Douxo S3 CALM Soothing Itchy, Hydrated Skin Dog & Cat Shampoo, 16.9-fl oz bottle

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At a Glance

  • Itch & Redness Remedy
  • All Lifestages
  • All Breeds

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$39.99 Chewy Price
($2.37 /fl oz)
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About This Item

Details

  • Shampoo for dogs and cats that helps soothe irritated skin.
  • Helps restore the balance of protective microbes.
  • Contains ophytrium, a natural ingredient that helps strengthen the skin barrier.
  • Made without soaps or sulfates.
  • Free of parabens, dyes and nanoparticles.

Ingredients

Instructions

Dermatological Treatment for Skin Issues

Developed with veterinary dermatologists, Douxo S3 offers expert solutions for pets with skin issues. The range includes shampoos, mousses, and pads—designed for daily use and to meet specific skin needs.

Made to Manage Common Skin Conditions

Douxo S3 is made to help manage common skin conditions like allergies, yeast or bacterial overgrowth, and seborrhea. Free from sulfates, parabens, colorants, and silicones, it’s pH-adjusted, soap-free, and hypoallergenic.

Featuring High-Performing Ingredients

 All Douxo S3 formulas contain Ophytrium, a natural-origin, triple-action ingredient that soothes, rebalances and strengthens the skin barrier. Other high-quality ingredients are selected to provide specific benefits in each formula. 

Easy Care for Pleasant Moments

Douxo S3 is designed to make every routine more pleasant for pets and people, with delightful textures and scents and ergonomic packaging. Co-developed with pet parents, it offers a complete skincare solution that’s easy and enjoyable to use.

About Douxo

Backed by 20+ years of expertise in veterinary dermatology, Douxo is designed to make grooming a better experience for both you and your pets.            

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Frequently bought together

Questions & Answers

4 Customer Questions

Is this good for dandruff

Answer by Chewy • Apr 08, 2023
DOUXO S3 Calm helps manage pruritus and inflamed skin associated with allergies. It is formulated to soothe and hydrate the skin. It detangles the fur and leaves the hair coat soft and shiny. We recommend the DOUXO S3 SEB line instead, which is specially formulated to reduce excess sebum and dandruff, strengthen the skin barrier, maintain skin hydration and prevent fungal overgrowth that is common in such conditions.

How often can I use this? Is twice a week too often?

Answer by Chewy • Mar 15, 2023
DOUXO S3 CALM shampoo and mousse are meant to be used together in a clinically proven and consumer-friendly protocol. Use one pump of shampoo for every 4 pounds of body weight. Double the dosage for long and/or thick fur. Wet with cool water from the neck down. First, gently massage shampoo onto the problem area. Repeat on the entire body and leave on for 5-10 minutes before rinsing. Repeat if necessary. Refer to the chart below for usage directions:

What are the ingredients?

Answer by Chewy • Aug 02, 2021
For a complete list of ingredients you may select the "Ingredients" tab next to the "Description" tab on the product page.

Can this be used on a kitten under 2 pounds?

Answer by Chewy • Jun 17, 2023
This shampoo is formulated for adult cats and dogs.
Reviews
Write a Review
4.6
Rated 4.6 out of 5 stars
725 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

85% Positive

Ease of Use

91% Positive

Effectiveness

88% Positive

Safety

85% Positive

239 Customer Reviews

Rated 5 out of 5 stars
By Susan on Jan 11, 2026

Great for itchy skin

This shampoo provides good itch relief for my Bull Terriers. I also use the Douxo foam for problem areas if they need extra relief in certain areas such as their

This shampoo provides good itch relief for my Bull Terriers. I also use the Douxo foam for problem areas if they need extra relief in certain areas such as their paws. My HOA sprays our grass which causes irritation on my dogs feet and body if they lay down in the grass. They are also allergic to grass. I have been using Douxo for a few years and would recommend.

Rated 4 out of 5 stars
By Makayla on Jan 13, 2026

Wonderful products

As a professional groomer for a vet office, and the owner of an allergy riddled dog myself, Douxo products are extremely effective when used properly!

As a professional groomer for a vet office, and the owner of an allergy riddled dog myself, Douxo products are extremely effective when used properly!

Rated 3 out of 5 stars
By Claire on Dec 10, 2025

Not bad...

I noticed that the scratching significantly reduced, but my pup is still licking his paws quite a bit. Honestly, not bad. I'll continue to use it and maybe even

I noticed that the scratching significantly reduced, but my pup is still licking his paws quite a bit. Honestly, not bad. I'll continue to use it and maybe even get the mousse, which I heard is rather effective.

Rated 5 out of 5 stars
By Joanne on Jan 15, 2026

Nice product

Used this a couple days ago. It was easy to lather, smelled good and left my pup clean, shiny and looking good. I will buy again.

Used this a couple days ago. It was easy to lather, smelled good and left my pup clean, shiny and looking good. I will buy again.

Rated 5 out of 5 stars
By Pepper on Oct 9, 2025

Wow surprised at the difference of his skin/fur

It didn’t look like a lot of shampoo for my big dog, but it really worked well and spread good. He has bad allergies and his skin was really getting and flaky,

It didn’t look like a lot of shampoo for my big dog, but it really worked well and spread good. He has bad allergies and his skin was really getting and flaky, and I used it twice. By the second time his skin was shiny again and so soft from it I didn’t even have to use aconditioner and I just kept brushing in the flakes eventually just has gone away After the shampoo. I am very happy with the purchase.

Rated 5 out of 5 stars
By Christa on Dec 27, 2025

Itchy skin

My dog was having severely itchy skin for about a week or 2. My vet recommended this and we used it 2Xs and ITCHINESS WAS GONE!

My dog was having severely itchy skin for about a week or 2. My vet recommended this and we used it 2Xs and ITCHINESS WAS GONE!

Rated 5 out of 5 stars
By Deepa on Nov 19, 2025

Amazing formula

My dog who is now almost 13 has been using this since she was one year old. She is allergic to anything else, this formula is amazing and suits my dog. I always

My dog who is now almost 13 has been using this since she was one year old. She is allergic to anything else, this formula is amazing and suits my dog. I always keep it in stock.

Rated 5 out of 5 stars
By George on Dec 5, 2025

The result was awesome!

My little puppy's fur was soft and fluffy as after her grooming! She was a velveteen pup!! Hopefully she feels better and it will help her old skin.

My little puppy's fur was soft and fluffy as after her grooming! She was a velveteen pup!! Hopefully she feels better and it will help her old skin.

Rated 5 out of 5 stars
By Roxanna on Dec 18, 2025

Works great on bad skin conditions, easy lather, pleasant odor.

Veterinary recommended. All the Douxo products work very well on bad skin conditions. I use them regularly.

Veterinary recommended. All the Douxo products work very well on bad skin conditions. I use them regularly.

Rated 4 out of 5 stars
By Brittany on Dec 19, 2025

Not as good as the Calm shampoo

Not as good as the Calm shampoo the manufacturer discontinued. It does not clean as well as the calm

Not as good as the Calm shampoo the manufacturer discontinued. It does not clean as well as the calm