Douxo S3 PYO Antiseptic Antifungal Chlorhexidine Dog & Cat Shampoo

By Douxo S3
Rated 4.1374 out of 5 stars


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About This Item


  • Shampoo soothes, cleans and strengthens irritated skin for dogs and cats.
  • Formulated with ophytrium, a natural ingredient that helps strengthen the skin’s physical barrier.
  • Helps restore the balance of protective microbes.
  • Made without soaps or sulfates.
  • Free of parabens, dyes and nanoparticles.

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Top IngredientsOphytrium, ChlorhexidineActive Ingredients: Chlorhexidine Gluconate: 2%, Ketoconazole: 1%., Inactive Ingredients: Water...Chlorhexidine Gluconate 4%Chlorhexidine Gluconate 2%, Ketoconazole 1%Chlorhexidine Gluconate (2.0%), Purified Water, Ammonium Laureth Sulfate...
Health FeatureAnti-Fungal / Anti-Bacterial, Skin & Coat HealthAnti-Fungal / Anti-Bacterial, Itch & Redness Remedy, Skin & Coat Health...Anti-Fungal / Anti-BacterialAnti-Fungal / Anti-BacterialAnti-Fungal / Anti-Bacterial, Itch & Redness Remedy, Skin & Coat Health...
Breed SizeSmall Breeds, Medium Breeds, Large BreedsSmall Breeds, Medium Breeds, Large Breeds

Questions & Answers

5 Customer Questions

What is the difference between this formula and the PS formula?
Answer by ChewyAug 25, 2021
The Douxo S3 Pyo has replaced the Douxo Chlorhexidine products. One of the main ingredients in the Douxo line, Phytospingosine, has been replaced by a combination of ingredients called Ophytrium. Ophytrium helps supports the skin's physical barrier, helps support the microbial flora of healthy skin, and helps sooth red, itchy, and irritated skin.

How often can I Shampoo my dog with this shampoo
Answer by ChewyOct 29, 2021
This shampoo should be used as recommended by your veterinarian. Shampoo amount can be doubled for dogs or cats with long and/or thick fur.

What are the inactive ingredients
Answer by ChewyAug 16, 2022
The inactive ingredients in this shampoo are water, Cocamidopropyl hydroxysultaine, decyl glucoside, capryloyl glycine, pentavitin (saccharide isomerate), panthenol, coco + vanilla hypoallergenic fragrance, PEG-200 glyceryl stearate, phenoxyethanol, citric acid, and sodium hydroxide.

Can I use doucos3 SHAMPOO on my kitten (18 weeks old)and has tested positive for ringworm but no lesions (lesions gone but still positive)
Answer by ChewySep 15, 2021
There is no age requirement for this shampoo, it is suitable for cats and dogs of all ages. Please reach out to your veterinarian as they know your pet and what is the best for your situation.

ReviewsWrite a Review

Rated 4.1374 out of 5 stars
131 Ratings
Would recommend to a friend

122 Customer Reviews

Rated 4 out of 5 stars
By Michelle on Nov 20, 2023

Works well

This doesn't work as well as the last formula, but it still does a good job. My lab has the worst skin allergies in the fall and this helps to keep the scratching under control. Smell is not terrible and overpowering like other chlorhexidine shampoos out there.

Rated 1 out of 5 stars
By Sondra on Oct 21, 2023


I shampooed my 7lb chihuahua with this shampoo, with hopes to eliminate his itchy paws and hair loss. Well he licked his wet paws after his bath as he normally does, and he got violently ill. He vomited off and on for an hour. Needless to say, I have no idea if this shampoo works as described, but I do know it's toxic. So be careful! A total waste of money!

Rated 5 out of 5 stars
By DogMom on Oct 15, 2023

very good product for sensitive and allergy prone pet

Was recommended this by our vet. Our golden has always had skin allergies and we have tried a lot of different shampoos from the pet store, they always seem to cause him to loose a lot of his hair or irritate his skin. For the first time he did not scratch after his bath. He was not shedding like crazy after either. This a shampoo I will continue to purchase for him.

Rated 5 out of 5 stars
By Nancy on Nov 12, 2023

Great skin relief during allergy episodes

So glad our vet recommended this product. It calms our dog's skin down when she is having skin reactions to pollen and such. We wash first with Zymox enzyme shampoo and then with this. It's a great combination.

Rated 3 out of 5 stars
By Kboom141 on Sep 25, 2023

Wishful thinking

I purchased this product after reading the mostly positive reviews. I was hoping this shampoo would help my Louie who has had issues with yeast ( and maybe allergies). I was trying to not do the expensive route of pet medicines. This has not helped him and made some of his red spots More red and he still scratches after being bathed. Perhaps I should have tried the allergy shampoo instead. Maybe next time.

Rated 5 out of 5 stars
By SA on Sep 11, 2023

Works for dog’s yeasty skin!

This shampoo was recommended by a vet tech who had used it prior while she was working as a groomer. I’ve been using it for 6 months now. My senior rescue dog’s allergies manifest through ear infections, raw itchy paws and an over production of yeast. When her environmental allergies start to spike she does a lot of head shaking, rubbing her ears and licking of her paws, tail and rear end. Then the yeast will begin to show via musty and oily skin. It’s taken a couple of years to work out a maintenance protocol that works for her, going through steroids, prescription foods and Apoquel. We’ve now done away with all of that and use fresh food, natural supplements and this shampoo. I bathe her once a week and per the directions let the shampoo soak in for 10 minutes. I’m sure to massage it into her paws especially. If her allergies are spiking, after the bath, her paws lose their red and inflamed appearance by the next morning. I highly recommend giving this shampoo a try if you’re searching for skin allergy and especially yeast relief for your dog. It works for my girl!

Rated 5 out of 5 stars
By laura on Oct 8, 2023

I’m really hooked

I was having problems with my dogs allergies. She (Jai) broke out with sores, and allot of itchy skin. Her vet told me to use this shampoo; I did, and within a few weeks, her itching stopped tremendously. Her skin looked so much better. Bottom line, I use this product, and her skin is wonderful.

Rated 4 out of 5 stars
By BEVERLY on Nov 16, 2023

bad packaging

I love the product, I've been using it for years. The bottle they currently put it in is a bad design. That would be my only complaint.

Rated 5 out of 5 stars
By TAG on Oct 1, 2023

Hot Spots Healed

My dog has allergies and she breaks out in hives and hot spots. This shampoo calms her skin and heals the hot spots. I noticed by the next day they looked better, not red and healed within a few days after showering my dog.

Rated 2 out of 5 stars
By Ash on Aug 18, 2023

Bottle Leaked (Mail Order)

This is an expensive bottle of shampoo and I was extremely disappointed when the bottle arrived and the packaging was soaked through for the pump leaking. Also, the pump it terribly made and flimsy. However, the shampoo works ok on treating my dog's allergy breakouts. So I would recommend it, only because I have not found any other brands that work.