Simparica Trio Chewable Tablet for Dogs, 2.8-5.5 lbs, (Gold Box)

By Simparica Trio
Rated 4.1818 out of 5 stars
Prescription Item

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$156.99Chewy Price
$149.14Autoship Price
(Save an extra 5%)

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Usually arrives in 3-5 days
We'll collect your pet's prescription information at Checkout.

This item requires prescription approval.

Medications ship separately. Delivery times may vary.

About This Item


Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 2.8 and 5.5 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer. One count orders of manufacturer-sealed blister packs will arrive in a resealable plastic bag.

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Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

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About Simparica Trio for Dogs

Go With Simparica Trio

Give your dog triple protection with Simparica Trio. It's the first monthly chewable that provides defense against heartworm disease, fleas & ticks*, roundworms**, and hookworms***.

Triple Protection, Made Simple

Just one Simparica Trio dose does the job of two or three products, protecting against common parasites that can threaten the health of your dog. It is easy to give and can help simplify your routine as you protect your dog every month.

Use Simparica Trio for Puppies

When puppies are exposed to parasites, it can lead to serious health concerns. Make sure to protect your little ones from the start with Simparica Trio. It is demonstrated safe for puppies 8 weeks and older who weigh at least 2.8 pounds.

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.


Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
Prescribing Information.

*Amblyomma americanum, Abylomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhicephalus sanguineus. **Toxocara canis and Toxascaris leonina. ***Ancylostoma caninum and Uncinaria stenocephala.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2021 Zoetis Services LLC. All rights reserved. STR-00337

About Simparica Trio

Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Dogs get all this protection with just one dose of Simparica Trio. Available by prescription only.
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ReviewsWrite a Review

Rated 4.1818 out of 5 stars
22 Ratings
Would recommend to a friend

21 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By Elizabeth on Nov 9, 2023

Wow! I am impressed

I placed an order one afternoon and the treats were here the NEXT day! The heart worm preventative was here the next day.

Rated 4 out of 5 stars
By Comethj on Aug 16, 2023

May cause skin irritation

I have 4 dogs on this. 3 do really well. Unfortunately, my 7yo teacup Yorkie had a bad reaction. Skin lesions, horrible itching, and goopy eyes. It took us a year to figure this out as the warnings don't mention it. I hope this helps someone else who is struggling with a similar issue.

Rated 3 out of 5 stars
By Nena on Sep 6, 2023

Simpatico Trio 2.8 - 5.5 lbs.

Really don’t know right now, just started the first dose on the first of Sept. Dug was sick with diarrhea, vomiting and didn’t feel so well. See what happens next month.

Rated 5 out of 5 stars
By Michelle on Sep 5, 2023

Great product!

Love how convenient it is to give my pup her heartworm and tic prevention in one easy to swallow pill. Works great!

Rated 5 out of 5 stars
By Cynthia on Jun 24, 2023

Simparica TRIO

Received Simparica TRIO promptly. Medication is easily given with a taste of peanut butter.

Rated 5 out of 5 stars
By Jack on May 2, 2023

The dog like it.

For the first time ever, our Buddy ate his meds. like a piece of candy. No more forcing it down his throat or hiding it in his regular food.

Rated 5 out of 5 stars
By Kimberly on Apr 7, 2023

Nice to give just 1 pill

My dog takes this and seems less lethargic and itchy then when I used to use the topical flea and tick stuff and the meds combined mean she only has 1 thing per month!

Rated 5 out of 5 stars
By Brenda on Nov 24, 2023

Flea and tick

Works very well.

Rated 5 out of 5 stars
By Hawkii25 on Feb 22, 2023

Cheaper than Vet office

The Vet recommended to order this med from chewy because it is cheaper than getting it from them and our dog is tinier than most dogs so it would be harder for the vet to keep fresh medicine.

Rated 5 out of 5 stars
By 122019 on Apr 25, 2023

Simparica Trio

Good Medication ....................................