Douxo S3 SEB Odor-Control Seboregulating Dog & Cat Shampoo, 16.9-fl oz bottle

Deal
Skip image gallery
Slide 1 of 11

At a Glance

  • Skin & Coat Health
  • All Lifestages
  • All Breeds

$25.34 First Time Autoship Price
this order
Save 35% (up to $20) today when you set up Autoship. 
$37.04 Autoship Price
(-5%) future orders
  • Keep saving 5% on every order
  • Get deliveries on your schedule
  • Skip, change, or cancel anytime
$38.99 Chewy Price
($2.31 /fl oz)
Promo, Spend $100, Get $30 eGift Card with code NEWYEAR
Promo, New Customers Only: Spend $49+, Get $20 eGift Card + Free Shipping with code: WELCOME
In Stock
FREE 1-3 day delivery
Free 365-day returns

No interest if paid in full in 6 months on PayPal purchases of $149+. .

About This Item

Details

  • Shampoo for dogs and cats helps remove excess sebum, oils and flaky skin buildup.
  • Formulated with ophytrium, a natural ingredient that helps strengthen the skin’s physical barrier.
  • Helps restore the balance of protective microbes.
  • Made without soaps or sulfates.
  • Free of parabens, dyes and nanoparticles.

Ingredients

Instructions

Dermatological Treatment for Skin Issues

Developed with veterinary dermatologists, Douxo S3 offers expert solutions for pets with skin issues. The range includes shampoos, mousses, and pads—designed for daily use and to meet specific skin needs.

Made to Manage Common Skin Conditions

Douxo S3 is made to help manage common skin conditions like allergies, yeast or bacterial overgrowth, and seborrhea. Free from sulfates, parabens, colorants, and silicones, it’s pH-adjusted, soap-free, and hypoallergenic.

Featuring High-Performing Ingredients

 All Douxo S3 formulas contain Ophytrium, a natural-origin, triple-action ingredient that soothes, rebalances and strengthens the skin barrier. Other high-quality ingredients are selected to provide specific benefits in each formula. 

Easy Care for Pleasant Moments

Douxo S3 is designed to make every routine more pleasant for pets and people, with delightful textures and scents and ergonomic packaging. Co-developed with pet parents, it offers a complete skincare solution that’s easy and enjoyable to use.

About Douxo

Backed by 20+ years of expertise in veterinary dermatology, Douxo is designed to make grooming a better experience for both you and your pets.            

Shop Douxo

Frequently bought together

Questions & Answers

2 Customer Questions

is this good on long hair cats

Answer by Chewy • May 24, 2022
This shampoo is for dogs or cats to help manage all seborrhea types, including dry, flaky, greasy and combination skin. It can be used with any type of fur.

Is there a dilution ratio for this product?

Answer by Chewy • Sep 15, 2025
There is no dilution ratio for this shampoo. It can be used as is. Using 1 pump for every 4 lbs, gently massage shampoo onto skin abnormalities to reach the skin. Repeat until entire body is lightly coated with shampoo and leave on for 10 minutes. Rinse thoroughly with cool water. Shampoo amount can be doubled for dogs or cats with long and/or thick fur.
Reviews
Write a Review
4.6
Rated 4.6 out of 5 stars
236 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

75% Positive

Ease of Use

82% Positive

Effectiveness

89% Positive

Safety

85% Positive

83 Customer Reviews

Rated 5 out of 5 stars
By V on Oct 30, 2025

Working For My Dog with Skin Allergies

We have tried everything out there for my allergy beagle. This is the first product we can see major improvement from in just 1 use! She’s allergic to every tree

We have tried everything out there for my allergy beagle. This is the first product we can see major improvement from in just 1 use! She’s allergic to every tree and grass in our environment, dust, and several foods. She is constantly itchy, dandruffy, scabby. Between this product and consistent apoquel, I’m hopeful it will continue to make her more comfortable. Our Vet recommended it after trying everything else on the market. I’m so happy to find something that works!

Rated 5 out of 5 stars
By Tammy on Sep 23, 2025

Great smell

My puppy has a food allergy and has to eat a prescription can and now dry food in which after a few days of her being groomed she smelled dirty like she had not

My puppy has a food allergy and has to eat a prescription can and now dry food in which after a few days of her being groomed she smelled dirty like she had not had a bath but the can food does that. My vet said to purchase this shampoo and I am 200% happy with it. She still has a good smell to her a week after getting groomed. I will continue to use this product and would recommend it to anyone who has the same issues. It works wonders!!

Rated 5 out of 5 stars
By Melanie on Nov 29, 2025

Good for acne

My dog had terrible acne on her back and the vet suggested that I use this. It worked extremely well at reducing the inflammation and acne onher back. Plus, it has

My dog had terrible acne on her back and the vet suggested that I use this. It worked extremely well at reducing the inflammation and acne onher back. Plus, it has a nice fragrance to it.

Rated 5 out of 5 stars
By Cassidy on Oct 22, 2025

Skin saver for my oily coat dog

My Aussie would often have oily spots along his back where his hair would thin out and the skin appeared to be developing a hot spot. I started using this shampoo

My Aussie would often have oily spots along his back where his hair would thin out and the skin appeared to be developing a hot spot. I started using this shampoo regularly and now his skin is happy, healthy, and his thick hair has grown back. Definitely recommend for anyone who’s dogs produce too much oil

Rated 5 out of 5 stars
By Deneen on Jan 12, 2026

Decrease in the number and size of scaly patches

I have two small dogs dry skin. Even after the first bath, their dandruff and scaley patches were much improved.

I have two small dogs dry skin. Even after the first bath, their dandruff and scaley patches were much improved.

Rated 5 out of 5 stars
By Nadine on Aug 29, 2025

Amazing

We have a dog that has a very unfortunate smell from her sebaceous oil glands. We Barely gets three days after a bath without a stink. I’ve done so much research

We have a dog that has a very unfortunate smell from her sebaceous oil glands. We Barely gets three days after a bath without a stink. I’ve done so much research and asked everywhere and nothing worked until this. After the first use, we went a month without a bath! We were all thrilled, including our dog. We’ve used it for three consecutive months once a month, and this time we used our old regular dog shampoo to see if we could alternate and she doesn’t stink! We’re having to do so much dog bedding, the laundry was exhausting. Life just got a lot easier. and a happier dog, And owners.

Rated 4 out of 5 stars
By Deb on Dec 30, 2025

Gabby

It works quite well for our little Gabby. Relief is achieved but only lasted for a couple of days.

It works quite well for our little Gabby. Relief is achieved but only lasted for a couple of days.

Rated 5 out of 5 stars
By Polly on Dec 16, 2025

Chewy

Chewy. Com is amazing for all Duoxo products! If you ever carry them in spray option i will buy that too!

Chewy. Com is amazing for all Duoxo products! If you ever carry them in spray option i will buy that too!

Rated 4 out of 5 stars
By Jacquelin on Oct 3, 2025

Nice Lather

I was surprised that this lathered up as well as it does! Usually these type of shampoos tend to lather less. Unscented is great. Will see how it works out for my

I was surprised that this lathered up as well as it does! Usually these type of shampoos tend to lather less. Unscented is great. Will see how it works out for my SA poodle

Rated 5 out of 5 stars
By Deborah on Jul 31, 2025

Great shampoo!

My cat has severe seborrhea and we’ve been having him bathed with this shampoo. It’s really helping his appearance. It leaves his fur soft and smelling good. I hope

My cat has severe seborrhea and we’ve been having him bathed with this shampoo. It’s really helping his appearance. It leaves his fur soft and smelling good. I hope people don’t need this, but if you do, I heartily recommend it.