Advantage II Flea Spot Treatment for Cats, 2-5 lbs, 2 Doses (2-mos. supply)

By Advantage II
Rated 4.3544 out of 5 stars
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Advantage II Flea Spot Treatment for Cats, 2-5 lbs, 2 Doses (2-mos. supply) slide 1 of 13
$27.98Chewy Price
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About This Item

  • Veterinarian-recommended treatment kills all life stages of fleas on kittens and cats 8 weeks or older and weighing 2-5 pounds.
  • Begins working within 12 hours and kills pests on contact.
  • Kills eggs, larvae and adult fleas to break the life-cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing.
  • 4-pack of convenient, monthly topical treatments contain imidacloprid and pyriproxyfen.
Play Video: Learn More About Advantage II From Our Team of Experts
Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Cat

Experience the Benefits of Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended topical formula works to kill adult fleas as well as flea larvae and eggs, so your cat can focus on you. It only needs to be applied once a month and is for cats and kittens 8 weeks of age or older.

Why Choose Advantage II?

Advantage II is waterproof, fragrance-free and kills fleas directly through contact. That means pesky fleas dont have to bite to perish. It kills fleas within 12 hours of the first application and can protect against further infestation for up to a month. Best of all, with Advantage II, you can stop multiple flea life stages, to effectively break the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas. The first active ingredient kills adult fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Cat?

Whether your cat is a winter sunspot-stealer or a summer backyard explorer, an sunseeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your cat, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Cats of All Sizes


2-5 pounds


5-9 pounds


Over 9 pounds

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with effective flea prevention that lasts all month.
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Top IngredientsActive Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Spinetoram 11.2% Other Ingredients: 88.8%Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.N/A
Small Pet TypeN/AN/AN/AFerretN/A

Questions & Answers

21 Customer Questions

Is it safe for when the kittens lick themselves or each other?
Answer by ChewySep 01, 2017
The treatment needs time to dry after being applied, once dried it is safe for the kittens to lick each other and themselves.

Can you use advantage for kittens on a ferret?
Answer by ChewyAug 22, 2018
Advantage II for Small Cats 5-9 Pounds was recently approved to be used for ferret flea control. It would be best to use that product with your ferrets instead. Ferrets using Advantage II must be 1 lb or over and be 10 weeks of age or older.

Does this also kill ticks and mites like some of the other products?
Answer by ChewyAug 12, 2021
This highly-effective, veterinarian-recommended treatment is specifically formulated to kill all life stages of fleas on contact.

I am wondering if advantage kittens is safe for rabbits?
Answer by ChewyAug 07, 2019
At this time, there are no rabbit-specific treatments for managing fleas. We recommend consulting with a veterinarian familiar with rabbits regarding the proper topical and environmental treatments.

ReviewsWrite a Review

Rated 4.3544 out of 5 stars
237 Reviews
Would recommend to a friend

237 Customer Reviews

Rated 5 out of 5 stars
By Sandy on Jan 19, 2022

great product

I worked at a vet for over 30 years, and in my experience fleas became immune to many products, but not Advantage. It is also very safe, and I used it on my kittens (over 8 weeks of age!). It is very effective. Love Chewy, too!

Rated 5 out of 5 stars
By Heather on Apr 29, 2022

Works great

I use the kitten advantage for my 6 pound bunny. It’s safe and works great!

Rated 5 out of 5 stars
By PatC on Nov 29, 2021

Small Cat Solution

My new cat is over a year old, but health problems early on made it hard for her to grow and gain weight. Since she was under 5 pounds when she came to live with me, this was the perfect solution - and it worked! No fleas - confirmed by a recent vet visit. Now that she's gaining weight, she will soon be able to "graduate" to the small cat version.

Rated 5 out of 5 stars
By Donald on Nov 4, 2021

Kill fleas as advertised

I treat the cats monthly with Advantage II during flea season (usually 3-4 months) and dust the carpet with food grade diatomaceous earth (after putting a mask on and whooshing the cats out of the room, as the dust is not toxic but will irritate the lungs). Though the Advantage II has little odor that I can detect I have two cats that really hate it, so I have to sneak up on them to apply it. The other cats could care less (“you are petting me so I don’t care if you squish something on me, just keep petting”). I have used it for years and so far the fleas keep dying.

Rated 5 out of 5 stars
By Karen on Dec 6, 2021

Awesome medication for a reasonable price.

Both of my kittens were flea free when I adopted them. My male kitten was free of fleas until he came home from the vet after being fixed. He then gave them to my female kitten, his sister, and hence the flea problem. This medication is great. One application and no more fleas!! It’s the best I’ve tried without breaking the bank.

Rated 5 out of 5 stars
By Timberline18 on Mar 11, 2022

Good stuff

This stuff works well, I put it on my cats and it Worked. I will definitely be buying this again.

Rated 5 out of 5 stars
By FurMomma on Oct 27, 2021

Worked for us

I adopted 2 kittens this past summer and they had fleas. Advantage II for kittens cleared it up and prevented an infestation from occurring in my house. It’s the only brand I generally use on my babies. I never see any skin irritation or side effects after applying it, and it’s fairly priced. Those kittens have since moved on to Advantage II for small cats (they are growing so fast!) and it works just as well. Highly recommend this brand.

Rated 5 out of 5 stars
By Cyndy on Dec 1, 2021

Helped our kittens

Our new kittens are indoor but there are stray cats near and I think the cats sitting in the windows were able to pass them to our kittens. This did very well and we were finding dead fleas the same evening we treated them! Pleased with the product.

Rated 5 out of 5 stars
By Patsy on Feb 9, 2022

Seems to work good for my bunnies!

Was crushed by the 40 lb dog food. But know that’s not Chewy’s fault. Maybe bubble wrap next time.

Rated 5 out of 5 stars
By Karoline on Oct 27, 2021

Great Product

The Advantage II flea treatment is easy to apply and is very effective. More importantly, the associates at Chewy are awsome. They are friendly, professional and compassionate. I will always be a loyal customer.