Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs

By Frontline
Rated 3.6985 out of 5 stars
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Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply) slide 1 of 13
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Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply) slide 1 of 13

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About This Item

  • Promotes a fast-acting and long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle.
  • Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
  • Simply apply once a month.
  • Designed for a waterproof protection after 24 hours.
Play Video: Learn More About Frontline From Our Team of Experts
Learn More About Frontline From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Cats

#1 Name in Flea and Tick Protection*

FRONTLINE Plus has been trusted by pet parents for over 20 years.** This fast-acting flea and tick protection contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent further infestations, and provide continuous protection for a full month.  

Protect Your Cat Here, There and Everywhere

Fleas and ticks can be found outdoors and indoors, too! That’s why it’s important to keep your cat companion protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

For Cats Old and Young

FRONTLINE Plus for Cats can be used on cats and kittens as young as 8 weeks and weighing 1.5 lbs. lbs. or more.

Options to Fit Your Needs

Available in 3-, 6-, and 8-dose packs.

Formulation Available for Dogs

You can protect your dogs, too, with FRONTLINE Plus for Dogs!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your cat, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your cat with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%.Active Ingredients: Fipronil, (S)-methoprene.Dinotefuran, Fipronil and PyriproxyfenActive Ingredients : Fipronil , (S)-methoprene , Pyriproxyfen.Fipronil: 9.58%, Pyriproxyfen: 11.65%, Glycol Ether:75 - 85%.
Small Pet TypeN/AN/AN/AN/AN/A

Questions & Answers

35 Customer Questions

I bought this Frontline plus for my cats and one weighs 22 lbs and my other cat weighs 30 lbs. will this be sufficient to kill all their fleas? Also, I applied the Frontline plus 2 days ago and I am still seeing alot of active adult fleas on their tails and necks. Is this normal? Thank you.
Answer by ChewyJul 16, 2017
You should only need 1 application, even for larger cats. You should apply the entire contents of the applicator in a single spot directly onto the animal's skin, not to their fur. In a study, Frontline Plus began killing fleas 4 hours after application. Another study showed that within 12 hours, Frontline Plus killed 100% of fleas when applied as directed, however to fully eradicate an infestation, treatment of the environment may also be required.

im confused so do i give my cat all of them or just 1 per month
Answer by ChewySep 03, 2017
This treatment should be used once a month and not reapplied for 30 days.

What’s the difference between Frontline Gold & Frontline Plus? I have two adult cats. One is overweight at 25lbs, one is average weight.
Answer by ChewyApr 01, 2020
FRONTLINE Gold is the latest innovation in flea and tick protection from the maker of FRONTLINE Plus. In addition to having fipronil and (S)-methoprene, they now added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop into adult fleas. Both products require monthly applications and are safe to use on cats and kittens 8 weeks or older and over 1.5 pounds

Is there an expiration date on these treatment packs?
Answer by ChewyAug 29, 2018
This product does not have an expiration date. As long as you keep it at room temperature and sealed in its original packaging, it will remain ready for use.

ReviewsWrite a Review

Rated 3.6985 out of 5 stars
1529 Reviews
Would recommend to a friend

1529 Customer Reviews

Rated 5 out of 5 stars
By Karlitos on May 20, 2022

Works great for fleas and lice

My house cat mingled with some feral cats that I feed and got lice. I took one of the feral cats to get neutered and the Vet said it was polluted with lice, so they gave it a treatment. My cat had been playing with them so I put this between his shoulder blades and he hasn’t been scratching. No fleas and I can’t see or sense any lice. I am going to use the other two months doses on the feral cats that I can pet and give them some relief.

Rated 5 out of 5 stars
By goodnplenty on Apr 26, 2022

Been working for years

I have been using this on my cat for years. As long as I do it every month we have no problems with fleas or ticks. There are lots of cats around here, deer and other wildlife so the tick part is important. I also like that they now have a 8 month one, which I bought, which is cost effective and one less thing to deal with through the year. I also love about Chewy that they have a great customer relations team.

Rated 1 out of 5 stars
By Pbmi on May 6, 2022

Fake product?

I have always relied on frontline when my cats have gotten little “friends” as we call fleas. My indoor cats have not needed flea treatment in years and I had heard good things about Chewy’s prices. This was my first and last frontline purchase from chewy. Product did not work!

Rated 1 out of 5 stars
By catlover on May 9, 2022


I put this on all my cats and absolutely did not kill one flea. I have used in the past and worked well, but this time it did nothing. I am so upset because now I have to wait 30 days and spend more money that I don't have.

Rated 5 out of 5 stars
By Todd on May 4, 2022

Great Company

One of the very few really great companies there are. They always do the right thing for the best customer experience. They are quick, efficient and reliable. A+ all the way around.

Rated 2 out of 5 stars
By Milchkaffee on Apr 7, 2022

Still got ticks embedded in face of cat

Used this last year. We have used Bravecto in the past but it’s more expensive. Maybe tics are getting resistant.. found an embedded tic on my cats cheek. I may bite the bullet and go back to Bravecto. .

Rated 4 out of 5 stars
By Cats on Apr 14, 2022

Jury’s Out

The first application certainly seems to have worked better than the Pet Armour. I am holding my breath and will have to order more rounds but so far, this product is an improvement

Rated 5 out of 5 stars
By Mickeymouse on Apr 1, 2022

Great product

After having a major flea problem this product works great. It took a couple months to start killing all the fleas but he finally cleared them up and have been flea free for months now. It cost but it Works !

Rated 5 out of 5 stars
By Cherrel26 on Apr 3, 2022

Very good protection for cats

We buy Frontline Plus which protects our cat for 6 full months. There has never been any problems with this brand and have not found any fleas on him since we started using it. Very good product

Rated 5 out of 5 stars
By kittypal on Feb 18, 2022

This works for our cat in Maine

Regrettably there are getting to be more and more ticks in Maine. While we never see fleas (no dog or other cats) we have more than our share of wood's edge ticks coming from the grass/woods edges. Once we started using frontline on our last cat the tick issues were reduced. (I wish there was an agent to use on my husband, another tick collector). I like the applicator in the "Plus" version.