Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs

By Frontline Plus
Rated 4.0642 out of 5 stars
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Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 8 Doses (8-mos. supply) slide 1 of 13
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Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 8 Doses (8-mos. supply) slide 1 of 13

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This Item - Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 8 Doses (8-mos. supply)
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About This Item

  • Promotes a fast-acting and long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle.
  • Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
  • Simply apply once a month.
  • Designed for a waterproof protection after 24 hours.
Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

Shop Frontline

* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil , (S)-methoprene , Pyriproxyfen.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.
LifestagePuppy, Adult, SeniorAdult, Puppy, SeniorAdult, Senior, PuppyAdult, Puppy, SeniorAdult
Breed SizeExtra Small & Toy Breeds, Small BreedsSmall Breeds, Extra Small & Toy BreedsSmall Breeds, Medium BreedsMedium Breeds, Large BreedsLarge Breeds

Questions & Answers

35 Customer Questions

Does frontline plus expire
Answer by ChewySep 19, 2019
This product doesn't expire. It will be usable until each individual dosage is opened.

Is Frontline Plus and Frontline Gold the same?
Answer by ChewyMay 15, 2018
FRONTLINE Gold is the latest innovation in flea and tick protection from the maker of FRONTLINE Plus. In addition to having fipronil and (S)-methoprene, they now added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop into adult fleas. Regular use of FRONTLINE Gold helps prevent new flea infestations.

Is this safe for dogs under 5lbs?
Answer by ChewyJul 16, 2017
Frontline Plus for Small Dogs & Puppies is for 5-22 pounds. For smaller dogs, consult with a veterinarian to determine the best method of protection.

I regularly use Frontline, but not frontline plus. I can not get the fleas under control during peak months and still see a few during the winter. I use this product year long. I also use flea spray around the 4th week.Will frontline plus help?
Answer by ChewyJan 30, 2018
Frontline Plus protects against all stages adult fleas, ticks, chewing lice, mites, and flea eggs and larvae,

ReviewsWrite a Review

Rated 4.0642 out of 5 stars
1230 Reviews
Would recommend to a friend

1230 Customer Reviews

Rated 1 out of 5 stars
By Rose on Jul 31, 2022

This did not help!

I have a chihuahua who lives inside. I haven't needed to get Frontline Plus for years. In the past, it worked great with other dogs that lived outside. This did not help. I ordered 3 treatments and it did not kill fleas. Every time I checked her, there were fleas. She has to take medicine for her heart, so if I try to get them off, it causes her stress. She is almost all white and isn't covered with fleas, but I don't want her to have any. I applied this correctly, and it did not help at all. I want a refund.

Rated 5 out of 5 stars
By Gabs on Jul 13, 2022

No more ticks!

My Porter has had issues with ticks this year, after finding a 3rd one within weeks, I needed to get him started on treatment. I chose a topical treatment as he is a Cavalier King Charles spaniel and is prone to issues such as seizures and neurological issues that other products may cause. 1 day after putting this on, I saw a tick crawling around on him, but it didn't attach so I know this must've been why. Very happy that I haven't seen any more ticks since applying and that was 2 weeks ago!

Rated 2 out of 5 stars
By frontline on Jul 9, 2022

No expiration date

i was disappointed in my last order that there is no expiration date. when i contacted Chewy the initial response was that it is on side of package and pipette. it is not on my package. further discussion said that they are not putting expiration dates on the package, but it has a life of 3 years. how do i know how old it is when i receive it? I am not going to buy Frontline anymore, hopefully the other competitors still use expiration dates.

Rated 3 out of 5 stars
By TonyR on Jul 12, 2022

Item is good as always just dont see what the big deal about Chewy is

The product is good, I heard the prices were better but it was actually more expensive than at Petland or my vets and I had to wait for it. when I could have just run down the street and picked it up myself for less, They then split this and my heartguard up into two seperate orders as it took them 3 days to contact my vet, Also the heart guard which took a week to get here was cheaper at my vets

Rated 5 out of 5 stars
By Annette on Jun 22, 2022

Excellent protection against fleas and ticks!

I have used this product for years for flea and tick protection for both dogs and cats. It is easy to use--just once per month topical application is quick--no fuss, no muss. I recommended it to a neighbor, and her veterinarian approved it, and even carries it for sale in his practice. Of course it's more affordable through and arrives in lightening-fast time!

Rated 4 out of 5 stars
By Katt on Jun 21, 2022

Frontline Plus is Okay

That's a generous 4 stars, but from what I hear there really aren't any great options. I am grateful the fleas don't seem as bad as they did before. I wish someone would come out with a product the actually works as intended.

Rated 1 out of 5 stars
By MeOrTheDog on Jul 26, 2022

Did not work

Used two months, still finding fleas and ticks on my puppies that were not infested before I started using the product. It is also messy to apply.

Rated 5 out of 5 stars
By Samantha on Jun 28, 2022

Messy, but works great!

We've used frontline for years and it has never failed us. The few times we've tried other products, we ended up with ticks, fleas or both. It's a messy application, but it works.

Rated 5 out of 5 stars
By Ozzy on Jul 18, 2022

I have used this flea & tick med since my twelve yr old chihuahua was a puppy.

This med really works. Kills fleas asap. Have never found one live tick of any species alive on my dog. I wouldn’t use any other med.

Rated 5 out of 5 stars
By Dachshundmom on Jun 26, 2022

Frontline is a good product

I have used Frontline for years, to prevent fleas and ticks from infesting my dog and house. The convenience os ordering from Chewy and having it delivered here is wonderful.