Advantage II Flea Spot Treatment for Dogs, 3-10 lbs, 6 Doses (6-mos. supply)

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About This Item

Details

  • Flea protection for dogs weighing 3 to 10 pounds, at least 7 weeks old.
  • Easy-to-apply monthly topical treatment.
  • Delivers total flea protection and kills adult fleas, flea larvae and flea eggs through contact.
  • Starts killing fleas the same day and keeps working for 30 days.
  • Fragrance-free formula is waterproof after 24 hours of application.

Ingredients

Instructions

Size

FAQ

Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II for Dogs

Get the Advantage Over Fleas

Advantage II topical flea treatment and prevention for dogs kills fleas on your dog within 12 hours, and it continues to protect for 30 days. It’s easier to use than hard-to-swallow pills—simply apply the convenient drops once a month. Best of all, Advantage II is available without a prescription.

How Advantage II for Dogs Works

The active ingredients in Advantage II for Dogs (imidacloprid and pyriproxyfen) spread over the skin and hair coat. Fleas are killed through contact, so they don’t have to bite your dog to die. Do not use on cats.

Flea Treatment and Prevention

Advantage II doesn't just treat fleas––it breaks the flea lifecycle to prevent reinfestation.

Reliable Flea Protection

These flea drops kill adult fleas, flea larvae, flea eggs, and chewing lice.

Same-Day Effectiveness

Advantage II kills fleas on dogs within 12 hours, and it continues to prevent reinfestations for four weeks.

No Prescription Needed

You don’t have to go to the vet to get quality flea protection for your dog—simply buy and apply.

Fragrance-Free

This flea topical formula is fragrance-free and waterproof 24 hours after application.

Frequently Asked Questions

Can I Use Advantage II on My Dog?

Advantage II is for dogs 7 weeks of age and older. The product comes in four sizes: Small Dog (3-10 lbs.), Medium Dog (11-20 lbs.), Large Dog (21-55 lbs.), and Extra Large Dog (over 55 lbs.). Choose the right size based on your dog’s weight. Not for use on cats.

How Do I Apply Advantage II?

Break the seal on the tube, then part the hair on your dog’s back between the shoulder blades to show the skin. Squeeze the tube to expel the entire contents directly onto the skin. The number of application spots will depend on the weight of your dog—see product label for detailed instructions.

The Advantage Family

Get the Advantage over fleas with complete flea protection for your pet, home, and yard. The Advantage family of products has everything you need for a complete flea treatment and prevention plan, including monthly topical treatments, pet shampoos and sprays, household sprays for carpets and crevices, and even a yard and premise spray. Just be sure to get the right product for each need and use only as directed.

Shop K9 Advantix II

Questions & Answers

11 Customer Questions


We have a very small puppy, weighs 3 lbs at 3 months. This product says 4 lbs, and up. Can we use this or is there another product for those puppies under 4 lbs?

Answer by ChewyMar 13, 2018
This treatment can be used on dogs and puppies 7 weeks and older and weighing 3 to 10 pounds.

My puppy is 9 weeks but her weight is only 1,9 lbs. Can she use this product?

Answer by ChewyJul 21, 2020
For dog's weighing under 3 pounds, we recommend consulting with your vet to determine the safest dosage amount.

Is it ok to bathe my puppy before applying this flea medicine?

Answer by ChewyMar 25, 2024
You can bathe your dog before applying Advantage II. Just make sure your dog is thoroughly towel-dried before application. If you choose to bathe your dog in between treatments, it is recommended using a general grooming shampoo for pets. Keep in mind that more frequent bathing may keep the product from working the full 30 days.

How many cc's/mL's in this tube ?

Answer by ChewyJan 03, 2024
One tube contains 0.4 milliliters of treatment.

4.3
Rated 4.3 out of 5 stars
498 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

79% Positive

Effectiveness

75% Positive

Ingredients

74% Positive

Long-Term Benefits

74% Positive

274 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Laurie on Dec 7, 2025

Timely delivery and good pricing on a crucial preventative product.

So glad they have an appropriate dosage option for puppies and small dogs like my little Abbie.

So glad they have an appropriate dosage option for puppies and small dogs like my little Abbie.


Rated 1 out of 5 stars
By Robert on Aug 7, 2025

Expired products

I ordered advantage I and received product manufacturer 8/22. All online information says after 2 years it effectively is out of date. I just returned the same for

I ordered advantage I and received product manufacturer 8/22. All online information says after 2 years it effectively is out of date. I just returned the same for same reason. Just the basic money grab. Sell old products as new


Rated 5 out of 5 stars
By Mark on Dec 20, 2025

Did bot require prescription

Easy to apply. Seems to work. No more tick infestations.

Easy to apply. Seems to work. No more tick infestations.


Rated 5 out of 5 stars
By Laura on Jul 14, 2025

Toxicity

I was told by a holistic vet years back that Advantage II does NOT go through the kidneys of the pet...but rather stays in the sebaceous glands. Promoting a healthier

I was told by a holistic vet years back that Advantage II does NOT go through the kidneys of the pet...but rather stays in the sebaceous glands. Promoting a healthier alternative for flea control. So I've used it every since.


Rated 1 out of 5 stars
By Cherie on Jul 16, 2025

Didn't work at all!

It's like I didn't apply it at all. It did not work. It angers me when people sell stuff that doesn't do a thing they claim it does. Its the same as stealing your

It's like I didn't apply it at all. It did not work. It angers me when people sell stuff that doesn't do a thing they claim it does. Its the same as stealing your money, and giving you nothing at all.


Rated 5 out of 5 stars
By Nancy on Aug 29, 2025

Advantage Ii

Love ordering from chewy. They have fast shipping and great customer service. Never disappointed.

Love ordering from chewy. They have fast shipping and great customer service. Never disappointed.


Rated 2 out of 5 stars
By Barbara on Sep 6, 2025

It’s not working for him.

Seems it was pretty good for awhile, but these last few times not so good.

Seems it was pretty good for awhile, but these last few times not so good.


Rated 4 out of 5 stars
By Jan on Dec 21, 2025

Flea

No matter I did, still there

No matter I did, still there


Rated 1 out of 5 stars
By nareesha on May 26, 2025

doesn't work anymore

I have used this treatment for years and it has worked well, but I have found flees on my dog every time I have used this for the past 3 months (i purchased a 3

I have used this treatment for years and it has worked well, but I have found flees on my dog every time I have used this for the past 3 months (i purchased a 3 month dose). Will not be buying again.


Rated 5 out of 5 stars
By Mildred on Sep 30, 2025

Flea killer

Please count in 2 days after application

Please count in 2 days after application