Douxo S3 CALM Soothing Itchy, Hydrated Skin Dog & Cat Shampoo

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Your pet will love getting a little extra TLC for her skin at bath time with Douxo S3 CALM Dog & Cat Shampoo. This shampoo is formulated with skin-soothing ingredients like ophytrium, which helps strengthen the skin barrier. It helps restore the balance of protective microbes and soothe that annoying itchy, irritated skin. It’s made without soaps, sulfates, parabens, dyes and nanoparticles––just safe skincare goodness! As a bonus, it even moisturizes and detangles the fur, leaving behind a silky, shiny coat and soothed skin.

Key Benefits
  • Shampoo for dogs and cats that helps soothe irritated skin.
  • Helps restore the balance of protective microbes.
  • Contains ophytrium, a natural ingredient that helps strengthen the skin barrier.
  • Made without soaps or sulfates.
  • Free of parabens, dyes and nanoparticles.

For external use on dogs or cats only; avoid contact with eyes. If eye contact occurs, rinse thoroughly and consult your veterinarian. If skin irritation occurs or increases, discontinue use and consult with your veterinarian. Wash hands after using.
If your furry friend is using a topical flea and tick treatment, please remember to follow the bathing instructions on the flea and tick packaging. Each treatment works differently and may require different wait times before water exposure.

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  • Item Number
  • Lifestage
  • Breed Size
    Small Breeds, Medium Breeds, Large Breeds
  • Grooming Feature
  • Product Form

Ophytrium, Chlorhexidine

Recommended Dosage

Use as recommended by your veterinarian. Wet the fur with cool water from the neck down. Using 1 pump for every 4 lbs, gently massage shampoo onto skin abnormalities to reach the skin. Repeat until entire body is lightly coated with shampoo and leave on for 10 minutes. Rinse thoroughly with cool water. Shampoo amount can be doubled for dogs or cats with long and/or thick fur.

Apply, lather and rinse.

Soothing Skincare for Pets

DOUXO S3 features Ophytrium, a purified natural ingredient that acts in three key ways to encourage healthy and comfortable skin. Ophytrium helps support supple and hydrated skin to reinforce the skin’s physical barrier, and it helps nurture healthy microbial skin flora, too. It also helps soothe red, itchy and irritated skin.

Product Grouping
Dog Scratching

Targeted Skin Care

DOUXO S3 comes in four formulations to help support common pet skin concerns. DOUXO S3 CALM helps soothe itchy, irritated allergic skin, while antiseptic and antifungal DOUXO S3 PYO helps control skin infections. There is also DOUXO S3 SEB, which offers dandruff control for greasy, flaky or dry skin, and DOUXO S3 CARE, which is an ultra-gentle formula designed for regular use.

Formulated by Vets

Products in the DOUXO S3 line are formulated by veterinary dermatologists and tested using an enhanced protocol to ensure safety for pets and the people who care for them. The formulas are easy to use, too. Simply shampoo once to remove dirt, debris and allergens, then use the mousse every 2-3 days afterward for three weeks.

Dog in Bath
Cat Bath

No Controversial Ingredients

DOUXO S3 formulas are made without soap, sulfates, parabens, colorants, phthalates or nanoparticles. They feature a hypoallergenic “summertime” coconut and vanilla fragrance and an adjusted pH optimized specifically for your pet’s skin. The easy to use bottles make application a breeze, too.

About DOUXO S3

DOUXO S3 is a line of non-prescription topical pet skincare products designed to nourish and nurture healthy, problem-free skin. The formulas contain Ophytrium, a proprietary active ingredient that helps support the protective skin barrier. Veterinarian-recommended S3 products are made without potentially irritating soap, sulfates, parabens, colorants, phthalates or nanoparticles and are clinically tested for safety.


Rating: 3.9 of 5 stars 12 Reviews 12 Reviews 3.9 out of 5 Stars

92% Recommend

92% of reviewersrecommend this product

Rating: 3.9 of 5 stars 3.9 / 5

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12 Reviews

Showing 1-10 of 12 Reviews

  • 3 out of 5 stars

    DouxoS3 shampoo

    By Girlfriend on Oct 12, 2021

    My friend had a bath the day after we received the product. She did not itch on the way home, which was about 20 minutes. Then she did start again, this was the first time we used it. I will be taking her to the groomer to get her hair cut shorter and will ask them to use it again.

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  • 5 out of 5 stars

    Amazing product

    By Douxoshampoo on Aug 16, 2021

    This was recommended to my GSD puppy who was having red bumps like a heat rash all over her belly. After the second use the redness was completely gone and the rashes have now all disappeared. I would definitely give this product more than 5 stars. The price was a bit high for the size of the bottle but the product works.

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  • 5 out of 5 stars

    Best Wash for Dry Skin

    By Betty on Oct 7, 2021

    This wash helped soothe my dogs skin. I even took it to the groomers and my dogs groomer loves using it. It helps with the itchiness and smells good too.

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  • 4 out of 5 stars

    Works good but

    By Mooksmom on Aug 6, 2021

    Works good but I don’t like the smell. The original Duoxo had a nice fresh scent. Not a fan of the vanilla coconut. But it seems to work and help with my Boston terriers itching.

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  • 1 out of 5 stars

    packaging was not sufficient

    By Jackie on Aug 31, 2021

    I ordered 2 bottles of shampoo and one of them leaked out about half of the bottle in the box. The tops need sealed.

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  • 5 out of 5 stars

    Excellent shampoo

    By DebM on Jun 5, 2021

    My dog has allergies and was biting at her paws and behind. This shampoo worked. I noticed a difference immediately. Only problem someone might have is you have to leave it on for 10 minutes. My dog is very good with baths so she was fine. I just massaged her and she loved it.

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  • 4 out of 5 stars

    Skin issues

    By Emma on Jun 30, 2021

    Vet recommended this shampoo for my dog who was scratching incessantly and she didn’t have fleas. So far so good and seems to help a lot would recommend to anyone who has a dog with skin issues

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  • 5 out of 5 stars

    Wonderful coat

    By cacklein on Apr 29, 2021

    I have my cockerpoo's coat cut short for the hot summer months which makes her skin susceptible to skin rashes from the chemicals used on the lawns and general allergies. I tried this shampoo and it left her coat and skin hydrated and looking the best ever. She has stopped her itching and I like that It is not heavily scented.. It may be expensive but a little goes a long way and it is now my go - to shampoo for her. Her comfort is my goal!

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  • 5 out of 5 stars

    Love it! New favorite shampoo

    By AmberJ on Jun 2, 2021

    Our vet recommended and it’s working great. Smells nice and does not seem it irritate our sensitive dog. Leaves her soft and fluffy with no need for a separate conditioner.

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  • 2 out of 5 stars

    not same formulation

    By Becky on Apr 14, 2021

    This shampoo used to be amazing. It was clear, scent free and was wonderful for my dachshund’s sensitive skin. They changed the formula. It’s now milky white in color and has an odd “coconut” smell. Haven’t used on my dog because I can’t stand the smell.

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