Advantage II Flea Spot Treatment for Dogs, over 55 lbs

By Advantage II
Rated 4.3056 out of 5 stars

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$63.98Chewy Price
$60.78Autoship Price
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About This Item


  • Flea protection for dogs weighing over 55 pounds, at least 7 weeks old.
  • Easy-to-apply monthly topical treatment.
  • Delivers total flea protection and kills adult fleas, flea larvae and flea eggs through contact.
  • Starts killing fleas the same day and keeps working for 30 days.
  • Fragrance-free formula is waterproof after 24 hours of application.

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Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

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Top IngredientsActive Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients : Imidacloprid 9.10% , Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 8.80%, Permethrin 44.00%, Pyriproxyfen 0.44%....
LifestageAdultPuppy, Adult, SeniorPuppy, Adult, SeniorPuppy, Adult, SeniorAdult
Breed SizeLarge Breeds, Giant BreedsSmall BreedsExtra Small BreedsSmall Breeds, Medium BreedsLarge Breeds, Giant Breeds

Questions & Answers

15 Customer Questions

Is this safe to reapply initially after 14 days? And then monthly after fleas are no longer seen
Answer by ChewyNov 26, 2020
Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 7 days. After flea control is attained, return to a monthly retreatment schedule.

What country is this from
Answer by ChewyMay 09, 2020
This flea treatment is made in Germany.

If my dog is right on the line for weight, which dosage should I choose?
Answer by ChewyOct 23, 2017
If your pup is between weights, you want to choose the size up.

Will the Advantage II for xtra large dogs be enough for a 175 lb. dog?
Answer by ChewyJun 23, 2018
Advantage II Flea Treatment for Extra Large Dogs is safe and effective for all dogs over 55 pounds when used as directed.

ReviewsWrite a Review

Rated 4.3056 out of 5 stars
396 Ratings
Would recommend to a friend

396 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By SixCatGuy1dog on Aug 31, 2023

Advantage II works for all

My brother was coming for a visit and bringing his dog with him. The last visit, the dog picked up fleas and transferred them to my oldest cat, which caused me to treat all 6 cats. This purchase was preemptive to treat the dog before fleas caused me issues.

Rated 1 out of 5 stars
By Dee on Jun 3, 2023

Doesn't work at all

I bought this and waited to try a few times but my dog is still having issues with these fleas and now is getting ear mites I hope to get my money back and I will go else where never buying from chewy again

Rated 5 out of 5 stars
By RagnarsMom on Mar 30, 2023

Only thing that works here.

Advantage ii is the only flea product that fleas are not immune to around here, and it works fast enough to kill the fleas before they can bite (our dog has a flea allergy). We tried out another med last year for one dose (after doing Advantage for several months) and the fleas were left alive long enough to cause his allergy to flare again. Hopefully, it continues to work for years to come. We combine this with treatment of our property and surrounding areas that he can get to, as well as an IGR in our house.

Rated 5 out of 5 stars
By Moose on Jun 4, 2023

Advantage II

This product works great. We have 8 cats - all go outside - in the spring all get fleas (some ticks). This product kills both - is effective for over a month.

Rated 5 out of 5 stars
By BF on Jul 17, 2023

Great Product

I have been using this product for years. It's safe and effective. I highly recommend this product.

Rated 3 out of 5 stars
By Sharon on Feb 13, 2023


We are having so much trouble finding a flea med that will work. After trying other brands because Advantage stopped working, I returned to Advantage to see if maybe it would work since the other brands didn't. We're a week into treatment & fleas are still rampant.

Rated 5 out of 5 stars
By Roger on Mar 15, 2023

This product does work

I have used this product for 5 years and have not had one flea or tick on any of my 4 dogs and one cat and they have access to a large, wooded back yard. This product just works.

Rated 1 out of 5 stars
By Jayr on Apr 20, 2023

Not sure about this...

Put this on the dogs 10 days ago and have had multiple ticks getting a good meal.

Rated 5 out of 5 stars
By MARTY on Feb 4, 2023


I would definitely recommend CHEWY and this product. Every time I order from them I am not disappointed, The prices are great,the shippimg is fast and the products are amazing, Thanks CHEWY

Rated 4 out of 5 stars
By Dogmom on Jan 13, 2023

Flea spot treatment

Great product. Shipping was fast. My box was half open due to the box NOT being taped closed properly. Could've lost my product.