On Sale

Frontline Plus Flea & Tick Treatment for Cats & Kittens

  • Was:


  • Price:

    $62.99 FREE 1-2 Day Shipping on this item

  • You Save:

    $7.92 (11%)

In stock
6 treatments
  • 3 treatments
  • 6 treatments
- Quantity +


Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on cats. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for cats.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on cats and kittens 8 weeks or older and over 1.5 pounds
  • Kills adult fleas, ticks, chewing lice, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for cats
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths


Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.

Active Ingredients

  • Fipronil 9.8%
  • (S)-methoprene 11.8%

See all items by Frontline

  • Item Number
  • Lifestage
    Kitten, Adult, All Stages


  • Remove Applicator: Lift and remove the plastic tab to expose foil backing. Then peel away the foil. Or use scissors to open
  • Open Applicator: Hold upright with foil side toward you and snap applicator tip
  • Apply FRONTLINE Plus: Part your cat's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal's skin. Do not apply on top of the haircoat. Avoid contact with treated area until dry

Additional Tips

  • Remove the cat's collar
  • Apply as a spot between your cat's shoulder blades in 1 area that can't be licked
  • Avoid touching the wet application spot
  • Wait 24 hours to allow solution to dry before bathing or letting your cat get wet
  • Give each of your cats its own complete dose

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.

Frequently Asked Questions

How does FRONTLINE Plus kill fleas and ticks?

FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.

How long does it take for FRONTLINE Plus to kill fleas?

In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2

Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?

No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.

Why am I seeing more fleas on my pet after applying FRONTLINE Plus?

Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

After using FRONTLINE Plus, I still see fleas in my home. Why?

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Does FRONTLINE Plus have an expiration date?

No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.

How long after application can my pet be bathed or go swimming?

FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.

Can I use it if my pet is on medication?

Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.

Can I use FRONTLINE Plus if I have already applied another flea and tick control product?

Before using, consult your veterinarian.

Does FRONTLINE Plus kill anything else besides fleas and ticks?

You bet. FRONTLINE Plus also kills chewing lice.

Can FRONTLINE Plus be used on pets other than dogs and cats?

No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.

Can I apply it more than once a month?

Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.

How old does my pet need to be in order to have FRONTLINE Plus applied?

At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.

  1. Frontline Plus Use & Care Instructions

Pet Lovers Also Bought

Customer Reviews

498 reviews 498 Reviews 4 out of 5 Stars

82% Recommend

82% of reviewersrecommend this product

4 / 5
Write a Review

You've Already Reviewed This Item

Showing 1-10 of 498 Reviews

Sort by:
Filter by:
  • Frontline does the deed.

    By on

    I have 2 cats to protect. Purrcy is 9 years old and Abby Lynn is 1. These flea treatments are so expensive that I was looking for the least expensive but also something with a good reputation. And this was recommended frequently on the internet. I protected little Abby (she's already had 2 ticks this summer) and Purrcy who doesn't seem to have a problem even if he isn't protected. He is one grumpy cat so I figure the ticks don't even want to come near him. It seems to work well. It's been 3 weeks and all is well so far. I'm not expecting any problems. I've used it before and it did a very good job. Good Price too.

    You liked it! Something went wrong. Please try again later. Report
  • Frontline Plus

    By on

    The neighborhood cat owners all use Revolution, but this year, we all had issues with it not working. My cats (8) never had a problem with fleas with Revolution. I would put it on as soon as I saw the first sign or any sign of fleas. However, whether it wasn't working or the fleas were stronger, it didn't work this year and all of my cats ended up with fleas and they are indoor cats. So, we used Frontline Plus. So far, so good. I'm hoping this has taken care of the problem. I will use it from now on.

    You liked it! Something went wrong. Please try again later. Report
  • Frontline flea &tick prevention

    By on

    I've never had to use this type of product before,my cats have always stayed inside.Where I live now,I have an enclosed outside space and my youngest furbaby,Bailey has decided he's king of the jungle out there,so my roommate suggested I used a flea and tick repellent and said Frontline is what she used for her cats.So far it's working great and he tolerated it fine,I give it a thumbs up.Also,I love Chewy,the prices,selection of products and fast delivery time is awesome.Thank you!

    You liked it! Something went wrong. Please try again later. Report
  • Does not work, fleas are immune.

    By on

    I have already left a review on Frontline for dogs, and Chewy did refund me, but I want to warn people about the cat version as well. Please talk to your vet about Frontline before purchasing. My vet does not even carry Frontline anymore because fripronil doesn't work on many types of fleas anymore. I found this out the hard way, spending months and months fighting fleas and spending hundreds trying to get rid of them, but not only did Frontline not get rid of the fleas, they seemed to get worse each month. I recommend trying Advantage through Chewy since it has a different ingredient and my vet recommended it over Frontline.

    You liked it! Something went wrong. Please try again later. Report
  • Does work after months of treatment!!

    By on

    I have never had fleas until about 4 months ago when my new kittens got them before you could put flea treatments on them. I have bought frontline plus 4 times now for all my animals with no change. I am enraged that they would sell such an expensive product that does not work even a little. I am going to try advantage II next because I dont know what else to do. I have bathed them and spent hours with a flea comb then treated and stillthey survive! !!! Save yourselves A LOT of money and try something else!! Frontline does not even a little!!

    You liked it! Something went wrong. Please try again later. Report
  • Did Not Work

    By on

    I am sad to report that I had to take my cats to the vet for skin allergies and found out that it is due to fleas. The vet found fleas on my cats even though I have been using Frontline Plus. The vet recommended that I use Revolution or a Seresto Flea Collar. I am trying the collar and paid a fortune for it. I am really discouraged. I like Chewy.com but will not be buying Frontline Plus anymore. Lot No. P41102AX is what I had purchased.

    You liked it! Something went wrong. Please try again later. Report
  • It works very well but not long enough for outdoor cats

    By on

    My outdoor cats were so tormented by fleas, this is the first product that worked. It was so nice to see them relaxing instead of jumping and scratching and biting at the unseen torturers. I wish it would last longer than 2 weeks! But they are indeed outdoor cats who hang out around the barn, the horses, the field, eat varmints, etc., so probably can't expect more from a topical agent.

    You liked it! Something went wrong. Please try again later. Report
  • Best of the best

    By on

    The Flea & Tick treatment I purchased for my cat came exactly when it was supposed to. I spoke to Andres and he told me all I needed to know about the delivery. The treatment is one half the price that I would have to pay at a pet store. I LOVE everything about Chewy!

    You liked it! Something went wrong. Please try again later. Report

    By on

    I put this on my cats and it failed to keep fleas off of them. 3 days after initial treatment they were scratching like crazy. I could see fleas crawling on my poor little tabby's face. She was so uncomfortable. My big guy Jacy was miserable too! This stuff may keep ticks off but it isn't effective for fleas.

    You liked it! Something went wrong. Please try again later. Report
  • Great for preventing flea infestations at the start of flea season

    By on

    I use this on my lovely little cats before flea season starts (when the snow begins to melt). One cat is 7 lbs while the other is 12 lbs. Both were protected against fleas and ticks this year even though they spend 50% of their time outside. No infestations for us!

    You liked it! Something went wrong. Please try again later. Report