PANCREPLUS Tablets for Dogs & Cats, 425-mg, 100 tablets -

PancrePlus Tablets for Dogs & Cats, 425-mg

By PancrePlus
Rated 4.3333 out of 5 stars
Prescription Item
Count: 100 tablets
Count: 100 tablets

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$59.77Chewy Price
$60.00Chewy Price
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About This Item


PancrePlus is prescribed as a digestive aid and replacement therapy for pets whose digestion of proteins, carbohydrates and fats are affected by exocrine pancreatic insufficiency (EPI).

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About PancrePlus From Our Team of Experts
Learn More About PancrePlus From Our Team of Experts

Also available in a [powder] (

ReviewsWrite a Review

Rated 4.3333 out of 5 stars
9 Ratings
Would recommend to a friend

9 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 3 out of 5 stars
By GSMax on Apr 4, 2022

Too soon to tell.

Rx is for our 7 year old German Shepard's pancreatic condition causing weight loss. Have used 30 days and are seeing only slight improvements. But it took several months to loss the weight so it may take a similar period for substantial improvement.

Rated 1 out of 5 stars
By JDog on Feb 9, 2022

Buyer Beware

The price has been so inconsistent with this product. In December I paid about 89 in January about 133 for 400 pills. Also, this product is the same as PanaKare Plus (which is 26 cents per pill compared to 36 for PancrePlus). Same ingredients and levels of enzymes. The crazy thing is since they stopped arriving in the pancreplus bottles, there's no way to tell if I'm actually getting this brand anymore. So I'm pretty sure I have been paying 0.36 per pill instead of 0.26 for the same thing. I know it's only ten cents per pill, but when you used 12 pills per day it adds up. Feel extremely disappointed in chewy for this.

Rated 5 out of 5 stars
By Kitty on Feb 5, 2022

Dog with pancreas issues

After testing everything we can test through the vet, the final estimate was the dog was having pancreas issues. So they put him on a perscription diet and weekly VitB-12 shots and PancrePlus for enzymes. So far it has only been three weeks but I can see an improvement. I will say Chewy's delivery time is amazing!!

Rated 5 out of 5 stars
By Lroy on Oct 12, 2021

Good product, but epi is a complicated condition

This is a good enzyme for epi. It gave us another year and a half with our GSD after an epi diagnosis that we wouldn't have had otherwise. Unfortunately she passed away from lymphoma just 3 months short of her 3rd birthday. If your dog or cat has epi you need to find a knowledgeable vet, do your research and most of all: STAY VIGILANT!!! EPI animals are at high risk to develop a host of other problems and this was not emphasized to us.

Rated 5 out of 5 stars
By CatsMama3 on Dec 11, 2020

Does the job

My cat has chronic pancreatitis. Pancrea Plus helps break down the wet food for easier digestion. It's strong and will burn if in contact with skin. Be sure to grind the pill into fine powder before adding to the wet food, mix well and allow to sit 5 or 10 minutes before serving. I give broth or some liquid after eating to ensure the residual enzymes in the mouth are flushed out to prevent ulcers. Don't give vitamins or other medication with this. Wait at least a 1/2 hour. it may cause diarrhea, in which case pre-pro biotics will help alleviate it.

Rated 5 out of 5 stars
By PankyPlus on Nov 15, 2020

Saved my cat!

One of my cats, Penny Lane, has had a heck of a year. She was diagnosed with IBD, EPI, and a poultry allergy this summer. We initially tried the vet-preferred powder since it’s ideally consumed on food. We had a heck of a time trying to sneak it into her food at first. Penny’s no fool. We initially had some success mixing in Churu treats and syringing it into her mouth after eating. We were then eventually able to just feed spiked Churu treats in a bowl with food. Both methods ended up getting very expensive since she needs it at least twice a day. Fortunately for our wallets, she eventually grew tired of it. It took some getting used to, but after pilling her for a few months, she’s used to it. I think she now associates this with feeling better because we don’t even struggle to get it into her—she eats it right out of our hands like a treat. (She’s allergic to chicken, so pill pockets were a no-go!) She may get fussy later on and need a piller, but this is working out well for her now. She’s gained weight and has much better stool. The family now calls these Panky Plus Pills. Of the other medications she needs, this one is the easiest for both her and the humans. Yay.

Rated 5 out of 5 stars
By Jrose on Jun 3, 2019

Great for EPI

I use these for my GSD that has EPI. 1 tablet per cup of food + 1 for the bowl. I feed him 4 times a day and it works GREAT. I have found that they should be crushed though, mix with a little water and sit for about 5 minutes. They are cheaper than the powder. The PancrePlus along with B12 and monitoring his Poo....he went from a skinny 74 pounds to 102 pounds and healthy.

Rated 5 out of 5 stars
By SamsMom on Apr 29, 2019

Sam the cat is so much better

Our cat Sam apparently has Exocrine Pancreatic Insufficiency. He will eat voraciously but he has suffered catastrophic weight loss. He was literally starving in front of our eyes. After taking the PancrePlus tabs for a month now, he has gained weight and strength. Our vet says there is a powdered product that is given mixed with the food, that is very expensive, and that giving these PancrePlus tabs is a more economical option. What I love about the tabs is: I know my cat can take a tablet, but if I mix something in his food, he may or may not eat it. Plus, if he swallows the tab before he eats, he will not get any of the medicine on his nose. He does not need to have irritating residue of medicine on his tender nose.

Rated 5 out of 5 stars
By Rebecca on Sep 29, 2018

Exocrine Pancreatic Insufficiency

This enzyme has worked very well for my German Shepherd. He was starving, and now is of good weight.