Frontline Plus Flea & Tick Treatment for Cats & Kittens

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Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on cats. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for cats.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on cats and kittens 8 weeks or older and over 1.5 pounds
  • Kills adult fleas, ticks, chewing lice, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for cats
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths

Additional Details

Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.

Active Ingredients

  • Fipronil 9.8%
  • (S)-methoprene 11.8%

See all items by Frontline

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  • Brand
  • Lifestage
    Kitten, Adult, All Stages


  • Remove Applicator: Lift and remove the plastic tab to expose foil backing. Then peel away the foil. Or use scissors to open
  • Open Applicator: Hold upright with foil side toward you and snap applicator tip
  • Apply FRONTLINE Plus: Part your cat's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal's skin. Do not apply on top of the haircoat. Avoid contact with treated area until dry

Additional Tips

  • Remove the cat's collar
  • Apply as a spot between your cat's shoulder blades in 1 area that can't be licked
  • Avoid touching the wet application spot
  • Wait 24 hours to allow solution to dry before bathing or letting your cat get wet
  • Give each of your cats its own complete dose

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
  1. Frontline Plus Use & Care Instructions


Frequently Asked Questions

How does FRONTLINE Plus kill fleas and ticks?

FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.

How long does it take for FRONTLINE Plus to kill fleas?

In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2

Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?

No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.

Why am I seeing more fleas on my pet after applying FRONTLINE Plus?

Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

After using FRONTLINE Plus, I still see fleas in my home. Why?

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Does FRONTLINE Plus have an expiration date?

No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.

How long after application can my pet be bathed or go swimming?

FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.

Can I use it if my pet is on medication?

Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.

Can I use FRONTLINE Plus if I have already applied another flea and tick control product?

Before using, consult your veterinarian.

Does FRONTLINE Plus kill anything else besides fleas and ticks?

You bet. FRONTLINE Plus also kills chewing lice.

Can FRONTLINE Plus be used on pets other than dogs and cats?

No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.

Can I apply it more than once a month?

Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.

How old does my pet need to be in order to have FRONTLINE Plus applied?

At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.

Customer Reviews

567 reviews 567 Reviews 4 out of 5 Stars

82% Recommend

82% of reviewersrecommend this product

4 / 5

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  • Doesn't work on my cats

    By on

    I used Frontline for years with no problems. Then one of my cats developed a flea allergy. I struggled with trying to keep her flea-free and discovered a different feline-only topical that worked well for her and the others. Unfortunately, it was sold out, so I bought Frontline plus to tide us over, thinking something was better than nothing. Not in this case. Despite my problem child getting daily allergy medication and an application of of Frontline Plus, she groomed most of the hair off her butt, belly and tail head and now has hots spots too. It may work well for other people's pets, but not in my house. I must have bionic fleas.

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  • No Fleas Or Ticks!

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    In 2012 my indoor cat got fleas. We had not had her on any prevention, because we figured she was an indoor cat. After that summer of fleas I have used this product on all of my cats. I've had many foster cats and cats of my own, and since we started using frontline intothousand12 we have not had any fleas or ticks. We will continue to use this product. Price is great here on Chewy, because vets charge a lot more for the same product.

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  • GREAT Item...and it works...!!!

    By on

    I noticed our cat and our 2 dogs were scratching a lot. So I called Chewy and asked the best long lasting flea 'n tick thing to buy .... The young lady I spoke with said Frontline seemed to be the biggest seller right now....so I ordered one for each of the animals...!!! IT WORKS TOO.....No more scratching....!!!!

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  • Does Its Job

    By on

    I like Frontline for prevention, because it works really well. I wish it was a little stronger when it came to killing fleas that may already be on the animals, but other than that I have found it trustworthy in keeping new ones off.

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  • Frontline Plus for Cats

    By on

    Even though I could have bought this locally, you just can't beat the prices, service, or shipping with Chewy. My poor cat has only recently started going outside and that's resulted in her getting fleas and subsequently worms. This Frontline and the Bayer tapeworm pills have gotten her all sorted out and a much happier cat.

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    By on

    It's that time of when fleas start rearing their ugly head around my home, and with four indoor cats starting to scratch more the usual, it's time bring out the big gun. Frontline is what I use. Not right away, but within a day cats not scratching.

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  • Great Stuff

    By on

    This product works really well for my indoor cat. We've got two dogs that are in/out and they inevitably bring fleas in the house. About 2 hours after application, the fleas seemed to have left her. So we're happy. And price is fair.

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  • I hope this works

    By on

    I am hoping that this product will do as advertised. Applied to both cats this morning. Will see how well it works. In the meantime, price for 2 cats for 3 months compared for 2 cats in the vets office for 1 month. I will take this any day !

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  • Works great!

    By on

    My cats have never had fleas, but this product works excellent for keeping them away. I apply it monthly and have never had a problem with fleas. I can't speak for pets that are already infested with fleas, but it works great for prevention.

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  • Great Product

    By on

    Have used this product for years on my dogs. Wanted to get it for the two stray cats who sometimes enter our homes to eat and stay out of the weather. Working great...no fleas or ticks!!

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