Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, slide 1 of 1

Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs

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Help protect your kitty from pests with Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs. This treatment kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks. It’s formulated with two active ingredients—fipronil and (S)-methoprene—to help disrupt the flea life cycle and inhibit future infestations. Plus, it’s designed to be waterproof after 24 hours, fast-acting, and long-lasting—one easy topical application works for 30 days. This treatment is paw-fect for cats weighing over 1.5 pounds.

Key Benefits
  • Promotes a fast-acting and long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle.
  • Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
  • Simply apply once a month.
  • Designed for a waterproof protection after 24 hours.

Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing dogs. Consult with veterinarian before using on sick, medicated or aged animals. Keep cats away from treated dogs for 24 hours or until product has dried. If applied to a dog or ingested by a pet, contact your veterinarian immediately.

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

See all items by Frontline

  • Item Number
  • Usage
  • Lifestage
    Kitten, Adult, Senior
  • Product Form
  • Health Condition
    Fleas, Ticks

Active Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%.

  • Remove Applicator: Lift and remove the plastic tab to expose foil backing. Then peel away the foil. Or use scissors to open
  • Open Applicator: Hold upright with foil side toward you and snap applicator tip
  • Apply FRONTLINE Plus: Part your cat's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal's skin. Do not apply on top of the haircoat. Avoid contact with treated area until dry

Additional Tips

  • Remove the cat's collar
  • Apply as a spot between your cat's shoulder blades in 1 area that can't be licked
  • Avoid touching the wet application spot
  • Wait 24 hours to allow solution to dry before bathing or letting your cat get wet
  • Give each of your cats its own complete dose

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
Cat Weight FRONTLINE Plus for Cats
>1.5 lbs FRONTLINE Plus for Cats (Green Box)

How does FRONTLINE® Plus for Cats work?

FRONTLINE® PLUS for Cats contains the active ingredients fipronil and (S)-methoprene. The dual action protects your cat against fleas and ticks.

FRONTLINE® PLUS for Cats spreads from the single point of application, rapidly covering the entire cat and localizing in the hair, on the surface of the skin and in the sebaceous glands. These glands act as a reservoir, continuously replenishing FRONTLINE® PLUS for Cats onto the skin and hair coat, so it keeps working even if the cat gets wet. Fleas and ticks are killed quickly after coming into contact with a treated cat. Fleas and ticks do not need to bite in order to die.

FRONTLINE® PLUS for Cats also has the additional ingredient (S)-methoprene. This ingredient is an insect growth regulator (IGR) which prevents all flea stages (eggs, larvae, and pupae) from developing

How often do I need to use FRONTLINE® Plus for Cats?

One dose (pipette) of FRONTLINE® Plus for Cats should be applied once per month to protect against fleas and ticks. Year-round application is essential for pets in many parts of the country.

Do I need to use other flea & tick treatments while using FRONTLINE® Plus for Cats?

No, FRONTLINE® Plus for Cats is an effective treatment against fleas and ticks that works for a full month. If applied correctly and on a regular monthly basis, you do not need to use any other treatments while using FRONTLINE® Plus for Cats.

Do I need to treat my cat for fleas and ticks even in colder months?

Yes, although the likelihood of your cat being affected by fleas decreases in the winter months, climates can vary and result in mild winters, favoring the survival of fleas outdoors for much longer. Fleas can also continue to develop indoors in homes thanks to warmer temperatures. Ticks can also be a problem year-round with some species of ticks attempting to acquire a host when temperatures are just above freezing. Therefore, it’s important to keep protecting your cat throughout the year.

My cat doesn’t go outside much, do I still need to treat them for fleas and ticks?

Yes, even indoor-only cats can become exposed to fleas if an untreated pet visits your home or if you or a friend brings in fleas on shoes or clothing.

What are the signs of fleas on my cat?

Apart from visually seeing fleas on your cat or in your home, other signs that your cat might have fleas include increased itching, scratching, licking, nibbling and over-grooming which can lead to damaged hairs or patches of hair loss. You may also see small dark red or black specks on your cat’s skin, bedding or on furniture.

How do cats pick up fleas?

Cats pick up fleas from anywhere untreated cats have been – indoors or outdoors. Fleas on an untreated cat (or other animal host) can lay many eggs. Each female flea can lay up to 50 eggs per day. These eggs fall off into the environment, and over a period of weeks to months, these eggs develop into new adult fleas ready to jump onto your cat.

Why might I see fleas on my cat after treatment?

You are likely seeing NEW fleas on your cat, which are jumping on your cat as it moves through infested areas in and around your home. These fleas will be killed by FRONTLINE® PLUS for Cats before they can reproduce. Depending on the severity of the existing infestation, you may continue to see new fleas jumping on your pet for three months or more. To prevent new infestations, continue to apply FRONTLINE® PLUS for Cats MONTHLY throughout the year.

FRONTLINE® PLUS for Cats kills fleas by overstimulating the flea nervous system, and hyperexcited fleas may move to the top of the haircoat before they die. So, seeing fleas on top of the haircoat after applying FRONTLINE® PLUS for Cats can be an indication that the product is working.

FRONTLINE® PLUS for Cats kills ticks, but after treatment, ticks may still attach to your pet. If you see an attached tick on your cat, it is recommended for the tick to be removed and discarded (please see CDC recommendations on Tick Removal)

What is the best way to remove a flea infestation in my home? Flea infestations are unpleasant for you and your cat, and can take three months or more to resolve, so be patient. Follow these steps to help resolve the problem:

  1. Ensure all pets in your home are treated with an appropriate product, such as FRONTLINE® PLUS for Cats on cats and FRONTLINE® PLUS for Dogs on dogs, at the recommended intervals for at least three consecutive months.
  2. Vacuum more often than usual – ideally daily – and focus on places your cat spends a lot of time, for example, carpets, the floor and furniture.
  3. Regularly wash your cat's bedding in hot water.
  4. Ensure your cat has access to all the same parts of the home that they usually do. Fleas present in those areas will be killed when they hop onto your treated cat.
  5. In some cases, it may be helpful to contact a pest control specialist.

Can my cat get wet right after applying FRONTLINE® Plus for Cats?

Your cat needs to be dry at the time FRONTLINE® Plus for Cats is applied and remain dry 24 hours after application.

Where can I find the expiration date for FRONTLINE® Plus for Cats and how long will it last once I’ve bought it?

FRONTLINE® Plus for Cats has no expiration date.

What should I do before I treat my cat?

Read entire label and enclosed directions before each use.

Can FRONTLINE® PLUS for Cats be used on any breed of cat?

Yes, FRONTLINE® PLUS for Cats can be used on any breed of cat.

My cat is pregnant/lactating. Can I use FRONTLINE® PLUS for Cats during this time?

FRONTLINE® PLUS for Cats is approved for use in pregnant and lactating cats.

I did not see the answer to my questions. Where can I find the additional information?

If you have any additional questions about our FRONTLINE® Plus for Cats, feel free to reach out to the Veterinary Technical Solutions Team anytime at 1-888-637-4251.

About FRONTLINE Plus Cat Flea & Tick Treatment

Trusted for Over 20 Years

Made with two active ingredients, FRONTLINE Plus for Cats kills adult fleas and ticks and prevents new infestations by killing flea eggs and larvae. This fast-acting, long-lasting topical formulation provides protection for a full 30 days.

Product Packaging

Breaks the Flea Life Cycle

FRONTLINE Plus contains fipronil and (S)-methoprene to kill existing adult fleas as well as flea eggs and larvae. After application, FRONTLINE Plus rapidly spreads to cover the entire surface of your cat’s body, localizing in the hair, on the skin and in the oil glands. This helps provide continuous protection for a full month, preventing future infestations if properly applied every month.

From Kittens to Adults

FRONTLINE Plus for Cats comes in three different pack count sizes: choose from 3-count, 6-count and 8-count packages. It is approved for use in felines 8 weeks of age or older who weigh over 1.5 lbs.


How to Apply

Read entire label and directions before each use. Part the cat’s hair above the shoulder blades, at the base of the neck. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the cat’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your cat to ingest this product. Do not use more than one application per cat per month.


FRONTLINE Plus has been trusted by pet parents for over 20 years. It combines two active ingredients to kill existing fleas and ticks and prevent new infestations from developing. The easy-to-apply, topical formula protects for up to 30 days and can be used on pets as young as 8 weeks and over a certain minimum weight. Help your best friend enjoy a pest-free lifestyle year-round with FRONTLINE!


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