Advantage II Flea Spot Treatment for Dogs, over 55 lbs

By Advantage II
Rated 4.3556 out of 5 stars
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Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 4 Doses (4-mos. supply) slide 1 of 11
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Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 4 Doses (4-mos. supply) slide 1 of 11

$44.98Chewy Price
$42.73Autoship Price
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About This Item

  • Veterinarian-recommended treatment kills all life stages of fleas on puppies and dogs 7 weeks or older and weighing over 55 pounds.
  • Begins working within 12 hours to kill fleas on contact.
  • Kills eggs, larvae and adult fleas to break the life cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing or swimming.
  • Convenient, monthly topical application contains imidacloprid and pyriproxyfen; available in packs of 4 or 6 treatments.
Play Video: Learn More About Advantage II From Our Team of Experts
Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

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Top IngredientsActive Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients : Imidacloprid 9.10% , Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 8.80%, Permethrin 44.00%, Pyriproxyfen 0.44%....Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.
LifestageAdultAdult, Puppy, SeniorAdult, Puppy, SeniorAdultAdult, Puppy, Senior
Breed SizeLarge Breeds, Giant BreedsSmall BreedsExtra Small BreedsLarge Breeds, Giant BreedsSmall Breeds, Medium Breeds

Questions & Answers

18 Customer Questions

Is this safe to reapply initially after 14 days? And then monthly after fleas are no longer seen
Answer by ChewyNov 26, 2020
Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 7 days. After flea control is attained, return to a monthly retreatment schedule.

What country is this from
Answer by ChewyMay 09, 2020
This flea treatment is made in Germany.

If my dog is right on the line for weight, which dosage should I choose?
Answer by ChewyOct 23, 2017
If your pup is between weights, you want to choose the size up.

Will the Advantage II for xtra large dogs be enough for a 175 lb. dog?
Answer by ChewyJun 23, 2018
Advantage II Flea Treatment for Extra Large Dogs is safe and effective for all dogs over 55 pounds when used as directed.

ReviewsWrite a Review

Rated 4.3556 out of 5 stars
374 Reviews
Would recommend to a friend

374 Customer Reviews

Rated 3 out of 5 stars
By Elizabeth on Jul 2, 2022

Not for people with Allergies

It seems to be doing it job with the fleas. Buyer beware, it is scented. The floral sent which most people probably like on a stinky pet. But if you’re allergic to perfumes or are you simply don’t like it, I don’t recommend this product. I think the packaging should have indicated it is scented.

Rated 5 out of 5 stars
By Elizabeth on May 10, 2022

This Product Helped my Dog

My dog wasn’t on any prevention, and my neighbor’s dog had fleas which spread to my yard. I would see them crawling under my dog’s fur and she was scratching non stop, but when I used this, the fleas on her were gone the next morning! All the scratching stopped and I have not seen a single flea in over a month

Rated 5 out of 5 stars
By DeeJaa on Aug 5, 2022

Works well!

I’ve been using this on my dog for several years. It works really well.

Rated 5 out of 5 stars
By kare on May 28, 2022

Works great have had good luck with this product.

Works great I tried other that haven't worked that great but have had good luck with this for my 3 dogs.

Rated 5 out of 5 stars
By DOLLY on Jul 29, 2022


The price was perfect and there was super fast shipping.

Rated 5 out of 5 stars
By Satisfiedcustomer on Mar 26, 2022

Highly recommend ordering from Chewy.

This was my first time ordering from Chewy. The price was less than any retail store, the site was easy to navigate, and delivery was very fast. The driver was pleasant, also. I wish I would have ordered from them sooner.

Rated 1 out of 5 stars
By AlMa on Jan 15, 2022

No longer effective

Pets were treated regularly, but a stray cat got into my apartment and my cat and dog both got fleas. The fleas were able to survive and the infestation got worse later, leading to tapeworm. Talked with my vet and they said Advantage was no longer as effective because the fleas in my area have built up an immunity to the product.

Rated 5 out of 5 stars
By Jitterbug2 on Dec 10, 2021

well tolerated

My dogs tolerate this flea treatment the best out of all the topical treatments. It does what the company says it will do.

Rated 5 out of 5 stars
By Blakesmom on Sep 9, 2021

Reliable for my needs

I have used the advantage II for many years. It kills fleas in all of the life cycles. I know that there are other brands that take care of different issues but this has always been exactly what I needed. I am very satisfied with this product.

Rated 2 out of 5 stars
By Toni on Jun 21, 2021

The Smell is Horrible

My dog had seizures with oral flea prevention meds and my vet recommended Advantage II since it doesn’t contain the same class of medicine. The day after application and three or for days after my dog stinks to high heaven, kind of like a chemical, rotten, moldy smell, to the point where I’m actually nauseated being around her. The product seems to work, but I dread using it and may have to find an alternative. A google search reveals others are having the same problem with Advantage.