Frontline Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs
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Help protect your pup from pests with FRONTLINE Plus For Dogs Flea & Tick Small Breed Dog Spot Treatment. This treatment helps kill adult fleas, flea eggs, flea larvae, chewing lice, and ticks. It’s formulated with two active ingredients—fipronil and (S)-methoprene—to help disrupt the flea life cycle and inhibit future infestations. Plus, it’s designed to be waterproof, fast-acting, and long-lasting. This treatment is paw-fect for pooches who are eight weeks old and older.
Key Benefits- Promotes a fast-acting and long-lasting protection from fleas and ticks.
- Formulated with two active ingredients to help disrupt the flea life cycle.
- Helps kill adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
- Simply apply once a month.
- Designed for a waterproof protection.
Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately.
Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
Important Information
Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.
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Item Number49539
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UsagePrevention
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BrandMerial, Boehringer Ingelheim
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LifestagePuppy, Adult, Senior
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Breed SizeExtra Small & Toy Breeds, Small Breeds
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Product FormSolution
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Health ConditionFleas, Ticks
Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.
- Snap open the tip of the Frontline applicator away from your body and face.
- Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
- Squeeze applicator to apply entire contents in a single spot on the skin monthly.
- Allow 24 hours before bathing or swimming.
Additional Tips
- Remove dog's collar
- Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
- Avoid touching the wet application spot.
- Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
- Give each of your dogs its own complete dose.
Frequency of Application
- When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
- FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
- FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
- FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
- FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
- FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
Where is this product sourced from?
We source all our products from manufacturer approved distributors or directly from the manufacturers. Chewy takes pride in ensuring that our furry friends’ wellbeing is always our top priority. We have worked hard to partner with all of the manufactures to deliver 100% authentic products
How does FRONTLINE Plus kill fleas and ticks?
FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.
How long does it take for FRONTLINE Plus to kill fleas?
In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2
Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?
No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.
Why am I seeing more fleas on my pet after applying FRONTLINE Plus?
Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.
After using FRONTLINE Plus, I still see fleas in my home. Why?
The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.
Does FRONTLINE Plus have an expiration date?
No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.
How long after application can my pet be bathed or go swimming?
FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.
Can I use it if my pet is on medication?
Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.
Can I use FRONTLINE Plus if I have already applied another flea and tick control product?
Before using, consult your veterinarian.
Does FRONTLINE Plus kill anything else besides fleas and ticks?
You bet. FRONTLINE Plus also kills chewing lice.
Can FRONTLINE Plus be used on pets other than dogs and cats?
No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.
Can I apply it more than once a month?
Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.
How old does my pet need to be in order to have FRONTLINE Plus applied?
At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.
What is the best number to call regarding any specific product questions?
For any specific product questions, please call Boehringer Ingelheim Animal Health’s customer service line number at 1-888-637-4251.

Keeping Your Pets Protected Against Ticks and Fleas
FRONTLINE Plus will help you protect your pet from irritating fleas and ticks. It is a simple-to-use topical treatment that is easy to apply and provides lasting protection for a full 30 days. This flea and tick protection contains two powerful ingredients to stop fleas and ticks in their tracks and help prevent future flea infestations.


The Flea and Tick Protection Vets Have Trusted for Nearly 20 Years
FRONTLINE Plus is a veterinarian-recommended flea and tick treatment that is both fast-acting and long-lasting. It works to break the flea life cycle and also kills adult ticks that may transmit diseases. It offers waterproof protection as well, so you can rest assured knowing that FRONTLINE Plus has your pets covered with FRONTLINE Plus for Dogs and FRONTLINE Plus for Cats.
Tough Ingredients To Arm Pets as Young as 8 Weeks
FRONTLINE Plus for Dogs is approved for puppies at least 8 weeks old and weighing as little as 5 lbs all the way to senior dogs. And with FRONTLINE Plus for Cats, kittens weighing at least 1.5 pounds can start protection as young as 8 weeks, too. To stop fleas and ticks in their tracks and prevent future flea infestations, FRONTLINE Plus uses two tough ingredients, fipronil and (S)-methoprene. Fipronil kills adult fleas and ticks that come into contact with your pet, while (S)-methoprene works to kill flea eggs and larvae before they can develop.


Tough on Fleas and Ticks, Easy to Apply
Applying FRONTLINE Plus for Dogs and FRONTLINE Plus for Cats is simple and quick.Simply part your pet's hair between the shoulders, place the applicator tip just above the skin, and squeeze directly onto the skin. Avoid contact with the treated area until dry. Read the entire product label before each use. Once applied, FRONTLINE Plus will protect your pet from fleas and ticks for a full 30 days. Monthly application is simple so peace of mind comes easy month after month. As long as FRONTLINE Plus is fighting, you can forget about fleas and ticks.
About FRONTLINE Plus
FRONTLINE Plus is a trusted flea and tick control product that has been recommended by veterinarians for nearly 20 years. This topical flea and tick treatment uses two tough ingredients, fipronil and (S)-methoprene, which have been tested and proven to protect your pet from fleas and ticks and prevent new flea infestations for a full 30 days.

Customer Reviews
83% Recommend
83% of reviewersrecommend this product
You've Already Reviewed This Item
1066 Reviews
Showing 1-10 of 1066 Reviews
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Put on Autoship and be safe
By NorthernCalifDogs on Jan 19, 2021
Dogs are lucky to be able to roam in a non-urban area on land with horses, deer, squirrels, raccoons, skunks, coyotes, cats, mice, birds small and large, which is nice. However, all these wild animal friends do harbor fleas and ticks, so this is a MUST for the dogs. Put on Auto Ship and never worry. Easy to apply in 10 seconds tho they don't like the smell, they will get over it quickly - and it keeps the fleas and ticks outside not inside. Hint: ALWAYS hand-search for ticks!
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Easy to use no RX required
By Caholtz on Feb 14, 2021
We love this product my little dog hates the trip to the vet more than the actual visit. Any care we can do at home is a god send he’s an escape artist and will wiggle his way out of any flea tick collar these are easy to apply. He does not react during application
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Frontline Flea Treatment
By GrandmaG on Jan 5, 2021
Frontline is the ONLY brand of Flea Treatment I spend money on. It's the best! The other thing about this particular order is that it was a replacement. The first box came to me partially opened, so I contacted Chewy.com to let them know. In a short week, I had this replacement box of treatments; Chewy didn't even ask any questions. .they just completely showed WHY I order my little Bentley's needs ONLY from Chewy. Thank you CHEWY!
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Worth every penny
By Vincent on Jan 20, 2021
Best flea and tick treatment. When we bought our house, which was a fixer upper, unknown to our knowledge there was an infestation of fleas in the backyard. Our poor dog got fleas and we tried every treatment out there to get rid of the fleas. The only thing that worked was frontline. Will not buy anything else for flea and thick treatment.
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Problem with fleas
By Doggrandma on Jan 6, 2021
Over a week since used it and still have fleas doesn't seem to work as well as the one I get from the vet. Have been told over the counter ones don't work as well as they are weaker will be picking them up from the vet. I have three small house dogs it should have worked on one of them .but been happy with everything else I order from chewy!
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Good, not great
By AndyH on Jan 9, 2021
We hike often with our dog in New England and plenty of ticks abound. We search after for any ticks to remove them and there are always plenty including some biting already. We have found some days later too when we are away from ticks that are roaming our pup. We will get a more aggressive product next time.
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Go to brand! We've been using this for years!
By MouseMom on Dec 6, 2020
I love Frontline plus! I have 4 Chihuahuas and this has been working for us for over 3 years now. I've used other brands and they do not work nearly as well as Frontline to keep fleas away. With this product, I let it sit on my dogs for about 24 hours. Once it's fully soaked in and dried up, I will give them a bath the next day to get rid of that greasy residue that sits on their fur. Great packaging, easy instructions and application, and no smell!
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Great price, timely delivery
By Dave on Jan 9, 2021
I was first impressed with the variety of different treatments I could choose from including various quantities and prices. Then the delivery could not be matched as it was quick, literally the next day and at no additional cost. What not to like?
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Great for small dogs
By Debb on Feb 22, 2021
Finding flea & tick meds that work and is safe for very small dogs is not easy. Frontline plus works great so far.. Great price. Fast shipping!!
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Bye bye fleas
By Roscoe on Nov 10, 2020
We stayed at a 3 star motel in Santa Cruz, and the motel gave my sister and me fleas! We were scratching like nobody’s business! Grr! So my mom bought Frontline from Chewy and applied it on me and my sister, Halo. The next morning, I was feeling much better. My sister, a Pomeranian was still itchy but not because of the fleas. She had a reaction to the shampoo my mom used. Sigh. My mom swears by Frontline. She has used other products before, and even the flea collars, and oral flea remedies, but she always comes back to Frontline. Yes, it’s pricey, but it works! And that’s why she didn’t try something else this time, she went straight for the Frontline. She likes Frontline because it’s safe We stayed at a 3 star motel in Santa Cruz, and the motel gave my sister and me fleas! We were scratching like nobody’s business! Grr! So my mom bought Frontline from Chewy and applied it on me and my sister, Halo. The next morning, I was feeling much better. My sister, a Pomeranian was still itchy but not because of the fleas. She had a reaction to the shampoo my mom used. Sigh. My mom swears by Frontline. She has used other products before, and even the flea collars, and oral flea remedies, but she always comes back to Frontline. Yes, it’s pricey, but it works! And that’s why she didn’t try something else this time, she went straight for the Frontline. She likes Frontline because it’s safe to use around our feline sister. And we won’t get ticks either! … more