FRONTLINE PLUS Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs, 8 Doses (8-mos. supply) -

Frontline Plus Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs

By Frontline Plus
Rated 4.0574 out of 5 stars
Pet Weight

$61.99Chewy Price
$104.99Chewy Price
$58.89Autoship Price
Autoship (Save an extra 5%)

Why Autoship?

  • Save 5% on all future Autoship orders
  • Set your schedule based on your pet's needs
  • No fees, no commitments - skip, change or cancel anytime.

In Stock
FREE 1-3 day shipping

About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

See More





Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

Shop Frontline

* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

Questions & Answers

22 Customer Questions

What is the difference between Frontline Gold and Frontline Plus?
Answer by ChewyJun 03, 2020
Both products are effective against ticks, fleas, and lice in both immature and adult versions. The only difference is that Frontline Gold kills fleas faster than Frontline Plus does. Frontline Gold has added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop in to adult fleas. Both products require monthly applications and are safe to use in all dogs and puppies above 8 weeks of age.

Does the fle/tick have to bite the dog before the medication works i.e. the medication is systemically absorbed and flea/tick must ingest rather than just coming into skin contact before it is lethal?
Answer by ChewySep 25, 2017
This treatment kills fleas and ticks through contact with your pet's haircoat, no biting is necessary.

Does Frontline contain Isoxazoline?
Answer by ChewyMay 25, 2020
This flea and tick treatment does not contain Isoxazoline. For a complete ingredient list, click on the 'Ingredients' tab, just under the product photos.

How many months do you need to apply frontline plus.
Answer by ChewyAug 15, 2018
This treatment is available in 3 doses or 6 doses which provides 3 months of protection or 6 months of protection. The amount needed depends on the severity of the infestation. In a study, FRONTLINE Plus began killing fleas 4 hours after application. Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.

ReviewsWrite a Review

Rated 4.0574 out of 5 stars
645 Reviews
Would recommend to a friend

645 Customer Reviews

Filter by reviews that mention

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Marlie on Mar 15, 2023

Dog tested Lyme +

My poodle has been on Frontline Plus monthly since she was 2 months old. Today at 10 months she has tested positive for Lyme disease and will need to be treated with antibiotics for a month. This could have canceled her surgery today as Lyme can affect platelets, but thankfully did not in her case. Cannot recommend.

Rated 1 out of 5 stars
By Lynn on Jan 29, 2023

Very disappointed

This is the second time I received frontline from Chewy where the box holding the medicine was already open. Not ordering from them again. Who knows what someone might have switched the medicine for. I have had other companies tell me they no longer sell this because someone tampered with their medicine. I thought Chewy would be more careful with their products. Guess not

Rated 1 out of 5 stars
By Gabby on Mar 7, 2023

Would not recommend

I have two dogs, thought I would try it out. I have used three months supply for both of them and yet I continue to find fleas crawling in their white fur. Would not recommend.

Rated 5 out of 5 stars
By FoxterrierOwner on Nov 17, 2022

Great product

We live in a tick infested area of the country. Product is easy to apply and repels ticks in my dog who spends a lot of time outdoors. While we find an occasional tick crawling on his fur after hikes in the woods, the ticks do not attach to our dog. Very happy with this product!

Rated 5 out of 5 stars
By Proudparent on Jan 25, 2023

Good product

We have used this product for years. No adverse effects on our dog with no fleas or ticks. Works well.

Rated 5 out of 5 stars
By Bbmmrrbb on Nov 4, 2022

Not a single tick!

Love everything about this- no ticks, easy to apply, dries quick, doesn't smell. pharmacy worked directly with my vet to get it approved, had it in days!

Rated 1 out of 5 stars
By Lorena01 on Feb 24, 2023

This does it work

I had to switch to prescription, this does not work.

Rated 5 out of 5 stars
By Dogdays on Sep 6, 2022

Totally WORKS!

Best product on the market!!! Anyone complaining is obviously using it wrong. You need to be treating your dog YEAR ROUND not wait until your dog is infested. Also there is a method on how to apply DIRECTLY to the skin NOT the hair!!! Duh people come on hooked on phonics works try it.

Rated 1 out of 5 stars
By Gloria on Aug 9, 2022

worthless product

This did absolutely nothing to stop fleas and ticks on my 40 lb Aussie. We live in an urban area where the ticks shouldn’t even be that bad and he’s never outside longer than 20-30 min at a time but I found several ticks and a few fleas on him. It hadn’t even been 3 weeks since last applying it but online it says you can reapply after 2 weeks, if needed. Three days after the second application there’s no difference. Totally worthless waste of money.

Rated 1 out of 5 stars
By MeOrTheDog on Jul 26, 2022

Did not work

Messy to apply. My dogs have a thick undercoat so it is hard to get product directly on the skin, especially when they are squirmy puppies. Once applied, their fur acted as a sort of siphon and sucked the product to the outer coat where it stayed greasy and damp for some time. The next application I was more careful and didn’t have as much of that problem. Both times though, we still found the occasional flea. My pets weren’t actually infested but we were pre-empting. It didn’t work. The last straw was our dog-sitter finding ticks on my girl’s ears. I want my money back.