Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 3 Doses (3-mos. supply)

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About This Item

Details

  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

Ingredients

Instructions

Size

FAQ

Learn More About Frontline Plus From Our Team of Experts
Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

Fast-Acting, Long-Lasting Protection

Frontline Plus is formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. It’s waterproof 24 hours after application, lasts for a full 30 days, and comes in formulas for cats or dogs.

Easy One-Spot Topical Application

Frontline Plus is a spot-on solution that’s available without a prescription. 1 dose = 30 days of protection.

Protects Your Pet

  • Starts killing fleas and ticks fast and protects against reinfestation.
  • Waterproof for a full 30 days starting 24 hours after application.
  • Monthly dosing keeps your dog protected for every season.

How to Apply

Follow these simple steps for application:

  1. Hold upright with foil side toward you and snap applicator tip.
  2. Part hair and apply on shoulder blades, completely emptying the pipette.
  3. Leave the solution to spread through your pet's coat.

About Frontline Plus

To ensure your dog stays protected from fleas and ticks all year round, treat them monthly with Frontline Plus. This simple, easy, one-spot topical solution helps keep your pet free from infestations, providing you with peace of mind.

Shop Frontline Plus

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Questions & Answers

34 Customer Questions

Can you treat a 4 month old puppy with Frontline?

Answer by Shanquisha.G • Apr 22, 2025
This product can be used on puppies as young as 8 weeks and weighing at least 5 lbs. for small dogs, 23lbs. for medium dogs, 45 lbs. for large dogs, and 89 lbs. for extra-large dogs.

What type of ticks is Frontline effective on? As there are 6 different types of ticks in my area and not all Tropicals cover all 6.

Answer by Chewy • Jun 11, 2019
Frontline Plus treats against Lone Star Ticks, American Dog Ticks, Deer Ticks, Brown Dog Ticks, and Western Blacklegged Ticks.

How long after applying Frontline does it take for fleas and ticks to die

Answer by Chewy • Jul 21, 2019
In a study, FRONTLINE Plus began killing fleas 4 hours after application. Another study showed that within 12 hours, Frontline Plus killed 100% of fleas. This kills fleas and ticks through contact with your pet's haircoat so no biting is necessary. Fleas rise to the top of your pet's haircoat as they die. So, if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

What’s the difference between frontline plus and frontline gold?

Answer by Chewy • Nov 25, 2020
Both, Frontline Plus and Frontline Gold, are effective against ticks, fleas, and lice in both immature and adult versions. The only difference is that Frontline Gold kills fleas faster than Frontline Plus does. Frontline Gold has added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop in to adult fleas. Both products require monthly applications and are safe to use in all dogs and puppies above 8 weeks of age.
Reviews
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4.4
Rated 4.4 out of 5 stars
6488 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

81% Positive

Effectiveness

79% Positive

Ingredients

78% Positive

Long-Term Benefits

81% Positive

2701 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 1 out of 5 stars
By Linda on Dec 23, 2025

Does not work.

I applied this medication a week ago and my dog still has fleas alive inviting her. I shampooed her two days after applying the medication with flea killing shampoo

I applied this medication a week ago and my dog still has fleas alive inviting her. I shampooed her two days after applying the medication with flea killing shampoo. Unfortunately, that has not worked. I shampooed her six days later and she still has a problem. When I comb her, I can find no more than one at a time. In the last three weeks, I have combed approximately five fleas off her, yet after all this she still itches. Frontline is not working and I bought two of them so I am disappointed.

Rated 3 out of 5 stars
By Jesse on Jan 5, 2026

Not sure product is performing optmum

We switched to Frontline liquid from chewable for our dogs some years ago due to acquiring our heeler who has seizures and had learned that chewables may be a seisure

We switched to Frontline liquid from chewable for our dogs some years ago due to acquiring our heeler who has seizures and had learned that chewables may be a seisure trigger for some pets. No noticeable change in the seisure patterns since and rather dismayed that the fall of this year we had found multiple ticks on our dog whole using Frontline liquid regularly.

Rated 4 out of 5 stars
By Susan on Jan 8, 2026

Quick delivery!

This time was a bit quirky. I’ve had no problems for the many years of getting frontline plus. This time by the time I saw the email about my next shipment, it

This time was a bit quirky. I’ve had no problems for the many years of getting frontline plus. This time by the time I saw the email about my next shipment, it was already being packed up-in about 4 hours. I didn’t need it for another month but wasn’t given the chance to change the delivery date. Always great service prior to this one incident.

Rated 1 out of 5 stars
By Tamara on Dec 16, 2025

I have not got it yet!

It has not arrived yet today. I have had a battle here, *chatting* with someone , probably no one, . I have chatted with them about 3 times, this package was finally

It has not arrived yet today. I have had a battle here, *chatting* with someone , probably no one, . I have chatted with them about 3 times, this package was finally supposed to arrive today, and it did not. My autoship that was supposed to arrive at my Moms' house today, did not arrive either. This Ontrac is not working for me. I will be calling, to find out the problem,

Rated 1 out of 5 stars
By K on Nov 25, 2025

Defective Formula

I am canceling this auto ship and also will be requesting info for a return and refund for both the dog and cat frontline. Unfortunately frontline does not protect

I am canceling this auto ship and also will be requesting info for a return and refund for both the dog and cat frontline. Unfortunately frontline does not protect from fleas and ticks. Following my previous order and application of frontline, my dog suffered a skin allergy and needed the vet (2.5/3weeks after application of the frontline). The vet stated she had flees which was creating an allergic reaction. I shared I was using frontline and told the application date. The vet explained that Frontline’s formulation no longer works due to flees and ticks having built an immunity to it. She put her on a prescription based formula. I immediately brought my other dog and two cats in that same week and sure enough, they too had flees. The vet stated this is a known issue with Frontline’s formula for years. Adding that vets and Frontline are aware of this! I used frontline years ago with a pet that is now passed and I loved frontline so I was so shocked. Very disappointed in frontline because I truly thought frontline was a trusted company but for this to be a known issue and they continue to market and sell to pet owners is very deceptive! The vet put all my pets on a prescription based formula now that is working perfectly. I did not realize that I was signed up for a subscription to frontline until receiving the lasted package recently. So I not only want to cancel the auto ship but I would like a refund for the defective products as well. Though this is a Frontline issue and I love CHEWY, I am a bit taken back that CHEWY is allowing the sell of a known defective product and hope they look into what their stance should be with backing products on their site to customers.

Rated 2 out of 5 stars
By Joyce on Dec 3, 2025

Better than nothing

Doesn't help much with the flea problem. She even has a flea collar on. She is still fighting the flea. I wish that you would have left her on Trifexis. Her weight

Doesn't help much with the flea problem. She even has a flea collar on. She is still fighting the flea. I wish that you would have left her on Trifexis. Her weight was 58 according to the scale. I still think that it was wrong. Because she was two pounds short of the required 60 pounds, I had to buy something else. I hope to change her back to Trifexis next year.

Rated 1 out of 5 stars
By Kathleen on Nov 29, 2025

It was delivered to the wrong city, wrong address in that city.

I had changed the address on your site after we moved 2 1/2 hours away. When I got notification that my automatic shipment was being sent to the prior address,

I had changed the address on your site after we moved 2 1/2 hours away. When I got notification that my automatic shipment was being sent to the prior address, I called and spoke with someone who said they could intercept the meds. That didn’t happen and they were delivered to the old address. Thankfully, the new folks contacted someone who drove it the 2 1/2 hours to us.

Rated 2 out of 5 stars
By Meagan on Dec 13, 2025

Led to hot spot

First time using this, I usually use Soresto collars when weather starts getting warm and never had any issues, but we were in between seasons so I thought Id try

First time using this, I usually use Soresto collars when weather starts getting warm and never had any issues, but we were in between seasons so I thought Id try this. Did not seem to help and our dog ended up chewing a hot spot for the first time in 5 years. Do not recommend.

Rated 1 out of 5 stars
By Jennifer on Oct 30, 2025

Kills ticks too late to prevent infection and serious illness

After correctly and promptly using this product for three months, I recently noticed two ticks crawling on my dog's legs. Upon further inspection, I found two attached

After correctly and promptly using this product for three months, I recently noticed two ticks crawling on my dog's legs. Upon further inspection, I found two attached ticks. My dog was recently diagnosed with anaplasmosis, which can be transmitted after a tick is attached for 12-24 hours. This product claims to kill attached ticks within 48 hours, but for anaplasmosis and lymes, this is far too late. The bacteria has already been transmitted. I wish I had done more research before I bought this product, and i regret buying an eight month supply! I will not be purchasing this again. It did not protect my pet from infections transmitted by ticks.

Rated 5 out of 5 stars
By Dianne on Jan 8, 2026

Frontline Plus Delivery

This is a good product and, as usual, Chewy packed it carefully and it arrive undamaged and in a timely fashion. It's why we've been Chewy customers for years and

This is a good product and, as usual, Chewy packed it carefully and it arrive undamaged and in a timely fashion. It's why we've been Chewy customers for years and recommend it to our friends.