PROIN ER (phenylpropanolamine hydrochloride extended-release tablets) for Dogs, 145-mg, 60 tablets

Have a Chewy account?
Sign in to quickly add pet health details.
Skip image gallery
Slide 1 of 7

$80.08 First Time Autoship Price
this order
Save 35% (up to $20) today when you set up Autoship. 
$100.08 Autoship Price
future orders
  • Never miss a dose with easy refills
  • Skip, change, or cancel anytime
$100.08 Chewy Price
($1.66 /ea)
Promo, Save 20% on first Rx order with code RX20
Promo, New Customers Only: Spend $49+, Get $20 eGift Card + Free Shipping with code: WELCOME
In Stock
FREE delivery
Usually arrives in 3-5 days
Prescription approval made easy
We’ll reach out to your vet clinic.

No interest if paid in full in 6 months on PayPal purchases of $149+. .

Check if we can ship this item to you. This item can't be shipped to certain states.
Medications ship separately. Delivery times may vary.

About This Item

Details

  • A Trusted Veterinarian-Prescribed Solution: Proin ER is the only once-a-day FDA approved medication for the control of Urinary Incontinence due to the urethral sphincter hypotonus in dogs.
  • Consistent Control: Patented extended-release technology provides controlled release that ensures steady absorption, reducing accidents caused by Urinary Incontinence.
  • Clinically Proven Effectiveness: In a 6-month study, dogs taking Proin ER had an 85.6% reduction in average daily Urinary Incontinence incidences compared to baseline.
  • Tailored Strengths for All Sizes: Available in 18mg, 38mg, 74mg, and 145mg tablets to accomodate your dog's weight and dosage needs. Use only as directed by a veterinarian.

Ingredients

Instructions

FAQ

Learn More About Proin ER From Our Team of Experts

These Proin Extended-Release Tablets have the same efficacy as Proin Chewable Tablets.

If You Like PROIN, You’ll Love PROIN ER

PROIN has been trusted by veterinarians for nearly 15 years to safely and effectively treat urinary incontinence (UI) due to urethral sphincter hypotonus in dogs. Now, there’s PROIN ER — a canine UI medication that’s just as effective as PROIN with only one pill a day.

Signs of Urinary Incontinence

  • Dripping, leaking urine 
  • Wet spots where the dog sleeps
  • Excessive licking of genitals
  • Red, irritated skin in the genital area

About PROIN ER

PROIN  ER (phenylpropanolamine hydrochloride extended-release tablets) employs patented technology to help reduce involuntary urine leakage in dogs, all in a once-daily dose. Ask your veterinarian before using PROIN  ER with any other medications.

Shop PROIN ER

Important Safety Information

PROIN ER IMPORTANT SAFETY INFORMATION: For oral use in dogs only. Not for human use. Keep out of reach of children. If accidentally ingested by humans, contact a physician immediately.

The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases death, including euthanasia has been reported. Sudden death was sometimes preceded by vocalization or collapse.

Instances of dogs chewing through closed vials of PROIN and eating the vial contents have been reported, in some cases resulting in overdose. Keep the product in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN Chewable Tablets or PROIN ER tablets. Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN Chewable tablets or PROIN ER tablets.

PROIN and PROIN ER may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure. Dogs may transition from PROIN Chewable Tablets to PROIN ER without a break in administration. However, do not alternate PROIN ER with PROIN Chewable Tablets because the effectiveness and safety of interchangeable use have not been evaluated.

The safe use of PROIN and PROIN ER in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated. Contact your veterinarian if you notice restlessness or irritability, loss of appetite, the incontinence persists or worsens, or any other unusual signs. See prescribing information for complete details regarding adverse events, warning and precautions or visit prnpharmacal.com.

Frequently bought together

Reviews
Write a Review
4.7
Rated 4.7 out of 5 stars
1954 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

88% Positive

Effectiveness

87% Positive

Ingredients

86% Positive

Long-Term Benefits

86% Positive

722 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Jen on Dec 28, 2025

Sadly my dog needs this to control incontinence

Fawn most likely had a nerve knicked during spay surgery at a shelter, she’s the second rescue thats happened to in my life. So I have to give her proin daily to

Fawn most likely had a nerve knicked during spay surgery at a shelter, she’s the second rescue thats happened to in my life. So I have to give her proin daily to control it. Its fantastic! Shes really deep and shy and peeing herself is very obviously embarrassing to her, when she wales up wet she will jump up and go hide. My poor girl. When we give her proin every night before bed she has zero accidents. The only problem is dosing with this medication. Shes an 80lb white German Shepherd and supposedly her dose is 145mg, but the vet said with this med its trial and error till you get the dose right. And he was right!! But remember I buy the extended release so its a bit higher - but I take a 145mg pill and cut it into 6 small pieces! All she needs is one - so her actual dose is about 25mg. When I gave her the whole 145mg the first day by the doctors orders, Fawn couldnt get up, couldnt walk, couldnt eat or drink or even open her eyes bc her third eyelid was sooo exposed. It was terrifying and we immediately cut the pills up to give her the smallest dose possible and that ended up being about 25mg. So yes it works, she’s still a baby and will need to take this for life, just like our previous German Shepherd who lived on it daily for 14 years. Side effects could include weight gain so exercise is a must.

Rated 1 out of 5 stars
By Masha on Dec 17, 2025

Real nightmare to get this prescription

I will not shop with Chewy again, they made me mail in an actual prescription and then promptly lost it, it took us around 10 days to get our prescription. I found

I will not shop with Chewy again, they made me mail in an actual prescription and then promptly lost it, it took us around 10 days to get our prescription. I found out that I could have mailed it registered one day mail for reimbursement against your order total only after a week of back and forth with customer service. Thankfully now I know that my dog doesn't need this prescription constantly but imagine if it was something critical. These days you have to provide email, mailing address, phone number and full name they won't talk to you without this information and if you talk to different departments you have to provide this information multiple times. I am appalled at how dysfunctional this experience has been. I

Rated 5 out of 5 stars
By Jerry on Jan 5, 2026

Works Wonderfully

Within less than 2 weeks, a very noticeable difference in our sweet girl, she's 11 now and had been spayed at 7 weeks old at a rescue shelter. After 2 1/2 months

Within less than 2 weeks, a very noticeable difference in our sweet girl, she's 11 now and had been spayed at 7 weeks old at a rescue shelter. After 2 1/2 months of use, we've only noticed a very small leak a few times, these were times when we had been out for 3 hrs or more. This has been an absolute miracle to us, this medication and prayers to Jesus for our precious girl, Tiny.

Rated 3 out of 5 stars
By Valerie on Nov 16, 2025

Other solutions

Proin absolutely worked but it came with side effects for sure. I have a 14 year old mix that has some liver failure. Proin caused my dog to have high blood pressure,

Proin absolutely worked but it came with side effects for sure. I have a 14 year old mix that has some liver failure. Proin caused my dog to have high blood pressure, constant panting, constant pacing, which resulted in destructive behavior. She could never settle down and couldn't rest. She kept us up all night. She would walk through the house at night and get onto anything and everything. Note that she was on proin for 1.5 months. It became so bad that we had to start closing our bedroom door. She would bump her head against our door, constantly chew on her bed, very strange behavior. Im not saying not to try it because every dog is different but for us, the incontinence was better than the side effects. We consulted a holistic vet which was cheaper than you'd think and we started chinese concentrated crystal stone. As we weened her off the proin, we added the concentrated crystal stone and it worked. The other symptoms went away. She sleeps through the night, doesn't pant, and is more relaxed. She's been on the holistic meds for two weeks and so far so good. She rests well, no panting, and it doesn't impact her kidneys and liver the way proin does. I should also point out that the proin cost me 100 bucks for 30 days and the crystal stone is about 60. You have options but ultimately, it depends on your dogs reaction.

Rated 4 out of 5 stars
By Janet on Dec 29, 2025

Worked immediately but

Worked right away but still dealing with diarrhea after 2 weeks. Does seem to finally be getting better. Also threw her off eating for several days and we had

Worked right away but still dealing with diarrhea after 2 weeks. Does seem to finally be getting better. Also threw her off eating for several days and we had to hide it in treats. Now that she is more interested in eating, we just hide it in her food.

Rated 3 out of 5 stars
By Roxanne on Nov 14, 2025

Works great, but bad GI upset

My dog was on this medication for a week and a half and her signs of urinary incontinence had virtually resolved within that time, but then started her awful G.I

My dog was on this medication for a week and a half and her signs of urinary incontinence had virtually resolved within that time, but then started her awful G.I. upset. My dog had a severe case of diarrhea and loss of anppe due to not feeling well. Even though the medication did what it was supposed to do, I elected to discontinue the medication entirely because the side effect largely outweigh the benefit. I will not try this again.

Rated 5 out of 5 stars
By Donald on Nov 26, 2025

Very effective & helpful

We have my daughter’s almost 15 year old dog (Layla) living with us because it’s much easier for Layla to get in and out of the house than at my daughter’s apartment

We have my daughter’s almost 15 year old dog (Layla) living with us because it’s much easier for Layla to get in and out of the house than at my daughter’s apartment. The Proin has been very good at eliminating any bladder leaks in the house.

Rated 5 out of 5 stars
By Stephanie on Dec 6, 2025

Dry bed, happy Mom!

Proin did not help our sweet old beagle, but has been a miracle for our fox hound, Amber. I’ve missed giving her a dose twice and had a wet bed, but NEVER when

Proin did not help our sweet old beagle, but has been a miracle for our fox hound, Amber. I’ve missed giving her a dose twice and had a wet bed, but NEVER when she takes it every day.

Rated 5 out of 5 stars
By Toni on Dec 16, 2025

Perfect!

I used to give my baby girl a giant pill (crushed) in her breakfast, then another pill at dinner. Now, I give her one little pill in a pill pocket, and it lasts

I used to give my baby girl a giant pill (crushed) in her breakfast, then another pill at dinner. Now, I give her one little pill in a pill pocket, and it lasts all day.

Rated 5 out of 5 stars
By Kathleen on Oct 18, 2025

My foster dog had a leakage problem

I was going to give her back to the rescue group because of incontinence. They told me about this medication and so glad that I can keep my rescue doggie now with

I was going to give her back to the rescue group because of incontinence. They told me about this medication and so glad that I can keep my rescue doggie now with no problems. Got her as an 8 year old, glad to give her more years in a loving home. Once I sent the vet's prescription, Chewy was very fast in shipping the Proin ER. Have it on auto-renew.