ADVANTAGE II Flea Treatment for Dogs, 21-55 lbs, 4 Doses (4-mos. supply) -

Advantage II Flea Treatment for Dogs, 21-55 lbs

By Advantage II
Rated 4.2434 out of 5 stars
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About This Item


  • Veterinarian-recommended treatment kills all life stages of fleas on puppies and dogs 7 weeks or older and weighing 21-55 pounds.
  • Begins working within 12 hours to kill fleas on contact.
  • Kills eggs, larvae and adult fleas to break the life cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing or swimming.
  • Convenient, monthly topical application contains imidacloprid and pyriproxyfen; available in packs of 4 or 6 treatments.

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Play Video: Learn More About Advantage II From Our Team of Experts
Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Dog

About Advantage II Dog

Help stop the misery of biting fleas with Advantage II. This vet-recommended, monthly topical formula works to kill adult fleas as well as flea larvae, eggs and lice, so your pup is ready for fun. Plus, it's for dogs and puppies 7 weeks of age or older. Help your pal get the effective protection he needs by experiencing Advantage II.

Why Choose Advantage II?

Advantage II is fragrance-free, odorless, waterproof after 24 hours of application and kills fleas directly through contact. That means pesky fleas don't have to bite to perish. With just one application, you can prevent further flea infestations for up to 4 weeks and can even help prevent, control and treat lice infestations. With Advantage II, you can stop multiple flea life stages, effectively breaking the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas in their tracks. The first active ingredient kills fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Dog?

Whether your dog is a winter snow hound or a summer backyard explorer, an indoor sun seeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your dog, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Every Size Dog


3-10 pounds


11-20 pounds


21-55 pounds


55 pounds and over

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with protection they need.
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Top IngredientsActive Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 8.80%, Permethrin 44.00%, Pyriproxyfen 0.44%...Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients : Imidacloprid 9.10% , Pyriproxyfen 0.46%.
LifestageAdult, Puppy, SeniorAdultAdult, Puppy, SeniorAdult, Puppy, SeniorAdult, Puppy, Senior
Breed SizeSmall Breeds, Medium BreedsLarge Breeds, Giant BreedsSmall Breeds, Medium BreedsSmall BreedsExtra Small Breeds

Questions & Answers

9 Customer Questions

Is it possible to apply half the tube, then the other half at a later day, say a week after?
Answer by ChewySep 05, 2017
The treatment is measured for the dosage to be used all at the same time to repel fleas, it may not be as effective if you split the days.

what dose is the medication (mL)for the large dog
Answer by ChewyJun 14, 2021
Each of the tubes contain about 2.5 milliliters of flea treatment.

How long will this product protect my dogs if they are swimmers???
Answer by ChewyApr 03, 2018
This product is waterproof and swimming will not have any effect on it.

will advantage II kill or repel mosquitoes?
Answer by ChewySep 08, 2022
This treatment does not repel mosquitoes.

ReviewsWrite a Review

Rated 4.2434 out of 5 stars
226 Reviews
Would recommend to a friend

226 Customer Reviews

Filter by reviews that mention

Rated 1 out of 5 stars
By Daniel on Jun 30, 2022

another one bites the dust

WHY are fleas so resilient ?? I’ve tried everything under the sun that is OTC and even came back to Advantage because it seemed to have worked the best. But not any longer. I am so disheartened. This latest purchase plus one more for the cats without them getting a break is awful. I’ve vacuumed everything daily, washed bedding, done everything possible and nada, zilch. My poor babies! This now would mean I will have to save up for the vet, which I definitely could have afforded by now with all the wasted monies spent on products that are not effective!

Rated 5 out of 5 stars
By plcollins on Sep 18, 2022

Safe flea treatment for a pregnant dog

I am extremely pleased to find out from several different reputable sources that Advantage is safe on pregnant dogs.

Rated 5 out of 5 stars
By Skiludd on Oct 30, 2022

Flea drops

Have always used advantage and advantix. Have tried the pills with no success

Rated 5 out of 5 stars
By Linda on Nov 18, 2022

Flea meds advantage 11 dog

Sadie no longer has fleas. Worked really well and quickly! Yea!

Rated 5 out of 5 stars
By Dawne on Nov 27, 2022

Advantage Large Dog

Good product - does what is intended. I would buy again.

Rated 2 out of 5 stars
By Wesson on Apr 4, 2022


After finding tons of ticks on the dog, I came here to look at the product that's when I realized it doesn't even say it works on Ticks. That is kind of my fault but why would you even have a product that doesnt do both? I guess I need to put something else on the dog to prevent Ticks... Annoying.

Rated 5 out of 5 stars
By LoPo on Apr 2, 2022

Trust this brand!

I’ve been using Advtg 2 for a few years now and it’s kept the fleas off my small girl every season. I also have to buy the XL for my other two and year after year we never have a flea issue! Until I started using this brand, we really struggled but now it’s a peace of mind knowing they’re all protected.

Rated 5 out of 5 stars
By LizH on Apr 2, 2022

Great product & price!

I got the 6 month supply on hand so my groomer can apply after my Albee's wash! I can apply it also because it's easy to do. Looking forward to summer!

Rated 4 out of 5 stars
By thatvickichick on May 23, 2022

Not for ticks

Before ordering, read the details of your item. I assumed this protected from fleas and ticks.

Rated 5 out of 5 stars
By 63Vette on Apr 14, 2022

Great protection

We gave veen using this product on our larger dogs fir a number of years. Not one if our dogs got fleas with this product.