Advantage II Flea Spot Treatment for Cats, 5-9 lbs, & Ferrets

By Advantage II
Rated 4.2102 out of 5 stars

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$47.98Chewy Price
$45.58Autoship Price
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About This Item


  • Flea protection for small cats weighing 5 to 9 pounds, at least 8 weeks of age.
  • Easy-to-apply monthly topical treatment.
  • Delivers total flea protection and kills adult fleas, flea larvae and flea eggs through contact.
  • Starts killing fleas the same day and keeps working for 30 days.
  • Fragrance-free formula is waterproof after 24 hours of application.

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Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

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Total Price: $100.96

About Advantage II Cat

Experience the Benefits of Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended topical formula works to kill adult fleas as well as flea larvae and eggs, so your cat can focus on you. It only needs to be applied once a month and is for cats and kittens 8 weeks of age or older.

Why Choose Advantage II?

Advantage II is waterproof, fragrance-free and kills fleas directly through contact. That means pesky fleas dont have to bite to perish. It kills fleas within 12 hours of the first application and can protect against further infestation for up to a month. Best of all, with Advantage II, you can stop multiple flea life stages, to effectively break the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas. The first active ingredient kills adult fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Cat?

Whether your cat is a winter sunspot-stealer or a summer backyard explorer, an sunseeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your cat, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Cats of All Sizes


2-5 pounds


5-9 pounds


Over 9 pounds

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with effective flea prevention that lasts all month.
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Top IngredientsActive Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%.Dinotefuran, Fipronil and Pyriproxyfen
LifestageAdultAdultKittenKitten, Adult, SeniorKitten, Adult, Senior
Small Pet TypeFerret

Questions & Answers

28 Customer Questions

Since the fleas do not have to bite my cat to be killed do they have to crawl over the specific application site to be killed?
Answer by ChewySep 07, 2017
This product doesn't require fleas to bite for it to take effect but it must come into contact with the pest.

Is this safe for Nursing cats? If so will it also protect the newborn kittens from fleas?
Answer by ChewyJul 26, 2017
As with any product, it's best to consult your veterinarian before using this product on pregnant or nursing cats.

how many cc are in one application tube?
Answer by ChewyAug 04, 2018
Each application tube contains 0.4 cc.

Does Advantage 2 protect against mosquitoes also?
Answer by ChewyJun 16, 2018
This product has not been tested to repel mosquitoes.

ReviewsWrite a Review

Rated 4.2102 out of 5 stars
1199 Ratings
Would recommend to a friend

1184 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Maddy on Nov 12, 2023

No longer effective

I've used this for the last couple of years with my cats. It's seemed to work until recently. I've purchased 2 different boxes from separate retailers to make sure it wasn't just a bad batch, with no luck. I treated my cats at the first sign of fleas and continued with monthly doses for the last 2 months. The problem has only continued to get worse!! We went from a couple pesky fleas to a full blown infestation despite treatment! We're stuck treating every room in the house, vacuuming multiple times a day, steaming the carpets and washing every piece of bedding. DO NOT WASTE YOUR MONEY

Rated 1 out of 5 stars
By Veronica on Nov 7, 2023

Not effective anymore

I’ve purchased two boxes of this for my cat. (And two other dogs and a small kitten!). In the past, we’ve used Advantage on our animals and it’s always worked. But, after two boxes used this Spring/Summer - now. We are still dealing with fleas!! It’s safe to say, the efficacy is no longer there for Advantage. I’m not sure if they changed their formula or what. It’s expensive and doesn’t work. Save your money and try something else! Lesson learned.

Rated 1 out of 5 stars
By JessicaB on Oct 22, 2023

Doesn't Work!

Have been battling fleas using Advantage for 5 months without success. After talking to my vet I was told most fleas are becoming immune to the active ingredients in Advantage, making it much less affective. Switched to a product with the active ingredient as Selamectin and fleas are officially eradicated 2 weeks later. Although selamectin is rx only, it's definitely worth it and is typically cheaper! Don't waste your time and money on Advantage.

Rated 5 out of 5 stars
By Jesus on Nov 3, 2023

10/10 product

My cat had a flea infestation, causing a whole rash of scabbies all over her fur. She even scratched/pulled off a lot of hair from the flea allergy she got. After the second dose of this advantage II on the 3rd week I instantly saw progress. Her hair is growing back fast and strong. I highly recommend this

Rated 5 out of 5 stars
By Charlee on Sep 30, 2023

Cats and Fleas

For my cats, Advantage II has worked quicker then other flea products that i have tried. I like that they are now making it for different sizes of cats. There is one for Kittens, then Small Cats which is 5 to 9 pounds and Large Cats which is Over 9 pounds. I have several cats so I have a variety of sizes from Sugar who is 4 years old and weighs 5 pounds to Billy who is part Maine Coon who weighs 20 pounds. The Advantage II for fleas works very well for all of my Cats.

Rated 1 out of 5 stars
By Patti on Oct 8, 2023

Fleas on two feral kittens

I bought this in hopes of it working. I’ve tried Frontline Plus, chemical free products, treated the whole house several times, Vacuum every day, etc. But, the fleas are getting impossible to control. We literally have to bathe them in Dawn way too often and find tons along with eggs so it does not work and I’m very disappointed. If anyone can suggest something that works, please tell me. I’m desperate.

Rated 2 out of 5 stars
By Trsneezy on Oct 3, 2023

Didn't work !

We bought Advantage ll for kittens up to 5lb and it worked, but I recently bought this one for 5-9lbs and I don't get what happened but it seems to have actually created MORE of a flea problem ! On the page it does say that you can reapply after about a week but this product is expensive and should've worked the 1st time ! Not that I have to pay another $40+ to see if another dose will work. The one for little kittens under 5lbs works, this 5-9lb is garbage imo. Now I have to find something else, very annoyed.

Rated 5 out of 5 stars
By James on Nov 14, 2023

Advantage II works!

Can't find any fleas or ticks on the cats or in the house. This is great stuff. Even use it on our 19 year old cat after her Memorial Day stroke this year. That's when I started using Advantage II for our two small, 5-9 Lb. very mature cats.

Rated 5 out of 5 stars
By neeko on Oct 10, 2023

Go in between flea treatment when you can't afford revolution

Having a lot of rescues sometimes money is tight and I can't keep paying for revolution prescriptions so this is my in between go to treatment to keep ontop of fleas that I trust for my babies. I'm a very paranoid pet parent so wary of what I put on my babies and Advantage is the only one that has proven effective for me personally and safe.

Rated 1 out of 5 stars
By AmyR on Oct 1, 2023

Cat had a reaction

First time using on my cat and About 30 minutes after treatment cat started foaming at the mouth. This happened about 5 times over the next 4 hours. I called the vet and said this can happen sometimes and to keep an eye on her. She seemed like she didn’t feel good the rest of the day. I will not be using this on my cat again in the future.