Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs

By Frontline Plus
Rated 3.4205 out of 5 stars


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$25.19Chewy Price
$44.99Chewy Price
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  • Save 5% on all future Autoship orders
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About This Item


  • Promotes fast-acting, long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.
  • Purr-fect for cats and kittens ages eight weeks or older weighing 1.5 pounds or more.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • Waterproof protection means your pal can still enjoy their favorite outdoor activities and regular grooming routine.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

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About FRONTLINE Plus for Cats

#1 Name in Flea and Tick Protection*

FRONTLINE Plus has been trusted by pet parents for over 20 years.** This fast-acting flea and tick protection contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent further infestations, and provide continuous protection for a full month.  

Protect Your Cat Here, There and Everywhere

Fleas and ticks can be found outdoors and indoors, too! That’s why it’s important to keep your cat companion protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

For Cats Old and Young

FRONTLINE Plus for Cats can be used on cats and kittens as young as 8 weeks and weighing 1.5 lbs. lbs. or more.

Options to Fit Your Needs

Available in 3-, 6-, and 8-dose packs.

Formulation Available for Dogs

You can protect your dogs, too, with FRONTLINE Plus for Dogs!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your cat, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your cat with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

Shop Frontline

* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%.Dinotefuran, Fipronil and PyriproxyfenActive Ingredients: Fipronil 9.8%, (S)-Methoprene 11.8%.Active Ingredient s: Fipronil: 9.70%Active Ingredients: Fipronil, (S)-methoprene.
LifestageKitten, Adult, SeniorKitten, Adult, SeniorAdultKitten, AdultKitten, Adult, Senior

Questions & Answers

33 Customer Questions

Is there an expiration date on these treatment packs?
Answer by ChewyAug 29, 2018
This product does not have an expiration date. As long as you keep it at room temperature and sealed in its original packaging, it will remain ready for use.

the Frontline Gold has a 3rd ingredient that kills the eggs, (pyriproxyfen) but Frontline plus also kills eggs?? so what makes this specific ingredient (pyriproxyfen)better if both products kill the eggs?
Answer by ChewyDec 02, 2020
While Frontline Plus and Frontline Gold treat adult fleas in the exact same way, the addition of pyriproxyfen allows Frontline Gold to kill flea eggs and larvae more effectively than Frontline Plus. Frontline Plus can begin killing these pests 4 hours after application, and Frontline Gold may begin killing them as quickly as 30 minutes after application.

Will this kill ticks that are already on my cat?
Answer by ChewyApr 18, 2019
Once applied, FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Kills all life stages of ticks (larva, nymph and adult).

How often should I give my kitten to use this product?
Answer by ChewyOct 14, 2019
One treatment will last 30 days. This treatment should only be used on cats and kittens 8 weeks or older and over 1.5 pounds.

ReviewsWrite a Review

Rated 3.4205 out of 5 stars
1988 Ratings
Would recommend to a friend

1969 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Rebecca on Nov 8, 2023

Was not delighted.

We were originally ordering "Pet Amore" but we must have clicked on the Front Line by mistake. When we received it we decided what the heck let's try it out. we were very disappointed in its efficacy. We had to use all six treatments provided for our two kitties in only one month's time. It did not work well at all the kitties were scratching after a week to a week and a half. We almost had a flea infestation but avoided it by spraying for fleas & ticks and vacuuming every day for a week straight. Sorry just didn't like it. Disappointed in Massachusetts.

Rated 1 out of 5 stars
By Rachel on Nov 14, 2023

Sad waste of money, fleas uneffected

Couldn’t afford brevecto due to our multiple cat household, so we purchased this in the hopes of at least some reprieve for our cats. This product did nothing. Just combed my cat and immediately picked up several very healthy looking fleas. Applied this to her 10 days ago. That’s been the only thing that has helped. Flea combs and a jar of soapy water. Don’t waste your money. You won’t be satisfied and your cat most certainly will get zero relief from fleas. Such a bummer

Rated 1 out of 5 stars
By Gina on Oct 31, 2023

This was the kind I have been using on my cats for years. It worked great, but however, the last 4 times hasn’t worked on fleas at all! Still working on ticks for the most part. What’s going on??? Watering it down too much to keep their supply fees down ,I guess. The cats have been scratching and I have found live fleas crawling on me!!!! I have multiple cats (9), that are In And out throughout the day. I am so disappointed and upset. I am having to find another brand. It’s frustrating because they are all so expensive but I cannot have fleas!!!! Whatever you did to cut costs… stop it! Your product isn’t working anymore.

Rated 1 out of 5 stars
By Teresa on Oct 19, 2023

This Chewy item did not work at all.

I have been using this flea treatment on my 2 outside cats for 1-1/2 years now and I have never had a problem with it until this particular order from Chewy. I read the reviews but since it has always worked I ordered it from Chewy this time. I used it on my 2 cats recently and one cat has come home covered in ticks 2 of the last 3 days. My 2nd cat who never has fleas was covered in fleas today. I don't know what the difference is with this item compared to where I have purchased it in the past but I will no longer buy it from Chewy. I now have 4 more doses that I don't even want to use anymore.

Rated 5 out of 5 stars
By Christina on Oct 25, 2023

🚫 ticks!

I have four outdoor/indoor cats. Frontline eliminates those disgusting parasites from my kitty cats and I don't have to busy myself with picking them off. With Frontline, the ticks don't even attach. I have never had issues with lice, fleas, or anything else and that must be thanks to Frontline because we do have our fair share of wild animals around these parts.

Rated 5 out of 5 stars
By Susan on Nov 19, 2023

Frontline Plus is still 100% effective in my area

My small animal veterinarian and I agree that it is not good strategy to prematurely develop resistance to next generation products. I will also say Advantage products have never been successful for me and I don’t think there has been adequate testing on edibles.

Rated 1 out of 5 stars
By Lorraine on Oct 29, 2023

Doesn't Work Anymore

I've been using this product monthly on my cats for years and have never had a problem, but this time around it didn't work at all. My cats now have fleas and one of them came in with a tick attached to his neck. I'm going to try the Frontline Gold and hope for the best.

Rated 5 out of 5 stars
By RainLady on Oct 1, 2023

Frontline Works!

We have a cat that wandered up as a feral about a year ago. With time she has warmed up and become a wonderful pet. Because she was a feral, we were not sure if she was allergic to flea meds, given she most likely never had any before. Frontline has been a wonderful way to test her acceptance to flea meds and has worked very well. Did not need to go through a vet to do it. Thanks, Chewy!

Rated 5 out of 5 stars
By Em on Aug 17, 2023

Love Chewy and keeping my cats safe & healthy

This product frontline we use for all five of our cats. Our cats are indoors but we live in the country so fleas can get inside our home just by jumping on us and coming in doors. Frontline is a non prescription preventative for our cats. It costs less that prescription treatments yet prevents fleas from getting on our cats or trying to bite them. Our cats are kept safe this way and we love chewy for offering this option for our indoor cats. We had once had an infestation of fleas when we first moved to the country and since treating them with this we have had no further problems.

Rated 5 out of 5 stars
By Kathleen on Oct 14, 2023

Worked as advertised

It's been two weeks and my cat and my house are flea-free. Saw more fleas right after using Frontline, was forewarned, but they're gone now. My cat has a tiny spot between her shoulders with no hair but the skin isn't irritated. She isn't scratching now and seems more comfortable. Thank goodness!