Simparica Trio Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box)

By Simparica Trio
Rated 4.5714 out of 5 stars
Prescription Item
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Simparica Trio Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box), 12 Chewable Tablets (12-mos. supply) slide 1 of 7
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Simparica Trio Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box), 12 Chewable Tablets (12-mos. supply) slide 1 of 7

$301.94Chewy Price
$286.84Autoship Price
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About This Item

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 11.1 and 22 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Gold2.8-5.5 lbs3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg PyrantelAdminister orally once a month✓-Click Here
Purple5.6-11.0 lbs6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg PyrantelAdminister orally once a month✓-Click Here
Caramel11.1-22.0 lbs12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg PyrantelAdminister orally once a month✓-Click Here
Teal22.1-44.0 lbs24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg PyrantelAdminister orally once a month✓-Click Here
Green44.1-88.0 lbs48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg PyrantelAdminister orally once a month✓-Click Here
Brown88.1-132.0 lbs72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg PyrantelAdminister orally once a month✓-Click Here

About Simparica Trio for Dogs

Go With Simparica Trio

Give your dog triple protection with Simparica Trio. It's the first monthly chewable that provides defense against heartworm disease, fleas & ticks*, roundworms**, and hookworms***.

Triple Protection, Made Simple

Just one Simparica Trio dose does the job of two or three products, protecting against common parasites that can threaten the health of your dog. It is easy to give and can help simplify your routine as you protect your dog every month.

Use Simparica Trio for Puppies

When puppies are exposed to parasites, it can lead to serious health concerns. Make sure to protect your little ones from the start with Simparica Trio. It is demonstrated safe for puppies 8 weeks and older who weigh at least 2.8 pounds.

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.


Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
Prescribing Information.

*Amblyomma americanum, Abylomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhicephalus sanguineus. **Toxocara canis and Toxascaris leonina. ***Ancylostoma caninum and Uncinaria stenocephala.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2021 Zoetis Services LLC. All rights reserved. STR-00337

About Simparica Trio

Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Dogs get all this protection with just one dose of Simparica Trio. Available by prescription only.
Shop Simparica Trio

ReviewsWrite a Review

Rated 4.5714 out of 5 stars
168 Reviews
Would recommend to a friend

168 Customer Reviews

Rated 1 out of 5 stars
By Joyce on Sep 21, 2022


10 days after giving my 2 dogs this supposed flea killer, I find 10+ LIVE FLEAS on my dogs!!!! I was using this confident that I would not have to worry about fleas in my home as I have cats as well who do not go outside and therefore I do not flea treat them as I would need another mortgage to do that on a monthly basis. THIS PRODUCT DOES NOT WORK!!!!! I have had to give them a topical, spray them and everywhere they go, plus give them Capstar. THIS VERY EXPENSIVE MEDICINE DOES NOT WORK!!!!!!

Rated 3 out of 5 stars
By LJinVA on Jul 30, 2022

Product Will Expire Before Able to Be Used!

I am very disappointed. I ordered a 12 month supply and looked at the expiration dates of the two boxes. Both boxes will expire in January 2023. Douglas the dachshund took his first Simpirica Trio this month (July) - single dose from vet to see how he did with it. Today I opened the box from Chewy - I didn't want to open it if I had to send the order back to Chewy because he didn't tolerate the medicine.... Too expensive to not be able to use!!!!! Now I see that 6 of the doses will be expired before the box will even be opened. Not acceptable. 12 month supply should not be sold if product cannot be provided appropriately.

Rated 4 out of 5 stars
By Gwooms on Aug 13, 2022

As expensive as effective!

Very pleased with the efficacy of the Simparica Trio but may not be affordable by many, especially by those on a fixed income, like myself. Recommend asking your vet if there are rebates available, and checking for further discounts like automatic re-order etc. to help manage the overall cost.

Rated 5 out of 5 stars
By erinne on Jul 8, 2022

Seems to work fine

We've been giving this to our puppy for a few months now, ever since she got her first tick at about 3 months. She outgrew the weight limit midway through the box and our vet advised us to give her 2 tablets per month to finish up the box, then buy the next size up. The only side effect we've noticed is diarrhea which is never good but at least it doesn't last too long. She also eats the tablets willingly, with or without food. I wish this wasn't so expensive, but glad it's protecting my dog with minimal side effects.

Rated 5 out of 5 stars
By Maria on Jun 28, 2022

Simple & Effective

I have tried all sorts of prevantitve products for my older pet over the years (Bravecto, Heartgard+, preventative shots from the vet, etc). All worked well, but this is the first treatment that is an all-in-one preventative for intestinal parasites and fleas/ticks that I've tried. I was a little weary about the initial price for both of my dogs, but I am happy I made the purchase. A single pill and total coverage is so simple and it works well with my pet. She liked the tablet well enough to take it completely by itself and its been a month with no side effects.

Rated 5 out of 5 stars
By Lynn on Sep 18, 2022

Stop pestering me with emails!

I was satisfied with my service and the product. I am not satisfied With these continuing emails to my inbox. I have asked to be unsubscribed to no avail.

Rated 5 out of 5 stars
By Bodie on Jul 2, 2022

A big help for a super pet!

We are very pleased with how easy it was to break apart the tablet and put it into Bodie's food. He ate it right up, no prob! We also like that this product was first recommended by our great vet...and very pleased that she did not hesitate to approve having Chewy fulfill the prescription, which Chewy did at a much appreciated discount. Chewy, you are the best! We are hopeful this medicine proves to be the best for Bodie, too!

Rated 5 out of 5 stars
By Sallie on Sep 11, 2022

Chewy is great

I switched to chewy for Simpirica supply. They contacted my vet and were so quick in their response I will continue to use chewy for food and medications.

Rated 5 out of 5 stars
By Svenzky on Jul 17, 2022

Simparica Chewable

Recieved very quickly, Chewy reached out to our veterinarian of choice who must have promptly given a prescription for this and was sent out quickly. Our pup didn't like the hard pill but after a couple tries took it and had 0 reaction from it and has had no ticks since. Happy with results after 1 month.

Rated 1 out of 5 stars
By DaisysMom on Jun 24, 2022

Gave my dog tremors

My 12yr old, 14 lb Chiweenie has been on Simparica Trio for 3 months and she has developed tremors. This medication is known to cause neurological defects, and my dog obviously is one of the dogs affected. With every dose, her tremors get worse. Now she's practically falling over. There have been no other additions of medications or changes in her diet, the Simparica Trio is at fault. Hardly worth the protection from fleas and ticks and heartworm when your dog has tremors that are making her fall over. I plan to call Chewy and I hope they will be reasonable and give me my money back, at least a partial refund would be nice. Especially since now I have to buy a special separate heartworm tablet and also a flea and tick medication, I think I'm going to go with the topical flea and tick medication this time.