Simparica Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. supply)

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$271.64 Autoship Price
(-5%)
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$285.94 Chewy Price
($23.82 /ea)
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Usually arrives in 3-5 days
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No interest if paid in full in 6 months. .

Medications ship separately. Delivery times may vary.

About This Item

Details

  • 35-Day Flea and Tick Prevention for Dogs: Simparica is a tasty, once-a-month chewable that protects your dog from fleas and ticks for 35 days, even if the next dose is a few days late.
  • Kills 6 Types of Ticks: Proven to kill Gulf Coast, Brown Dog, Deer, American Dog, Lone Star, and Asian Longhorned ticks.
  • Helps Prevent Lyme Infections: FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
  • Fast-Acting Relief: Starts killing fleas within 3 hours and ticks within 8 hours. Kills adult fleas before they lay eggs to help stop infestations fast.
  • Tasty, Once-a-Month Chewable: Pork-liver flavored for easy dosing. Approved for dogs 6 months and older weighing at least 2.8 lbs, and backed by a 100% satisfaction guarantee on prevention.

Ingredients

Instructions

FAQ

Learn More About Simparica From Our Team of Experts

Protects Dogs From Ticks & Fleas for 35 days

Simparica is tasty pork liver-flavored, veterinarian-recommended monthly chew that protects your dog from fleas and ticks for a full 35 days.[1] It works fast and starts to kill fleas in 3 hours and ticks in 8 hours.[2] Simparica is approved for dogs 6+ months of age, weighing 2.8 lbs or more.

FDA-Approved to Prevent Lyme Infections*

Because it kills deer ticks, Simparica is FDA-approved to block infections that may cause Lyme disease. It kills 6 different types of ticks, including:

  • Gulf Coast Tick
  • Deer Tick
  • American Dog Tick
  • Lone Star Tick
  • Brown Dog Tick
  • Asian Longhorned Tick

Satisfaction Guaranteed

Simparica comes with a 100% satisfaction guarantee on prevention—so you can feel confident choosing fast, reliable protection. It’s a simple way to stay proactive about your dog’s care, with support you can count on.

Protect Your Dog & Earn Rewards From Zoetis

Your 6-or 12-count Simparica purchase may be eligible for Petcare Rewards points. Redeem your points for Rewards toward future vet care and more! Learn More at zoetispetcare.com/rewards

About Zoetis, the Makers of Rimadyl

At Zoetis, we’ve helped pets live their best lives for over 70 years. Zoetis offers a comprehensive range of products to support your pet’s health—from pest prevention and pain management to allergic itch relief and more. Know that we’ll always be here for you and your pet, no matter what.

Shop Zoetis

IMPORTANT SAFETY INFORMATION

Simparica is for use only in dogs 6 months of age and older. Simparica, which contains sarolaner, a member of the isoxazoline class, may cause neurologic signs such as tremors, unsteadiness, and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding, or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaPI.com.

*Data on file, Zoetis Services LLC.

References:Six RH, Liebenberg J, Honsberger NA, Mahabir SP. Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ctenocephalides felis on dogs. Parasit Vectors. 2016;9:90Honsberger NA, Six RH, Heinz TJ, et al. Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs. Vet Parasitol. 2016;222:67–72 (AR-04287).

SMP-00748

4.7
Rated 4.7 out of 5 stars
2922 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

90% Positive

Effectiveness

89% Positive

Ingredients

85% Positive

Long-Term Benefits

93% Positive

991 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 2 out of 5 stars
By myriam on Feb 4, 2026

Worked for a while until it didnt

My dog has been on it for one year. I was ok until lately. Took my dog to the dog park she started scratching. Then it went away. Two months after I take the dog

My dog has been on it for one year. I was ok until lately. Took my dog to the dog park she started scratching. Then it went away. Two months after I take the dog to the beach. Full on scratches, I removed 12 tick or flea from her fur. They were big and full of blood. That thing doesn’t do the job. Unfortunately have to go back to pricier Bravecto that is actually always been working great.


Rated 2 out of 5 stars
By Regina on Feb 1, 2026

Why has the cost increased so much?

Our dog has been on this for 8 years and used to cost $110 for a 6 month supply in 2022. We’ve never had any issues with this medication and chewy is wonderful,

Our dog has been on this for 8 years and used to cost $110 for a 6 month supply in 2022. We’ve never had any issues with this medication and chewy is wonderful, but the steep skyrocketing price has us questioning alternatives.


Rated 5 out of 5 stars
By Corene on Nov 29, 2025

Best flea and tick product

Simparica has always kept our dogs free from any issues with fleas and ticks. We are outside and hiking in the mountains so they are always exposed to fleas and

Simparica has always kept our dogs free from any issues with fleas and ticks. We are outside and hiking in the mountains so they are always exposed to fleas and ticks. Any ticks found are always dead and never engorged. None of our dogs have had any reactions. We habe 2 adult German Shepherds and a senior Australian Cattle Dog.


Rated 5 out of 5 stars
By Kellie on Dec 9, 2025

The way you all do business

It’s not the item as much as it is the way your company runs deals with situations. I’ve just never dealt with anyone like you guys at chewy. The compassion that

It’s not the item as much as it is the way your company runs deals with situations. I’ve just never dealt with anyone like you guys at chewy. The compassion that you shared when I told you about my dog, Meko was unbelievable You guys are just amazing


Rated 5 out of 5 stars
By Karen on Dec 5, 2025

Auto Refill

The Auto refill feature for our pup's meds worked seamlessly! Even when our vet needed to be contacted to confirm the refill, Chewy did it all, even notifying me

The Auto refill feature for our pup's meds worked seamlessly! Even when our vet needed to be contacted to confirm the refill, Chewy did it all, even notifying me that they were taking these steps and there was nothing I needed to do. Thank you, Chewy!


Rated 5 out of 5 stars
By James on Feb 2, 2026

Great ordering process

Easy ordering process for this prescription product. Great communication from Chewry as well.

Easy ordering process for this prescription product. Great communication from Chewry as well.


Rated 1 out of 5 stars
By Lisa on Nov 6, 2025

Auto ship is late

The first order got here fine and the product is great but the auto ship is late and this isn’t the first time this has happened with my pets medication . I don’t

The first order got here fine and the product is great but the auto ship is late and this isn’t the first time this has happened with my pets medication . I don’t like running late on hw prevention and/or not having my pets meds. I’m getting frustrated


Rated 1 out of 5 stars
By Judi on Nov 8, 2025

Made my dog sick immediately

I returned this. I gave it to my dog and he immediately started vomiting. He was sick for days there was nothing I could do I’d already given it to him he didn’t

I returned this. I gave it to my dog and he immediately started vomiting. He was sick for days there was nothing I could do I’d already given it to him he didn’t have any appetite for over a month. Never again. I will stick with the topical


Rated 5 out of 5 stars
By Richard on Dec 25, 2025

No ticks, No fleas

I have had my dogs on Simpatico for years in an area with lots of ticks and fleas, but none have made a home on my dogs.

I have had my dogs on Simpatico for years in an area with lots of ticks and fleas, but none have made a home on my dogs.


Rated 5 out of 5 stars
By David on Dec 10, 2025

Quick Delivery

Once our order was placed, I was surprised by the quick delivery as it was in time to give Mozzy his monthly chewable tablet. Thank you!

Once our order was placed, I was surprised by the quick delivery as it was in time to give Mozzy his monthly chewable tablet. Thank you!