FRONTLINE PLUS Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 8 Doses (8-mos. supply) -

Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs

By Frontline Plus
Rated 3.9319 out of 5 stars
Pet Weight

$88.99Chewy Price
$104.99Chewy Price
$84.54Autoship Price
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About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

Questions & Answers

34 Customer Questions

Can I I bath my dog after using

What would happen if I give my dog who is slightly under the weight limit the same amount as my dog who is slightly over the weight limit? I don't want anything to happen to her but I'd much rather just split the 6 month pack between them as I've never used this brand before.
Answer by ChewyDec 05, 2017
You may be slightly under or over as long as your dog is within 5 pounds of the limit. If not, we recommend going with the next size.

How does it protect your dog when you only apply by the back of the neck
Answer by ChewyNov 21, 2017
Once FRONTLINE Plus is applied, it stores itself in the oil glands in your pet's skin. It then self-distributes continuously for one month to your pet's hair and skin through the hair follicles, killing fleas and ticks.

Can this be taken by a dog that also takes a heart worm pill with flea prevention in it?
Answer by ChewyJun 09, 2021
We encourage speaking with your Veterinarian before combining flea and tick preventatives, for the safest opinion.

ReviewsWrite a Review

Rated 3.9319 out of 5 stars
1454 Ratings
Would recommend to a friend

1453 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By kittymom on Apr 25, 2023


Im not only a kitty mom I’m a dog mom. I’ve been using frontline plus for a very long time it’s an excellent product! The only thing I would suggest is that you overlap it by about a week to insure maximum protection. I depend on Chewy to provide quality products to help care for all my fur babies. Chewy customer care associates are unparalleled in their skills when it comes to not only product knowledge but they listen and they share their own experiences. They relate and they have empathy. When you finish your call you know you’re not alone. Great job Chewy!!

Rated 5 out of 5 stars
By Lis on May 28, 2023

Front line plus flea medicine for dogs

So far it's been good no fleas yet I have never bought this before for my dog I usly got the flea medicine from his vet,but a lot of friends and family saying it works on there dogs so I am trying it for the first time and we live in Illinois so let's see I hope so cause we don't want fleas ever

Rated 5 out of 5 stars
By Shannon on May 18, 2023

Great so far

We applied this 2 weeks ago and it seems to be doing the job. Although, we have caught a couple on ourselves, im not sure if it was from falling off due to this product or if it was on us in general. So after this month we are hoping to never see any flea or tick again!

Rated 5 out of 5 stars
By Alexpa on May 19, 2023

Frontline Plus

Order was processed and received quickly. It was well packaged and easy to use. The best part was the WOW! price. I have used Frontline for my dog for many years and the sale price @ the time of purchase was the best ever. Thank you, Chewy

Rated 1 out of 5 stars
By Debra on Apr 28, 2023

Horrible Customer Service

I purchased this Frontline for my dog. It is great and I have used it in the past. However, I will not be purchasing this or anything from in the future! I was charged twice for this product and I have been fighting with Chewy to get a refund for one of the charges! Terrible Customer Service!

Rated 4 out of 5 stars
By Mar on Apr 28, 2023

Pretty Good

Frontline seems to be working pretty well. I have found a few ticks on my dogs but I’m honestly not sure if it’s partly because it’s a bad year for ticks. My dogs do have fewer ticks than some other dogs I know of on a different product or (unfortunately) no product at all.

Rated 5 out of 5 stars
By Suzanne on May 1, 2023

I can rely on Chewy for all my dog's needs

About a week ago, I realized that I had no more Frontline Plus. My home backs up to a heavily wooded area, and using Frontline, I am confident that my dog is protected from fleas and ticks. I ordered a supply from Chewy, and it arrived in two days!!

Rated 5 out of 5 stars
By Jenny on Apr 21, 2023

Frontline Plus for Dogs

I switched from credelio to Frontline Plus because my dog started having seizures and his doctor told us not to give them credelio or any other brand that's taken orally. I just switched to Frontline Plus so I am not sure if this will work as good as credelio its too early to tell.

Rated 5 out of 5 stars
By Pmar on Apr 22, 2023

Great product and convenience

One of our boxers is only able to tolerate Frontline for flea control, and we've never had any infestation or bad reaction. It doesn't get much easier than ordering through Chewy and getting delivery in a day or two. Very pleased.

Rated 5 out of 5 stars
By Bobbie on May 24, 2023


I have used frontline for my pets for many years cats and dogs. It does the job it promises. I have tried some other brands but Frontline is my choice.