Simparica Trio Chewable Tablet for Dogs, 5.6-11.0 lbs, (Purple Box), slide 1 of 1

Simparica Trio Chewable Tablets for Dogs, 5.6-11.0 lb, 6 treatments (Purple Box)

Prescription Item

  • Price:

    $139.19 FREE Shipping on this item

Autoship: &Save

$132.23(Save an extra 5%)

Simply select Autoship at checkout for easy regular deliveries.


In stock

This item requires prescription approval. Details

Medications ship separately. Delivery times may vary. Details

We'll collect your pet's prescription information at Checkout.

cw-icon-heart Created with Sketch. Add to Favorites
Description

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 5.6 and 11 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Uses

Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and adult hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

Possible Side Effects

The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Drug & Food Interactions

There are no known contraindications for the use of SIMPARICA TRIO.

Precautions

Not for use in humans. Keep this and all drugs out of reach of children. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Gold2.8-5.5 lbs3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg PyrantelAdminister orally once a month✓-Click Here
Purple5.6-11.0 lbs6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg PyrantelAdminister orally once a month✓-Click Here
Caramel11.1-22.0 lbs12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg PyrantelAdminister orally once a month✓-Click Here
Teal22.1-44.0 lbs24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg PyrantelAdminister orally once a month✓-Click Here
Green44.1-88.0 lbs48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg PyrantelAdminister orally once a month✓-Click Here
Brown88.1-132.0 lbs72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg PyrantelAdminister orally once a month✓-Click Here
  1. Prescribing Information

See all items by Simparica Trio

  • Item Number
    224817
  • For Use With
    Dogs
  • Generic Name
    sarolaner, moxidectin, and pyrantel (as pamoate salt).
  • Administration Form
    Oral
  • Common Brand Name(s)
    Simparica Trio
  • Brand
    Zoetis
  • Lifestage
    Adult, Puppy
  • Breed Size
    Small Breeds
  • Product Form
    Chewable Tablet
  • Strength
    6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg Pyrantel
  • Health Condition
    Heartworms, Ticks, Fleas, Roundworms, Hookworms
  • Drug Type
    Parasiticide
Ingredients
Ingredients

sarolaner, moxidectin, and pyrantel (as pamoate salt).

Instructions
Recommended Dosage

This medication should be administered orally at monthly intervals. Consult your veterinarian for proper dosing instructions.

Storage Instructions

Store at or below 30°C (86°F).

FAQ

What are the key benefits of Simparica Trio?

Comprehensive Protection with Potent Heartworm Coverage

  • Trio of Parasite Protection:
    • Heartworm disease
    • Ticks and fleas
    • Hookworms and roundworms

Convenience: One Monthly Product Does the Job of Two or More

  • Greater than 75% of pet owners aren't protecting dogs from all parasites Simparica Trio covers
  • Around 50% of pet owners protect against just ticks & fleas or heartworm

Tasty Chew for Puppies and Dogs

  • Demonstrated safety in dogs as young as 8 weeks of age
  • Highly palatable (91.9% of dogs voluntarily consumed)

What is the efficacy of Simparica Trio?

In clinical trials, Simparica Trio:

  • Was 100% effective against heartworm disease in dogs after one dose
  • Started killing fleas within 4 hours and achieved 100% efficacy 8 hours after treatment
  • Was >98.9 % effective against tick infestations in 48 hours
  • Resulted in 99.2% efficacy for adult roundworm and reduction in fecal egg count, and >94% efficacy for hookworm

What should I do if a dose is missed, or if my dog vomits after administration?

  • If a dose is missed, a new dose should be given immediately. If a dose is vomited or spit out, a new dose should be given again. Then, continue on the prescribed monthly dosing schedule.

Why should I recommend Simparica Trio or Simparica?

  • Simparica and Simparica Trio are both highly palatable chews that protect against ticks and fleas in dogs, but Simparica Trio also has the added benefit of moxidectin and pyrantel to protect dogs against heartworms disease, roundworms, and hookworms.

How do Simparica Trio’s active ingredients work?

  • Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
  • Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
  • Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

How old does my dog have to be to start using Simparica Trio?

  • Simparica Trio has been demonstrated safe for puppies as young as 8 weeks, and weighing as little as 2.8 lbs.

Are Simparica Trio tablets able to be split for administration?

  • Simparica Trio chewables are not scored and cannot be divided.

Is administering Simparica Trio at the same time as other heartworm, tick, or flea medications safe?

  • At this time, No studies have been conducted to evaluate Simparica Trio administered alongside with other medications. But, Simparica Trio has demonstrated efficacy against heartworm disease, ticks and fleas in one chewable so there is no need to administer another product.

Can Simparica Trio be administered to cats?

  • Simparica Trio has only been approved for dogs and cannot be administered to cats.

How does Simparica Trio differ from other preventatives?

  • Simparica Trio is a first of its kind monthly chewable to protect dogs against heartworm disease, fleas, five types of ticks, hookworms and roundworms.

How often should I give Simparica Trio to my dog?

  • Administer Simparica Trio chewable once a month to your dog.

How do I switch from a flea and tick medication or another heartworm medication?

  • To ensure your dog is kept protected through the process, talk to your veterinarian before switching to Simparica Trio from another preventive medication.

Does Simparica Trio require a prescription?

  • Simparica Trio does require a prescription. Talk to your vet today about Simparica Trio, and your veterinarian can prescribe the correct dose for your dog.

If I’m late giving a Simparica Trio dose, what should I do?

  • Give a new dose immediately if a dose is missed. A new dose should be given again if a dose is spit out. Then, continue on the monthly prescribed dosing schedule.

What are some signs and symptoms of heartworm disease in dogs?

  • The first signs of heartworm disease may be mild and hard to notice. As time progresses, you might see something known as heartworm cough, a decreased appetite, or a reluctance to exercise. More advanced stages of heartworm disease result in symptoms including trouble breathing, pale gums or dark urine—a result of blocked blood flow.

Is there a cure for heartworm disease?

  • Thankfully, heartworm disease can be treated, but the process can be pricey, lengthy and hard on your dog’s health. While heartworms can be removed, the damage to your dog’s heart and lungs may remain. Heartworm disease preventatives for dogs protect your dog from the effects of heartworm disease and prevent this trauma.

What should I do if my dog has already tested positive for heartworm disease?

  • If your veterinarian has confirmed this diagnosis, they will talk to you about how to treat heartworm disease in your dog.

How fast does Simparica Trio work to kill ticks and fleas?

  • Simparica Trio works fast to get rid of ticks and fleas on dogs. It starts to kill deer ticks within 8 hours, and fleas within 4 hours.

Are hookworms contagious?

  • Dogs become infected with hookworms from contact with contaminated feces, contaminated environments, from mother to pup, as well as eating wild animals. Hookworms in dog feces can lead to contaminated outdoor areas, which is how people can get hookworm infection.

What are intestinal parasite symptoms?

  • Both hookworms and roundworms can cause malnutrition in dogs, shown by anemia, weakness, weight loss or stunted growth.
  • Roundworms can also cause vomiting, diarrhea or a pot-bellied appearance.
  • Hookworms can cause pale gums and itchy paws. Hookworms can be deadly if left untreated, especially in young puppies or adult dogs with a weakened immune system.
Rating: 4.7 of 5 stars 14 Reviews 14 Reviews 4.8 out of 5 Stars

Filter reviews by star rating

100% Recommend

100% of reviewersrecommend this product

Rating: 4.7 of 5 stars 4.8 / 5

You've Already Reviewed This Item

14 Reviews

Showing 1-10 of 14 Reviews

  • 5 out of 5 stars

    Fast and easy

    By Angel on Nov 15, 2020

    I was worried that my dog would not eat it. I sat it on a plate with some treats and she sniffed it and pawed it out the way to eat her treats. I offered it to her by hand, she sniffed it then licked it up but spit it out. So I was getting worried that I would have to fight with her to get it down her throat. My son said we should wrap it in bacon and give it to her so we did just that and she gobbled it down. We watched her closely over the next few days and she did not vomit and have stool issues (I heard it’s common for dogs to have those side effects sometimes). I’m happy that she did not waste my money and I did not have to fight/chase her around to do the squeeze tube flea stuff just for I was worried that my dog would not eat it. I sat it on a plate with some treats and she sniffed it and pawed it out the way to eat her treats. I offered it to her by hand, she sniffed it then licked it up but spit it out. So I was getting worried that I would have to fight with her to get it down her throat. My son said we should wrap it in bacon and give it to her so we did just that and she gobbled it down. We watched her closely over the next few days and she did not vomit and have stool issues (I heard it’s common for dogs to have those side effects sometimes). I’m happy that she did not waste my money and I did not have to fight/chase her around to do the squeeze tube flea stuff just for her to rub it off on the sofa or in the dirt. … more

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Convenient Protection

    By Training on Dec 30, 2020

    I received a sample of this from my vet and I really like the option of having several protections all in one pill. I had been giving heartworm and flea/tick meds separately and this allows me to give both things in one dose along with also protecting from round worms and hook worms which is an added bonus.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Heartworm Medicine

    By Nellenosflow on Jan 11, 2021

    I was given a sample pill for my rescue dog at the veterinarian's office and decided to order from Chewy. I appreciate that Chewy made the call to my veterinarian to get the prescription that was needed. Chloe is doing very well on this brand of heartworm.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Best Price Ever

    By Star on Dec 13, 2020

    There are 6 tablets in the purple box. My puppy takes one per month. Since its 2 dollar cheaper per tablet than anywhere else I save 12 dollar in all which I can use to get extra treats or toys.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    These work wonderfully

    By Debbie on Jan 8, 2021

    Chewy gets my dogs medications to me on time every month and I don’t have to worry. Also so much cheaper than the vet

    You liked it! Something went wrong. Please try again later. Report
  • 2 out of 5 stars

    Product is good but service wasn't

    By Cody on Aug 30, 2020

    My vet who prescribed this product is a mobile vet. My request for Chewy to contact my vet sat at Chewy for a week and nothing was done. I called after the week and had to give the vet's information AGAIN before anything was done. Poor customer service.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Great product

    By Pets1234 on Aug 20, 2020

    I've only just started using this, but so far so good. My puppy liked it, but it was a bit difficult for her to chew; she's very small. I'm hoping as she gets bigger, it will become easier to chew. I love that it's an all in one chewable.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    GREAT PRODUCT!

    By Jamie on Sep 1, 2020

    This product does it all (except tape worms) and I couldn't be happier. Why buy several medications for your pooches when you can buy just Simparica? I highly recommend! Ask your vet about it - you wont regret it!

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Flee & Tick

    By Lizy on Aug 24, 2020

    This product is Great. One pill for flee / tick/ & heart worm. It's nice that there is free shipping, and delivered straight to your dooor. You don't need to worry about giving your dog 2 pills, and forgetting one of them. The expensive I found is better than buying two seperate products. My dog takes it as a treat.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    superior company to work with

    By terry on Oct 15, 2020

    very caring company knows my animals names and always available by phone to answer questions on various products or concerns.

    You liked it! Something went wrong. Please try again later. Report