Pilocarpine (Generic) Ophthalmic Solution 1%, slide 1 of 1

Pilocarpine (Generic) Ophthalmic Solution 1%, 15-mL

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Pilocarpine is a prescription medication used to treat glaucoma and other, similar conditions of the eye. It works to reduce pressure by increasing the amount of fluid that is drained, helping to relieve uncomfortable symptoms. This safe and effective formula is a topical medication that's administered directly. Veterinarians may use this in the treatment of companion animals. Customers may receive this drug under the names Isopto, Akarpine, Pilocar.

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The primary use of pilocarpine in pets is to treat neurogenic KCS, which is caused by interrupted neurological signaling to the lacrimal glands. In dogs with coinciding dryness of the nasal mucous membranes, pilocarpine will also increase nasal secretions. Oral administration, but not topical ocular administration, increases tear production in dogs.

Possible Side Effects

Call your vet if any of these occur: itching or hives, swelling, trouble breathing, fast, slow, or uneven heartbeat.

Drug & Food Interactions

Always tell your vet about all medications and supplements your pet is taking before using Pilocarpine.


Pilocarpine is contraindicated in pets with a history of hypersensitivity to it or any component of the formulation. Avoid use in dogs with glaucoma secondary to uveitis or lens luxation, as the induction of miosis may lead to blockage of aqueous humor flow through the pupil, thus worsening glaucoma.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs, cats and horses.

NOTE: For Generic Medications, picture displayed may not depict actual product. Generic medications may vary from one order to the next by size, color and shape depending on manufacturer. Please note product may arrive in a Chewy Pharmacy vial.

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  1. Prescribing Information

See all items by Pilocarpine

  • Item Number
  • Generic Name
  • Common Brand Name(s)
    Isopto Carpine, Akarpine, Pilocar
  • For Use With
    Dogs, Cats & Horses
  • Administration Form
  • Product Form
  • Health Condition
  • Drug Type

Active Ingredients: Pilocarpine Hydrochloride 10 mg (1%).

Inactive Ingredients: Hypromellose (2910) 5 mg (0.5%), Boric Acid, Sodium Chloride, Sodium Citrate, Hydrochloric Acid and/or Sodium Hydroxide may be added to adjust pH (3.5 to 5.5) and Water for Injection.

Recommended Dosage

Diagnosis of ocular parasympathetic denervation (cranial nerve III) lesions (extra-label): 1 drop of 0.2% solution applied to the affected eye(s). Neurogenic keratoconjunctivitis sicca (extra-label): 2 drops/20 pounds of a 2% solution in food to be consumed orally every 12 hours. The dose is increased weekly until signs of toxicity occur or until symptoms are controlled. If signs of toxicity (as detailed above) develop, the dosage must be decreased. Primary glaucoma (extra-label): 1 drop in the affected eye(s) every 8 hours. Not recommended for first-line or chronic therapy.

Storage Instructions

Store at temperatures between 68° - 77°F. Protect from freezing. Keep tightly closed.


What is Pilocarpine?

Pilocarpine is an eye solution used to treat glaucoma.

What are the benefits of Pilocarpine?

Relieves eye pressure. Easy to administer.

How is this medication given?

Give Pilocarpine exactly as directed by your veterinarian.

How does this medication work?

Reduces pressure in the eye by increasing the amount of fluid that drains from the eye.

What results can I expect?

Local irritation is reported to resolve after 3 days.

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