Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs
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Help protect your kitty from irritating insects with FRONTLINE Plus For Cat & Kitten Flea & Tick Spot Treatment. This treatment helps kill adult fleas, flea eggs, flea larvae, chewing lice, and ticks. It’s formulated with two active ingredients—fipronil and (S)-methoprene—to help disrupt the flea life cycle and inhibit future infestations. Plus, it’s designed to be waterproof, fast-acting, and long-lasting. This treatment purr-fect for both cats and kittens who are eight weeks old and older, and who weigh 1.5 pounds and over.
Key Benefits- Promotes a fast-acting and long-lasting protection from fleas and ticks.
- Formulated with two active ingredients to help disrupt the flea life cycle.
- Helps kill adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
- Simply apply once a month.
- Designed for a waterproof protection.
Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately.
Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.
Important Information
Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.
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Item Number49535
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UsagePrevention
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BrandMerial, Boehringer Ingelheim
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LifestageKitten, Adult, Senior
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Product FormSolution
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Health ConditionFleas, Ticks
Active Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%.
- Remove Applicator: Lift and remove the plastic tab to expose foil backing. Then peel away the foil. Or use scissors to open
- Open Applicator: Hold upright with foil side toward you and snap applicator tip
- Apply FRONTLINE Plus: Part your cat's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal's skin. Do not apply on top of the haircoat. Avoid contact with treated area until dry
Additional Tips
- Remove the cat's collar
- Apply as a spot between your cat's shoulder blades in 1 area that can't be licked
- Avoid touching the wet application spot
- Wait 24 hours to allow solution to dry before bathing or letting your cat get wet
- Give each of your cats its own complete dose
Frequency of Application
- When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
- FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
- FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
- FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
- FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
- FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
Where is this product sourced from?
We source all our products from manufacturer approved distributors or directly from the manufacturers. Chewy takes pride in ensuring that our furry friends’ wellbeing is always our top priority. We have worked hard to partner with all of the manufactures to deliver 100% authentic products
How does FRONTLINE Plus kill fleas and ticks?
FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.
How long does it take for FRONTLINE Plus to kill fleas?
In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2
Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?
No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.
Why am I seeing more fleas on my pet after applying FRONTLINE Plus?
Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.
After using FRONTLINE Plus, I still see fleas in my home. Why?
The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.
Does FRONTLINE Plus have an expiration date?
No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.
How long after application can my pet be bathed or go swimming?
FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.
Can I use it if my pet is on medication?
Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.
Can I use FRONTLINE Plus if I have already applied another flea and tick control product?
Before using, consult your veterinarian.
Does FRONTLINE Plus kill anything else besides fleas and ticks?
You bet. FRONTLINE Plus also kills chewing lice.
Can FRONTLINE Plus be used on pets other than dogs and cats?
No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.
Can I apply it more than once a month?
Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.
How old does my pet need to be in order to have FRONTLINE Plus applied?
At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.
What is the best number to call regarding any specific product questions?
For any specific product questions, please call Boehringer Ingelheim Animal Health’s customer service line number at 1-888-637-4251.

Keeping Your Pets Protected Against Ticks and Fleas
FRONTLINE Plus will help you protect your pet from irritating fleas and ticks. It is a simple-to-use topical treatment that is easy to apply and provides lasting protection for a full 30 days. This flea and tick protection contains two powerful ingredients to stop fleas and ticks in their tracks and help prevent future flea infestations.


The Flea and Tick Protection Vets Have Trusted for Nearly 20 Years
FRONTLINE Plus is a veterinarian-recommended flea and tick treatment that is both fast-acting and long-lasting. It works to break the flea life cycle and also kills adult ticks that may transmit diseases. It offers waterproof protection as well, so you can rest assured knowing that FRONTLINE Plus has your pets covered with FRONTLINE Plus for Dogs and FRONTLINE Plus for Cats.
Tough Ingredients To Arm Pets as Young as 8 Weeks
FRONTLINE Plus for Dogs is approved for puppies at least 8 weeks old and weighing as little as 5 lbs all the way to senior dogs. And with FRONTLINE Plus for Cats, kittens weighing at least 1.5 pounds can start protection as young as 8 weeks, too. To stop fleas and ticks in their tracks and prevent future flea infestations, FRONTLINE Plus uses two tough ingredients, fipronil and (S)-methoprene. Fipronil kills adult fleas and ticks that come into contact with your pet, while (S)-methoprene works to kill flea eggs and larvae before they can develop.


Tough on Fleas and Ticks, Easy to Apply
Applying FRONTLINE Plus for Dogs and FRONTLINE Plus for Cats is simple and quick.Simply part your pet's hair between the shoulders, place the applicator tip just above the skin, and squeeze directly onto the skin. Avoid contact with the treated area until dry. Read the entire product label before each use. Once applied, FRONTLINE Plus will protect your pet from fleas and ticks for a full 30 days. Monthly application is simple so peace of mind comes easy month after month. As long as FRONTLINE Plus is fighting, you can forget about fleas and ticks.
About FRONTLINE Plus
FRONTLINE Plus is a trusted flea and tick control product that has been recommended by veterinarians for nearly 20 years. This topical flea and tick treatment uses two tough ingredients, fipronil and (S)-methoprene, which have been tested and proven to protect your pet from fleas and ticks and prevent new flea infestations for a full 30 days.

Customer Reviews
74% Recommend
74% of reviewersrecommend this product
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1369 Reviews
Showing 1-10 of 1369 Reviews
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2 new kittens 2 older felines & Fleas
By ManageryMoM on Jan 30, 2021
I have made the decision to have indoor cats after loosing my best friend a Red Cat named Finnick this summer to a Coyote/Bob Cat - broken hearted my 2 older cats, one a Big Hug (overweight.. working on it) Cat & one Feral adopted fluffy kitty from Queens with FIV - these two will never go outside again - making them so sad. So I recently added for fun - 2 kittens to make things interesting for all cats in my household with plans to construct a Catio Adventure Park this spring. Everyone was showing signs of scratching licking (including my husband!!). I ordered Frontline Plus formula to treat all the cats - Treatment was safe and effective - I was skeptical because when my cats were outdoor I have made the decision to have indoor cats after loosing my best friend a Red Cat named Finnick this summer to a Coyote/Bob Cat - broken hearted my 2 older cats, one a Big Hug (overweight.. working on it) Cat & one Feral adopted fluffy kitty from Queens with FIV - these two will never go outside again - making them so sad. So I recently added for fun - 2 kittens to make things interesting for all cats in my household with plans to construct a Catio Adventure Park this spring. Everyone was showing signs of scratching licking (including my husband!!). I ordered Frontline Plus formula to treat all the cats - Treatment was safe and effective - I was skeptical because when my cats were outdoor kitties Flea control with Frontline did not work well. However with everyone Indoors my immune compromised kitty & the two little Tikes stopped itching including my husband!! … more
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Useless. A waste of money. Does not work on adult fleas nor the eggs.
By CosmosLuvr on Jan 27, 2021
I decided to try this for my 4 cats as we have been using a much higher priced rx flea med for the furbies and living on a stricter budget now means we have to make adjustments in where the money goes. Having said that, I absolutely will not buy this ever again. I applied it on all 4 of them on 5 Jan and found fleas on 2 of them today, 22 says later, which of course means they all have fleas now. I’ll check the other 2 in a few minutes but I know what I’m going to find. They’ve been scratching for a couple of days but we’ve had the heat on more frequently and I thought perhaps they were getting dry skin which is why they were scratching. Also, in addition to the actual adult fleas, I found I decided to try this for my 4 cats as we have been using a much higher priced rx flea med for the furbies and living on a stricter budget now means we have to make adjustments in where the money goes. Having said that, I absolutely will not buy this ever again. I applied it on all 4 of them on 5 Jan and found fleas on 2 of them today, 22 says later, which of course means they all have fleas now. I’ll check the other 2 in a few minutes but I know what I’m going to find. They’ve been scratching for a couple of days but we’ve had the heat on more frequently and I thought perhaps they were getting dry skin which is why they were scratching. Also, in addition to the actual adult fleas, I found a couple of colonies of flea eggs on one of our female cats who has light fur. I am SO angry because I HATE fleas!! This is advertised as killing not only the adult fleas but also flea eggs. Nope. Not at all. I’ll go back to the rx med which is $99 for 6 tubes. It’s pricey but it works! I’ll make the monetary changes elsewhere but won’t cut corners on the flea medication ever again. Do yourselves and your cats a huge favor and do not buy this useless product. … more
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Don't buy this
By ChaCha on Feb 4, 2021
I bought fontline for my dog and cat treated them both at the same time and I haven't seen ANY improvement in fact I feel like I see more fleas now than I did before (on them). We don't have carpet, I switched out all the beds upon the treatment, and I also treated the outside of my house... I have gone through this process before with prescription strength flea medication and my animals were flea free for months and I saw immediate relief but with this I see nothing.
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Much Needed Relief For Dear Tully!!
By Cricket on Jan 3, 2021
We care for a feral cat in a rural area surrounded by woods and water. Now that our dear Tully has trusted us enough with more care than just his feeding we can finally provide him with relief from ticks and fleas. Frontline thus far has worked miracles!! In less than 24 hours we noted a HUGE positive change in his behavior (no twitching from flea irritation and no intense scratching and biting at irritated areas....). It is wonderful to be able to give him love and attention without having to worry about pulling off ticks or fleas "jumping"!! Also noted that his "house blankets" are critter free as well.
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Do not waste your money
By 4catsandadog on Feb 4, 2021
This product does not work. I used this for months and months and the fleas would just laugh and multiply. The infestation got really bad where I had to vacuum, mop, clean flea dirt and blood everyday. It was exhausting! Do not waste your money! We finally found something that works, (Act....) and everyone at home is so much happier!
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Simply does not work
By petecool on Jan 29, 2021
We have indoor cats. Receintly we were infested with fleas. We dosed our cats and about a week later we saw no reduction in the flea population. It has been a month and the problem is WORSE. This has never happened in the decades we have cats. Something is very wrong with this product. Do not buy!
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No longer works
By Sarah on Dec 30, 2020
I always used Frontline every month on my 3 indoor cats and my dog. This summer, all of my pets and home became infested with fleas. In addition, we found a tick on our dog. We never miss a dose! I tried every product/treatment type imaginable for our pets and house, but the fleas were out of control. I can't help but wonder if they changed the product in some way?? ~Finally, I got all 4 pets a Seresto collar and the problem was solved in days!!!~
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Don’t use this product
By Goodyearcatguy on Jan 24, 2021
I wish I would have read the many negative reviews I applied this to my cat two weeks ago within 12 hrs he was having seizures and we had to go to the emergency room to fix the issue, he is still somewhat out of it, I should have never stopped using the saresto collars, those I recommend, frontline 0 stars
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Didn't work for us
By Emily on Feb 19, 2021
This was a year for fleas in Oregon. My cats had fleas on them within 24 hours of properly applying the medicine. After consulting with my Vet, she said there are very few OTC flea treatments that work.
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Flea treatment
By Kitty on Feb 1, 2021
Unfortunately we no longer had our cat and had to request to return the Frontline flea treatment. We received an immediate response back that our account was being credited and that we could donate the treatment to a shelter. Thank you Chewy