Advantage II Flea Spot Treatment for Cats, 2-5 lbs, 2 Doses (2-mos. supply)

By Advantage II
Rated 4.276 out of 5 stars
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$27.98Chewy Price
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About This Item

  • Veterinarian-recommended treatment kills all life stages of fleas on kittens and cats 8 weeks or older and weighing 2-5 pounds.
  • Begins working within 12 hours and kills pests on contact.
  • Kills eggs, larvae and adult fleas to break the life-cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing.
  • 2 monthly doses of topical treatments contain imidacloprid and pyriproxyfen.
Play Video: Learn More About Advantage II From Our Team of Experts
Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Cat

Experience the Benefits of Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended topical formula works to kill adult fleas as well as flea larvae and eggs, so your cat can focus on you. It only needs to be applied once a month and is for cats and kittens 8 weeks of age or older.

Why Choose Advantage II?

Advantage II is waterproof, fragrance-free and kills fleas directly through contact. That means pesky fleas dont have to bite to perish. It kills fleas within 12 hours of the first application and can protect against further infestation for up to a month. Best of all, with Advantage II, you can stop multiple flea life stages, to effectively break the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas. The first active ingredient kills adult fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Cat?

Whether your cat is a winter sunspot-stealer or a summer backyard explorer, an sunseeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your cat, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Cats of All Sizes


2-5 pounds


5-9 pounds


Over 9 pounds

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with effective flea prevention that lasts all month.
Shop Advantage II

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Top IngredientsActive Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Spinetoram 11.2% Other Ingredients: 88.8%Active Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.
LifestageKittenAdultAdultKitten, Adult, SeniorAdult
Small Pet TypeFerret

Questions & Answers

21 Customer Questions

Is it safe for when the kittens lick themselves or each other?
Answer by ChewySep 01, 2017
The treatment needs time to dry after being applied, once dried it is safe for the kittens to lick each other and themselves.

Can you use advantage for kittens on a ferret?
Answer by ChewyAug 22, 2018
Advantage II for Small Cats 5-9 Pounds was recently approved to be used for ferret flea control. It would be best to use that product with your ferrets instead. Ferrets using Advantage II must be 1 lb or over and be 10 weeks of age or older.

Does this also kill ticks and mites like some of the other products?
Answer by ChewyAug 12, 2021
This highly-effective, veterinarian-recommended treatment is specifically formulated to kill all life stages of fleas on contact.

I am wondering if advantage kittens is safe for rabbits?
Answer by ChewyAug 07, 2019
At this time, there are no rabbit-specific treatments for managing fleas. We recommend consulting with a veterinarian familiar with rabbits regarding the proper topical and environmental treatments.

ReviewsWrite a Review

Rated 4.276 out of 5 stars
250 Reviews
Would recommend to a friend

250 Customer Reviews

Rated 5 out of 5 stars
By Krisha on Sep 18, 2022

Works As Good As Seresto

I bought this product when the vet recommended it for my 12 week old kitten because she is intolerant to the material that the Seresto collar is made from. It caused her skin to become a little red and irritated and itchy from the collar and the vet ruled out it wasn’t the active ingredients. My other two cats do well with Seresto and this product has one of the 2 active ingredients as Seresto, Imidacloprid. The few days she was without any flea treatment, she had a few fleas on her that she came into contact with because we had someone come in to our home for a day or two that had a flea problem at their house. Ever since we treated our kitten with the Advantage, there hasn’t been 1 sign of a flea and no scratching as well. It was easy to use also. We made sure we treated the house just in case but reading up on this product, the skin and hair they shed contains the Imidacloprid in it because it’s designed to get into the fatty layer of skin and distribute there and when they do shed, they shed the flea medicine in that skin and hair that get into the carpet and upholstery of your home and it further prevents fleas and flea eggs and flea larvae that way. I’ve been using products from Elanco for a few years now and I am highly satisfied with the results their products produce 100%!! This is one of the most safe and effective methods of treating your kitten for fleas.

Rated 1 out of 5 stars
By mama2piratekitty on Sep 24, 2022

Did nothing

I bought this aswe recently rescued a stray kitten, of course covered in fleas, so I thought this was supposed to be a good brand, but nope, fleas ended up spreading to the other cats we have. On top of this not working, packaging was awful, they put this tiny box in with 20lb bag of litter... needless to say that flea med box was destroyed, luckily the meds didn't get damaged, but med ended up not working regardless, just be mindful will packaging small items with heavy. Now off to find a different flea med.

Rated 4 out of 5 stars
By gabbi on Sep 4, 2022

love the product but..

I have used this flea treat for my cats for years and have found chewy to be the best priced out of dozens of stores online and in person. I was pretty disappointed and almost scared with this purchase though when I opened the chewy box and my kitten size treatment was totally opened. The second dose wasn’t even in the package anymore, it was laying in the chewy box. The other three I bought were fine. I’m assuming it was an issue with the manufacturer or whoever packaged it but I have never had this issue with chewy before so it was odd.

Rated 1 out of 5 stars
By Rose on Sep 21, 2022


I waited a while before posting a review, wanting to be fair and give it time to work. But have to say, with two kittens this didnt work on neither of them sadly. They don't even have much fleas to begin with but this hasn't helped with what they do and doesn't even help as a deterrent. Upsetting for the price. Id look for something else honestly. I know I am.

Rated 5 out of 5 stars
By TimmysMom on Sep 16, 2022

Worked Quickly and Well

I don't know where Timmy picked up fleas because he's an indoor cat but he was scratching like crazy. I put the Advantage II on him as soon as it arrived and within a few hours he stopped scratching. I don't know how long it'll last but he's never gotten fleas before and probably won't again and now that they're gone, he won't need it to last long.

Rated 5 out of 5 stars
By Robyn on Jul 20, 2022

Advantage Only

I have used other flea products before and some were really expensive. I have always gone back to Advantage and I stay only with Advantage. now. I just recently added kittens to the mix and the Advantage line has also for kittens. Its great and affordable. Very happy and so are my cats.

Rated 1 out of 5 stars
By KitKat on Jul 8, 2022

Didn’t Last Long

Took in 3 stray kittens with a bad flea problem. Treated them with the Advantage treatment for kittens. Had high hopes when within the first week I was finding dead fleas. However, right after the second week, the fleas were back in full form. Very disappointed this didn’t last the full month.

Rated 1 out of 5 stars
By nick on Sep 15, 2022

Elanco AdvantageII

This product is not as effective as the BAYER Advantage product that I thought I was buying. I am extremely dissatisfied.

Rated 5 out of 5 stars
By FleaTreatmentoncats on Jun 29, 2022

Awesome! Fleas don't stand a chance.

As a cat owner here in Florida, this product is a must. When I used it on Smoky, he showed no ill effects. Kept playing after I put it on him. Fleas no loner bother him....or me.

Rated 1 out of 5 stars
By HeatherB on Jun 22, 2022

Didn’t help

My cats are ate up with fleas and we religiously give them flea meds. Fleas are terrible this year and our vet said only the pill is working right now.