FRONTLINE PLUS Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs, 8 Doses (8-mos. supply) -

Frontline Plus Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs

By Frontline Plus
Rated 4.053 out of 5 stars
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$93.99Chewy Price
$104.99Chewy Price
$89.29Autoship Price
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About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

Questions & Answers

22 Customer Questions

What is the difference between Frontline Gold and Frontline Plus?
Answer by ChewyJun 03, 2020
Both products are effective against ticks, fleas, and lice in both immature and adult versions. The only difference is that Frontline Gold kills fleas faster than Frontline Plus does. Frontline Gold has added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop in to adult fleas. Both products require monthly applications and are safe to use in all dogs and puppies above 8 weeks of age.

Does the fle/tick have to bite the dog before the medication works i.e. the medication is systemically absorbed and flea/tick must ingest rather than just coming into skin contact before it is lethal?
Answer by ChewyApr 11, 2023
This treatment kills fleas and ticks through contact with your pet's haircoat, no biting is necessary. FRONTLINE® Plus for Dogs spreads from the single point of application, rapidly covering the entire dog and localizing in the hair, on the surface of the skin, and in the sebaceous glands. These glands act as a reservoir, continuously replenishing FRONTLINE Plus for Dogs onto the skin and hair coat, so it keeps working even if the dog gets wet.​​​​​​​

Does Frontline contain Isoxazoline?
Answer by ChewyMay 25, 2020
This flea and tick treatment does not contain Isoxazoline. For a complete ingredient list, click on the 'Ingredients' tab, just under the product photos.

How many months do you need to apply frontline plus.
Answer by ChewyAug 15, 2018
This treatment is available in 3 doses or 6 doses which provides 3 months of protection or 6 months of protection. The amount needed depends on the severity of the infestation. In a study, FRONTLINE Plus began killing fleas 4 hours after application. Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.

ReviewsWrite a Review

Rated 4.053 out of 5 stars
660 Ratings
Would recommend to a friend

660 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By Aurora on Apr 25, 2023

Great Product!

I have a 9 month old border collie, and he has so much energy so he plays outside a lot! We also have woods surrounding us so there is a lot of fleas and ticks. Any time I see that he is getting ticks or fleas I apply safe guard and they are gone in about a day. It says to apply monthly but with the high amount we have of ticks I apply about twice a month. It works great and would highly recommend it!!

Rated 1 out of 5 stars
By Jimmy13 on May 19, 2023

Does not work

I recently purchased these items and they do not work I am getting 20 fleas a day of of my dog and cat a lot of my hard earned cash for a product that does not work

Rated 1 out of 5 stars
By Marlie on Mar 15, 2023

Dog tested Lyme +

My poodle has been on Frontline Plus monthly since she was 2 months old. Today at 10 months she has tested positive for Lyme disease and will need to be treated with antibiotics for a month. This could have canceled her surgery today as Lyme can affect platelets, but thankfully did not in her case. Cannot recommend.

Rated 5 out of 5 stars
By Bonnie on May 24, 2023

Banana boat

Love Chewy and so does my pup. Everything has arrived promptly and products are always great. Will continue ordering from Chewy.

Rated 1 out of 5 stars
By Gailbeth on Apr 19, 2023

cannot recommend

My poor dog is suffering so much, because this flea med did not help her at all. I just put it on two weeks ago, but she is itching and scratching multiple times a day.

Rated 5 out of 5 stars
By 1jan262 on May 18, 2023

good stuff

Been using this item, for many years on one of my dogs and it's always done what it should. Never fleas on her body.

Rated 1 out of 5 stars
By Lynn on Jan 29, 2023

Very disappointed

This is the second time I received frontline from Chewy where the box holding the medicine was already open. Not ordering from them again. Who knows what someone might have switched the medicine for. I have had other companies tell me they no longer sell this because someone tampered with their medicine. I thought Chewy would be more careful with their products. Guess not

Rated 5 out of 5 stars
By Julieko on Mar 24, 2023

The right product

I tried a different flea treatment and it didn't work. Chewy had the one that we've used in the past. It came in time and I was able to ward off additional infestation.

Rated 1 out of 5 stars
By Gabby on Mar 7, 2023

Would not recommend

I have two dogs, thought I would try it out. I have used three months supply for both of them and yet I continue to find fleas crawling in their white fur. Would not recommend.

Rated 5 out of 5 stars
By Whisk on Apr 16, 2023


I’ve used this product for my fur babies for over 10+ years. I’m very satisfied with the protection received.