Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle

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At a Glance

  • Itch & Redness Remedy
  • Skin & Coat Health
  • All Lifestages
  • All Breeds
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$16.99 Autoship Price
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$16.99 Chewy Price
($8.50 /fl oz)
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$18.99 List Price
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About This Item

Details

  • Gentle, enzymatic approach to provide natural and effective first aid care for wounds, cuts, hot spots and even mild skin infections.
  • LP3 Enzyme System reacts with the infectious pus and debris to form its antimicrobial properties. Even without antibiotics, this spray is effective against hot spots, wet eczema, pyoderma, Staphylococcus, MRSA, Epidermophyton (ringworm), and more.
  • The enzymes in Zymox install a natural protective topical barrier that creates an active residual effect that kills bacteria, fungus and viruses.
  • Hydrocortisone is included to reduce swelling and itch relief, resulting in a soothing treatment for your pet.
  • Made in the USA.

Ingredients

Instructions

Learn More About Zymox From Our Team of Experts

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Questions & Answers

17 Customer Questions

Is it safe for a dog if they accidentally lick it?

Answer by Chewy • Jan 19, 2019
This spray is safe, gentle and non-toxic and worry-free if a pet licks application site.

Is this safe to use on/in my dogs ears?

Answer by Chewy • Aug 28, 2017
This spray is for external use only.

It’s is effective for dermatitis in cats?

Answer by Chewy • Mar 12, 2019
This product will relieve dermatitis by reducing the swelling and soothing the affected area.

Is this spray safe for sensitive areas like stomach and genitals for a male puppy?

Answer by Chewy • Sep 29, 2019
This spray is safe to apply to sensitive areas.
Reviews
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4.5
Rated 4.5 out of 5 stars
508 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

83% Positive

Ease of Use

91% Positive

Effectiveness

86% Positive

Safety

80% Positive

271 Customer Reviews

Rated 5 out of 5 stars
By Melissa on Aug 11, 2025

Zymox Hydrocortisone

Really helped keep the itching and excessive paw licking down. My poor black lab has had a tough time this year with allergies. He licked his paws so much they were

Really helped keep the itching and excessive paw licking down. My poor black lab has had a tough time this year with allergies. He licked his paws so much they were bare and sore. I sprayed Zymox 3 times on each paw and distracted him for 15 minutes or so and then the Zymox took over. He was more at ease and didn't want to lick anymore. I used twice a day for a few weeks, and his fur is finally starting to grow back on his paws. I have had really good luck with Zymox products.

Rated 3 out of 5 stars
By Diane on Aug 10, 2025

Good Brand, but didn't work for what I needed.

I love this brand and have used it for other issues in the past. Unfortunately, this did not work well for my Labradors itchy paws. She has allergies and we've tried

I love this brand and have used it for other issues in the past. Unfortunately, this did not work well for my Labradors itchy paws. She has allergies and we've tried everything. Unfortunately, lavette shots have worked, but we're off and a couple weeks and at a couple hundred dollars a shot, we can't swing that. I did find alternative pads from a different brand that seemed to work better. This may work well for your dog since it is a good brand.

Rated 5 out of 5 stars
By Tracey on Sep 4, 2025

So good, I must share!!

My Frenchie has struggled with hot spots: loss of fur, broken skin and continuous itching. After 1 week of using this topical treatment, the itching stopped!! His

My Frenchie has struggled with hot spots: loss of fur, broken skin and continuous itching. After 1 week of using this topical treatment, the itching stopped!! His skin is smooth! And I am not being kept awake at night with constant itching!

Rated 3 out of 5 stars
By Olivia on Jan 8, 2026

Ease of use, pleasant scent, well tolerated by Tigger.

Product left a greasy residue matting Tigger’s coat.

Product left a greasy residue matting Tigger’s coat.

Rated 4 out of 5 stars
By Patsy on Jul 11, 2025

good product!

the Zymox topical spray works pretty good! our dog's hot spots had grown and were now bleeding when she was out running/walking/stretching. this seems to be shrinking

the Zymox topical spray works pretty good! our dog's hot spots had grown and were now bleeding when she was out running/walking/stretching. this seems to be shrinking them some and healing them. we were skeptic at first but happy with the product now.

Rated 5 out of 5 stars
By Linda on Jul 20, 2025

The Zymox seemed to quickly relieve Jonesy's obsessive liking & scratching.

It is non-greasy, & seems to bring relief. I brush his fur in the opposite direction (he actually loves this) Then, I spritz the Zymox close to his skin. I rub it

It is non-greasy, & seems to bring relief. I brush his fur in the opposite direction (he actually loves this) Then, I spritz the Zymox close to his skin. I rub it in with my hands.

Rated 5 out of 5 stars
By JULIE on Nov 13, 2025

It works stains white fur

Kept cat from continuing to constantly scratch area on neck.

Kept cat from continuing to constantly scratch area on neck.

Rated 1 out of 5 stars
By Shelly on Jul 17, 2025

Damaged product

Item arrived lid was not tightened, leaked out of unsealed plastic bag. Totally empty.

Item arrived lid was not tightened, leaked out of unsealed plastic bag. Totally empty.

Rated 5 out of 5 stars
By Adriana on Jun 14, 2025

Works

Bella suffers from bad allergies this product helps so well that i always have it handy. Thanks for a good product

Bella suffers from bad allergies this product helps so well that i always have it handy. Thanks for a good product

Rated 5 out of 5 stars
By Snow on Jun 25, 2025

Topical Spray

This topical spray is really helping with my dog's seasonal allergies. Good stuff!

This topical spray is really helping with my dog's seasonal allergies. Good stuff!