PROIN ER (phenylpropanolamine hydrochloride extended-release tablets) for Dogs, 38-mg, 30 tablets

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About This Item

Details

  • A Trusted Veterinarian-Prescribed Solution: Proin ER is the only once-a-day FDA approved medication for the control of Urinary Incontinence due to the urethral sphincter hypotonus in dogs.
  • Consistent Control: Patented extended-release technology provides controlled release that ensures steady absorption, reducing accidents caused by Urinary Incontinence.
  • Clinically Proven Effectiveness: In a 6-month study, dogs taking Proin ER had an 85.6% reduction in average daily Urinary Incontinence incidences compared to baseline.
  • Tailored Strengths for All Sizes: Available in 18mg, 38mg, 74mg, and 145mg tablets to accomodate your dog's weight and dosage needs. Use only as directed by a veterinarian.

Ingredients

Instructions

FAQ

Learn More About Proin ER From Our Team of Experts

These Proin Extended-Release Tablets have the same efficacy as Proin Chewable Tablets.

Frequently bought together

Reviews
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4.7
Rated 4.7 out of 5 stars
1954 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

88% Positive

Effectiveness

87% Positive

Ingredients

86% Positive

Long-Term Benefits

86% Positive

722 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Jen on Dec 28, 2025

Sadly my dog needs this to control incontinence

Fawn most likely had a nerve knicked during spay surgery at a shelter, she’s the second rescue thats happened to in my life. So I have to give her proin daily to

Fawn most likely had a nerve knicked during spay surgery at a shelter, she’s the second rescue thats happened to in my life. So I have to give her proin daily to control it. Its fantastic! Shes really deep and shy and peeing herself is very obviously embarrassing to her, when she wales up wet she will jump up and go hide. My poor girl. When we give her proin every night before bed she has zero accidents. The only problem is dosing with this medication. Shes an 80lb white German Shepherd and supposedly her dose is 145mg, but the vet said with this med its trial and error till you get the dose right. And he was right!! But remember I buy the extended release so its a bit higher - but I take a 145mg pill and cut it into 6 small pieces! All she needs is one - so her actual dose is about 25mg. When I gave her the whole 145mg the first day by the doctors orders, Fawn couldnt get up, couldnt walk, couldnt eat or drink or even open her eyes bc her third eyelid was sooo exposed. It was terrifying and we immediately cut the pills up to give her the smallest dose possible and that ended up being about 25mg. So yes it works, she’s still a baby and will need to take this for life, just like our previous German Shepherd who lived on it daily for 14 years. Side effects could include weight gain so exercise is a must.

Rated 1 out of 5 stars
By Masha on Dec 17, 2025

Real nightmare to get this prescription

I will not shop with Chewy again, they made me mail in an actual prescription and then promptly lost it, it took us around 10 days to get our prescription. I found

I will not shop with Chewy again, they made me mail in an actual prescription and then promptly lost it, it took us around 10 days to get our prescription. I found out that I could have mailed it registered one day mail for reimbursement against your order total only after a week of back and forth with customer service. Thankfully now I know that my dog doesn't need this prescription constantly but imagine if it was something critical. These days you have to provide email, mailing address, phone number and full name they won't talk to you without this information and if you talk to different departments you have to provide this information multiple times. I am appalled at how dysfunctional this experience has been. I

Rated 5 out of 5 stars
By Jerry on Jan 5, 2026

Works Wonderfully

Within less than 2 weeks, a very noticeable difference in our sweet girl, she's 11 now and had been spayed at 7 weeks old at a rescue shelter. After 2 1/2 months

Within less than 2 weeks, a very noticeable difference in our sweet girl, she's 11 now and had been spayed at 7 weeks old at a rescue shelter. After 2 1/2 months of use, we've only noticed a very small leak a few times, these were times when we had been out for 3 hrs or more. This has been an absolute miracle to us, this medication and prayers to Jesus for our precious girl, Tiny.

Rated 3 out of 5 stars
By Valerie on Nov 16, 2025

Other solutions

Proin absolutely worked but it came with side effects for sure. I have a 14 year old mix that has some liver failure. Proin caused my dog to have high blood pressure,

Proin absolutely worked but it came with side effects for sure. I have a 14 year old mix that has some liver failure. Proin caused my dog to have high blood pressure, constant panting, constant pacing, which resulted in destructive behavior. She could never settle down and couldn't rest. She kept us up all night. She would walk through the house at night and get onto anything and everything. Note that she was on proin for 1.5 months. It became so bad that we had to start closing our bedroom door. She would bump her head against our door, constantly chew on her bed, very strange behavior. Im not saying not to try it because every dog is different but for us, the incontinence was better than the side effects. We consulted a holistic vet which was cheaper than you'd think and we started chinese concentrated crystal stone. As we weened her off the proin, we added the concentrated crystal stone and it worked. The other symptoms went away. She sleeps through the night, doesn't pant, and is more relaxed. She's been on the holistic meds for two weeks and so far so good. She rests well, no panting, and it doesn't impact her kidneys and liver the way proin does. I should also point out that the proin cost me 100 bucks for 30 days and the crystal stone is about 60. You have options but ultimately, it depends on your dogs reaction.

Rated 4 out of 5 stars
By Janet on Dec 29, 2025

Worked immediately but

Worked right away but still dealing with diarrhea after 2 weeks. Does seem to finally be getting better. Also threw her off eating for several days and we had

Worked right away but still dealing with diarrhea after 2 weeks. Does seem to finally be getting better. Also threw her off eating for several days and we had to hide it in treats. Now that she is more interested in eating, we just hide it in her food.

Rated 3 out of 5 stars
By Roxanne on Nov 14, 2025

Works great, but bad GI upset

My dog was on this medication for a week and a half and her signs of urinary incontinence had virtually resolved within that time, but then started her awful G.I

My dog was on this medication for a week and a half and her signs of urinary incontinence had virtually resolved within that time, but then started her awful G.I. upset. My dog had a severe case of diarrhea and loss of anppe due to not feeling well. Even though the medication did what it was supposed to do, I elected to discontinue the medication entirely because the side effect largely outweigh the benefit. I will not try this again.

Rated 5 out of 5 stars
By Donald on Nov 26, 2025

Very effective & helpful

We have my daughter’s almost 15 year old dog (Layla) living with us because it’s much easier for Layla to get in and out of the house than at my daughter’s apartment

We have my daughter’s almost 15 year old dog (Layla) living with us because it’s much easier for Layla to get in and out of the house than at my daughter’s apartment. The Proin has been very good at eliminating any bladder leaks in the house.

Rated 5 out of 5 stars
By Stephanie on Dec 6, 2025

Dry bed, happy Mom!

Proin did not help our sweet old beagle, but has been a miracle for our fox hound, Amber. I’ve missed giving her a dose twice and had a wet bed, but NEVER when

Proin did not help our sweet old beagle, but has been a miracle for our fox hound, Amber. I’ve missed giving her a dose twice and had a wet bed, but NEVER when she takes it every day.

Rated 5 out of 5 stars
By Toni on Dec 16, 2025

Perfect!

I used to give my baby girl a giant pill (crushed) in her breakfast, then another pill at dinner. Now, I give her one little pill in a pill pocket, and it lasts

I used to give my baby girl a giant pill (crushed) in her breakfast, then another pill at dinner. Now, I give her one little pill in a pill pocket, and it lasts all day.

Rated 5 out of 5 stars
By Kathleen on Oct 18, 2025

My foster dog had a leakage problem

I was going to give her back to the rescue group because of incontinence. They told me about this medication and so glad that I can keep my rescue doggie now with

I was going to give her back to the rescue group because of incontinence. They told me about this medication and so glad that I can keep my rescue doggie now with no problems. Got her as an 8 year old, glad to give her more years in a loving home. Once I sent the vet's prescription, Chewy was very fast in shipping the Proin ER. Have it on auto-renew.