Adequan Canine (polysulfated glycosaminoglycan) Injectable for Dogs, 100-mg/ml, 5-mL, 2 count

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About This Item

Details

Adequan Injectable for Dogs is an injectable medication prescribed to help manage arthritis and joint problems in dogs. It may also help restore joint lubrication, relieve inflammation and renew the foundation of healthy cartilage. For over 20 years, this medication has been prescribed and trusted by veterinarians to help moderate signs connected with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.

Qualifying purchases of 8-dose series (two 5mL vials) of Adequan Canine may be eligible for a $20 rebate. Learn how to claim your rebate in the Rebate Instructions PDF link below.

We directly source prescription medications from manufacturers and wholesale distributors registered with the FDA and licensed by applicable state boards. Guaranteed genuine, and where applicable, backed by the manufacturer.

Ingredients

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4.7
Rated 4.7 out of 5 stars
1737 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

91% Positive

Effectiveness

91% Positive

Ingredients

90% Positive

Long-Term Benefits

91% Positive

771 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Peter on Jan 1, 2026

Easy ordering process; flawless delivery

The process for ordering this medicine was incredibly easy. I verified that it was the same strength and formulation that was prescribed by the vet, added it to

The process for ordering this medicine was incredibly easy. I verified that it was the same strength and formulation that was prescribed by the vet, added it to my cart, and placed the order. Chewy handled the communications with the vet and received approval for the medication. A few days later, the medicine was delivered; package was perfect, protecting the two vials. I certainly could have purchased this medicine from our vet - in fact, that's where the first two doses came from. I'm receiving prescription medicine for our other dog from Chewy already and have been very happy with how that's worked out, so this was a no-brainer. As an aside, our dog Bradley responded very well to the injections. We saw a noticeable improvement beginning after the third shot (out of a series of eight).

Rated 5 out of 5 stars
By Genny on Jan 5, 2026

This has made such a positive impact on his mobility

Duff is around 90-100+ pound mastiff Shepard mix and 13 and a half years old at the time of this writing.he has one blown knee we just can’t replace. his other leg

Duff is around 90-100+ pound mastiff Shepard mix and 13 and a half years old at the time of this writing.he has one blown knee we just can’t replace. his other leg was having issues due to over compensation and this has been key for him being able to get up unaided more often and tolerate more, albeit light, exercise. he started once per month after the initial ramp up, then to 3 weeks and are now settled with every other week. If, for whatever reason we forget his injection, we can tell almost immediately. this is well worth the money. he gets 2cc every other week.

Rated 5 out of 5 stars
By Jonathan on Jan 13, 2026

My dog jumps again and limping stopped!! Highly recommend.

After only a few weeks of Adequan injections, my seven year old Lab started jumping into the car again and the on and off limping she had for years stopped. My dog

After only a few weeks of Adequan injections, my seven year old Lab started jumping into the car again and the on and off limping she had for years stopped. My dog is also on high quality joint supplements, which are important, but never achieved the same result as Adequan. I'm so happy we finally tried Adequan and we'll definitely use it once a year to keep this result.

Rated 5 out of 5 stars
By Sharon on Jan 19, 2026

Game Changer!

My 10 year old Sheltie was starting to get stiff and limped a little after lying down for awhile or running in the yard. On my vet’s recommendation, I started giving

My 10 year old Sheltie was starting to get stiff and limped a little after lying down for awhile or running in the yard. On my vet’s recommendation, I started giving him injections (now once a month maintenance) and have seen a big difference. He no longer limps and runs around our 2 acre property with ease.

Rated 5 out of 5 stars
By Christine on Dec 7, 2025

This medication is absolutely incredible!

My dog is a 100lb silver Labrador Retriever who is 9yrs old and has had both rear knees replaced and has generalized arthritis throughout her joints and spine. We

My dog is a 100lb silver Labrador Retriever who is 9yrs old and has had both rear knees replaced and has generalized arthritis throughout her joints and spine. We have done everything to help decrease her pain we tried: pain meds, water therapy, exercises, acupuncture, massage and chiropractics but she kept getting worse. I then took her to our Vet again and she recommended trying Adequan. It is expensive but I couldn’t pass up a chance to help her. Within a few hours after the injection she seemed to be getting up a bit easier but I thought that was impossible. The next day and I am being truly honest about this, she wanted to go outside and play ball toss. I threw the ball and she actually ran, she really ran to chase the ball!!!! She is doing so well on this medication it’s amazing! I only wish that this could be prescribed for people. Truly wonderful results! Chewy’s price is very good even though it’s still expensive but seeing my dog get around so much easier is worth it!

Rated 5 out of 5 stars
By Elizabeth on Dec 8, 2025

Excellent Coordination of Care

Chewy worked quickly with my veternarian's office to obtain the prescription details and then send the medicine to me. I am so appreciative. As someone who already

Chewy worked quickly with my veternarian's office to obtain the prescription details and then send the medicine to me. I am so appreciative. As someone who already feels comfortable with IM and subQ injections, it was ideal to avoid the cost--both financial and time--of coordinating this medication start through my vet. Working just with Chewy meant that my pup get started weeks earlier than we would have been able to otherwise. Hopefully, we also notice even small improvements in her mobility! She's an old lady pup, so anything to add quality at this point is worth it. I'm not sure she loves anything more in life than her walks and am hopeful we have many more comfortable long or short walks in our future together.

Rated 2 out of 5 stars
By Pamela on Dec 4, 2025

No needles included

First I received an email on Friday saying the order had been approved by my veterinarian and that it was being reviewed by a Pharmacist. Then late Saturday afternoon,

First I received an email on Friday saying the order had been approved by my veterinarian and that it was being reviewed by a Pharmacist. Then late Saturday afternoon, I received another email saying the order was still being reviewed by a Pharmacist. At that point I started a chat to determine the hold up. Apparently the Pharmacist simply had started but not finished the order. Now the order could not ship until Monday so I lost a couple of days. Then when the order arrived, it did not include any needles which was not mentioned in the description. I did receive needles with a previous order for Adequan a few years back for a different pet so naturally I assumed needles would come with this order as well. Luckily, I had a couple of needles leftover from the previous order but had to order more needles from my veterinarian. It was a frustrating process and was one I had never experienced with a Chewy order before.

Rated 2 out of 5 stars
By Megan on Nov 25, 2025

Unfortunately didn’t work for my dog

I have an 11 year old lab and was recommended this medication from her vet to help her joints as she ages. I was so excited for this option after reading the reviews

I have an 11 year old lab and was recommended this medication from her vet to help her joints as she ages. I was so excited for this option after reading the reviews from other pet parents. Giving the shot was easy, but within 12 hours my dog had the most violent and persistent diarrhea of her life. It continued for over a week, even with anti diarrheal meds from the vet and a diet of chicken and rice. I brought her to the vet and they informed me that while side effects are rare on this med, this is the most common one (IF your dog reacts to it). It unfortunately didn’t work for my dog and I’m posting this review just so others know this could happen. However, I would like to acknowledge that this side effect seems rare and it shouldn’t scare you from trying to help your dog. My dog is completely back to normal after the medication left her system without medical intervention - so it’s worth a try!

Rated 5 out of 5 stars
By Shari on Jan 13, 2026

Timely delivery

Dodger James has an issue with his right knee and this medicine is a miracle for him. The delivery came quickly; HOWEVER, I wish you had overnight/expedited delivery

Dodger James has an issue with his right knee and this medicine is a miracle for him. The delivery came quickly; HOWEVER, I wish you had overnight/expedited delivery. My life would be so much easier!

Rated 1 out of 5 stars
By Todd on Nov 18, 2025

No accountability

I have ordered the same medication 4 times and only received my prescription once. Shipping problems from both Chewy and their shipping service has been horrendous

I have ordered the same medication 4 times and only received my prescription once. Shipping problems from both Chewy and their shipping service has been horrendous. Nothing was done to resolve the issue aside from an apology or two. Even after I offered to pay for expedited shipping, they were unable to accommodate my request. Now my pet has missed a dose of medication due to their inability to provide customer service. This will be my last order with Chewy.