Advantage II Flea Spot Treatment for Cats, over 9 lbs

By Advantage II
Rated 4.3432 out of 5 stars
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Advantage II Flea Spot Treatment for Cats, over 9 lbs, 2 Doses (2-mos. supply) slide 1 of 12
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Advantage II Flea Spot Treatment for Cats, over 9 lbs, 2 Doses (2-mos. supply) slide 1 of 12

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About This Item

  • Veterinarian-recommended treatment kills all life stages of fleas on kittens and cats 8 weeks or older and weighing over 9 pounds.
  • Begins working within 12 hours to kill fleas on contact.
  • Kills eggs, larvae and adult fleas to break the life-cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing.
  • Convenient, monthly topical application contains imidacloprid and pyriproxyfen; available in packs of 2, 4 or 6 treatments.
Play Video: Learn More About Advantage II From Our Team of Experts
Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Cat

Experience the Benefits of Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended topical formula works to kill adult fleas as well as flea larvae and eggs, so your cat can focus on you. It only needs to be applied once a month and is for cats and kittens 8 weeks of age or older.

Why Choose Advantage II?

Advantage II is waterproof, fragrance-free and kills fleas directly through contact. That means pesky fleas dont have to bite to perish. It kills fleas within 12 hours of the first application and can protect against further infestation for up to a month. Best of all, with Advantage II, you can stop multiple flea life stages, to effectively break the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas. The first active ingredient kills adult fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Cat?

Whether your cat is a winter sunspot-stealer or a summer backyard explorer, an sunseeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your cat, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Cats of All Sizes


2-5 pounds


5-9 pounds


Over 9 pounds

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with effective flea prevention that lasts all month.
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Top IngredientsActive Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Fipronil + (s)-MethopreneN/A
Small Pet TypeN/AN/AFerretN/AN/A

Questions & Answers

34 Customer Questions

How many treatments in box?
Answer by ChewyJun 03, 2021
This product is available in single doses, 2, 4 or 6 dose treatment boxes.

Do the fleas haveto bite my cat to die or do they die on contact
Answer by ChewyDec 06, 2021
This treatment is specifically formulated to kill all life stages of fleas on contact with no painful biting required.

Since the product is applied to your cats neck, what about the fleas on the cats belly will they move to the neck?
Answer by ChewySep 19, 2017
The active ingredients of Advantage II work to attack the fleas, no matter where they're located on your cat.

Do I have to treat for fleas all year, I live in TN?
Answer by ChewyAug 26, 2017
One convenient application of Advantage II cat flea treatment keeps working for 1 month. If your cat still has fleas after the 1 month, we'd recommend treatment for another month until the fleas are gone.

ReviewsWrite a Review

Rated 4.3432 out of 5 stars
2308 Reviews
Would recommend to a friend

2308 Customer Reviews

Rated 1 out of 5 stars
By CRae on Jun 1, 2022

Does not stop ticks. Doesn’t even slow them down.

I had hoped something might have changed from last year, it has not. This absolutely DOES NOT WORK for ticks. Every single day I’m pulling 2-6 ticks off my cat. And they have bitten and are still very much alive. This just has zero affect on them. This really is unfortunate, because with all the scary products out there you just never know what you can use on your cat that won’t cause health issues. This was the last topical treatment I trusted wouldn’t hurt him. Now what do I do?

Rated 5 out of 5 stars
By Nancy on May 26, 2022

Great Item, Stops Fleas, Stops Scratching!

Chewy has a great selection, great prices and sales. Their customer service is fast/quick. They care about all their customers and their responses, good and bad. They make sure all are happy and if a customer is unhappy they reach out to them, and from what I have seen, refund their money and direct the customer to donate the item to an animal charity of their choice! How can anyone do better? Faithful Customer! Nancy Pashkoff

Rated 1 out of 5 stars
By Eleven on Jun 13, 2022

Doesn't do anything for fleas

I got this for my cat who who a few fleas on him. I put it on May 29th and i just picked off 30+ fleas from him. I am so sad this didn't work cause my cat was suffering for weeks all because i thought this would help him. I love chewy but this product sucks.

Rated 5 out of 5 stars
By Tybee on Jun 1, 2022

Great Product

I have 5 indoor cats and one dog. Because the dog goes outside, I take no chances with the possibility of fleas and apply this product monthly to the cats. Never have a problem with fleas on the cats and no adverse reaction to the treatment although 4 of my 5 cats are over 10 years old.

Rated 1 out of 5 stars
By colts321 on Jun 4, 2022

Advantage flea medicine

Very disappointed after buying this again from Chewy I don’t no if they are selling expired medicine. Didn’t work!! I never had any problems with outside buying from here. This isn’t exactly cheap & should of worked. Very disappointed

Rated 5 out of 5 stars
By Nancy on May 25, 2022

Advantage II Flea Spot Treatment

We have used this treatment for many years now. Our cat Murray, after treatment, goes about his day with no adverse effects from the drops. The drops work well, and I can usually wait a month & a half before re-treatment, instead of a month. The applicators are neat and tidy, very convenient. Chewy offers different quantity options when purchasing, which I was very pleased about. Thank you Chewy.

Rated 4 out of 5 stars
By Madelon on Jun 2, 2022

Advantage flea’s gone

I have been using this anti flea medication for my two pet felines for years. They never like the application of Advantage but I sure do. It curtailed the flea infestation dramatically.

Rated 5 out of 5 stars
By David on Jun 6, 2022

Great Product!

I use this in my elderly cat and it has worked very well for us so far. Haven’t seen any kind of pest on him, though he is mostly inside with some supervised outside time.

Rated 5 out of 5 stars
By Saeki on Mar 29, 2022

it worked for me

I have a senior cat and she has always had sensitive skin. I have used other top of the line flea drops but in the end would irritate her skin. I decided to try this one mainly because it was just for fleas, the other drops would kill ticks and lice etc and Maybe the chemicals where just to harsh. Well she is a inside cat, and I don’t live in tick country so I just wanted flea control. Well I applied it, put a white cloth down in her bed, the next day there was a lot of dead fleas and she’s not having a bad reaction. Win win for me and her.

Rated 5 out of 5 stars
By Catcommunity on May 27, 2022

Very affordable

We have lots of stray cats that hang out in our yard plus our own. The bundle pack I purchased was very affordable. Now I don't mind when the cats sneak in to get a break from the heat.