Credelio Chewable Tablets for Cats, 4.1-17 lbs, (Teal Box)

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Count: 6 Chewable Tablets (6-mos. supply)
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Credelio Chewable Tablets for Cats, 4.1-17 lbs. comes in a small, flavored chewable tablet form and is prescribed to provide monthly protection against ticks and fleas for cats and kittens. Credelio is rapidly absorbed, and after 24 hours kills at least 99% of ticks and 100% of fleas for a whole month. This medication is easy to administer and can either be placed directly in your cat companion’s mouth or easily disguised in her favorite food!

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CREDELIO CAT kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) for one month in cats and kittens 8 weeks of age and older, and weighing 2.0 pounds or greater. CREDELIO CAT is also indicated for the treatment and control of Ixodes scapularis (black-legged tick) infestations for one month in cats and kittens 6 months of age and older, and weighing 2.0 pounds or greater.

Possible Side Effects

In a well-controlled U.S. field study, which included 341 cats (228 cats treated with CREDELIO CAT and 113 cats treated with a topical active control), there were no serious adverse reactions.

Drug & Food Interactions

There are no known contraindications for the use of CREDELIO CAT.


Lotilaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, incoordination, and seizures. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Use with caution in cats with a history of neurologic disorders. The safety of Credelio CAT has not been established in breeding, pregnant and lactating cats. The most frequently reported adverse reactions are weight loss, rapid breathing and vomiting. For complete safety information, please see Credelio CAT product label or ask your veterinarian.

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  1. Package Insert

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  • Item Number
  • Administration Form
  • For Use With
  • Generic Name
  • Common Brand Name(s)
  • Breed Size
    Small Breeds, Medium Breeds, Large Breeds
  • Product Form
    Chewable Tablet
  • Strength
    48 mg Lotilaner
  • Health Condition
  • Drug Type


Recommended Dosage

Use only as directed by your veterinarian

Storage Instructions

Store between 59 - 77 F


Why would an indoor cat need flea and tick protection?

One of the most common misconceptions about indoor cats is that they are not at risk for fleas and ticks. Fleas and ticks can be brought into the home on people’s shoes and clothing, and readily infest cats from there. Other pets in the home can also put indoor cats at risk. For example, if a pet owner also has a dog that regularly goes outside, that cat is also at risk for fleas and ticks. Additionally, indoor cats may not be as “indoor” as they seem with short trips to the yard, patio or porch where they can be exposed to fleas and ticks as well.

What are some common signs of fleas on cats?

Common clinical signs include increased, over-active grooming, itchiness, patches of hair loss with reddened skin, small bumpy scabs along the flanks or back end and large scabs around the face. These signs can mimic a number of other issues in cats, including allergies, so it is always a good idea to proactively treat for fleas. Ironically, cats with flea infestations often have an apparent absence of fleas. This is because they are commonly removed by cats through their daily grooming and is a major reason why cat owners and even veterinarians have difficulty realizing a cat has fleas. If fleas are found, they are most often found around the head and neck area.

How fast does Credelio CAT (lotilaner) start killing fleas?

In a well-controlled laboratory study, Credelio Cat began to kill fleas six hours after administration, with >98% of fleas killed within 12 hours after administration. In another well-controlled laboratory study, Credelio Cat demonstrated 100% effectiveness against adult fleas 24 hours after administration or infestation for 35 days. Credelio maintains high, fast-acting and sustained flea efficacy throughout the month.

Which ticks are Credelio Cat labeled for?

Credelio Cat is labeled for the black-legged tick, also known as Ixodes scapularis. This is the most common tick infesting cats in the United States1 and is a threat to cats spring through fall. They transmit Lyme disease and anaplasmosis to cats. True prevalence of these diseases in cats is difficult to determine.

What is the best way to administer Credelio Cat?

All owners have different comfort levels with their cat when it comes to administering medication. There are three basic ways to administer Credelio Cat: 1. Offer by hand or place in area where your cat feels comfortable eating. Many cats will eat the chewable by free choice. Tempting with treats can also help. 2. Offer with food during a meal. If your cat is a grazer, try placing it around a few pieces of kibble or covered in wet food and checking to make sure it has been consumed out of the bowl. 3. Place the chewable on the back of your cat’s tongue. The chewables were designed to be very small and easy to administer in these situations. It is important to always administer Credelio Cat with a meal or 30 minutes after feeding.

Why is food so important when administering Credelio Cat?

Food enhances the absorption and bioavailability of lotilaner in cats. In fact, when given with food, 100% of lotilaner reached systemic circulation as opposed to only 8% in unfed cats. Credelio Cat needs to be administered with food or within 30 minutes of feeding. This will ensure high blood concentrations and sustained efficacy throughout the month.

Is Credelio CAT (lotilaner) safe?

Credelio Cat is FDA-approved as safe and effective when used according to the label.

Rating: 4.5 of 5 stars 16 Reviews 16 Reviews 4.5 out of 5 Stars

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94% Recommend

94% of reviewersrecommend this product

Rating: 4.5 of 5 stars 4.5 / 5

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16 Reviews

Showing 1-10 of 16 Reviews

  • 4 out of 5 stars

    Better than others

    By Hanson on Nov 28, 2021

    I have a sweet kitty that’s afraid of her shadow. I can’t just pick her up and put a topical flea medicine on her, so I use pills. She doesn’t like any chewables. I used to use Program but it is no longer produced. This is the best I have found. She doesn’t love the vanilla taste but I hide it in Fancy Feast Ocean Fish and she eats most of it. I wish it had NO taste but it’s the best I’ve found.

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  • 5 out of 5 stars


    By 1988 on Oct 22, 2021

    My cat found a flea bed and brought them home! After a trip to the vet and and a hard research of the best topical, injection or pill, Credelio has had the best reviews and best results. My cat had no bad side effect, which was my biggest concern. Within an hour, the fleas were falling off of her and dying. This is amazing as long as your vet says its right for your cat. I'd recommend this product to anyone dealing with fleas on their cat and at home. She even seems relieved about them falling off of her. GREAT PRODUCT!

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  • 4 out of 5 stars

    Cats ate it readily

    By Lyonette on Nov 24, 2021

    All 5 cats ate this with thier food. I did not do a 5-star rating because ideally I'd like a preventative that would not require the parasite to bite the cat BUT I have several cats who have local reactions to topicals. And I find topicals to sometimes be challenging to apply.

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  • 5 out of 5 stars

    Works great. No fighting, no mess,

    By Meikiberry on Nov 22, 2021

    I dread putting topical flea drops on cat. She shakes it off or rubs it off on the rug. This credelio for cats is so much easier, I just hide it in a tube of "churu' cat treat and she licks and swallow it down, no problem

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  • 5 out of 5 stars


    By Radiopam on Nov 9, 2021

    Our cats do NOT like the spot flea treatments ... it's a battle to get it on them and a waste of money when we can't. Our vet recommended this once a month treatment. Small pill that we cut in half and mix into their food or give orally. Much easier and takes care of flea prevention!

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  • 4 out of 5 stars

    Credelio for cats

    By Walli on Oct 9, 2021

    This pill was small enough to put inside a treat. I hallowed out a greenies hair ball treat and used edible glue to glue the pill and treat back together. This is how I gave a Feral cat flea treatment!! It seems to work really fast, cat gets jittery for about an hour. I didn't give 5 stars because the product is new for cats and people need to consult their vets before using this product. There is the unknown I guess. worked great for my situation.

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  • 1 out of 5 stars

    Not a fan of this product

    By Bama2dads on Oct 21, 2021

    This was the first and last time I will use this product. Before the 30 days was even over you could see where the fleas were getting bad. When I first read the information on this product I was excited to give it a try. To me it did not work as well as Comfortis.

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  • 5 out of 5 stars

    works great

    By fluff on Nov 8, 2021

    had been using drops this is so much better. he had no trouble with this and he hated the drops made him crazy wish i had seen this way sooner must try you will be happy

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  • 4 out of 5 stars

    Works Great until the last few weeks

    By Vanessa on Oct 23, 2021

    The pills act fast and work great, the last week and a half of the monthly dose isn't as strong as the beginning so fleas still pop up but still not as bad. It is still the best flea pill I have used so far!

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  • 5 out of 5 stars

    Vet Support

    By Keely on Oct 10, 2021

    Thanks again for excellent support from Chewy Pharmacy. I’m new to being adopted by a stray and not really a “cat person”. Because all cats are “Kenton-persons,” having exquisite taste requires they also get the best!

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