ZYMOX Ear Infection Solution with .5% Hydrocortisone for Dogs & Cats, 1.25-oz bottle - Chewy.com

Zymox Ear Infection Solution with .5% Hydrocortisone for Dogs & Cats, 1.25-oz bottle

By Zymox
Rated 4.8368 out of 5 stars
$22.49Chewy Price
$29.99Chewy Price

In Stock
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About This Item


  • Highly effective for aiding in the treatment of bacterial, fungal and yeast infections including Staphylococcus, Pseudomonas, Proteus and Malassezia.
  • Contains three natural bio-active enzymes that when combined, form a powerful antimicrobial defense system that is safe for all ages of cats and dogs.
  • The solution works with the body to react with present pus and debris to kill infectious and antibiotic resistant microorganisms.
  • The non-invasive protocol requires no cleaning before and during use so that the enzyme activity is not disrupted. Hydrocortisone and natural bio-active enzymes, form an antimicrobial defense system in your pet's ears.
  • Made in the USA.

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Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

Questions & Answers

17 Customer Questions

What is the difference between this and the one that has 1% hydrocortisone?
Answer by ChewyFeb 04, 2018
This Solution contains 0.5% Hydrocortisone. The Zymox Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Solution has a higher level of hydrocortisone for more serious cases.

Can i use it once a week after treatment to maintain ?
Answer by ChewyOct 17, 2019
Zymox Ear Solution is intended to eradicate a broad range of infections ranging from mild to severe, but many veterinarians have also found Zymox Ear Solution to be effective in maintenance of the ears, especially during the allergy season.

Is this safe to use inside of a dog’s ear?
Answer by ChewyFeb 11, 2019
This was meant to be applied liberally to un-cleaned ear, filling ear canal.

Does this have an instant, soothing effect on pain?
Answer by ChewyDec 30, 2019
This product is intended to help in the treatment of bacterial, fungal and yeast infections. The hydrocortisone found in this solution will relieve itching due to irritation and inflammation. Fellow pet parents have noticed results after approximately 3-4 days of using this product as instructed.

ReviewsWrite a Review

Rated 4.8368 out of 5 stars
288 Ratings
Would recommend to a friend

288 Customer Reviews

Rated 5 out of 5 stars
By Jennifer on May 19, 2023

Ear infection solution

Daisy is a 4 yr old AmStaff. We struggle with her allergies and the problems they cause. This year the allergies hit early and hard. She had skin, sinus and ear infections. 2 trips to the vet confirmed that they were treatable with antihistamines and environmental control steps. These ear drops gave her same day relief from the itching and irritation she'd struggled with for 2 weeks. We absolutely will continue with these until she is pain and itch free. Thank you for making her comfortable and back to her happy goofy loving self.

Rated 5 out of 5 stars
By Eileen on May 13, 2023

It worked!

I ordered this for Beamer, one of our cats, that is almost 16 years old, because by scratching his right ear I could tell it was bothering him. I chose this one because of the great reviews, and no pre-cleaning of his ear was needed. After one week of following the directions he seemed better. We then took him to the vet for his check-up (for another issue,) and I asked the vet to please check his right ear, and Dr Evans said it looked good, except for being a little dirty. Beamer hasn’t scratched his ear since, so I know this worked!

Rated 5 out of 5 stars
By Bromom on Jun 3, 2023

Works fast

If my dog's ears get inflamed or itchy due to a food he shouldn't have eaten, this clears them up super fast. If they are bad i put in a few drops, then put a wrap hoodie around his ears so that he can't shake his floppy ears and cause bleeding. I love this stuff.

Rated 5 out of 5 stars
By Madrid89 on Apr 17, 2023

tail wagg!!

If i could give this 6 stars I would. I think My dog had an ear infection. Would always shake uncontrollably. So I went online . Did my research and came across this product. Followed the instructions . Applied it. And it did wonders. You apply it for 7 days straight. Really easy to use. Worth every penny!! Louie says thanks!

Rated 5 out of 5 stars
By plunger on Jan 24, 2023

Cleared up my dog’s painful itchy ears in 4 uses

My lab had red, inflamed ears that she was constantly shaking and scratching at. In an attempt to avoid a vet visit I bought these and they worked so well! We only needed to use them for three days before her ears were better. We went ahead and did one more day to make sure they were good and she’s stayed healthy since. That was at least 6 weeks ago. Highly recommend for itchy, painful looking doggie ears.

Rated 5 out of 5 stars
By Jmacdogs on Feb 19, 2023

Ear relief

This product was a savior for our dog Lola. She has very dirty and itchy ears which drive her nuts. Our veterinarian suggested this product, but couldn't find at our local pharmacies. Thank you Chewy for having this product available.

Rated 5 out of 5 stars
By Kimberly on Jan 4, 2023

Worked Perfectly

Product worked amazingly well on my daughter's dogs ear infection! The vets expensive scripts didn't work, not any one of the 3 of them! So I turned to Chewy and put my 30 yr nursing experience to work! She used this to flush his ears for one week and by the 5th day they were completely clear not even slightly pink anymore let alone blood red as they had been! So 2 extra days to be sure! The infection didn't return either!

Rated 5 out of 5 stars
By Angel2014 on Jan 31, 2023

Ear infection

This product is awesome. My 8 year old female chihuahua has a problem with ear infections. And this is the only product that has worked to help clear them up. I highly recommend this product. I can’t say enough good things about it.

Rated 5 out of 5 stars
By Cindy on Jan 21, 2023

Save a trip to the vet

This stuff works. Itchy ears, scratching head and not feeling well. This is the same stuff I got by prescription from my vet. Rather than go back for a refill and pay another vet bill, I checked Chewy and sure enough it's available over the counter. Yay!

Rated 5 out of 5 stars
By Lib on Jun 3, 2023

Product worked great!

This was recommended by my girl's VET! And it worked fast!