Frontline Plus Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs, 8 Doses (8-mos. supply)

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About This Item

Details

  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

Ingredients

Instructions

Size

FAQ

Learn More About Frontline Plus From Our Team of Experts
Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

Fast-Acting, Long-Lasting Protection

Frontline Plus is formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. It’s waterproof 24 hours after application, lasts for a full 30 days, and comes in formulas for cats or dogs.

Easy One-Spot Topical Application

Frontline Plus is a spot-on solution that’s available without a prescription. 1 dose = 30 days of protection.

Protects Your Pet

  • Starts killing fleas and ticks fast and protects against reinfestation.
  • Waterproof for a full 30 days starting 24 hours after application.
  • Monthly dosing keeps your dog protected for every season.

How to Apply

Follow these simple steps for application:

  1. Hold upright with foil side toward you and snap applicator tip.
  2. Part hair and apply on shoulder blades, completely emptying the pipette.
  3. Leave the solution to spread through your pet's coat.

About Frontline Plus

To ensure your dog stays protected from fleas and ticks all year round, treat them monthly with Frontline Plus. This simple, easy, one-spot topical solution helps keep your pet free from infestations, providing you with peace of mind.

Shop Frontline Plus

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Questions & Answers

20 Customer Questions

If my dog fluctuates between 44-45 lbs - is it better to give her the Medium or Large dose?

What is the difference between Frontline Gold and Frontline Plus?

Answer by Chewy • Jun 03, 2020
Both products are effective against ticks, fleas, and lice in both immature and adult versions. The only difference is that Frontline Gold kills fleas faster than Frontline Plus does. Frontline Gold has added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop in to adult fleas. Both products require monthly applications and are safe to use in all dogs and puppies above 8 weeks of age.

Does Frontline contain Isoxazoline?

Answer by Chewy • May 25, 2020
This flea and tick treatment does not contain Isoxazoline. For a complete ingredient list, click on the 'Ingredients' tab, just under the product photos.

After applying topically to the dog, is it safe for humans to have skin to skin contact with the dog. If not, how long should one avoid touching the dog where the medication was applied?

Answer by Chewy • Mar 25, 2024
It is recommended that you allow 24 hours for the solution to dry.
Reviews
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4.5
Rated 4.5 out of 5 stars
3291 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

84% Positive

Effectiveness

82% Positive

Ingredients

82% Positive

Long-Term Benefits

82% Positive

1275 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Laurie on Jan 5, 2026

It actually worked!

I had a bad flea infestation after a stray cat came in my house. My dog and indoor cat both got the. For months I tried multiple different things for both of them

I had a bad flea infestation after a stray cat came in my house. My dog and indoor cat both got the. For months I tried multiple different things for both of them. Drops, pills, sprays, flea shampoo. Even k9 advantix. I upped the weight slightly when I ordered these and with one dose as well as a home and dog spray for stragglers, 2 days and not a single flea. What a relief after months of trying everything and spending so much.

Rated 1 out of 5 stars
By Belinda on Dec 9, 2025

Yet another disappointment

While not overwhelmed with them, I did pick up a few after one of the dogs got into our chicken coop. This product didn't even slow them down. I guess it's my fault

While not overwhelmed with them, I did pick up a few after one of the dogs got into our chicken coop. This product didn't even slow them down. I guess it's my fault for trying to save some money and getting the less expensive stuff. So because of that, now I have to try something else and the money was wasted anyway.

Rated 2 out of 5 stars
By Paula on Dec 27, 2025

Name recogition

Seemed to work for possible flea infection but also caused continuing scratching and licking for over a week. Very disturbing as she sleeps in bed with us. If this

Seemed to work for possible flea infection but also caused continuing scratching and licking for over a week. Very disturbing as she sleeps in bed with us. If this could be the cause we won't be use ing the rest if the product.

Rated 1 out of 5 stars
By Breanna on Dec 30, 2025

Vet Said NOT to use this product

Vet told me this is no longer effective. Why did I think to ask? Both pets have fleas after using this product every month for the last 7 years. The fleas have apparently

Vet told me this is no longer effective. Why did I think to ask? Both pets have fleas after using this product every month for the last 7 years. The fleas have apparently grown resistant to this product.

Rated 5 out of 5 stars
By Madian on Nov 14, 2025

Effective topical treatment

It’s affordable and effective for the whole month! I’ve been on a strict budget lately and haven’t been able to buy my dog the usual chewable treatment I get her,

It’s affordable and effective for the whole month! I’ve been on a strict budget lately and haven’t been able to buy my dog the usual chewable treatment I get her, so I got this one OTC and love it! Fleas are a nuisance in Texas heat, but she hasn’t been itchy at all, so I recommend over other topical brands.

Rated 5 out of 5 stars
By Denise on Jan 14, 2026

Vet recommended

Easy for mom to use. When Dookie and I rough housed back in mom’s backyard she didn’t have to worry about me losing Dookies collar from rough housing.

Easy for mom to use. When Dookie and I rough housed back in mom’s backyard she didn’t have to worry about me losing Dookies collar from rough housing.

Rated 3 out of 5 stars
By Rudolph on Oct 9, 2025

Unhappy with delivery

We've used Frontline + for years and has always worked for our dogs. Unfortunately, we live in a rural area and the Fedex driver did not deliver at our house, but

We've used Frontline + for years and has always worked for our dogs. Unfortunately, we live in a rural area and the Fedex driver did not deliver at our house, but instead left it in a US mail rural mailbox 1/2 miles from our house. It is illegal to put deliveries in US mail boxes othger that USPS, but they did it anyway.

Rated 5 out of 5 stars
By Agnes on Oct 13, 2025

Price

I have always used Frontline for our dogs. Last year I got some other kind from our Vet. It was a chewable kind. I could NOT get my dog to chew it with out force

I have always used Frontline for our dogs. Last year I got some other kind from our Vet. It was a chewable kind. I could NOT get my dog to chew it with out force No matter How I tried to diguise it. Frontline is so much esier to use without force and it always worked.

Rated 1 out of 5 stars
By Tanja on Sep 5, 2025

Isn't working!

My family has always sworn by Frontline. However, this year, no matter what I do, I can't get rid of the fleas. To the point that my dog and one cat are half bald

My family has always sworn by Frontline. However, this year, no matter what I do, I can't get rid of the fleas. To the point that my dog and one cat are half bald from scratching. I figured by month 2, I would see an improvement. I used flea shampoo and conditioner, Frontline and steam scrubbed my carpets more than once. Nothing seems to deter these fleas this year! I didn't have any until my daughter brought over her two dog, which she claimed just had allergies, but I suspected fleas.

Rated 3 out of 5 stars
By Christina on Dec 25, 2025

Disappointing

It worked for a month kind of disappointed. The frontline spray i used to get worked so I thought this would to

It worked for a month kind of disappointed. The frontline spray i used to get worked so I thought this would to