Simparica Trio Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box), slide 1 of 1
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Simparica Trio Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box), 6 Chewable Tablets (6-mos. supply)

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Description

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 11.1 and 22 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Uses

Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and adult hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

Possible Side Effects

The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Drug & Food Interactions

There are no known contraindications for the use of SIMPARICA TRIO.

Precautions

Not for use in humans. Keep this and all drugs out of reach of children. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Gold2.8-5.5 lbs3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg PyrantelAdminister orally once a month✓-Click Here
Purple5.6-11.0 lbs6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg PyrantelAdminister orally once a month✓-Click Here
Caramel11.1-22.0 lbs12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg PyrantelAdminister orally once a month✓-Click Here
Teal22.1-44.0 lbs24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg PyrantelAdminister orally once a month✓-Click Here
Green44.1-88.0 lbs48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg PyrantelAdminister orally once a month✓-Click Here
Brown88.1-132.0 lbs72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg PyrantelAdminister orally once a month✓-Click Here
  1. Prescribing Information

See all items by Simparica Trio

  • Item Number
    224819
  • For Use With
    Dogs
  • Generic Name
    sarolander, moxidectin, and pyrantel
  • Administration Form
    Oral
  • Common Brand Name(s)
    Simparica Trio
  • Usage
    Prevention, Treatment
  • Lifestage
    Adult, Puppy
  • Breed Size
    Small Breeds
  • Product Form
    Chewable Tablet
  • Strength
    12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg Pyrantel
  • Health Condition
    Heartworms, Ticks, Fleas, Roundworms, Hookworms
  • Drug Type
    Parasiticide
Ingredients
Ingredients

sarolaner, moxidectin, and pyrantel (as pamoate salt).

Instructions
Recommended Dosage

This medication should be administered orally at monthly intervals. Consult your veterinarian for proper dosing instructions.

Storage Instructions

Store at or below 30°C (86°F).

FAQ

What are the key benefits of Simparica Trio?

Comprehensive Protection with Potent Heartworm Coverage

  • Trio of Parasite Protection:
    • Heartworm disease
    • Ticks and fleas
    • Hookworms and roundworms

Convenience: One Monthly Product Does the Job of Two or More

  • Greater than 75% of pet owners aren't protecting dogs from all parasites Simparica Trio covers
  • Around 50% of pet owners protect against just ticks & fleas or heartworm

Tasty Chew for Puppies and Dogs

  • Demonstrated safety in dogs as young as 8 weeks of age
  • Highly palatable (91.9% of dogs voluntarily consumed)

What is the efficacy of Simparica Trio?

In clinical trials, Simparica Trio:

  • Was 100% effective against heartworm disease in dogs after one dose
  • Started killing fleas within 4 hours and achieved 100% efficacy 8 hours after treatment
  • Was >98.9 % effective against tick infestations in 48 hours
  • Resulted in 99.2% efficacy for adult roundworm and reduction in fecal egg count, and >94% efficacy for hookworm

What should I do if a dose is missed, or if my dog vomits after administration?

  • If a dose is missed, a new dose should be given immediately. If a dose is vomited or spit out, a new dose should be given again. Then, continue on the prescribed monthly dosing schedule.

Why should I recommend Simparica Trio or Simparica?

  • Simparica and Simparica Trio are both highly palatable chews that protect against ticks and fleas in dogs, but Simparica Trio also has the added benefit of moxidectin and pyrantel to protect dogs against heartworms disease, roundworms, and hookworms.

How do Simparica Trio’s active ingredients work?

  • Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
  • Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
  • Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

How old does my dog have to be to start using Simparica Trio?

  • Simparica Trio has been demonstrated safe for puppies as young as 8 weeks, and weighing as little as 2.8 lbs.

Are Simparica Trio tablets able to be split for administration?

  • Simparica Trio chewables are not scored and cannot be divided.

Is administering Simparica Trio at the same time as other heartworm, tick, or flea medications safe?

  • At this time, No studies have been conducted to evaluate Simparica Trio administered alongside with other medications. But, Simparica Trio has demonstrated efficacy against heartworm disease, ticks and fleas in one chewable so there is no need to administer another product.

Can Simparica Trio be administered to cats?

  • Simparica Trio has only been approved for dogs and cannot be administered to cats.

How does Simparica Trio differ from other preventatives?

  • Simparica Trio is a first of its kind monthly chewable to protect dogs against heartworm disease, fleas, five types of ticks, hookworms and roundworms.

How often should I give Simparica Trio to my dog?

  • Administer Simparica Trio chewable once a month to your dog.

How do I switch from a flea and tick medication or another heartworm medication?

  • To ensure your dog is kept protected through the process, talk to your veterinarian before switching to Simparica Trio from another preventive medication.

Does Simparica Trio require a prescription?

  • Simparica Trio does require a prescription. Talk to your vet today about Simparica Trio, and your veterinarian can prescribe the correct dose for your dog.

If I’m late giving a Simparica Trio dose, what should I do?

  • Give a new dose immediately if a dose is missed. A new dose should be given again if a dose is spit out. Then, continue on the monthly prescribed dosing schedule.

What are some signs and symptoms of heartworm disease in dogs?

  • The first signs of heartworm disease may be mild and hard to notice. As time progresses, you might see something known as heartworm cough, a decreased appetite, or a reluctance to exercise. More advanced stages of heartworm disease result in symptoms including trouble breathing, pale gums or dark urine—a result of blocked blood flow.

Is there a cure for heartworm disease?

  • Thankfully, heartworm disease can be treated, but the process can be pricey, lengthy and hard on your dog’s health. While heartworms can be removed, the damage to your dog’s heart and lungs may remain. Heartworm disease preventatives for dogs protect your dog from the effects of heartworm disease and prevent this trauma.

What should I do if my dog has already tested positive for heartworm disease?

  • If your veterinarian has confirmed this diagnosis, they will talk to you about how to treat heartworm disease in your dog.

How fast does Simparica Trio work to kill ticks and fleas?

  • Simparica Trio works fast to get rid of ticks and fleas on dogs. It starts to kill deer ticks within 8 hours, and fleas within 4 hours.

Are hookworms contagious?

  • Dogs become infected with hookworms from contact with contaminated feces, contaminated environments, from mother to pup, as well as eating wild animals. Hookworms in dog feces can lead to contaminated outdoor areas, which is how people can get hookworm infection.

What are intestinal parasite symptoms?

  • Both hookworms and roundworms can cause malnutrition in dogs, shown by anemia, weakness, weight loss or stunted growth.
  • Roundworms can also cause vomiting, diarrhea or a pot-bellied appearance.
  • Hookworms can cause pale gums and itchy paws. Hookworms can be deadly if left untreated, especially in young puppies or adult dogs with a weakened immune system.
Rating: 4.6 of 5 stars 45 Reviews 45 Reviews 4.6 out of 5 Stars

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96% Recommend

96% of reviewersrecommend this product

Rating: 4.6 of 5 stars 4.6 / 5

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45 Reviews

Showing 1-10 of 45 Reviews

  • 5 out of 5 stars

    Convenient With No Mess

    By 57Ragdoll on May 28, 2021

    I was extremely reluctant to try this chewable with my little dog after my larger dog had a bad reaction to Bravecto chewables. Now living in the mountains with ticks and tired of the messy, smelly chemical spot treatments. Had to disguise the chewable in a cheese ball so my dog would take it a few weeks ago and have had no apparent side effects. Love the convenience of 3 in 1 treatment with no fuss or mess!!

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  • 5 out of 5 stars

    Prescription Refill

    By Howard3305 on Mar 27, 2021

    My dog needed an RX refill and I didn't want to have to get out among people and go to the vets office. I told Chewy what I needed and they did the rest. Had my dogs RX within a week and I didn't have to go out. Thanks Chewy.

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  • 5 out of 5 stars

    So far, so good!

    By Stewie on Feb 26, 2021

    My vet recommended this for my pup who had been on a couple of different heartworm and flea/tick preventions prior to me adopting him. He’s into his second month, no side effects. I put the tablet in with his kibble and he eats it no problem. Super convenient to have protection rolled into one medication (plus to have Chewy auto-ship every 6 months so I never forget to order).

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  • 5 out of 5 stars

    One pill and done!

    By Lily on Apr 14, 2021

    My dog took the pill no need to mask it with something tasty! Super convenient easy to remember. Worth the price. Chewy always makes it easy to order.

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  • 5 out of 5 stars

    Give One and be Done

    By Marsha on Mar 12, 2021

    I'm so glad to have found a medication that covers heartworm, fleas and ticks all in one pill. No more oily topical drops that make a greasy mess on the dogs either. My dog had no side effects.

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  • 5 out of 5 stars

    Great product

    By Heidi on Apr 8, 2021

    It's easier to give because you only have to give your baby 1 tablet instead of 2 and it's much cheaper than what I usually buy

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  • 5 out of 5 stars

    TrioReview

    By LittleOtto on Apr 13, 2021

    Excellent product-we have 3 dachshunds-both short+long hair - no issues what-so-ever!!! One pill per month and done!!

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  • 5 out of 5 stars

    Affordable Need

    By Grumpy on Jan 13, 2021

    The SimparicaTrio is a good fit for our puppy but the ordering process left a lot to be desired. Instead of getting ALL of the requirements and formats at one time, we were "piece mealed" until finally the correct requirements and correct format were achieved. We made an error on our end to be sure and we may return as a customer.

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  • 5 out of 5 stars

    Works well

    By Cris on Jun 4, 2021

    It’s great these drugs have been combined. My dog wolfs it down

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  • 5 out of 5 stars

    Working great so far

    By Cristina on Dec 10, 2020

    My vet recommended this pill when I first brought my new puppy in for a checkup. She has had two doses so far, no side effects (fingers crossed). I went ahead and purchased the 6-month pack because it’s cheaper vs buying single dose. It’s not exactly chewable, my dog spits it out unless I split it in two pieces and hide the pieces in chicken-flavored pill pockets. She loves those. Maybe when she’s older she won’t need the pill hidden but for now, she’s picky. Currently, she’s an 18 week-old, 10.8 lb mini goldendoodle.

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