HEARTGARD Plus Chew for Dogs, 51-100 lbs, (Brown Box), 6 Chews (6-mos. supply) - Chewy.com

Heartgard Plus Chew for Dogs, 51-100 lbs, (Brown Box)

By Heartgard
Rated 4.8831 out of 5 stars
Prescription Item
Pet Weight
Pet Weight

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About This Item


For use in animals only. Heartgard Plus Chew for Dogs, 51-100 lbs. is a heartworm preventative that kills heartworms and also helps treat and control roundworms and hookworms. It comes in a delicious once-a-month, real-beef chew that dogs love and is safe for puppies 6 weeks and older. Head back to the dog park, reassured that your dog is protected from nasty parasites with this heartworm preventative that's trusted over 2 billion times! Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Heartgard From Our Team of Experts
Learn More About Heartgard From Our Team of Experts

About HEARTGARD Plus for Dogs

#1 with Dog and Vets*

When it comes to preventing the invisible threat of heartworm disease, pet parents and veterinarians can agree that HEARTGARD Plus (ivermectin/pyrantel) is the #1 choice.* Not only does it prevent heartworm disease, but it also treats and controls 3 species of hookworms and 2 species of roundworms all with the real-beef taste dogs love.*

Why Choose HEARTGARD Plus?

When it comes to preventing the invisible threat of heartworm disease, pet parents and veterinarians can agree that HEARTGARD Plus (ivermectin/pyrantel) is the #1 choice.* Not only does it prevent heartworm disease, but it also treats and controls 3 species of hookworms and 2 species of roundworms all with the real-beef taste dogs love.*

Heartworm Prevention

The invisible threat of heartworm disease can be caused by one bite from an infected mosquito.

Veterinarian #1 Choice*

With over 2 billion doses prescribed, HEARTGARD Plus is the #1 choice of vets for their patients and their own dogs.*

#1 Dog-Preferred Chew*

The real-beef chew makes monthly dosing easy and enjoyable.*

Monthly Protection

When given every 30 days, HEARTGARD Plus can help keep your dog protected year-round.

Hookworms and Roundworms

Also treats and controls 3 species of hookworms and 2 species of roundworms.

Safe for Puppies

Safe for puppies as young as 6 weeks old with no minimum weight requirement.

For Dogs of All Sizes

Comes in three sizes: Up to 25 lbs., 26-50 lbs. and 51-100 lbs.

Heartworm Disease is an Invisible Threat

A Year-Round Risk for All Dogs

1 million dogs are estimated to be heartworm positive in the USA with cases reported in all 50 states.* The American Heartworm Society (AHS) recommends protecting dogs year-round and testing for heartworm disease every 12 months.*

1.  A mosquito ingests heartworm microfilariae after feeding on an infected animal.

2. Microfilariae become larvae and the mosquito can infect the next dog.

3. Larvae left on the skin develop in dogs.

4. Heartworm larvae migrate from the skin into the bloodstream of their new host, maturing as they go

5. Juvenile and adult heartworms primarily live in the pulmonary blood vessels of an infected dog.

6. Within 6 months of infection, adult heartworms are present in the pulmonary arteries.

7. When a mosquito bites an infected dog, the cycle can begin again.

Product Guide

HEARTGARD Plus is available in a variety of sizes by dog weight. Choose the option that best fits your dog.


Up to 25 lbs

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26 - 50 lbs

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51 - 100 lbs

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Just one bite from an infected mosquito could put your dog at risk for heartworm disease, but HEARTGARD Plus offers the protection your dog needs. This heartworm preventive is made with real beef and has a savory taste, making it the #1 dog-preferred chew. HEARTGARD Plus makes protecting your dog year-round easy and enjoyable month after month.*



  1. Data on file at Boehringer Ingelheim.
  2. HEARTGARD® Plus (ivermectin/pyrantel) Chewables [Freedom of Information Summary; NADA 140-971]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.
  3. Heartworm prevalent in South, expanding in other hot spots. American Veterinary Medical Association. https://www.avma.org/javma-news/2020-08-01/heartwormprevalent-south-expanding-other-hot-spots. Accessed December 23, 2021.
  4. Heartworm Parasite Prevalence Maps. Companion Animal Parasite Council. https://capcvet.org/maps/#/2020/all/heartworm-canine/dog/united-states. Accessed November 18, 2021.
  5. Heartworm Guidelines. American Heartworm Society. https://www.heartwormsociety.org/veterinary-resources/ american-heartworm-society-guidelines. Accessed December 23, 2021.

ReviewsWrite a Review

Rated 4.8831 out of 5 stars
1377 Ratings
Would recommend to a friend

1375 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By jadeddame on May 31, 2023

A big shout out to the pharmacy

I placed an order and my vet was a little slow in sending the Scripps off so the order got canceled. And when my vet did finally sent them oh, he forgot to sign them so again they did not get filled…right away. But the pharmacy was on top of it. We spoke, they sent a request again. I spoke to my vet. They cleared up the issue product was sent and received. Thank you I’ve used Chewy all the time even before Covid because I love to have things shipped to me. Saves me the trouble of going out. As for the product I have never had any problem with my dog. I have never worried about her getting heartworm. I think it’s a good product and I recommend it to anybody who’s thinking about using the medicine for your dog. In fact, use the medicine for your beloved pet because heartworm is a horrible thing for them to get.

Rated 5 out of 5 stars
By JVS on May 29, 2023

Money Saver

Our vet clinic has taken on a scam of requiring multiple blood tests every six months to “allow” our dogs to continue taking their heartworm meds. After all is said and done, we end up paying about $600 a visit and then another $500 for the heartworm medicine for a 6-month supply. I was able to order two one-year supplies for my dogs and it was less than the one 6-month supply from my vet. I’ll be hard-pressed to order from a vet again!

Rated 5 out of 5 stars
By Shelley on May 8, 2023

Used for years

Even with the newer heartworm prevention medications, I still choose Heartguard for my dog's needs. I've been using Heartguard for over 30 years, and I've never had an issue. I use a separate flea and tick treatment, and I prefer to have medications for Heartworm Prevention and Flea and Tick Treatment separate. The price is still reasonable, and none of my dogs have ever had Heartworm disease. Heartguard has been around for many years for a reason - it's an effective treatment, and the price is very reasonable - especially compared to some of the newer Heartworm Prevention medications. I'm very happy with Heartguard and have no intention of switching to another brand.

Rated 5 out of 5 stars
By Anke on Jun 8, 2023

Great product!

I have used this product for MANY years. I'm using it on my current dogs and my sweet dogs that have passed on. I have never had any reactions or issues with my dogs taking them. They actually love the taste. And always have had negative heartworm tests. Yay!!! Will continue to use.

Rated 5 out of 5 stars
By Ted on May 24, 2023

First Chewy Order

This was my 1st order with Chewy though I've been aware of them for a long time. Having recently gotten a new 4 legged friend, Chewy was spot on with "all the goodies" and more. They even contacted my vet to order his monthly heartworm meds. Nothing but good things to say about Chewy

Rated 5 out of 5 stars
By MyNickname on Apr 15, 2023


Heartgard is the only med of it's kind that my dog will swallow and actually seems to enjoy. His vet had stopped carrying it about 4 years ago. The technician tried several other kinds putting her arm in his throat to force several different kinds of meds. Somehow he would spit out all of them except 1, which lasted until the car ride was over and he toss his cookies. From then on Chewy has saved the day providing the 1 and only heartworm prevention that he will allow. Thanks Heartgard and Chewy for providing quality products and services for the pickiest of pets!!

Rated 5 out of 5 stars
By RoseR on May 28, 2023

Prescriptions delivered

Love being able to send my prescription requests into chewy. They do all the work, they contact my vet & send me what I need to keep my pups healthy & protected.

Rated 5 out of 5 stars
By Oscarsmom on May 18, 2023

Safe and secure

I called Chewy to verify their source for this product and I am sure that it’s safe and comes straight from the manufacturer, not a foreign entity. I trust Chewy totally.

Rated 5 out of 5 stars
By Mel on Apr 25, 2023

Excellent product!

Heartgard Plus works perfectly for my Golden Retriever with no side effects and my dog takes it willingly! My vet doesn’t offer this one, so it is very convenient to purchase through Chewy after my vet approves. Thank you!

Rated 5 out of 5 stars
By Ann on Apr 28, 2023

Heartgard brown package

Bear thinks these are treats. Sometimes I break it up and use it as a topper to dinner; sometimes I just open it and hand it to him. He hears the box come from thepantry, and is at my knee. Thanks.