Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs

By Frontline Plus
Rated 4.0452 out of 5 stars
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Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 6 Doses (6-mos. supply) slide 1 of 11
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Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 6 Doses (6-mos. supply) slide 1 of 11
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About This Item

  • Promotes a fast-acting and long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle.
  • Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
  • Simply apply once a month.
  • Designed for a waterproof protection after 24 hours.
Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

Shop Frontline

* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients: Fipronil 9.8%, (S)-Methoprene 8.8%.Active Ingredients : Fipronil , (S)-methoprene , Pyriproxyfen.
LifestagePuppy, Adult, SeniorAdult, Senior, PuppyAdult, Puppy, SeniorAdultAdult, Puppy, Senior
Breed SizeExtra Small Breeds, Small BreedsSmall Breeds, Medium BreedsMedium Breeds, Large BreedsLarge Breeds, Giant BreedsSmall Breeds, Extra Small Breeds

Questions & Answers

35 Customer Questions

Does frontline plus expire
Answer by ChewySep 19, 2019
This product doesn't expire. It will be usable until each individual dosage is opened.

Is this safe for dogs under 5lbs?
Answer by ChewyJul 16, 2017
Frontline Plus for Small Dogs & Puppies is for 5-22 pounds. For smaller dogs, consult with a veterinarian to determine the best method of protection.

My dog has a thick coat as she's part Pomeranian & I never know if it's getting on her skin instead of her fur?
Answer by ChewySep 27, 2019
To apply, part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin. Then, squeeze applicator to apply entire contents in a single spot on the skin monthly.

Does it continue to work after bathing dog or do you need to reapply?
Answer by ChewyApr 03, 2018
This treatment provides waterproof effectiveness so that it won't wash off from swimming or baths.

ReviewsWrite a Review

Rated 4.0452 out of 5 stars
1260 Reviews
Would recommend to a friend

1260 Customer Reviews

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Rated 1 out of 5 stars
By Kristen on Nov 12, 2022

Frontline Plus not working

The past two times I have ordered the Frontline Plus from Chewy it has not helped my dogs by killing any fleas. I am not sure what is going on with it but I will not be ordering again from Chewy again.

Rated 1 out of 5 stars
By TDM1 on Nov 11, 2022

Dog still has fleas

2nd month of using meds and dog has fleas after two wks of treatment. Bought a 6 pack for $60+ and used 2 times. Unfortunately I am out the money and have to buy something else.

Rated 1 out of 5 stars
By Sara on Oct 20, 2022

This Stuff is Awful

This did not work at all. I used this on all my dogs and two weeks later all dogs were infested with fleas I will never buy this again do not waste your money.

Rated 1 out of 5 stars
By Rose on Jul 31, 2022

This did not help!

I have a chihuahua who lives inside. I haven't needed to get Frontline Plus for years. In the past, it worked great with other dogs that lived outside. This did not help. I ordered 3 treatments and it did not kill fleas. Every time I checked her, there were fleas. She has to take medicine for her heart, so if I try to get them off, it causes her stress. She is almost all white and isn't covered with fleas, but I don't want her to have any. I applied this correctly, and it did not help at all. I want a refund.

Rated 5 out of 5 stars
By davidbees on Oct 1, 2022

This does the job.

I tried different stuff and my Vet said this is what he likes, so i got some and i swear its stopped all threats of critters. I will use for the rest of my Dogs Life, very simple to use, fast .

Rated 5 out of 5 stars
By Pattie on Sep 30, 2022

Always back to Chewy

I always return to Chewy because I know that they will get my order right and ship quickly. I have been satisfied with their service from day one. Keep up the good work. Thanks

Rated 5 out of 5 stars
By LadyRoo on Oct 2, 2022

Freedom to run

Helps keep pesky fleas and ticks off my back. Also helps reduce me scratching myself due to grass bugs too. It allows me to run and play with my human nephews

Rated 1 out of 5 stars
By Lind on Nov 17, 2022

Does not work save your money

This was expensive and my dog is scratching her self to bits because she has fleas save your money

Rated 5 out of 5 stars
By Nemo on Nov 20, 2022

Best flea repellent for the price.

Used this for years on all my fur babies. Now I have a wholy husky so absolutely necessary.

Rated 5 out of 5 stars
By Gabs on Jul 13, 2022

No more ticks!

My Porter has had issues with ticks this year, after finding a 3rd one within weeks, I needed to get him started on treatment. I chose a topical treatment as he is a Cavalier King Charles spaniel and is prone to issues such as seizures and neurological issues that other products may cause. 1 day after putting this on, I saw a tick crawling around on him, but it didn't attach so I know this must've been why. Very happy that I haven't seen any more ticks since applying and that was 2 weeks ago!