyAug 24, 2018
Massage the base of your pet's ear until the treatment has coated the infected area.

Is this safe if ingested? I have three dogs that like to lick/clean each others ears and want to ensure this is safe.
Answer by ChewyOct 02, 2018
Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use.

ReviewsWrite a Review

Rated 4.854 out of 5 stars
2219 Reviews
Would recommend to a friend

2219 Customer Reviews

Rated 5 out of 5 stars
By petlover0501 on Aug 13, 2022

Saved me a trip to the vet!

My lab Cash had a pretty nasty smelly ear infection that came on quickly after a bath. It’s a bit ironic because we have a stream he often swims in but by this time, it had gone dry for the summer. He even scratched it so much he broke the skin on the flap of his ear in the middle of the night and let out a little cry. Knowing how under staffed our vet is and the likelihood of a prompt appt date being low, plus the cost of the visit, I searched Chewy for a solution. I’d never heard of anything like this product that didn’t require a prescription! Cleared it up right on timeline with the 7 day dosing suggestion. At first he hated me doing it, but once it started to help it was like he realized what was going on and would be happy to let me do it, especially massaging the base of his ear which I’m sure was itchy. Wish I had known about this before my previous pup, Molly Mae, passed. She had many ear infections and we took her to the vet often for them. Very grateful pup parent here and future buyer! I’ll be recommending this product to everyone I know.

Rated 5 out of 5 stars
By Rescuemomma on Jul 26, 2022

Love this.product!

Ear issues are frequent in rescued kittens. Have tried several products and saw reviews for this were great, so ordered it. Worked great on latest 2 kittens. Treating our dogs ear with it now, he woke up yesterday shaking his head and his ear is really red inside. Day 2, no more head shaking, or digging at his ear, not near as red inside canal. He sat still and let me put it in! Unheard of, so you know it helped the pain.

Rated 5 out of 5 stars
By CACinCA on Aug 10, 2022

Great & Effective

Our Weim has recurring problems/infections with his ears due to food sensitivities. We used an Rx in the past until this was recommended by our vet. It works GREAT!!! It's cost-effective & over-the-counter. This will be our "go -to" first. VERY happy.

Rated 5 out of 5 stars
By skitts on Aug 9, 2022

My cat may not appreciate this but...

It really does help his ears. Followed the instructions and he's no longer shaking his head or frantically scratching his ears. It's a lifesaver for an owner with a grumpy old cat. I highly recommend this for kitties who are constantly scratching their ears.

Rated 5 out of 5 stars
By Pickles on Jul 13, 2022

If I didn’t see it for my self wouldn’t of believed it.

My babies ear was so bad her head was tilted hard for her to eat even drinking water was hurting her my son found this Medication read the reviews we had to give it a try very glad we did the next day we seen results used for 7days like recommend and now she’s better Thank you so much will recommend to others.

Rated 5 out of 5 stars
By 4130 on Jun 18, 2022

Poppy of South Street

Our Puppy has floppy ears, very prone to infections. We treated them a few times with prescriptions from the vet. I found this product and did a seven day course with excellent results. Now I carefully smell her ears every few days - a little gross but necessary. One a week she gets a preventative Zymox treatment. If we miss a week, her ears will gunk up and the smell returns. Used every week, her ears wipe clean and look pink and healthy. No scratching. We do have to be vigilant and use it weekly, but it absolutely works. No infections. Ears always smell neutral. Get to know your dog’s ears!

Rated 2 out of 5 stars
By UncleD on Jul 25, 2022

Zymox Otic Treatment

I read all the reviews about how this helped get rid of the ear infection in dogs and decided to try it, unfortunately, it did not work on my Yorkie, who has ear infection on a regular basis. This is a very expensive product for it not to work. I guess to the vet we go, again.

Rated 5 out of 5 stars
By HappyCamper on Jun 12, 2022

Ear Problems

My Chi was scratching at her ear the previous night. Next day as I was rubbing her ears, which she usually enjoys, she yelped. Afraid that she was maybe getting an ear infection, I added a bottle of Zymox to her Chewy auto ship order & requested that it ship. Within 2 days I had the order containing the Zymox. Zymox is a great product and only required to use once daily. My dog seemed to like the feel of the Zymox when applied to each ear. After several days of application her ears seemed fine. As always I'm happy with Chewy's product, price and customer service. Thank you, Chewy!

Rated 5 out of 5 stars
By KikaM on Jun 27, 2022

Works for long time ear problem

My dog has allergy for dust, feather, mold, wool and etc etc.. spent so much money for these 10 years.. Specially, he had always had ear problem.. His allergy doctor recommended this so, I used for him this time.. First few days I was not sure... but 7 days use, his ear got no red no itch! now a month pass and his ears are sill no problem. I am so happy for him..

Rated 5 out of 5 stars
By Lizzy on Jul 17, 2022

works great. saved a trip to the vet

This stuff is amazing. My dog had an ear infection. Her ear was very swollen, stinky, and dirty. In a few days she was noticeably better. The swelling went down and it cleaned her ear. I put it in the other ear as well just to clean that one.