Credelio Chewable Tablets for Cats, 4.1-17 lbs, (Teal Box)

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Credelio Chewable Tablets for Cats, 4.1-17 lbs. comes in a small, flavored chewable tablet form and is prescribed to provide monthly protection against ticks and fleas for cats and kittens. Credelio is rapidly absorbed, and after 24 hours kills at least 99% of ticks and 100% of fleas for a whole month. This medication is easy to administer and can either be placed directly in your cat companion’s mouth or easily disguised in her favorite food!

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CREDELIO CAT kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) for one month in cats and kittens 8 weeks of age and older, and weighing 2.0 pounds or greater. CREDELIO CAT is also indicated for the treatment and control of Ixodes scapularis (black-legged tick) infestations for one month in cats and kittens 6 months of age and older, and weighing 2.0 pounds or greater.

Possible Side Effects

In a well-controlled U.S. field study, which included 341 cats (228 cats treated with CREDELIO CAT and 113 cats treated with a topical active control), there were no serious adverse reactions.

Drug & Food Interactions

There are no known contraindications for the use of CREDELIO CAT.


Lotilaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, incoordination, and seizures. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Use with caution in cats with a history of neurologic disorders. The safety of Credelio CAT has not been established in breeding, pregnant and lactating cats. The most frequently reported adverse reactions are weight loss, rapid breathing and vomiting. For complete safety information, please see Credelio CAT product label or ask your veterinarian.

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  1. Package Insert

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  • Item Number
  • Administration Form
  • For Use With
  • Generic Name
  • Common Brand Name(s)
  • Breed Size
    Small Breeds, Medium Breeds, Large Breeds
  • Product Form
    Chewable Tablet
  • Strength
    48 mg Lotilaner
  • Health Condition
  • Drug Type


Recommended Dosage

Use only as directed by your veterinarian

Storage Instructions

Store between 59 - 77 F


Why would an indoor cat need flea and tick protection?

One of the most common misconceptions about indoor cats is that they are not at risk for fleas and ticks. Fleas and ticks can be brought into the home on people’s shoes and clothing, and readily infest cats from there. Other pets in the home can also put indoor cats at risk. For example, if a pet owner also has a dog that regularly goes outside, that cat is also at risk for fleas and ticks. Additionally, indoor cats may not be as “indoor” as they seem with short trips to the yard, patio or porch where they can be exposed to fleas and ticks as well.

What are some common signs of fleas on cats?

Common clinical signs include increased, over-active grooming, itchiness, patches of hair loss with reddened skin, small bumpy scabs along the flanks or back end and large scabs around the face. These signs can mimic a number of other issues in cats, including allergies, so it is always a good idea to proactively treat for fleas. Ironically, cats with flea infestations often have an apparent absence of fleas. This is because they are commonly removed by cats through their daily grooming and is a major reason why cat owners and even veterinarians have difficulty realizing a cat has fleas. If fleas are found, they are most often found around the head and neck area.

How fast does Credelio CAT (lotilaner) start killing fleas?

In a well-controlled laboratory study, Credelio Cat began to kill fleas six hours after administration, with >98% of fleas killed within 12 hours after administration. In another well-controlled laboratory study, Credelio Cat demonstrated 100% effectiveness against adult fleas 24 hours after administration or infestation for 35 days. Credelio maintains high, fast-acting and sustained flea efficacy throughout the month.

Which ticks are Credelio Cat labeled for?

Credelio Cat is labeled for the black-legged tick, also known as Ixodes scapularis. This is the most common tick infesting cats in the United States1 and is a threat to cats spring through fall. They transmit Lyme disease and anaplasmosis to cats. True prevalence of these diseases in cats is difficult to determine.

What is the best way to administer Credelio Cat?

All owners have different comfort levels with their cat when it comes to administering medication. There are three basic ways to administer Credelio Cat: 1. Offer by hand or place in area where your cat feels comfortable eating. Many cats will eat the chewable by free choice. Tempting with treats can also help. 2. Offer with food during a meal. If your cat is a grazer, try placing it around a few pieces of kibble or covered in wet food and checking to make sure it has been consumed out of the bowl. 3. Place the chewable on the back of your cat’s tongue. The chewables were designed to be very small and easy to administer in these situations. It is important to always administer Credelio Cat with a meal or 30 minutes after feeding.

Why is food so important when administering Credelio Cat?

Food enhances the absorption and bioavailability of lotilaner in cats. In fact, when given with food, 100% of lotilaner reached systemic circulation as opposed to only 8% in unfed cats. Credelio Cat needs to be administered with food or within 30 minutes of feeding. This will ensure high blood concentrations and sustained efficacy throughout the month.

Is Credelio CAT (lotilaner) safe?

Credelio Cat is FDA-approved as safe and effective when used according to the label.

Rating: 4.8 of 5 stars 7 Reviews 7 Reviews 4.9 out of 5 Stars

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Rating: 4.8 of 5 stars 4.9 / 5

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7 Reviews

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  • 4 out of 5 stars

    Credelio for cats

    By Walli on Oct 9, 2021

    This pill was small enough to put inside a treat. I hallowed out a greenies hair ball treat and used edible glue to glue the pill and treat back together. This is how I gave a Feral cat flea treatment!! It seems to work really fast, cat gets jittery for about an hour. I didn't give 5 stars because the product is new for cats and people need to consult their vets before using this product. There is the unknown I guess. worked great for my situation.

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  • 5 out of 5 stars

    Vet Support

    By Keely on Oct 10, 2021

    Thanks again for excellent support from Chewy Pharmacy. I’m new to being adopted by a stray and not really a “cat person”. Because all cats are “Kenton-persons,” having exquisite taste requires they also get the best!

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  • 5 out of 5 stars

    Great product!

    By Alex on Jul 23, 2021

    We live in the Lowcountry where the fleas are insane and almost impossible to get rid of. I normally use comfortis because topicals and collars don’t work against the fleas here but I was completely out and the vet couldn’t get my pets in for another month. The fleas were starting to get bad so they gave me one of these pills to hold me over. It worked so well. In a couple of days the fleas were all gone! Would definitely recommend this product!!

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  • 5 out of 5 stars

    Excited to see results!

    By Karl on Jul 29, 2021

    I was so happy to hear there was a new alternative to Revolution - trying to catch our cat for a monthly squirt of topical flea medicine has become nearly impossible. It is a chewable pill, and wonder of wonders our finicky cat actually just ate it as soon as I put it in front of him! I will report back on how it does with fleas but I’m thrilled to have a flea alternative that’s so simply and easy to administer compared to Revolution!

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  • 5 out of 5 stars

    out of control fleas

    By Herbie on Sep 1, 2021

    the process to get prescription tablets was quick and easy plus the tablets worked immediately to relieve our cats of fleas.

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  • 5 out of 5 stars

    Flea and tick treatment

    By Bubba on Jul 13, 2021

    Not sure how long this has been out there but this is perfect . I would rather give a pill than put treatment on my cats neck. He hates it . So pill it is. Can’t wait till they make a chewable.(if this is possible

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  • 5 out of 5 stars

    Great Product!

    By TeHa on Aug 12, 2021

    My cat hated the liquid on her neck. I found these. She loves them! It makes us both so happy!

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