Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 12 Doses (12-mos. supply)

Skip image gallery
Slide 1 of 11

$104.16 First Time Autoship Price
this order
Save 35% (up to $20) today when you set up Autoship. 
$117.95 Autoship Price
(-5%) future orders
  • Keep saving 5% on every order
  • Get deliveries on your schedule
  • Skip, change, or cancel anytime
$124.16 Chewy Price
($10.34 /ea)
Save $13.80 (-10%)
$137.96 List Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card + Free Shipping with code: WELCOME
In Stock
FREE 1-3 day delivery
Free 365-day returns

No interest if paid in full in 6 months on PayPal purchases of $149+. .

About This Item

Details

  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

Ingredients

Instructions

Size

FAQ

Learn More About Frontline Plus From Our Team of Experts
Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

Fast-Acting, Long-Lasting Protection

Frontline Plus is formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. It’s waterproof 24 hours after application, lasts for a full 30 days, and comes in formulas for cats or dogs.

Easy One-Spot Topical Application

Frontline Plus is a spot-on solution that’s available without a prescription. 1 dose = 30 days of protection.

Protects Your Pet

  • Starts killing fleas and ticks fast and protects against reinfestation.
  • Waterproof for a full 30 days starting 24 hours after application.
  • Monthly dosing keeps your dog protected for every season.

How to Apply

Follow these simple steps for application:

  1. Hold upright with foil side toward you and snap applicator tip.
  2. Part hair and apply on shoulder blades, completely emptying the pipette.
  3. Leave the solution to spread through your pet's coat.

About Frontline Plus

To ensure your dog stays protected from fleas and ticks all year round, treat them monthly with Frontline Plus. This simple, easy, one-spot topical solution helps keep your pet free from infestations, providing you with peace of mind.

Shop Frontline Plus

Frequently bought together

Questions & Answers

34 Customer Questions

Can you treat a 4 month old puppy with Frontline?

Answer by Shanquisha.G • Apr 22, 2025
This product can be used on puppies as young as 8 weeks and weighing at least 5 lbs. for small dogs, 23lbs. for medium dogs, 45 lbs. for large dogs, and 89 lbs. for extra-large dogs.

What type of ticks is Frontline effective on? As there are 6 different types of ticks in my area and not all Tropicals cover all 6.

Answer by Chewy • Jun 11, 2019
Frontline Plus treats against Lone Star Ticks, American Dog Ticks, Deer Ticks, Brown Dog Ticks, and Western Blacklegged Ticks.

How long after applying Frontline does it take for fleas and ticks to die

Answer by Chewy • Jul 21, 2019
In a study, FRONTLINE Plus began killing fleas 4 hours after application. Another study showed that within 12 hours, Frontline Plus killed 100% of fleas. This kills fleas and ticks through contact with your pet's haircoat so no biting is necessary. Fleas rise to the top of your pet's haircoat as they die. So, if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

What’s the difference between frontline plus and frontline gold?

Answer by Chewy • Nov 25, 2020
Both, Frontline Plus and Frontline Gold, are effective against ticks, fleas, and lice in both immature and adult versions. The only difference is that Frontline Gold kills fleas faster than Frontline Plus does. Frontline Gold has added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop in to adult fleas. Both products require monthly applications and are safe to use in all dogs and puppies above 8 weeks of age.
Reviews
Write a Review
4.4
Rated 4.4 out of 5 stars
6579 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

81% Positive

Effectiveness

79% Positive

Ingredients

78% Positive

Long-Term Benefits

81% Positive

2722 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 1 out of 5 stars
By Ari on Jan 21, 2026

Used to work

While our pups have been completely fine over the last few years with Frontline. I don’t think I can trust this any longer. It’s not only given one of my dogs a

While our pups have been completely fine over the last few years with Frontline. I don’t think I can trust this any longer. It’s not only given one of my dogs a rash every time we put it on her, we’ve noticed for the last two months (at least) that these are not repelling ticks at all. This was found ALIVE on the bed next to our girls, meaning it had fed and released, and now I’m hoping they don’t get sick. Either these dosages are old, or they changed, because they’re no longer working.

Rated 5 out of 5 stars
By Carol on Jan 29, 2026

It works

My vet had me purchase from them one of those new multi chews. I found a tick crawling in me, several on her, attached and feeding, alive and dead, attached. After

My vet had me purchase from them one of those new multi chews. I found a tick crawling in me, several on her, attached and feeding, alive and dead, attached. After that I went back to the Frontline. I have only ever found dead, unattached ticks, never any fleas and have had no strays wandering around on me. Frontline works on contact with her skin,killing them before they bite. The other only kills them after being bitten and feeding for several minutes.

Rated 1 out of 5 stars
By Linda on Dec 23, 2025

Does not work.

I applied this medication a week ago and my dog still has fleas alive inviting her. I shampooed her two days after applying the medication with flea killing shampoo

I applied this medication a week ago and my dog still has fleas alive inviting her. I shampooed her two days after applying the medication with flea killing shampoo. Unfortunately, that has not worked. I shampooed her six days later and she still has a problem. When I comb her, I can find no more than one at a time. In the last three weeks, I have combed approximately five fleas off her, yet after all this she still itches. Frontline is not working and I bought two of them so I am disappointed.

Rated 3 out of 5 stars
By Jesse on Jan 5, 2026

Not sure product is performing optmum

We switched to Frontline liquid from chewable for our dogs some years ago due to acquiring our heeler who has seizures and had learned that chewables may be a seisure

We switched to Frontline liquid from chewable for our dogs some years ago due to acquiring our heeler who has seizures and had learned that chewables may be a seisure trigger for some pets. No noticeable change in the seisure patterns since and rather dismayed that the fall of this year we had found multiple ticks on our dog whole using Frontline liquid regularly.

Rated 4 out of 5 stars
By Susan on Jan 8, 2026

Quick delivery!

This time was a bit quirky. I’ve had no problems for the many years of getting frontline plus. This time by the time I saw the email about my next shipment, it

This time was a bit quirky. I’ve had no problems for the many years of getting frontline plus. This time by the time I saw the email about my next shipment, it was already being packed up-in about 4 hours. I didn’t need it for another month but wasn’t given the chance to change the delivery date. Always great service prior to this one incident.

Rated 1 out of 5 stars
By Tamara on Dec 16, 2025

I have not got it yet!

It has not arrived yet today. I have had a battle here, *chatting* with someone , probably no one, . I have chatted with them about 3 times, this package was finally

It has not arrived yet today. I have had a battle here, *chatting* with someone , probably no one, . I have chatted with them about 3 times, this package was finally supposed to arrive today, and it did not. My autoship that was supposed to arrive at my Moms' house today, did not arrive either. This Ontrac is not working for me. I will be calling, to find out the problem,

Rated 5 out of 5 stars
By Raymond on Jan 28, 2026

Chewy’s too easy

I’ve been using Frontline for going on 30 years over four different dogs. Never had any adverse effects, which as I understand are not uncommon with other products. And,

I’ve been using Frontline for going on 30 years over four different dogs. Never had any adverse effects, which as I understand are not uncommon with other products. And, as always, Chewy makes it easy.

Rated 1 out of 5 stars
By K on Nov 25, 2025

Defective Formula

I am canceling this auto ship and also will be requesting info for a return and refund for both the dog and cat frontline. Unfortunately frontline does not protect

I am canceling this auto ship and also will be requesting info for a return and refund for both the dog and cat frontline. Unfortunately frontline does not protect from fleas and ticks. Following my previous order and application of frontline, my dog suffered a skin allergy and needed the vet (2.5/3weeks after application of the frontline). The vet stated she had flees which was creating an allergic reaction. I shared I was using frontline and told the application date. The vet explained that Frontline’s formulation no longer works due to flees and ticks having built an immunity to it. She put her on a prescription based formula. I immediately brought my other dog and two cats in that same week and sure enough, they too had flees. The vet stated this is a known issue with Frontline’s formula for years. Adding that vets and Frontline are aware of this! I used frontline years ago with a pet that is now passed and I loved frontline so I was so shocked. Very disappointed in frontline because I truly thought frontline was a trusted company but for this to be a known issue and they continue to market and sell to pet owners is very deceptive! The vet put all my pets on a prescription based formula now that is working perfectly. I did not realize that I was signed up for a subscription to frontline until receiving the lasted package recently. So I not only want to cancel the auto ship but I would like a refund for the defective products as well. Though this is a Frontline issue and I love CHEWY, I am a bit taken back that CHEWY is allowing the sell of a known defective product and hope they look into what their stance should be with backing products on their site to customers.

Rated 5 out of 5 stars
By Charlene on Jan 31, 2026

Trust this product

Have been using this item on my other dog Gracie who crossed the Rainbow Bridge. It just made sense to use the same product with my new pup Dottie. It has proven

Have been using this item on my other dog Gracie who crossed the Rainbow Bridge. It just made sense to use the same product with my new pup Dottie. It has proven that it works

Rated 1 out of 5 stars
By Jessica on Jan 27, 2026

Don’t waste your money

I wish I had read recent reviews before purchase. Not only did it not kill the fleas my dog had but he got worse after applying. Even with a bath. Absolutely a waste

I wish I had read recent reviews before purchase. Not only did it not kill the fleas my dog had but he got worse after applying. Even with a bath. Absolutely a waste of money.