Best Puppy Milk Replacers 2026: According to Reviews | Chewy

Best Puppy Milk Replacers

Newborn puppies have specific nutritional needs, especially if they can't nurse from their mother. Milk replacers are made to closely match canine milk and support early growth. When comparing the best puppy milk replacers, it's important to look at nutrient completeness, ease of mixing, and how well puppies tolerate the formula. When caring for very young litters, veterinary guidance is essential.

Our Top Picks

How we created this puppy milk replacer list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best puppy milk replacer.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best puppy milk replacers.

Key puppy milk replacer considerations

Digestibility

Ease of Preparation

Nutritional Content

Palatability

1
PetAg Esbilac Puppy Milk Replacer Powder for Puppies, 5-lb bag
PetAg Esbilac Puppy Milk Replacer Powder for Puppies, 5-lb bag
PetAg Esbilac Puppy Milk Replacer Powder for Puppies, 5-lb bag
PetAg Esbilac Puppy Milk Replacer Powder for Puppies, 5-lb bag
PetAg Esbilac Puppy Milk Replacer Powder for Puppies, 5-lb bag
PetAg Esbilac Puppy Milk Replacer Powder for Puppies, 5-lb bag
PetAg Esbilac Puppy Milk Replacer Powder for Puppies, 5-lb bag

PetAg Esbilac Puppy Milk Replacer Powder for Puppies, 5-lb bag

Rated 4.7 out of 5 stars
405
$152.99 Chewy Price
($30.60/lb)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

4.6/5
Excellent

Ease of Preparation

4.7/5
Excellent

Nutritional Content

4.5/5
Great

Palatability

4.4/5
Great

Is this puppy milk replacer right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Vegetable Oil (With Tocopherols And Ascorbyl Palmitate (Preservatives), Rosemary Extract), Casein, Dried Whey Protein Concentrate, Maltodextrins

Special Diet

High Fat
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2
Four Paws Pet Nurser Bottles, 2-oz, 2 count
Four Paws Pet Nurser Bottles, 2-oz, 2 count
Four Paws Pet Nurser Bottles, 2-oz, 2 count
Four Paws Pet Nurser Bottles, 2-oz, 2 count
Four Paws Pet Nurser Bottles, 2-oz, 2 count
Four Paws Pet Nurser Bottles, 2-oz, 2 count
Four Paws Pet Nurser Bottles, 2-oz, 2 count
Four Paws Pet Nurser Bottles, 2-oz, 2 count
Four Paws Pet Nurser Bottles, 2-oz, 2 count

Four Paws Pet Nurser Bottles, 2-oz, 2 count

Rated 4.3 out of 5 stars
315
$6.49 Chewy Price
($1.63/oz)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

3.7/5
Good

Ease of Preparation

4.2/5
Great

Nutritional Content

4.3/5
Great

Palatability

4.2/5
Great

Is this puppy milk replacer right for my pet?

Breed Size

Extra Small Breeds, Small Breeds

Lifestage

Nursing

Health Feature

First Aid
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3
PetAg Esbilac Healthy Development Puppy Supplement, 14-oz can
PetAg Esbilac Healthy Development Puppy Supplement, 14-oz can
PetAg Esbilac Healthy Development Puppy Supplement, 14-oz can
PetAg Esbilac Healthy Development Puppy Supplement, 14-oz can
PetAg Esbilac Healthy Development Puppy Supplement, 14-oz can
PetAg Esbilac Healthy Development Puppy Supplement, 14-oz can
PetAg Esbilac Healthy Development Puppy Supplement, 14-oz can

PetAg Esbilac Healthy Development Puppy Supplement, 14-oz can

Rated 4.5 out of 5 stars
193
$17.14 Chewy Price
($1.23/oz)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

4.8/5
Excellent

Ease of Preparation

4.7/5
Excellent

Nutritional Content

4.6/5
Excellent

Palatability

4.7/5
Excellent

Is this puppy milk replacer right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Rice flour, dried skimmed milk, beef broth, animal fat (preserved with BHA and BHT), dried whey protein concentrate

Special Diet

High-Protein
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4
Hartz Powdered Milk Replacer Formula for Puppies, 12-oz jar
Hartz Powdered Milk Replacer Formula for Puppies, 12-oz jar
Hartz Powdered Milk Replacer Formula for Puppies, 12-oz jar

Hartz Powdered Milk Replacer Formula for Puppies, 12-oz jar

Rated 4.4 out of 5 stars
50
$13.00 Chewy Price
($1.09/oz)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

4.7/5
Excellent

Ease of Preparation

4.7/5
Excellent

Nutritional Content

4.7/5
Excellent

Palatability

4.7/5
Excellent

Is this puppy milk replacer right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Animal Fat and Vegetable Fat (preserved with BHA and BHT), Dried Whey Protein Concentrate, Dried Whey, Sodium Caseinate, Dicalcium Phosphate

Food Flavor

Unflavored
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5
PetAg Goat's Milk Esbilac Puppy Milk Replacer Powder for Puppies, 12-oz can
PetAg Goat's Milk Esbilac Puppy Milk Replacer Powder for Puppies, 12-oz can
PetAg Goat's Milk Esbilac Puppy Milk Replacer Powder for Puppies, 12-oz can
PetAg Goat's Milk Esbilac Puppy Milk Replacer Powder for Puppies, 12-oz can
PetAg Goat's Milk Esbilac Puppy Milk Replacer Powder for Puppies, 12-oz can
PetAg Goat's Milk Esbilac Puppy Milk Replacer Powder for Puppies, 12-oz can
PetAg Goat's Milk Esbilac Puppy Milk Replacer Powder for Puppies, 12-oz can

PetAg Goat's Milk Esbilac Puppy Milk Replacer Powder for Puppies, 12-oz can

Rated 4.6 out of 5 stars
284
$36.54 Chewy Price
($3.05/oz)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

4.4/5
Great

Ease of Preparation

4.5/5
Great

Nutritional Content

4.3/5
Great

Palatability

4.5/5
Great

Is this puppy milk replacer right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Vegetable Oil (With Tocopherols And Ascorbyl Palmitate (Preservatives), Rosemary Extract), Dried Whole Goat Milk Powder, Casein, Dried Whey Protein Concentrate

Special Diet

High Fat
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6
PetAg PetLac Puppy Milk Replacement Powder for Puppies, 10.5-oz can
PetAg PetLac Puppy Milk Replacement Powder for Puppies, 10.5-oz can
PetAg PetLac Puppy Milk Replacement Powder for Puppies, 10.5-oz can
PetAg PetLac Puppy Milk Replacement Powder for Puppies, 10.5-oz can
PetAg PetLac Puppy Milk Replacement Powder for Puppies, 10.5-oz can
PetAg PetLac Puppy Milk Replacement Powder for Puppies, 10.5-oz can
PetAg PetLac Puppy Milk Replacement Powder for Puppies, 10.5-oz can

PetAg PetLac Puppy Milk Replacement Powder for Puppies, 10.5-oz can

Rated 4.7 out of 5 stars
139
$17.84 Chewy Price
($1.70/oz)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

4.8/5
Excellent

Ease of Preparation

4.6/5
Excellent

Nutritional Content

4.5/5
Great

Palatability

4.5/5
Great

Is this puppy milk replacer right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Dried Skimmed Milk, Vegetable Oil (Preserved With Tocopherols), Soy Protein Isolate, Animal Fat (Preserved With Bha And Bht), Casein

Food Flavor

Unflavored
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7
PetAg Esbilac Puppy Milk Replacer Liquid, 16-fl oz
PetAg Esbilac Puppy Milk Replacer Liquid, 16-fl oz
PetAg Esbilac Puppy Milk Replacer Liquid, 16-fl oz
PetAg Esbilac Puppy Milk Replacer Liquid, 16-fl oz
PetAg Esbilac Puppy Milk Replacer Liquid, 16-fl oz
PetAg Esbilac Puppy Milk Replacer Liquid, 16-fl oz

PetAg Esbilac Puppy Milk Replacer Liquid, 16-fl oz

Rated 4.5 out of 5 stars
43
$14.02 Chewy Price
($0.88/fl oz)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

4.5/5
Great

Ease of Preparation

4.6/5
Excellent

Nutritional Content

4.5/5
Great

Palatability

4.5/5
Great

Is this puppy milk replacer right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Water, dried whole milk, casein, soybean oil (preserved with mixed tocopherols and ascorbyl palmitate), dicalcium phosphate

Packaging Type

Bottle
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8
K9 POWER Puppy Gold Pork Flavored Powder Milk Supplement for Dogs, 8-oz

K9 POWER Puppy Gold Pork Flavored Powder Milk Supplement for Dogs, 8-oz

Rated 4.6 out of 5 stars
61
$39.99 Chewy Price
($5.00/oz)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

4.8/5
Excellent

Ease of Preparation

4.6/5
Excellent

Nutritional Content

4.8/5
Excellent

Palatability

4.7/5
Excellent

Is this puppy milk replacer right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Milk Protein Isolate, Protein Free Beef Tallow, Maltodextrin, Creatine, Silicon Dioxide

Special Diet

No Corn No Wheat No Soy
View Item Details
9
Vets Preferred Advanced Milk Rx Dog Supplement, 12-oz jar
Vets Preferred Advanced Milk Rx Dog Supplement, 12-oz jar
Vets Preferred Advanced Milk Rx Dog Supplement, 12-oz jar
Vets Preferred Advanced Milk Rx Dog Supplement, 12-oz jar
Vets Preferred Advanced Milk Rx Dog Supplement, 12-oz jar
Vets Preferred Advanced Milk Rx Dog Supplement, 12-oz jar
Vets Preferred Advanced Milk Rx Dog Supplement, 12-oz jar
Vets Preferred Advanced Milk Rx Dog Supplement, 12-oz jar

Vets Preferred Advanced Milk Rx Dog Supplement, 12-oz jar

Rated 4.7 out of 5 stars
27
$27.97 Chewy Price
($2.34/oz)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

4.6/5
Excellent

Ease of Preparation

4.7/5
Excellent

Nutritional Content

4.6/5
Excellent

Palatability

4.4/5
Great

Is this puppy milk replacer right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Animal & Vegetable Fat (Preserved With Bha And Bht, Dried Whey Protein Concentrate, Dried Whey, Sodium Casinate, Dicalcium Phosphate

Special Diet

High-Protein
View Item Details
10
PetAg Goat's Milk Esbilac Puppy Milk Replacer Liquid for Puppies, 16-fl oz
PetAg Goat's Milk Esbilac Puppy Milk Replacer Liquid for Puppies, 16-fl oz
PetAg Goat's Milk Esbilac Puppy Milk Replacer Liquid for Puppies, 16-fl oz
PetAg Goat's Milk Esbilac Puppy Milk Replacer Liquid for Puppies, 16-fl oz
PetAg Goat's Milk Esbilac Puppy Milk Replacer Liquid for Puppies, 16-fl oz
PetAg Goat's Milk Esbilac Puppy Milk Replacer Liquid for Puppies, 16-fl oz

PetAg Goat's Milk Esbilac Puppy Milk Replacer Liquid for Puppies, 16-fl oz

Rated 4.6 out of 5 stars
24
$16.14 Chewy Price
($1.01/fl oz)
Promo, New Customers Only: Spend $49+, get $20 off

Our ratings

Digestibility

4.6/5
Excellent

Ease of Preparation

4.5/5
Great

Nutritional Content

4.6/5
Excellent

Palatability

4.3/5
Great

Is this puppy milk replacer right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Water, dried whole goat milk powder, casein, soybean oil (preserved with mixed tocopherols and ascorbyl palmitate), dicalcium phosphate

Packaging Type

Bottle
View Item Details
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Frequently Asked Questions about Puppy Milk Replacers

Can newborn puppies eat puppy food?

Newborn puppies cannot usually eat puppy food, as their digestive systems are not fully developed. Newborn puppies should nurse from their mother or be bottle-fed a milk replacer formulated specifically to meet their nutritional needs. See your vet for an exam and detailed instructions on care before attempting to feed very young or orphaned puppies.

How long do puppies need to stay on milk replacer?

Puppies usually need to stay on milk replacer until at least 3 to 4 weeks of age to ensure adequate nutrition and easy digestion, but only if mother's milk is not available. The best food for the youngest puppies is always natural mother's milk, although puppy milk replacer is a nutritious substitute in its absence. After 4 to 6 weeks, you can start introducing them to wet puppy food and decrease the amount of milk replacer you're feeding gradually. Always talk to your vet for the best guidance on feeding and caring for nursing puppies.

What can you substitute for puppy milk?

You can substitute specially formulated puppy milk replacers for puppy milk if the mother is not around or able to feed the puppies. If you are caring for nursing puppies, be sure to seek detailed feeding advice from your vet to ensure you are providing adequate nutrition. You can find a wide variety of puppy milk replacers at Chewy to help your furry friends grow up healthy and thrive!

What is the difference between powdered and ready-to-feed puppy milk replacers?

Powdered formulas are mixed with water so you can prepare fresh portions and adjust batch size for each feeding. Ready-to-feed liquids are convenient because there is no mixing, which can help for middle-of-the-night feedings or when you want to reduce prep steps. Choose the format that fits your schedule while following the label's directions for serving and storage.

When should puppies move from milk replacer to weaning food?

Puppies typically stay on milk replacer when mother's milk is not available until they are about 3 to 4 weeks old, then you can start offering a soft weaning gruel. From roughly 4 to 6 weeks, gradually increase the solid portion and decrease the milk replacer as they tolerate the change. Keep your vet involved, especially with very young or slow-growing pups.