SIMPARICA TRIO Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box), 6 Chewable Tablets (6-mos. supply) -

Simparica Trio Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box)

By Simparica Trio
Rated 4.4631 out of 5 stars
Prescription Item
Pet Weight

New Customers Only: Spend 49+ Get $20 Off With Code: WELCOME

See 'Details' tab for instructions to redeem
$161.99Chewy Price
$153.89Autoship Price
Autoship (Save an extra 5%)

Why Autoship?

  • Save 5% on all future Autoship orders
  • Set your schedule based on your pet's needs
  • No fees, no commitments - skip, change or cancel anytime.
This item requires prescription approval.

Delivery TimeA badge for delivery times
Medications ship separately. Delivery times may vary.

In Stock
FREE 1-3 day shipping
We'll collect your pet's prescription information at Checkout.

About This Item


Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 11.1 and 22 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

See More




Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

About Simparica Trio for Dogs

Go With Simparica Trio

Give your dog triple protection with Simparica Trio. It's the first monthly chewable that provides defense against heartworm disease, fleas & ticks*, roundworms**, and hookworms***.

Triple Protection, Made Simple

Just one Simparica Trio dose does the job of two or three products, protecting against common parasites that can threaten the health of your dog. It is easy to give and can help simplify your routine as you protect your dog every month.

Use Simparica Trio for Puppies

When puppies are exposed to parasites, it can lead to serious health concerns. Make sure to protect your little ones from the start with Simparica Trio. It is demonstrated safe for puppies 8 weeks and older who weigh at least 2.8 pounds.

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.


Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
Prescribing Information.

*Amblyomma americanum, Abylomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhicephalus sanguineus. **Toxocara canis and Toxascaris leonina. ***Ancylostoma caninum and Uncinaria stenocephala.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2021 Zoetis Services LLC. All rights reserved. STR-00337

About Simparica Trio

Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Dogs get all this protection with just one dose of Simparica Trio. Available by prescription only.
Shop Simparica Trio

ReviewsWrite a Review

Rated 4.4631 out of 5 stars
203 Reviews
Would recommend to a friend

203 Customer Reviews

Rated 5 out of 5 stars
By Hanna on Dec 17, 2022

Highly recommend

After trying a variety of options for my 11 pound maltese, simparica trio has by far been the best. Previously on heartguard and frontline, I would still frequently find ticks that would be attached. According to my vet frontline has been around for so long that some ticks have built immunity to it. I switched him to the seresto collar and within a day he became unwell. The vet recommended simparica trio and ive been very happy. Its easy to remember with just one medication and he loves the flavor. If i find ticks on him they are either dead or not attached.

Rated 5 out of 5 stars
By Mimi on Feb 1, 2023

Easy; Affordable; Fast

Ordering online was so easy and the prices much lower than at the veterinary office. The product arrived in only a couple of days. They even got the script from the vet! And to be able to put on auto delivery was the icing in the cake.

Rated 1 out of 5 stars
By TraceB24 on Dec 29, 2022

Mini aussie developed tremors

This product gave my mini aussie tremors. After each month on this product, the tremors got worse and would only occur when she was asleep. We've spent the last three months detoxing from this med and she is back to normal. Not to mention all the tests and vet bills accumulated to find out what was wrong.

Rated 5 out of 5 stars
By Ange96 on Nov 29, 2022

Bailey’s Covered with Chewy!

So grateful to Chewy for the RX discounts they provide and their assistance with getting the RX filled. My vet was being a little difficult and Chewy kept me informed throughout the whole process so that I could ensure Bailey had her flee & tick prevention in a timely manner. This brand is great for my senior Shih Tzu mix & I love love love Chewy!

Rated 5 out of 5 stars
By Gigi on Nov 22, 2022

Great Customer Service Recommendation!

My dog Charlie had lost a bit of wait and I was unsure whether or not her Simparica should reflect this change. The customer services rep. didn't hesitate at this and recommended a lower dose according to his reduced weight. Your reps are knowledgeable, friendly and professional. Who could ask for more?

Rated 5 out of 5 stars
By Nina on Nov 4, 2022

Great product

I finally found the right medication to give my puppy and he is fully protected heart, flee/tick, worms etc... He took the pill right away without a problem, I'm assuming its tasty LoL. It was difficult giving him the medication in the pill for. This little guy had no problem with the Simparica Trio, I highly recommend it. Chewy makes it easy to work with your vet to get a prescription, it was hassle free.

Rated 5 out of 5 stars
By DianaC on Dec 18, 2022

excellent protection

I have used this for my dachshund for 9 years. He takes it from my hand and chews it right up. He seems to love the flavor. I know it does a fabulous job protecting him from fleas, ticks, and other parasites.

Rated 5 out of 5 stars
By Polly on Dec 15, 2022

Simparico TRIO works great

When using a different brand my small dog tested positive for roundworms, tapeworms and others. Changing to Simparica TRIO worked and we'll be using this medication from now on for her.

Rated 4 out of 5 stars
By Katherine on Nov 29, 2022

Worked fast

This seemed to relieve a lot of itching for both my pups. But it definitely didn't last a month, which is disappointing. I live out in the country and have had a tough time finding a medication that works. This works.

Rated 1 out of 5 stars
By alyna on Dec 4, 2022

Not for my dog

This give horrible reaction to my dog. Tremors ,confusion puke and poop in the same time. This was the last time I gave it to him. I'm switching him back to Heartgard