FRONTLINE PLUS Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 6 Doses (6-mos. supply) -

Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs

By Frontline Plus
Rated 3.9368 out of 5 stars
Pet Weight

$69.00Chewy Price
$75.99Chewy Price
$65.55Autoship Price
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About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

Questions & Answers

35 Customer Questions

Does frontline plus expire
Answer by ChewySep 19, 2019
This product doesn't expire. It will be usable until each individual dosage is opened.

Is this safe for dogs under 5lbs?
Answer by ChewyJul 16, 2017
Frontline Plus for Small Dogs & Puppies is for 5-22 pounds. For smaller dogs, consult with a veterinarian to determine the best method of protection.

My dog has a thick coat as she's part Pomeranian & I never know if it's getting on her skin instead of her fur?
Answer by ChewySep 27, 2019
To apply, part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin. Then, squeeze applicator to apply entire contents in a single spot on the skin monthly.

Does it continue to work after bathing dog or do you need to reapply?
Answer by ChewyApr 03, 2018
This treatment provides waterproof effectiveness so that it won't wash off from swimming or baths.

ReviewsWrite a Review

Rated 3.9368 out of 5 stars
1346 Ratings
Would recommend to a friend

1345 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Michelle on May 15, 2023


I’m really disappointed and unhappy about this product! Even after using for fleas and ticks my little guy comes in from just going out to do his business in a designated rock pit just for this purpose & ticks crawling on him. He’s never in a wooded area and walks are in a parking lot around our condo building. There is 1 tree not even covering 10% of rock area so how he’s coming in with ticks after using this product is beyond me. The only conclusion is that it doesn’t work! So I’m assuming that when the cats go out for a walk they are at risk of ticks also even with the tick medicine. Sure wish I’d checked reviews or talked to other pet parents before wasting $230 as now I’m gonna have to try something else!

Rated 2 out of 5 stars
By BlondeGma on May 17, 2023

Still doesn’t work

I stopped using Frontline MANY years ago because it stopped working on fleas. It IS good for ticks though. Decided to give it one more try due to safety factors for a toy breed dog. Two weeks later and he’s still scratching and I find a flea or two every time I comb and/or bathe him. The rest of my large dogs get Advantix and have no issues. Very frustrating. I finally just bought an all-natural peppermint spray to use for a month until I can dose the toy dog with another product.

Rated 4 out of 5 stars
By Lauri on May 14, 2023

Much needed for my fur babies

Everything was almost ok. One of the treatment packs was completely empty. Didn’t realize it until I snapped the top and went to apply to my dog. I checked the others and they are fine. Frontline, you should send me another dose!! These are not cheap!

Rated 1 out of 5 stars
By Leah on May 26, 2023

Does not work

This product is NOT working. We have struggled with fleas on my dog for the last 2 months. This product worked well for a different dog I had in the past but it no longer works--Wasted my money!!

Rated 1 out of 5 stars
By Fleas on May 6, 2023

Not worth you money

I placed this on my yorkie on April 21st and today 2 weeks to the day my dog is infested with fleas. It hasn’t worked and if anything made things worse. I will be going back to the seresto collar.

Rated 1 out of 5 stars
By Trouble on May 17, 2023


I gave one to my 22 lb pound dog after a bath, and the next morning he had a seizure. I had bathed both my dogs and gave them the Frontline+. My 70 has had no effects thus far.

Rated 1 out of 5 stars
By Maria on May 18, 2023

Not working

I have followed the instructions exactly and my dog got an infestation of fleas. My vet said that chewable are better for flea control than frontline or other topical products.

Rated 3 out of 5 stars
By Mary on May 24, 2023

Hard to open

It was hard to open and then most of it drained out before I could get it applied. Needed to use the second one in order to ensure my puppy had full coverage.

Rated 5 out of 5 stars
By Laney on Apr 25, 2023

So Far So Good

This is what we use for ticks mostly we have never had an issue with fleas in our area I hope this remains the same because it is a great alternative for having my dogs NOT to have to eat the other products offered.

Rated 5 out of 5 stars
By Terre on May 9, 2023

Frontline is a great product.

Chewy is the absolute best company I have ever dealt with. They give me fantastic service. Every agent I've ever spoken with is so informative and extremely friendly.