Simparica Trio Chewable Tablets for Dogs, 44.1-88 lb (Green Box), slide 1 of 1

Simparica Trio Chewable Tablets for Dogs, 44.1-88 lb, 6 treatments (Green Box)

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Description

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 44.1 and 88 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Uses

Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and adult hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

Possible Side Effects

The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Drug & Food Interactions

There are no known contraindications for the use of SIMPARICA TRIO.

Precautions

Not for use in humans. Keep this and all drugs out of reach of children. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Gold2.8-5.5 lbs3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg PyrantelAdminister orally once a month✓-Click Here
Purple5.6-11.0 lbs6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg PyrantelAdminister orally once a month✓-Click Here
Caramel11.1-22.0 lbs12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg PyrantelAdminister orally once a month✓-Click Here
Teal22.1-44.0 lbs24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg PyrantelAdminister orally once a month✓-Click Here
Green44.1-88.0 lbs48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg PyrantelAdminister orally once a month✓-Click Here
Brown88.1-132.0 lbs72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg PyrantelAdminister orally once a month✓-Click Here
  1. Prescribing Information

See all items by Simparica Trio

  • Item Number
    224823
  • For Use With
    Dogs
  • Generic Name
    sarolander, moxidectin, and pyrantel
  • Administration Form
    Oral
  • Brand
    Zoetis
  • Lifestage
    Puppy, Adult
  • Breed Size
    Medium Breeds
  • Product Form
    Chewable Tablet
  • Strength
    48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg Pyrantel
  • Health Condition
    Heartworms, Ticks, Fleas, Roundworms, Hookworms
  • Drug Type
    Parasiticide
Ingredients
Ingredients

sarolaner, moxidectin, and pyrantel (as pamoate salt).

Instructions
Recommended Dosage

This medication should be administered orally at monthly intervals. Consult your veterinarian for proper dosing instructions.

Storage Instructions

Store at or below 30°C (86°F).

FAQ

What are the key benefits of Simparica Trio?

Comprehensive Protection with Potent Heartworm Coverage

  • Trio of Parasite Protection:
    • Heartworm disease
    • Ticks and fleas
    • Hookworms and roundworms

Convenience: One Monthly Product Does the Job of Two or More

  • Greater than 75% of pet owners aren't protecting dogs from all parasites Simparica Trio covers
  • Around 50% of pet owners protect against just ticks & fleas or heartworm

Tasty Chew for Puppies and Dogs

  • Demonstrated safety in dogs as young as 8 weeks of age
  • Highly palatable (91.9% of dogs voluntarily consumed)

What is the efficacy of Simparica Trio?

In clinical trials, Simparica Trio:

  • Was 100% effective against heartworm disease in dogs after one dose
  • Started killing fleas within 4 hours and achieved 100% efficacy 8 hours after treatment
  • Was >98.9 % effective against tick infestations in 48 hours
  • Resulted in 99.2% efficacy for adult roundworm and reduction in fecal egg count, and >94% efficacy for hookworm

What should I do if a dose is missed, or if my dog vomits after administration?

  • If a dose is missed, a new dose should be given immediately. If a dose is vomited or spit out, a new dose should be given again. Then, continue on the prescribed monthly dosing schedule.

Why should I recommend Simparica Trio or Simparica?

  • Simparica and Simparica Trio are both highly palatable chews that protect against ticks and fleas in dogs, but Simparica Trio also has the added benefit of moxidectin and pyrantel to protect dogs against heartworms disease, roundworms, and hookworms.

How do Simparica Trio’s active ingredients work?

  • Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
  • Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
  • Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

How old does my dog have to be to start using Simparica Trio?

  • Simparica Trio has been demonstrated safe for puppies as young as 8 weeks, and weighing as little as 2.8 lbs.

Are Simparica Trio tablets able to be split for administration?

  • Simparica Trio chewables are not scored and cannot be divided.

Is administering Simparica Trio at the same time as other heartworm, tick, or flea medications safe?

  • At this time, No studies have been conducted to evaluate Simparica Trio administered alongside with other medications. But, Simparica Trio has demonstrated efficacy against heartworm disease, ticks and fleas in one chewable so there is no need to administer another product.

Can Simparica Trio be administered to cats?

  • Simparica Trio has only been approved for dogs and cannot be administered to cats.

How does Simparica Trio differ from other preventatives?

  • Simparica Trio is a first of its kind monthly chewable to protect dogs against heartworm disease, fleas, five types of ticks, hookworms and roundworms.

How often should I give Simparica Trio to my dog?

  • Administer Simparica Trio chewable once a month to your dog.

How do I switch from a flea and tick medication or another heartworm medication?

  • To ensure your dog is kept protected through the process, talk to your veterinarian before switching to Simparica Trio from another preventive medication.

Does Simparica Trio require a prescription?

  • Simparica Trio does require a prescription. Talk to your vet today about Simparica Trio, and your veterinarian can prescribe the correct dose for your dog.

If I’m late giving a Simparica Trio dose, what should I do?

  • Give a new dose immediately if a dose is missed. A new dose should be given again if a dose is spit out. Then, continue on the monthly prescribed dosing schedule.

What are some signs and symptoms of heartworm disease in dogs?

  • The first signs of heartworm disease may be mild and hard to notice. As time progresses, you might see something known as heartworm cough, a decreased appetite, or a reluctance to exercise. More advanced stages of heartworm disease result in symptoms including trouble breathing, pale gums or dark urine—a result of blocked blood flow.

Is there a cure for heartworm disease?

  • Thankfully, heartworm disease can be treated, but the process can be pricey, lengthy and hard on your dog’s health. While heartworms can be removed, the damage to your dog’s heart and lungs may remain. Heartworm disease preventatives for dogs protect your dog from the effects of heartworm disease and prevent this trauma.

What should I do if my dog has already tested positive for heartworm disease?

  • If your veterinarian has confirmed this diagnosis, they will talk to you about how to treat heartworm disease in your dog.

How fast does Simparica Trio work to kill ticks and fleas?

  • Simparica Trio works fast to get rid of ticks and fleas on dogs. It starts to kill deer ticks within 8 hours, and fleas within 4 hours.

Are hookworms contagious?

  • Dogs become infected with hookworms from contact with contaminated feces, contaminated environments, from mother to pup, as well as eating wild animals. Hookworms in dog feces can lead to contaminated outdoor areas, which is how people can get hookworm infection.

What are intestinal parasite symptoms?

  • Both hookworms and roundworms can cause malnutrition in dogs, shown by anemia, weakness, weight loss or stunted growth.
  • Roundworms can also cause vomiting, diarrhea or a pot-bellied appearance.
  • Hookworms can cause pale gums and itchy paws. Hookworms can be deadly if left untreated, especially in young puppies or adult dogs with a weakened immune system.
Rating: 4.7 of 5 stars 14 Reviews 14 Reviews 4.8 out of 5 Stars

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Rating: 4.7 of 5 stars 4.8 / 5

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14 Reviews

Showing 1-10 of 14 Reviews

  • 5 out of 5 stars

    This is a miracle medication

    By on

    My 80 pound puppy white GS (9)month’s lives with us in Georgia near a lake and where a lot of deers hang around freely. With this med he never got a flea or tick also is protected for a and intestinal bugs. Apparently the flavor is good cause he take it easily. No side effects and we are a happy parents. No hassles just one pill monthly for all the protection. Before we buying 3 differents pills to give him less protection than with Simparica Trio provides. Isn’t that pricey if you add the cost of 2 or 3 meds you will need if not on Simparica Trio. Ask your Vet and if your dog is a candidate go for it.

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  • 5 out of 5 stars

    I like the all in one

    By on

    I like the fact that I only have to give my dog 1 pill every month and it covers everything I need. She still refuses to chew it; I have to hide it in a treat. It seems pricey but when you had up the cost of buying multiple pills and this does it all it comes out about the same. It is pure convenience. I have not heard of any major negative side effect with this either like I have with some others. My dog does just fine with it. I will keep her on this medication and watch for it to be on sale.

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  • 2 out of 5 stars

    Shipping times

    By on

    Took over a week for this to get approved from vet. I called chewy twice to see what the hold up is and was told they couldn't co tact my vet. I called my vet and they had to "find the fax" but were able to approve it. So I wonder if Chewy really called the vet or just sent a fax request and sat. BTW my order was about to be cancelled by chewy after 10 days.

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  • 5 out of 5 stars

    All in one product is a game changer!

    By on

    I LOVE the fact that I don't have to buy any other medications for my dog, and I don't need to use a flea collar or that liquid stuff. Just one chew--that she thinks is a treat--makes it so easy to make sure she's protected not only for heartworm issues, but fleas and ticks as well. I wish this product was available sooner!

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  • 5 out of 5 stars

    Thank you , no more deer ticks

    By on Top 100 Contributor

    I was using a topical Flee, tick and heartworm and it was not preventing deer ticks (the ones that spread Lyme Disease). Starting using Simparica Trio and deer all ticks are gone on day one. Even if you do not switch to Simparica Trio please make sure what ever you choose is is formulated to kill and prevent deer ticks if they are a problem in your area. I learned the hard way that some flee, tick and heartworm medication do are not effective on deer ticks and kill only the American Dog Tick.

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  • 5 out of 5 stars

    Hands down the best

    By on

    Had our aussie girl on a topical trio treatment that was just not holding up for the bugs in Florida. I called my vet and she said the one she was on is better for cats (they prescribed it!) and they’re now recommending Simparica Trio for all dogs in their office. I hopped on Chewy and found it for the better price, of course! The tablet is a chewable and it’s honestly kind of big. She held it in her mouth for a second but then chewed it all up like a champ. I stayed home with her just to make sure she didn’t get sick (our previous dog would get a little sickly after her meds) but she was completely fine. Within a couple hours she was bug free. Within a week she stopped itching completely. Apache Had our aussie girl on a topical trio treatment that was just not holding up for the bugs in Florida. I called my vet and she said the one she was on is better for cats (they prescribed it!) and they’re now recommending Simparica Trio for all dogs in their office. I hopped on Chewy and found it for the better price, of course! The tablet is a chewable and it’s honestly kind of big. She held it in her mouth for a second but then chewed it all up like a champ. I stayed home with her just to make sure she didn’t get sick (our previous dog would get a little sickly after her meds) but she was completely fine. Within a couple hours she was bug free. Within a week she stopped itching completely. Apache is a happy girl. We love Simparica Trio! … more

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  • 5 out of 5 stars

    Perfect Solution!

    By on

    This medication is so good! It’s effective and makes much more sense for my dog King. He takes it easily in peanut butter. Thank You for creating this once a month, all-in-one product!

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  • 5 out of 5 stars

    Great stuff!

    By on

    Nellie spends a lot of time outside in woods and tall grass. We've tried lots of different tick products and we've been using Simparica for about 2 years now-- once a month pill, she eats it like a treat, and kills ticks better than anything else we've tried. I'm switching to Simparica Trio so I can stop buying a separate heartworm pill.

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  • 5 out of 5 stars

    Great product

    By on

    This product is easy to give and I haven’t seen any fleas or ticks since I started it. No side effects seen and my dogs ate it willingly. Great 3 in 1 product!

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  • 5 out of 5 stars

    Chewy is Such a Plus!

    By on

    Chewy's service is quick and personalized! There was an issue with the delivery that was quickly remedied! I love ordering from Chewy for my dog!

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