Simparica Trio Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box)

By Simparica Trio
Rated 4.4342 out of 5 stars
Prescription Item

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$323.98Chewy Price
$307.78Autoship Price
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Usually arrives in 3-5 days
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Medications ship separately. Delivery times may vary.

Frequently Bought Together

Apoquel (oclacitinib) Tablets for Dogs, 5.4-mg, 1 tablet
Rated 4.6219 out of 5 stars
$2.70Chewy Price

40% Off First Autoship

Total Price: $507.67

About This Item


Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 11.1 and 22 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

About Simparica Trio for Dogs

Go With Simparica Trio

Give your dog triple protection with Simparica Trio. It's the first monthly chewable that provides defense against heartworm disease, fleas & ticks*, roundworms**, and hookworms***.

Triple Protection, Made Simple

Just one Simparica Trio dose does the job of two or three products, protecting against common parasites that can threaten the health of your dog. It is easy to give and can help simplify your routine as you protect your dog every month.

Use Simparica Trio for Puppies

When puppies are exposed to parasites, it can lead to serious health concerns. Make sure to protect your little ones from the start with Simparica Trio. It is demonstrated safe for puppies 8 weeks and older who weigh at least 2.8 pounds.

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.


Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
Prescribing Information.

*Amblyomma americanum, Abylomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhicephalus sanguineus. **Toxocara canis and Toxascaris leonina. ***Ancylostoma caninum and Uncinaria stenocephala.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2021 Zoetis Services LLC. All rights reserved. STR-00337

About Simparica Trio

Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Dogs get all this protection with just one dose of Simparica Trio. Available by prescription only.
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ReviewsWrite a Review

Rated 4.4342 out of 5 stars
304 Ratings
Would recommend to a friend

301 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Doglvr on Sep 20, 2023

Don’t purchase!

I have always purchased Heartguard chews and topical flea/tick control in the past. I decided to try this because our vet suggested it it as an option and because of the convenience to get all the protection in one dose a month. Although it’s very expensive, I thought I was choosing the better option. He vomited 2 months in a row after getting the medication. The third month I decided to make sure he had a base in his stomach thinking just like us humans he needs to have something to help absorb. He kept it down, but then ended up with diarrhea. I will go back to a safer, less expensive treatment for him,

Rated 5 out of 5 stars
By Jacq on Sep 6, 2023

Really works

We tried everything to get rid of our flea epidemic! This worked not only for the dogs but our house and cats are not full of fleas either! The kitties gat Cherestin drops. We had tried several other brands and this one did the trick. Only downside is very expensive. Thank you Chewy for the coupon!

Rated 5 out of 5 stars
By SophiesMom on Aug 26, 2023

Very happy!

I switched Sophie’s meds from another online pharmacy to Chewy. I already have her food and treats on auto order so it just made sense to have her meds as well. I couldn’t believe how fast they came! It took well over a week to get them before and I had the Chewy order in a matter of days.

Rated 5 out of 5 stars
By crossnf on Aug 24, 2023

No side effects

Our 10 year-old 14 lb rat terrier has no side effects from this medication. He used to get a painful reaction to the topical flea preventative which is why we switched. This tablet doesn't bother him at all and he eats it easily on its own. Good product, worth the price.

Rated 5 out of 5 stars
By WendyN on Jul 21, 2023

Great product at a great price!

Simparica Trio is a great product for my dog. She doesn’t like to chew it alone, so I crush it into a powder and mix it in her food. (I don’t think It tastes bad. I think she just has an aversion to medication due to having to take others that don’t taste good.) It works well, though. Tics die quickly if they find her, which they do pretty regularly in New England.

Rated 5 out of 5 stars
By Lulu on Aug 31, 2023

Great product

Great prescription. My mini dachshund takes it every month with no problem. I like this product because it’s 3 in one and it protects my baby. Highly recommend.

Rated 5 out of 5 stars
By Carol on Sep 18, 2023

The best!

So much easier with this one pill. and love Chewy. they make everything so easy for me with auto ship and great reps and pharmacy

Rated 5 out of 5 stars
By Bre on Jul 4, 2023

Order complete

The order was complete, in good condition and easy yo order on the app. However, delivery was delayed quite a bit. The carrier went from the shipping site to near Chicago then to South Carolina and back to Wisconsin! This caused a 6-7 day shipping time. I was expecting only 2-3 days.

Rated 5 out of 5 stars
By Dana on Sep 6, 2023

Best products

The trio is the best for flea, tick and heart worm. I’ve heard both good and bad things about it. I have had NO issues at all!

Rated 1 out of 5 stars
By SadMom on Jun 14, 2023

May Not Be Healthy

Within a week of using my girl started having slight seizures and falling down. Never made a connection. A neighbor, upon hearing of my girls passing asked if any meds changed. I told her I started using Simparica Trio and was informed her dog had exact reaction. Was never warned by vet, who prescribed, that there are warning labels with this med. PLEASE Google before giving to your pet. First dose has no reaction, it’s the second one that triggers these. Unfortunately I’m now stuck with 5 EXPENSIVE doses that I wouldn’t ever pass along to anyone else to use.