FRONTLINE PLUS Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply) -

Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs

By Frontline Plus
Rated 3.4442 out of 5 stars

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$70.90Chewy Price
$75.99Chewy Price
$67.36Autoship Price
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About This Item


  • Promotes fast-acting, long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.
  • Purr-fect for cats and kittens ages eight weeks or older weighing 1.5 pounds or more.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • Waterproof protection means your pal can still enjoy their favorite outdoor activities and regular grooming routine.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Cats

#1 Name in Flea and Tick Protection*

FRONTLINE Plus has been trusted by pet parents for over 20 years.** This fast-acting flea and tick protection contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent further infestations, and provide continuous protection for a full month.  

Protect Your Cat Here, There and Everywhere

Fleas and ticks can be found outdoors and indoors, too! That’s why it’s important to keep your cat companion protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

For Cats Old and Young

FRONTLINE Plus for Cats can be used on cats and kittens as young as 8 weeks and weighing 1.5 lbs. lbs. or more.

Options to Fit Your Needs

Available in 3-, 6-, and 8-dose packs.

Formulation Available for Dogs

You can protect your dogs, too, with FRONTLINE Plus for Dogs!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your cat, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your cat with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

Questions & Answers

32 Customer Questions

Is there an expiration date on these treatment packs?
Answer by ChewyAug 29, 2018
This product does not have an expiration date. As long as you keep it at room temperature and sealed in its original packaging, it will remain ready for use.

Will this kill ticks that are already on my cat?
Answer by ChewyApr 18, 2019
Once applied, FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Kills all life stages of ticks (larva, nymph and adult).

the Frontline Gold has a 3rd ingredient that kills the eggs, (pyriproxyfen) but Frontline plus also kills eggs?? so what makes this specific ingredient (pyriproxyfen)better if both products kill the eggs?
Answer by ChewyDec 02, 2020
While Frontline Plus and Frontline Gold treat adult fleas in the exact same way, the addition of pyriproxyfen allows Frontline Gold to kill flea eggs and larvae more effectively than Frontline Plus. Frontline Plus can begin killing these pests 4 hours after application, and Frontline Gold may begin killing them as quickly as 30 minutes after application.

How often should I give my kitten to use this product?
Answer by ChewyOct 14, 2019
One treatment will last 30 days. This treatment should only be used on cats and kittens 8 weeks or older and over 1.5 pounds.

ReviewsWrite a Review

Rated 3.4442 out of 5 stars
1837 Reviews
Would recommend to a friend

1837 Customer Reviews

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Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By Lori on Mar 10, 2023

I never had any problem with this product

I used this product on my cats and kittens when they got old enough .it took care of the fleas .never had they gotten any ticks. But if you get and Infestation of fleas in your house and in your cats first you use the capstar that kills all the adult fleas . Then you put the Frontline on or one of them you choice . I have put the advantage on my cats to not at same time if you going to change your cat flea treatment you have to give them a bath and wait three days that what my vet said. Even if it just a flea collar. So if I had Frontline on them and I want to put advantage on them I'd have to give my cats a bath with soap and water. The vet says wait 3 days. It be best to call your vet before you put so e thing in your cat and you only put one dose on them not two. If the kitten you don't know how much they weigh you need to take your cat to the vet. See if it is right for a kitten . But you only put one tube in the cat 1 a month .. if your not sure call the vet first . I had to have vet put it on my one cat it ran down his side and he licked it .so then I had to wash his mouth out vet said believe it wasn't want I wanted to do but I did it and no my cat didn't like it and after that the vet made me bring him in to get it put in him . Other wise nothing happen to any of them. They are not supposed to lick it . Or get it in there mouths.

Rated 1 out of 5 stars
By Cats on Mar 8, 2023

Cat reaction

One of my cats had an immediate reaction to this product. I have used this before with no problems. Called the company and will return and choose the flea control that Bayer produces. I called the company itself and they had no answers but took the lot number for a report.

Rated 5 out of 5 stars
By HankP on Feb 13, 2023

Non-greasy and no squirmy

Other topical flea/tick treatments have caused temporary skin reactions on my cat. The first time it happened, I was so worried I called animal poison control because my cat was almost literally bouncing off the walls. I was told these products can sometimes cause tingling sensations that freak the cat out. This product has not done that, so that’s a win.

Rated 5 out of 5 stars
By Sacha on Jan 20, 2023

No flea problems ever.

Don't like the greasy spot on kitty's back neck, but the protection works. Itching stops within a short time and I don't get flea bites from petting my cat. Never see any ticks. She is an indoor cat but mingles with the dogs. And on a rare occasion, will run out the door but come back within an hour. So, I never need to worry about her bringing home unwanted bugs while using Frontline. It is a little pricey, but I feel like it is necessary.

Rated 2 out of 5 stars
By Liesl on Jan 23, 2023

Fleas are evolving, but the formula hasn’t!

Bought a 6 month supply at a wholesale retailer and wanted to come here with a warning from my vet. PNW flea populations are growing immunity to this formula because it has been around for so long. Been treating my cats for 3 months and while I do believe it has kept it under relative control and I had yet to see any fleas myself (hence 2 stars instead of 1), both my cats are still covered in miliary dermatitis and the vets just found fleas on both today. I’m not happy at all. Going to switch to Revolution at my vet’s recommendation.

Rated 1 out of 5 stars
By DaisyAnn on Jan 30, 2023

didn't work

This didn't work on my cat. He has really thick fur, but I think we got a good application on his skin. Unfortunately, he still has a lot of fleas. We'll wait a month and try again, but this is disappointing.

Rated 4 out of 5 stars
By Rhonda on Jan 2, 2023

Damaged box

This was in the box where all the heavy stuff was thrown on it. I would recommend for future shipments to put in a small cardboard box so it does not get damaged during shipment. Box was opened but the individual packs were fine.

Rated 5 out of 5 stars
By Ashley on Dec 26, 2022

I have 4 cats, one with a flea allergy

I adopted two outside cats covered in fleas, used this, and within hours most of the fleas were dead. I have 4 cats, one of which has a flea allergy. We’ve been using this medicine for over 5 months now (before we used Revolution) and it seems to be doing the job- no allergy flare up or flea dirt. Would recommend.

Rated 1 out of 5 stars
By Annie on Dec 21, 2022

Have Been Using 3 Months - Doesn’t work

I have 2 indoor cats that I’ve had for 6 years and for some reason this year they both got fleas which they’ve never had. I have been using this on both cats for 3 months and even after this, cleaning, spraying the house, flea baths, etc they have live fleas. Giving cats a bath is not enjoyable I need something that actually works.

Rated 1 out of 5 stars
By Nathan on Feb 21, 2023

Doesnt work

Followed instructions to a T. Waited 24 hours for translocation a week later my cat still has fleas. Number 1 Scam, not number 1 Flea treatment.