FRONTLINE PLUS Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 6 Doses (6-mos. supply) -

Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs

By Frontline Plus
Rated 3.9433 out of 5 stars
Pet Weight

$75.99Chewy Price
$72.19Autoship Price
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About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

Shop Frontline

* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

Questions & Answers

35 Customer Questions

Does frontline plus expire
Answer by ChewySep 19, 2019
This product doesn't expire. It will be usable until each individual dosage is opened.

Is this safe for dogs under 5lbs?
Answer by ChewyJul 16, 2017
Frontline Plus for Small Dogs & Puppies is for 5-22 pounds. For smaller dogs, consult with a veterinarian to determine the best method of protection.

Does it continue to work after bathing dog or do you need to reapply?
Answer by ChewyApr 03, 2018
This treatment provides waterproof effectiveness so that it won't wash off from swimming or baths.

My dog has a thick coat as she's part Pomeranian & I never know if it's getting on her skin instead of her fur?
Answer by ChewySep 27, 2019
To apply, part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin. Then, squeeze applicator to apply entire contents in a single spot on the skin monthly.

ReviewsWrite a Review

Rated 3.9433 out of 5 stars
1323 Reviews
Would recommend to a friend

1323 Customer Reviews

Filter by reviews that mention

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By Maxinesmom on Jan 17, 2023

Pleased pet owner

I have been dealing with Chewy for a long time. I think it is one of the finest companies I have ever used. The representatives are all friendly and helpful. The service is superb and fast and I hope they continue to be such a fine company. It is very reassuring to know that I can get Maxines pet supplies so efficiently and expeditiously. Thank you, Chewy.

Rated 1 out of 5 stars
By Beth on Dec 11, 2022

Absolutely horrible!

Within hours of applying this product gave my puppy a terrible chemical burn. He is still suffering days later and has lost all his hair on his back. Beyond that it did not even kill the fleas. Absolutely horrible product. Frontline has changed for the worse. Buyer beware.

Rated 5 out of 5 stars
By KikiC on Jan 26, 2023

works very well for small dogs

Customer service is outstanding, they helped me order flea medicine for my Granddaughters dogs, they are so nice. The Frontline Plus worked!!!! Now they are flea free. easy to use. I recommend this product.

Rated 4 out of 5 stars
By Poodle on Jan 25, 2023

Frontline Plus

I recently learned of the dangers of most of the flea/tick preventive applications. But a dependable source, also aware of the hazards, apprised me that this product is the best choice, least dangerous.

Rated 1 out of 5 stars
By frontlinehater6000 on Dec 24, 2022


DOES NOT WORK. My dog has been on this religiously for over a year and got fleas. My vet informed me that frontline does not work anymore and recommended Revolution. I wish I had read the other reviews and stopped using this garbage. Huge waste of time and money.

Rated 5 out of 5 stars
By Tink on Feb 24, 2023

Frontline for dogs

Excellent product that I am happy that Chewy sells. Shipping was prompt and my pet and I are very happy.

Rated 5 out of 5 stars
By Arwen on Mar 15, 2023

Great Product!

I enjoy the fact that I can relax knowing that my doggie is protected daily!

Rated 1 out of 5 stars
By Terry on Nov 13, 2022

Frontline plus

It don't stop fleas like it use to I will not be buying this product NO more it doesn't even work I put on my dogs and it didn't even work for a 5 pound and 14 pound dog please don't buy this product Dawn dishwashing liquid works better then this mess .

Rated 5 out of 5 stars
By Denny on Feb 21, 2023


Easy application and good pricing. Chewy customer service is OUTSTANDING.

Rated 5 out of 5 stars
By Fran on Jan 23, 2023

Great product

I've been using this product for 2 years and never had a problem with it. Would recommend it highly.