Dorzolamide is used as a treatment for glaucoma, and is often prescribed by veterinarians for use with dogs and cats. This drug contains a carbonic anhydrase inhibitor which decreases intraocular pressure, a characteristic of many types of glaucoma.
Dorzolamide HCl Ophthalmic Solution is indicated in the treatment of elevated intraocular pressure in
patients with ocular hypertension or open-angle glaucoma.
Possible Side Effects
The most frequently reported adverse reactions associated with Dorzolamide HCl Ophthalmic Solution were ocular burning, stinging, or discomfort immediately following ocular administration (approximately one-third of patients). Approximately one-quarter of patients noted a bitter taste following administration. Superficial punctate keratitis occurred in 10 to 15% of patients and signs and symptoms of ocular allergic reaction in approximately 10%.
Drug & Food Interactions
There is a potential for an additive effect on the known systemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and Dorzolamide HCl Ophthalmic Solution. The concomitant administration of Dorzolamide HCl Ophthalmic Solution and oral carbonic anhydrase inhibitors is not recommended.
Although acid-base and electrolyte disturbances were not reported in the clinical trials with Dorzolamide HCl Ophthalmic Solution, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associatedwith high-dose salicylate therapy). Therefore, the potential for such drug interactions should be considered in patients receiving Dorzolamide HCl Ophthalmic Solution.
Dorzolamide HCl Ophthalmic Solution contains dorzolamide, a sulfonamide; and although administered topically, it is absorbed systemically. Therefore, the same types of adverse reactions that are attributable to sulfonamides may occur with topical administration of Dorzolamide HCl Ophthalmic Solution.
This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.
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